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Protein

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Gene

HSD3B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta5-steroid precursors to 3-oxo-Delta4-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD+ as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.13 µM for dehydroepiandrosterone (in the presence of NAD+)1 Publication
  2. KM=0.33 µM for pregnenolone (in the presence of NAD+)1 Publication
  3. KM=2.1 µM for dihydrotestosterone (in the presence of NADH)1 Publication
  1. Vmax=0.93 nmol/min/mg enzyme for dehydroepiandrosterone oxidation in the presence of NAD+1 Publication
  2. Vmax=2.43 nmol/min/mg enzyme for pregnenolone oxidation in the presence of NAD+1 Publication
  3. Vmax=14.12 nmol/min/mg enzyme for dihydrotestosterone reduction in the presence of NADH1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Steroid hormone biosynthesis

This protein is involved in Steroid hormone biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Steroid hormone biosynthesis.

Pathwayi: Steroid metabolism

This protein is involved in Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in Steroid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei155NAD or NADPBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei159Proton donorBy similarity1
Binding sitei159NAD or NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 15NAD or NADPBy similarity6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Steroidogenesis
LigandNAD, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS08829-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.1.1.145 2681
5.3.3.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193048 Androgen biosynthesis
R-HSA-193993 Mineralocorticoid biosynthesis
R-HSA-194002 Glucocorticoid biosynthesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P14060

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001297

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Alternative name(s):
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I1 Publication
Short name:
3-beta-HSD I
3-beta-hydroxy-5-ene steroid dehydrogenase1 Publication
3-beta-hydroxy-Delta(5)-steroid dehydrogenase1 Publication (EC:1.1.1.1451 Publication)
3-beta-hydroxysteroid 3-dehydrogenase1 Publication (EC:1.1.1.2701 Publication)
Delta-5-3-ketosteroid isomerase
Dihydrotestosterone oxidoreductase (EC:1.1.1.2101 Publication)
Steroid Delta-isomerase1 Publication (EC:5.3.3.11 Publication)
Trophoblast antigen FDO161G1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSD3B1Imported
Synonyms:3BH, HSDB3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000203857.9

Human Gene Nomenclature Database

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HGNCi
HGNC:5217 HSD3B1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
109715 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P14060

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei288 – 308HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3283

Open Targets

More...
OpenTargetsi
ENSG00000203857

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29486

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1958

Drug and drug target database

More...
DrugBanki
DB01536 4-Androstenedione
DB00157 NADH
DB01108 Trilostane

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HSD3B1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
112767

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000877742 – 3733 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1Add BLAST372

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P14060

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14060

PeptideAtlas

More...
PeptideAtlasi
P14060

PRoteomics IDEntifications database

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PRIDEi
P14060

ProteomicsDB human proteome resource

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ProteomicsDBi
53017

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P14060

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P14060

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta and skin (PubMed:1401999). Predominantly expressed in mammary gland tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000203857 Expressed in 89 organ(s), highest expression level in chorionic villus

CleanEx database of gene expression profiles

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CleanExi
HS_HSD3B1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P14060 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P14060 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043261
HPA043264
HPA044028

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109516, 1 interactor

Protein interaction database and analysis system

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IntActi
P14060, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000358421

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P14060

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P14060

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 3-beta-HSD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1430 Eukaryota
COG0451 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161374

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000167989

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000014

KEGG Orthology (KO)

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KOi
K00070

Identification of Orthologs from Complete Genome Data

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OMAi
HIVTLSN

Database of Orthologous Groups

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OrthoDBi
930591at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P14060

TreeFam database of animal gene trees

More...
TreeFami
TF343138

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002225 3Beta_OHSteriod_DH/Estase
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01073 3Beta_HSD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14060-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGWSCLVTG AGGFLGQRII RLLVKEKELK EIRVLDKAFG PELREEFSKL
60 70 80 90 100
QNKTKLTVLE GDILDEPFLK RACQDVSVII HTACIIDVFG VTHRESIMNV
110 120 130 140 150
NVKGTQLLLE ACVQASVPVF IYTSSIEVAG PNSYKEIIQN GHEEEPLENT
160 170 180 190 200
WPAPYPHSKK LAEKAVLAAN GWNLKNGGTL YTCALRPMYI YGEGSRFLSA
210 220 230 240 250
SINEALNNNG ILSSVGKFST VNPVYVGNVA WAHILALRAL QDPKKAPSIR
260 270 280 290 300
GQFYYISDDT PHQSYDNLNY TLSKEFGLRL DSRWSFPLSL MYWIGFLLEI
310 320 330 340 350
VSFLLRPIYT YRPPFNRHIV TLSNSVFTFS YKKAQRDLAY KPLYSWEEAK
360 370
QKTVEWVGSL VDRHKETLKS KTQ
Length:373
Mass (Da):42,252
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C76616E7EA7433A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRN7E9PRN7_HUMAN
3 beta-hydroxysteroid dehydrogenase...
HSD3B1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36001 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04809654T → I. Corresponds to variant dbSNP:rs3088283Ensembl.1
Natural variantiVAR_04809771R → I. Corresponds to variant dbSNP:rs4986952Ensembl.1
Natural variantiVAR_01417479I → V1 PublicationCorresponds to variant dbSNP:rs6201Ensembl.1
Natural variantiVAR_04809890G → S. Corresponds to variant dbSNP:rs6684974Ensembl.1
Natural variantiVAR_014175286F → L1 PublicationCorresponds to variant dbSNP:rs6205Ensembl.1
Natural variantiVAR_000005367T → N2 PublicationsCorresponds to variant dbSNP:rs1047303Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M27137 mRNA Translation: AAA36015.1
M28392, M28162, M28391 Genomic DNA Translation: AAA36001.1 Sequence problems.
X53321 mRNA Translation: CAA37408.1
M35493 mRNA Translation: AAA51538.1
M63397, M63395, M63396 Genomic DNA Translation: AAA51662.1
M38180 Genomic DNA Translation: AAA51831.1
X55997 mRNA Translation: CAA39469.1
S45679 mRNA Translation: AAB23543.1
AK291556 mRNA Translation: BAF84245.1
BC031999 mRNA Translation: AAH31999.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS903.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A36551 DEHUHS

NCBI Reference Sequences

More...
RefSeqi
NP_000853.1, NM_000862.2
NP_001315544.1, NM_001328615.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.364941

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369413; ENSP00000358421; ENSG00000203857
ENST00000528909; ENSP00000432268; ENSG00000203857

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3283

UCSC genome browser

More...
UCSCi
uc001ehv.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27137 mRNA Translation: AAA36015.1
M28392, M28162, M28391 Genomic DNA Translation: AAA36001.1 Sequence problems.
X53321 mRNA Translation: CAA37408.1
M35493 mRNA Translation: AAA51538.1
M63397, M63395, M63396 Genomic DNA Translation: AAA51662.1
M38180 Genomic DNA Translation: AAA51831.1
X55997 mRNA Translation: CAA39469.1
S45679 mRNA Translation: AAB23543.1
AK291556 mRNA Translation: BAF84245.1
BC031999 mRNA Translation: AAH31999.1
CCDSiCCDS903.1
PIRiA36551 DEHUHS
RefSeqiNP_000853.1, NM_000862.2
NP_001315544.1, NM_001328615.1
UniGeneiHs.364941

3D structure databases

ProteinModelPortaliP14060
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109516, 1 interactor
IntActiP14060, 3 interactors
STRINGi9606.ENSP00000358421

Chemistry databases

BindingDBiP14060
ChEMBLiCHEMBL1958
DrugBankiDB01536 4-Androstenedione
DB00157 NADH
DB01108 Trilostane
SwissLipidsiSLP:000001297

PTM databases

iPTMnetiP14060
PhosphoSitePlusiP14060

Polymorphism and mutation databases

BioMutaiHSD3B1
DMDMi112767

Proteomic databases

jPOSTiP14060
PaxDbiP14060
PeptideAtlasiP14060
PRIDEiP14060
ProteomicsDBi53017

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3283
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369413; ENSP00000358421; ENSG00000203857
ENST00000528909; ENSP00000432268; ENSG00000203857
GeneIDi3283
KEGGihsa:3283
UCSCiuc001ehv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3283
DisGeNETi3283
EuPathDBiHostDB:ENSG00000203857.9

GeneCards: human genes, protein and diseases

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GeneCardsi
HSD3B1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0028579
HGNCiHGNC:5217 HSD3B1
HPAiHPA043261
HPA043264
HPA044028
MIMi109715 gene
neXtProtiNX_P14060
OpenTargetsiENSG00000203857
PharmGKBiPA29486

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1430 Eukaryota
COG0451 LUCA
GeneTreeiENSGT00940000161374
HOGENOMiHOG000167989
HOVERGENiHBG000014
KOiK00070
OMAiHIVTLSN
OrthoDBi930591at2759
PhylomeDBiP14060
TreeFamiTF343138

Enzyme and pathway databases

BioCyciMetaCyc:HS08829-MONOMER
BRENDAi1.1.1.145 2681
5.3.3.1 2681
ReactomeiR-HSA-193048 Androgen biosynthesis
R-HSA-193993 Mineralocorticoid biosynthesis
R-HSA-194002 Glucocorticoid biosynthesis
SABIO-RKiP14060

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HSD3B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3283

Protein Ontology

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PROi
PR:P14060

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000203857 Expressed in 89 organ(s), highest expression level in chorionic villus
CleanExiHS_HSD3B1
ExpressionAtlasiP14060 baseline and differential
GenevisibleiP14060 HS

Family and domain databases

InterProiView protein in InterPro
IPR002225 3Beta_OHSteriod_DH/Estase
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01073 3Beta_HSD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei3BHS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14060
Secondary accession number(s): A8K691, Q14545, Q8IV65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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