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UniProtKB - P13987 (CD59_HUMAN)

Entry version 225 (07 Apr 2021)
Sequence version 1 (01 Jan 1990)
Previous versions | rss
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Protein

CD59 glycoprotein

Gene

CD59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • complement binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13987

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005, COPII-mediated vesicle transport
R-HSA-5694530, Cargo concentration in the ER
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-977606, Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD59 glycoprotein
Alternative name(s):
1F5 antigen
20 kDa homologous restriction factor
Short name:
HRF-20
Short name:
HRF20
MAC-inhibitory protein
Short name:
MAC-IP
MEM43 antigen
Membrane attack complex inhibition factor
Short name:
MACIF
Membrane inhibitor of reactive lysis
Short name:
MIRL
Protectin
CD_antigen: CD59
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD59
Synonyms:MIC11, MIN1, MIN2, MIN3, MSK21
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1689, CD59

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		107271, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13987

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000085063.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hemolytic anemia, CD59-mediated, with or without polyneuropathy (HACD59)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by infantile onset of chronic hemolysis and a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifested as hypotonia, limb muscle weakness, and hyporeflexia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07012489C → Y in HACD59. 1 PublicationCorresponds to variant dbSNP:rs397514767EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29Y → R: No loss of function. 1 Publication1
Mutagenesisi33N → R or Q: No loss of function. 1 Publication1
Mutagenesisi37D → R: No loss of function. 1 Publication1
Mutagenesisi48F → R: Some loss of function. Some lysis. 1 Publication1
Mutagenesisi49D → R: Loss of function. Lysis. 1 Publication1
Mutagenesisi58L → E: No loss of function. 1 Publication1
Mutagenesisi63K → E: No loss of function. 1 Publication1
Mutagenesisi65W → E: Complete loss of function. Lysis. 1 Publication1
Mutagenesisi66K → D: No loss of function. 1 Publication1
Mutagenesisi66K → Q: Loss of glycation mediated inactivation. 1 Publication1
Mutagenesisi67F → K: No loss of function. 1 Publication1
Mutagenesisi69H → Q: Loss of glycation mediated inactivation. 1 Publication1
Mutagenesisi72F → E: Almost complete loss of function. Lysis. 1 Publication1
Mutagenesisi78R → E: Loss of function. Lysis. 1 Publication1
Mutagenesisi79L → D: No loss of function. 1 Publication1
Mutagenesisi81E → R: Almost complete loss of function. Lysis. 1 Publication1
Mutagenesisi82N → K: No loss of function. 1 Publication1
Mutagenesisi87Y → R: No loss of function. 1 Publication1

Keywords - Diseasei

Disease variant, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...DisGeNETi		966

MalaCards human disease database

More...MalaCardsi		CD59
MIMi612300, phenotype

Open Targets

More...OpenTargetsi		ENSG00000085063

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169464, Primary CD59 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26228

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13987, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD59

Domain mapping of disease mutations (DMDM)

More...DMDMi		116021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Combined sources1 PublicationAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003610826 – 102CD59 glycoproteinAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000036109103 – 128Removed in mature form1 PublicationAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 511 Publication
Disulfide bondi31 ↔ 381 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi44 ↔ 641 Publication
Glycosylationi66N-linked (Glc) (glycation) lysine1 Publication1
Disulfide bondi70 ↔ 881 Publication
Glycosylationi76O-linked (GalNAc...) threonineCurated1
Glycosylationi77O-linked (GalNAc...) threonineCurated1
Disulfide bondi89 ↔ 941 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi102GPI-anchor amidated asparagine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.2 Publications
Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.

Keywords - PTMi

Disulfide bond, Glycation, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-43
CPTAC-44

Encyclopedia of Proteome Dynamics

More...EPDi		P13987

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13987

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13987

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13987

PeptideAtlas

More...PeptideAtlasi		P13987

PRoteomics IDEntifications database

More...PRIDEi		P13987

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		23185
53014

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		79, 115 N-Linked glycans (1 site), 17 O-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13987, 7 sites, 33 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13987

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13987

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13987

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000085063, Expressed in chorionic villus and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13987, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13987, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000085063, Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with T-cell surface antigen CD2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107404, 67 interactors

Protein interaction database and analysis system

More...IntActi		P13987, 37 interactors

Molecular INTeraction database

More...MINTi		P13987

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379191

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13987, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13987

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P13987

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108UPAR/Ly6Add BLAST83

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SA4P, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016309

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_147732_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13987

Identification of Orthologs from Complete Genome Data

More...OMAi		CSKQRDC

Database of Orthologous Groups

More...OrthoDBi		1586315at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13987

TreeFam database of animal gene trees

More...TreeFami		TF338524

Family and domain databases

Conserved Domains Database

More...CDDi		cd00117, LU, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018363, CD59_antigen_CS
IPR027101, CD59_glyco
IPR016054, LY6_UPA_recep-like

The PANTHER Classification System

More...PANTHERi		PTHR10036:SF9, PTHR10036:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00021, UPAR_LY6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00134, LU, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00983, LY6_UPAR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13987-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGIQGGSVLF GLLLVLAVFC HSGHSLQCYN CPNPTADCKT AVNCSSDFDA 
        60         70         80         90        100
CLITKAGLQV YNKCWKFEHC NFNDVTTRLR ENELTYYCCK KDLCNFNEQL 
       110        120 
ENGGTSLSEK TVLLLVTPFL AAAWSLHP
Length:128
Mass (Da):14,177
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F0D29CBE3C28505
GO
Isoform 2 (identifier: P13987-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-128: GGTSLSEKTVLLLVTPFLAAAWSLHP → DTFLKALKDEKLQGLKTKQPGKKSASLS

Show »
Length:130
Mass (Da):14,529
Checksum:iF761888BF8D8007C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2U3TZL5A0A2U3TZL5_HUMAN
CD59 glycoprotein
CD59
120Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C059A0A494C059_HUMAN
CD59 glycoprotein
CD59
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A499FJN7A0A499FJN7_HUMAN
CD59 glycoprotein
CD59
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI80E9PI80_HUMAN
CD59 glycoprotein
CD59
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0W4A0A494C0W4_HUMAN
CD59 glycoprotein
CD59
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07012489C → Y in HACD59. 1 PublicationCorresponds to variant dbSNP:rs397514767EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060064103 – 128GGTSL…WSLHP → DTFLKALKDEKLQGLKTKQP GKKSASLS in isoform 2. Add BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M27909 mRNA Translation: AAA60543.1
M95708 mRNA Translation: AAA60957.1
X16447 mRNA Translation: CAA34467.1
X17198 mRNA Translation: CAA35059.1
M34671 mRNA Translation: AAA51952.1
M84345 Genomic DNA No translation available.
M84349, M84346, M84348 Genomic DNA Translation: AAA88793.1
Z14113, Z14114, Z14115 Genomic DNA Translation: CAA78486.1
BT007104 mRNA Translation: AAP35768.1
AL049629 Genomic DNA No translation available.
KF455356 Genomic DNA No translation available.
BC001506 mRNA Translation: AAH01506.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7886.1 [P13987-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A46252, RWHU59

NCBI Reference Sequences

More...RefSeqi		NP_000602.1, NM_000611.5 [P13987-1]
NP_001120695.1, NM_001127223.1 [P13987-1]
NP_001120697.1, NM_001127225.1 [P13987-1]
NP_001120698.1, NM_001127226.1 [P13987-1]
NP_001120699.1, NM_001127227.1 [P13987-1]
NP_976074.1, NM_203329.2 [P13987-1]
NP_976075.1, NM_203330.2 [P13987-1]
NP_976076.1, NM_203331.2 [P13987-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000351554; ENSP00000340210; ENSG00000085063 [P13987-1]
ENST00000395850; ENSP00000379191; ENSG00000085063 [P13987-1]
ENST00000415002; ENSP00000404822; ENSG00000085063 [P13987-1]
ENST00000437761; ENSP00000410182; ENSG00000085063 [P13987-1]
ENST00000445143; ENSP00000403511; ENSG00000085063 [P13987-1]
ENST00000527577; ENSP00000432942; ENSG00000085063 [P13987-1]
ENST00000642928; ENSP00000494884; ENSG00000085063 [P13987-1]
ENST00000651785; ENSP00000498879; ENSG00000085063 [P13987-1]
ENST00000652678; ENSP00000498448; ENSG00000085063 [P13987-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:966

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

CD59base

CD59 mutation db

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27909 mRNA Translation: AAA60543.1
M95708 mRNA Translation: AAA60957.1
X16447 mRNA Translation: CAA34467.1
X17198 mRNA Translation: CAA35059.1
M34671 mRNA Translation: AAA51952.1
M84345 Genomic DNA No translation available.
M84349, M84346, M84348 Genomic DNA Translation: AAA88793.1
Z14113, Z14114, Z14115 Genomic DNA Translation: CAA78486.1
BT007104 mRNA Translation: AAP35768.1
AL049629 Genomic DNA No translation available.
KF455356 Genomic DNA No translation available.
BC001506 mRNA Translation: AAH01506.1
CCDSiCCDS7886.1 [P13987-1]
PIRiA46252, RWHU59
RefSeqiNP_000602.1, NM_000611.5 [P13987-1]
NP_001120695.1, NM_001127223.1 [P13987-1]
NP_001120697.1, NM_001127225.1 [P13987-1]
NP_001120698.1, NM_001127226.1 [P13987-1]
NP_001120699.1, NM_001127227.1 [P13987-1]
NP_976074.1, NM_203329.2 [P13987-1]
NP_976075.1, NM_203330.2 [P13987-1]
NP_976076.1, NM_203331.2 [P13987-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDQNMR-A26-102[»]
1CDRNMR-A26-102[»]
1CDSNMR-A26-102[»]
1ERGNMR-A26-95[»]
1ERHNMR-A26-95[»]
2J8BX-ray1.15A26-103[»]
2OFSX-ray2.12A26-99[»]
2UWRX-ray1.34A26-102[»]
2UX2X-ray1.80A/B/C26-102[»]
4BIKX-ray3.49B/D26-102[»]
5IMTX-ray2.70D26-102[»]
5IMYX-ray2.40C/D26-102[»]
6ZD0electron microscopy4.60B/D/F26-102[»]
SMRiP13987
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107404, 67 interactors
IntActiP13987, 37 interactors
MINTiP13987
STRINGi9606.ENSP00000379191

PTM databases

GlyConnecti79, 115 N-Linked glycans (1 site), 17 O-Linked glycans (4 sites)
GlyGeniP13987, 7 sites, 33 N-linked glycans (1 site)
iPTMnetiP13987
PhosphoSitePlusiP13987
SwissPalmiP13987

Genetic variation databases

BioMutaiCD59
DMDMi116021

Proteomic databases

CPTACiCPTAC-43
CPTAC-44
EPDiP13987
jPOSTiP13987
MassIVEiP13987
PaxDbiP13987
PeptideAtlasiP13987
PRIDEiP13987
ProteomicsDBi23185
53014

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P13987, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3667, 1922 antibodies

The DNASU plasmid repository

More...DNASUi		966

Genome annotation databases

EnsembliENST00000351554; ENSP00000340210; ENSG00000085063 [P13987-1]
ENST00000395850; ENSP00000379191; ENSG00000085063 [P13987-1]
ENST00000415002; ENSP00000404822; ENSG00000085063 [P13987-1]
ENST00000437761; ENSP00000410182; ENSG00000085063 [P13987-1]
ENST00000445143; ENSP00000403511; ENSG00000085063 [P13987-1]
ENST00000527577; ENSP00000432942; ENSG00000085063 [P13987-1]
ENST00000642928; ENSP00000494884; ENSG00000085063 [P13987-1]
ENST00000651785; ENSP00000498879; ENSG00000085063 [P13987-1]
ENST00000652678; ENSP00000498448; ENSG00000085063 [P13987-1]
GeneIDi966
KEGGihsa:966

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		966
DisGeNETi966

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD59
HGNCiHGNC:1689, CD59
HPAiENSG00000085063, Tissue enhanced (placenta)
MalaCardsiCD59
MIMi107271, gene
612300, phenotype
neXtProtiNX_P13987
OpenTargetsiENSG00000085063
Orphaneti169464, Primary CD59 deficiency
PharmGKBiPA26228
VEuPathDBiHostDB:ENSG00000085063.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SA4P, Eukaryota
GeneTreeiENSGT00390000016309
HOGENOMiCLU_147732_1_0_1
InParanoidiP13987
OMAiCSKQRDC
OrthoDBi1586315at2759
PhylomeDBiP13987
TreeFamiTF338524

Enzyme and pathway databases

PathwayCommonsiP13987
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-5694530, Cargo concentration in the ER
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-977606, Regulation of Complement cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		966, 4 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD59, human
EvolutionaryTraceiP13987

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD59

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		966
PharosiP13987, Tbio

Protein Ontology

More...PROi		PR:P13987
RNActiP13987, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000085063, Expressed in chorionic villus and 248 other tissues
ExpressionAtlasiP13987, baseline and differential
GenevisibleiP13987, HS

Family and domain databases

CDDicd00117, LU, 1 hit
InterProiView protein in InterPro
IPR018363, CD59_antigen_CS
IPR027101, CD59_glyco
IPR016054, LY6_UPA_recep-like
PANTHERiPTHR10036:SF9, PTHR10036:SF9, 1 hit
PfamiView protein in Pfam
PF00021, UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134, LU, 1 hit
PROSITEiView protein in PROSITE
PS00983, LY6_UPAR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD59_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13987
Secondary accession number(s): E9PR17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 7, 2021
This is version 225 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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