UniProtKB - P14046 (A1I3_RAT)
Protein
Alpha-1-inhibitor 3
Gene
A1i3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
GO - Molecular functioni
- endopeptidase inhibitor activity Source: GO_Central
- protease binding Source: GO_Central
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1-inhibitor 3Alternative name(s): Alpha-1-inhibitor 3 variant II Short name: Alpha-1-inhibitor III |
Gene namesi | Name:A1i3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1584999, LOC297568 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: InterPro
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Add BLAST | 24 | |
ChainiPRO_0000000061 | 25 – 1477 | Alpha-1-inhibitor 3Add BLAST | 1453 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 86 | By similarity | ||
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 247 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 251 ↔ 295 | By similarity | ||
Disulfide bondi | 269 ↔ 283 | By similarity | ||
Glycosylationi | 301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 321 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 393 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 468 ↔ 563 | By similarity | ||
Glycosylationi | 508 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 595 ↔ 774 | By similarity | ||
Disulfide bondi | 643 ↔ 678 | By similarity | ||
Glycosylationi | 750 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 777 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 850 ↔ 886 | By similarity | ||
Glycosylationi | 872 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 924 ↔ 1324 | By similarity | ||
Cross-linki | 975 ↔ 978 | Isoglutamyl cysteine thioester (Cys-Gln) | ||
Glycosylationi | 994 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1082 ↔ 1130 | By similarity | ||
Glycosylationi | 1143 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1314 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1355 ↔ 1470 | By similarity | ||
Glycosylationi | 1427 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Thioester bondProteomic databases
jPOSTi | P14046 |
PaxDbi | P14046 |
PRIDEi | P14046 |
PTM databases
GlyGeni | P14046, 13 sites, 2 N-linked glycans (1 site) |
iPTMneti | P14046 |
PhosphoSitePlusi | P14046 |
UniCarbKBi | P14046 |
Interactioni
Subunit structurei
Monomer.
GO - Molecular functioni
- protease binding Source: GO_Central
Protein-protein interaction databases
IntActi | P14046, 1 interactor |
STRINGi | 10116.ENSRNOP00000040516 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 601 – 750 | Bait region (approximate)Add BLAST | 150 |
Sequence similaritiesi
Keywords - Domaini
Bait region, SignalPhylogenomic databases
eggNOGi | KOG1366, Eukaryota |
PhylomeDBi | P14046 |
Family and domain databases
CDDi | cd02897, A2M_2, 1 hit |
Gene3Di | 2.60.40.10, 2 hits 2.60.40.690, 1 hit |
InterProi | View protein in InterPro IPR009048, A-macroglobulin_rcpt-bd IPR036595, A-macroglobulin_rcpt-bd_sf IPR011625, A2M_N_BRD IPR041813, A2M_TED IPR011626, Alpha-macroglobulin_TED IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR001599, Macroglobln_a2 IPR019742, MacrogloblnA2_CS IPR002890, MG2 IPR041555, MG3 IPR040839, MG4 IPR008930, Terpenoid_cyclase/PrenylTrfase IPR010916, TonB_box_CS |
Pfami | View protein in Pfam PF00207, A2M, 1 hit PF07703, A2M_BRD, 1 hit PF07677, A2M_recep, 1 hit PF01835, MG2, 1 hit PF17791, MG3, 1 hit PF17789, MG4, 1 hit PF07678, TED_complement, 1 hit |
SMARTi | View protein in SMART SM01360, A2M, 1 hit SM01359, A2M_N_2, 1 hit SM01361, A2M_recep, 1 hit |
SUPFAMi | SSF48239, SSF48239, 1 hit SSF49410, SSF49410, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00477, ALPHA_2_MACROGLOBULIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P14046-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKDREAQLC LFSALLAFLP FASLLNGNSK YMVLVPSQLY TETPEKICLH
60 70 80 90 100
LYHLNETVTV TASLISQRGT RKLFDELVVD KDLFHCVSFT IPRLPSSEEE
110 120 130 140 150
ESLDINIEGA KHKFSERRVV LVKNKESVVF VQTDKPMYKP GQSVKFRVVS
160 170 180 190 200
MDKNLHPLNE LFPLAYIEDP KMNRIMQWQD VKTENGLKQL SFSLSAEPIQ
210 220 230 240 250
GPYKIVILKQ SGVKEEHSFT VMEFVLPRFG VDVKVPNAIS VYDEIINVTA
260 270 280 290 300
CATYTYGKPV PGHVKISLCH GNPTFSSETK SGCKEEDSRL DNNGCSTQEV
310 320 330 340 350
NITEFQLKEN YLKMHQAFHV NATVTEEGTG SEFSGSGRIE VERTRNKFLF
360 370 380 390 400
LKADSHFRHG IPFFVKVRLV DIKGDPIPNE QVLIKARDAG YTNATTTDQH
410 420 430 440 450
GLAKFSIDTN GISDYSLNIK VYHKEESSCI HSSCTAERHA EAHHTAYAVY
460 470 480 490 500
SLSKSYIYLD TEAGVLPCNQ IHTVQAHFIL KGQVLGVLQQ IVFHYLVMAQ
510 520 530 540 550
GSILQTGNHT HQVEPGESQV QGNFALEIPV EFSMVPVAKM LIYTILPDGE
560 570 580 590 600
VIADSVKFQV EKCLRNKVHL SFSPSQSLPA SQTHMRVTAS PQSLCGLRAV
610 620 630 640 650
DQSVLLQKPE AELSPSLIYD LPGMQDSNFI ASSNDPFEDE DYCLMYQPIA
660 670 680 690 700
REKDVYRYVR ETGLMAFTNL KIKLPTYCNT DYDMVPLAVP AVALDSSTDR
710 720 730 740 750
GMYESLPVVA VKSPLPQEPP RKDPPPKDPV IETIRNYFPE TWIWDLVTVN
760 770 780 790 800
SSGVTELEMT VPDTITEWKA GALCLSNDTG LGLSSVASFQ AFQPFFVELT
810 820 830 840 850
MPYSVIRGEA FTLKATVLNY LPTSLPMAVL LEASPDFTAV PVENNQDSYC
860 870 880 890 900
LGANGRHTSS WLVTPKSLGN VNFSVSAEAR QSPGPCGSEV ATVPETGRKD
910 920 930 940 950
TVVKVLIVEP EGIKKEHTFS SLLCASDAEL SETLSLLLPP TVVKDSARAH
960 970 980 990 1000
FSVMGDILSS AIKNTQNLIQ MPYGCGEQNM VLFAPNIYVL KYLNETQQLT
1010 1020 1030 1040 1050
EKIKSKALGY LRAGYQRELN YKHKDGSYSA FGDHNGQGQG NTWLTAFVLK
1060 1070 1080 1090 1100
SFAQARAFIF IDESHITDAF TWLSKQQKDS GCFRSSGSLL NNAMKGGVDD
1110 1120 1130 1140 1150
EITLSAYITM ALLESSLPDT DPVVSKALSC LESSWENIEQ GGNGSFVYTK
1160 1170 1180 1190 1200
ALMAYAFALA GNQEKRNEIL KSLDKEAIKE DNSIHWERPQ KPTKSEGYLY
1210 1220 1230 1240 1250
TPQASSAEVE MSAYVVLARL TAQPAPSPED LALSMGTIKW LTKQQNSYGG
1260 1270 1280 1290 1300
FSSTQDTVVA LDALSKYGAA TFSKSQKTPS VTVQSSGSFS QKFQVDKSNR
1310 1320 1330 1340 1350
LLLQQVSLPY IPGNYTVSVS GEGCVYAQTT LRYNVPLEKQ QPAFALKVQT
1360 1370 1380 1390 1400
VPLTCNNPKG QNSFQISLEI SYMGSRPASN MVIADVKMLS GFIPLKPTVK
1410 1420 1430 1440 1450
KLERLGHVSR TEVTTNNVLL YLDQVTNQTL SFSFIIQQDI PVKNLQPAIV
1460 1470
KVYDYYETDE VAFAEYSSPC SSDDQNV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JUP5 | A0A0G2JUP5_RAT | Murinoglobulin-1 | Mug1 LOC297568 | 1,450 | Annotation score: | ||
A0A0G2K926 | A0A0G2K926_RAT | Murinoglobulin-1 | LOC297568 Mug1, rCG_29619 | 1,477 | Annotation score: | ||
D4AA52 | D4AA52_RAT | Murinoglobulin-1 | LOC297568 Mug1 | 1,477 | Annotation score: | ||
A0A0G2JUW7 | A0A0G2JUW7_RAT | Murinoglobulin-1 | Mug1 LOC297568 | 1,487 | Annotation score: | ||
D4A6E3 | D4A6E3_RAT | Murinoglobulin-1 | Mug1 | 1,487 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 677 | Y → T AA sequence (PubMed:2472396).Curated | 1 | |
Sequence conflicti | 1373 | M → T in AAH98768 (PubMed:2436907).Curated | 1 | |
Sequence conflicti | 1406 | G → E in AAA63494 (PubMed:2436907).Curated | 1 | |
Sequence conflicti | 1474 | D → N in AAA63494 (PubMed:2436907).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03552 mRNA Translation: AAA40628.1 M22993 Genomic DNA Translation: AAA79025.1 BC098768 mRNA Translation: AAH98768.1 M28297 mRNA Translation: AAA63493.1 M28298 mRNA Translation: AAA63494.1 |
PIRi | A29952 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03552 mRNA Translation: AAA40628.1 M22993 Genomic DNA Translation: AAA79025.1 BC098768 mRNA Translation: AAH98768.1 M28297 mRNA Translation: AAA63493.1 M28298 mRNA Translation: AAA63494.1 |
PIRi | A29952 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P14046, 1 interactor |
STRINGi | 10116.ENSRNOP00000040516 |
PTM databases
GlyGeni | P14046, 13 sites, 2 N-linked glycans (1 site) |
iPTMneti | P14046 |
PhosphoSitePlusi | P14046 |
UniCarbKBi | P14046 |
Proteomic databases
jPOSTi | P14046 |
PaxDbi | P14046 |
PRIDEi | P14046 |
Organism-specific databases
RGDi | 1584999, LOC297568 |
Phylogenomic databases
eggNOGi | KOG1366, Eukaryota |
PhylomeDBi | P14046 |
Miscellaneous databases
PROi | PR:P14046 |
Family and domain databases
CDDi | cd02897, A2M_2, 1 hit |
Gene3Di | 2.60.40.10, 2 hits 2.60.40.690, 1 hit |
InterProi | View protein in InterPro IPR009048, A-macroglobulin_rcpt-bd IPR036595, A-macroglobulin_rcpt-bd_sf IPR011625, A2M_N_BRD IPR041813, A2M_TED IPR011626, Alpha-macroglobulin_TED IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR001599, Macroglobln_a2 IPR019742, MacrogloblnA2_CS IPR002890, MG2 IPR041555, MG3 IPR040839, MG4 IPR008930, Terpenoid_cyclase/PrenylTrfase IPR010916, TonB_box_CS |
Pfami | View protein in Pfam PF00207, A2M, 1 hit PF07703, A2M_BRD, 1 hit PF07677, A2M_recep, 1 hit PF01835, MG2, 1 hit PF17791, MG3, 1 hit PF17789, MG4, 1 hit PF07678, TED_complement, 1 hit |
SMARTi | View protein in SMART SM01360, A2M, 1 hit SM01359, A2M_N_2, 1 hit SM01361, A2M_recep, 1 hit |
SUPFAMi | SSF48239, SSF48239, 1 hit SSF49410, SSF49410, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00477, ALPHA_2_MACROGLOBULIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1I3_RAT | |
Accessioni | P14046Primary (citable) accession number: P14046 Secondary accession number(s): Q4G042 Q6LDR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | August 12, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families