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Protein

Coiled-coil domain-containing protein 130

Gene

CCDC130

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • response to virus Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 130
Alternative name(s):
9 kDa protein
Gene namesi
Name:CCDC130
ORF Names:SB115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104957.13
HGNCiHGNC:28118 CCDC130
neXtProtiNX_P13994

Pathology & Biotechi

Organism-specific databases

DisGeNETi81576
OpenTargetsiENSG00000104957
PharmGKBiPA162381331

Polymorphism and mutation databases

BioMutaiCCDC130
DMDMi134037158

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000644011 – 396Coiled-coil domain-containing protein 130Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP13994
MaxQBiP13994
PaxDbiP13994
PeptideAtlasiP13994
PRIDEiP13994
ProteomicsDBi53015

PTM databases

iPTMnetiP13994
PhosphoSitePlusiP13994

Expressioni

Inductioni

By poly(RI), poly(RC) and Newcastle disease virus.1 Publication

Gene expression databases

BgeeiENSG00000104957 Expressed in 197 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CCDC130
ExpressionAtlasiP13994 baseline and differential
GenevisibleiP13994 HS

Organism-specific databases

HPAiHPA056977

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123536, 17 interactors
IntActiP13994, 23 interactors
MINTiP13994
STRINGi9606.ENSP00000221554

Structurei

3D structure databases

ProteinModelPortaliP13994
SMRiP13994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili182 – 214Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the CWC16 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2990 Eukaryota
COG5134 LUCA
GeneTreeiENSGT00530000063615
HOGENOMiHOG000239030
HOVERGENiHBG081031
InParanoidiP13994
KOiK13115
OMAiRTDPQNT
OrthoDBiEOG091G0ES6
PhylomeDBiP13994

Family and domain databases

InterProiView protein in InterPro
IPR007590 CWC16
PANTHERiPTHR12111 PTHR12111, 1 hit
PfamiView protein in Pfam
PF04502 DUF572, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P13994-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGERKGVNKY YPPDFNPEKH GSLNRYHNSH PLRERARKLS QGILIIRFEM
60 70 80 90 100
PYNIWCDGCK NHIGMGVRYN AEKKKVGNYY TTPIYRFRMK CHLCVNYIEM
110 120 130 140 150
QTDPANCDYV IVSGAQRKEE RWDMADNEQV LTTEHEKKQK LETDAMFRLE
160 170 180 190 200
HGEADRSTLK KALPTLSHIQ EAQSAWKDDF ALNSMLRRRF REKKKAIQEE
210 220 230 240 250
EERDQALQAK ASLTIPLVPE TEDDRKLAAL LKFHTLDSYE DKQKLKRTEI
260 270 280 290 300
ISRSWFPSAP GSASSSKVSG VLKKLAQSRR TALATSPITV GDLGIVRRRS
310 320 330 340 350
RDVPESPQHA ADTPKSGEPR VPEEAAQDRP MSPGDCPPET TETPKCSSPR
360 370 380 390
GQEGSRQDKP LSPAGSSQEA ADTPDTRHPC SLGSSLVADY SDSESE
Length:396
Mass (Da):44,802
Last modified:March 6, 2007 - v2
Checksum:i6D2EA8F4680EF89F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELI4K7ELI4_HUMAN
Coiled-coil domain-containing prote...
CCDC130
237Annotation score:
K7ES43K7ES43_HUMAN
Coiled-coil domain-containing prote...
CCDC130
102Annotation score:
K7EJZ6K7EJZ6_HUMAN
Coiled-coil domain-containing prote...
CCDC130
190Annotation score:
K7EP29K7EP29_HUMAN
Coiled-coil domain-containing prote...
CCDC130
60Annotation score:

Sequence cautioni

The sequence CAA32138 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAA32138 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05385422S → C. Corresponds to variant dbSNP:rs12974461Ensembl.1
Natural variantiVAR_053855336C → S. Corresponds to variant dbSNP:rs35761244Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250306 mRNA Translation: AAK37425.1
BC002905 mRNA Translation: AAH02905.1
X13956 Genomic DNA Translation: CAA32138.1 Sequence problems.
CCDSiCCDS12296.1
PIRiS02660
RefSeqiNP_001307490.1, NM_001320561.1
NP_001307493.1, NM_001320564.1
NP_001307494.1, NM_001320565.1
NP_001307495.1, NM_001320566.1
NP_001307496.1, NM_001320567.1
NP_001307497.1, NM_001320568.1
NP_001307498.1, NM_001320569.1
NP_110445.1, NM_030818.3
XP_005260143.1, XM_005260086.4
UniGeneiHs.24998
Hs.734421

Genome annotation databases

EnsembliENST00000221554; ENSP00000221554; ENSG00000104957
ENST00000586600; ENSP00000465776; ENSG00000104957
GeneIDi81576
KEGGihsa:81576
UCSCiuc002mxc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250306 mRNA Translation: AAK37425.1
BC002905 mRNA Translation: AAH02905.1
X13956 Genomic DNA Translation: CAA32138.1 Sequence problems.
CCDSiCCDS12296.1
PIRiS02660
RefSeqiNP_001307490.1, NM_001320561.1
NP_001307493.1, NM_001320564.1
NP_001307494.1, NM_001320565.1
NP_001307495.1, NM_001320566.1
NP_001307496.1, NM_001320567.1
NP_001307497.1, NM_001320568.1
NP_001307498.1, NM_001320569.1
NP_110445.1, NM_030818.3
XP_005260143.1, XM_005260086.4
UniGeneiHs.24998
Hs.734421

3D structure databases

ProteinModelPortaliP13994
SMRiP13994
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123536, 17 interactors
IntActiP13994, 23 interactors
MINTiP13994
STRINGi9606.ENSP00000221554

PTM databases

iPTMnetiP13994
PhosphoSitePlusiP13994

Polymorphism and mutation databases

BioMutaiCCDC130
DMDMi134037158

Proteomic databases

EPDiP13994
MaxQBiP13994
PaxDbiP13994
PeptideAtlasiP13994
PRIDEiP13994
ProteomicsDBi53015

Protocols and materials databases

DNASUi81576
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221554; ENSP00000221554; ENSG00000104957
ENST00000586600; ENSP00000465776; ENSG00000104957
GeneIDi81576
KEGGihsa:81576
UCSCiuc002mxc.2 human

Organism-specific databases

CTDi81576
DisGeNETi81576
EuPathDBiHostDB:ENSG00000104957.13
GeneCardsiCCDC130
HGNCiHGNC:28118 CCDC130
HPAiHPA056977
neXtProtiNX_P13994
OpenTargetsiENSG00000104957
PharmGKBiPA162381331
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2990 Eukaryota
COG5134 LUCA
GeneTreeiENSGT00530000063615
HOGENOMiHOG000239030
HOVERGENiHBG081031
InParanoidiP13994
KOiK13115
OMAiRTDPQNT
OrthoDBiEOG091G0ES6
PhylomeDBiP13994

Miscellaneous databases

ChiTaRSiCCDC130 human
GenomeRNAii81576
PROiPR:P13994

Gene expression databases

BgeeiENSG00000104957 Expressed in 197 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CCDC130
ExpressionAtlasiP13994 baseline and differential
GenevisibleiP13994 HS

Family and domain databases

InterProiView protein in InterPro
IPR007590 CWC16
PANTHERiPTHR12111 PTHR12111, 1 hit
PfamiView protein in Pfam
PF04502 DUF572, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC130_HUMAN
AccessioniPrimary (citable) accession number: P13994
Secondary accession number(s): Q9BQ72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 6, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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