ADRB3

Functionⁱ

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	117	Agonist or antagonistBy similarity		1
Binding siteⁱ	122	Agonist or antagonistBy similarity		1

GO - Molecular functionⁱ

beta3-adrenergic receptor activity
Source: HGNC
Inferred from mutant phenotypeⁱ
- 9892244
beta-3 adrenergic receptor binding Source: Ensembl
beta-adrenergic receptor activity
Source: HGNC
Inferred from direct assayⁱ
- 15123695
epinephrine binding Source: GO_Central
norepinephrine binding Source: Ensembl
protein homodimerization activity
Source: HGNC
Inferred from direct assayⁱ
- 15123695

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of adenylate cyclase activity
Source: HGNC
Inferred from direct assayⁱ
- 15123695
adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 1718744
aging Source: Ensembl
brown fat cell differentiation Source: Ensembl
carbohydrate metabolic process
Source: ProtInc
Traceable author statementⁱ
- 2570461
cell-cell signaling Source: GO_Central
diet induced thermogenesis Source: Ensembl
eating behavior Source: Ensembl
energy reserve metabolic process
Source: ProtInc
Traceable author statementⁱ
- 1718744
generation of precursor metabolites and energy
Source: ProtInc
Traceable author statementⁱ
- 2570461
G-protein coupled receptor signaling pathway Source: Reactome
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: ProtInc
Traceable author statementⁱ
- 2570461
heat generation Source: Ensembl
negative regulation of multicellular organism growth Source: Ensembl
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: GO_Central
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 12387862
- 7493988
positive regulation of MAPK cascade
Source: HGNC
Inferred from direct assayⁱ
- 15123695
response to antibiotic Source: Ensembl
response to cold Source: Ensembl
temperature homeostasis Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-3 adrenergic receptor Alternative name(s): Beta-3 adrenoreceptor Short name: Beta-3 adrenoceptor
Gene namesⁱ	Name:ADRB3 Synonyms:ADRB3R, B3AR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188778.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:288 ADRB3
MIMⁱ	109691 gene
neXtProtⁱ	NX_P13945

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 36	ExtracellularBy similarityAdd BLAST	36
Transmembraneⁱ	37 – 63	Helical; Name=1By similarityAdd BLAST	27
Topological domainⁱ	64 – 72	CytoplasmicBy similarity	9
Transmembraneⁱ	73 – 91	Helical; Name=2By similarityAdd BLAST	19
Topological domainⁱ	92 – 111	ExtracellularBy similarityAdd BLAST	20
Transmembraneⁱ	112 – 133	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	134 – 155	CytoplasmicBy similarityAdd BLAST	22
Transmembraneⁱ	156 – 178	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	179 – 203	ExtracellularBy similarityAdd BLAST	25
Transmembraneⁱ	204 – 225	Helical; Name=5By similarityAdd BLAST	22
Topological domainⁱ	226 – 292	CytoplasmicBy similarityAdd BLAST	67
Transmembraneⁱ	293 – 314	Helical; Name=6By similarityAdd BLAST	22
Topological domainⁱ	315 – 326	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	327 – 347	Helical; Name=7By similarityAdd BLAST	21
Topological domainⁱ	348 – 408	CytoplasmicBy similarityAdd BLAST	61

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Diabetes mellitus, Obesity

Organism-specific databases

DisGeNET More...DisGeNETⁱ	155
MalaCards human disease database More...MalaCardsⁱ	ADRB3
Open Targets More...OpenTargetsⁱ	ENSG00000188778
PharmGKBⁱ	PA24598

Chemistry databases

ChEMBLⁱ	CHEMBL246
Drug and drug target database More...DrugBankⁱ	DB00321 Amitriptyline DB00182 Amphetamine DB01102 Arbutamine DB00217 Bethanidine DB08807 Bopindolol DB06726 Bufuralol DB08808 Bupranolol DB01407 Clenbuterol DB06262 Droxidopa DB01363 Ephedra DB00668 Epinephrine DB01288 Fenoterol DB01064 Isoprenaline DB01365 Mephentermine DB08893 Mirabegron DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB00571 Propranolol DB06190 Solabegron DB05395 SR 58611 DB00726 Trimipramine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	30

Polymorphism and mutation databases

BioMutaⁱ	ADRB3
DMDMⁱ	461604

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069143	1 – 408	Beta-3 adrenergic receptorAdd BLAST		408

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	26	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	110 ↔ 196	PROSITE-ProRule annotation
Disulfide bondⁱ	189 ↔ 195	PROSITE-ProRule annotation
Lipidationⁱ	361	S-palmitoyl cysteineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P13945
PRIDEⁱ	P13945
ProteomicsDBⁱ	53011

PTM databases

PhosphoSitePlusⁱ	P13945

PhosphoSitePlusⁱ

P13945

Expressionⁱ

Tissue specificityⁱ

Expressed mainly in adipose tissues.

Gene expression databases

Bgeeⁱ	ENSG00000188778 Expressed in 36 organ(s), highest expression level in right ovary
CleanExⁱ	HS_ADRB3
ExpressionAtlasⁱ	P13945 baseline and differential
Genevisibleⁱ	P13945 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA061969

HPAⁱ

HPA061969

Interactionⁱ

Subunit structureⁱ

Interacts with ARRDC3.1 Publication

GO - Molecular functionⁱ

beta-3 adrenergic receptor binding Source: Ensembl
protein homodimerization activity
Source: HGNC
Inferred from direct assayⁱ
- 15123695

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106664, 2 interactors
Database of interacting proteins More...DIPⁱ	DIP-61451N
IntActⁱ	P13945, 6 interactors
STRINGⁱ	9606.ENSP00000343782

Chemistry databases

BindingDBⁱ

P13945

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13945
SMRⁱ	P13945
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	198 – 212	Agonist and antagonist bindingBy similarityAdd BLAST	15
Regionⁱ	305 – 312	Agonist and antagonist bindingBy similarity	8
Regionⁱ	332 – 336	Agonist and antagonist bindingBy similarity	5

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P13945
KEGG Orthology (KO) More...KOⁱ	K04143
OMAⁱ	SNMPYAL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P13945
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000681 ADRB3_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00563 ADRENRGCB3AR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P13945-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA 
        60         70         80         90        100
TVGGNLLVIV AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT 
       110        120        130        140        150
GHWPLGATGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT 
       160        170        180        190        200
KRCARTAVVL VWVVSAAVSF APIMSQWWRV GADAEAQRCH SNPRCCAFAS 
       210        220        230        240        250
NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG ELGRFPPEES 
       260        270        280        290        300
PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT 
       310        320        330        340        350
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP 
       360        370        380        390        400
DFRSAFRRLL CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL 

DGASWGVS

Length:408

Mass (Da):43,519

Last modified:February 1, 1994 - v3

Checksum:ⁱE98BD6C130DD977B

GO

Polymorphismⁱ

The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).1 Publication1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_003456	64	W → R5 PublicationsCorresponds to variant dbSNP:rs4994EnsemblClinVar.	1
Natural variantⁱVAR_029205	249	E → K. Corresponds to variant dbSNP:rs28364012Ensembl.	1
Natural variantⁱVAR_014166	265	T → M1 PublicationCorresponds to variant dbSNP:rs4995Ensembl.	1
Natural variantⁱVAR_025102	353	R → C1 PublicationCorresponds to variant dbSNP:rs36031925Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29932 Genomic DNA Translation: AAA35550.1 Different termination. X72861 Genomic DNA Translation: CAA51383.1 X70811 mRNA Translation: CAA50141.1 X70812 Genomic DNA Translation: CAA50142.1 Sequence problems. X70812 Genomic DNA Translation: CAA50143.1 Sequence problems. AY487247 mRNA Translation: AAR37414.1 DQ104441 Genomic DNA Translation: AAY88743.1 BC075017 mRNA Translation: AAH75017.1 S53291 mRNA Translation: AAB24837.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6099.1
PIRⁱ	I57941 S33751 QRHUBE
NCBI Reference Sequences More...RefSeqⁱ	NP_000016.1, NM_000025.2
UniGeneⁱ	Hs.2549

Genome annotation databases

Ensemblⁱ	ENST00000345060; ENSP00000343782; ENSG00000188778
GeneIDⁱ	155
KEGGⁱ	hsa:155
UCSC genome browser More...UCSCⁱ	uc003xkr.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13945	Adrenergic, beta-3-, receptor, isoform CRA_b		HUMAN		408	UniRef90_P13945
ADRB3 isoform 1		PONAB		408
Adrenoceptor beta 3		PANTR		408
Adrenoceptor beta 3		GORGO		408
Adrenoceptor beta 3		NOMLE		402
+4

Protein	Similar proteins		Species	Score	Length	Source
P13945	Beta-3 adrenergic receptor (Fragment)		CAVPO		351	UniRef50_P13945
Adrenergic, beta-3-, receptor, isoform CRA_b		HUMAN		408
Adrenoceptor beta 3		GORGO		408
ADRB3 isoform 1		PONAB		408
Adrenoceptor beta 3		PANTR		408
+47

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29932 Genomic DNA Translation: AAA35550.1 Different termination. X72861 Genomic DNA Translation: CAA51383.1 X70811 mRNA Translation: CAA50141.1 X70812 Genomic DNA Translation: CAA50142.1 Sequence problems. X70812 Genomic DNA Translation: CAA50143.1 Sequence problems. AY487247 mRNA Translation: AAR37414.1 DQ104441 Genomic DNA Translation: AAY88743.1 BC075017 mRNA Translation: AAH75017.1 S53291 mRNA Translation: AAB24837.1
CCDSⁱ	CCDS6099.1
PIRⁱ	I57941 S33751 QRHUBE
RefSeqⁱ	NP_000016.1, NM_000025.2
UniGeneⁱ	Hs.2549

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CDW	model	-	A	1-408	[»]
ProteinModelPortalⁱ	P13945
SMRⁱ	P13945
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106664, 2 interactors
DIPⁱ	DIP-61451N
IntActⁱ	P13945, 6 interactors
STRINGⁱ	9606.ENSP00000343782

Chemistry databases

BindingDBⁱ	P13945
ChEMBLⁱ	CHEMBL246
DrugBankⁱ	DB00321 Amitriptyline DB00182 Amphetamine DB01102 Arbutamine DB00217 Bethanidine DB08807 Bopindolol DB06726 Bufuralol DB08808 Bupranolol DB01407 Clenbuterol DB06262 Droxidopa DB01363 Ephedra DB00668 Epinephrine DB01288 Fenoterol DB01064 Isoprenaline DB01365 Mephentermine DB08893 Mirabegron DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB00571 Propranolol DB06190 Solabegron DB05395 SR 58611 DB00726 Trimipramine
GuidetoPHARMACOLOGYⁱ	30

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	P13945

PhosphoSitePlusⁱ

P13945

Polymorphism and mutation databases

BioMutaⁱ	ADRB3
DMDMⁱ	461604

Proteomic databases

PaxDbⁱ	P13945
PRIDEⁱ	P13945
ProteomicsDBⁱ	53011

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000345060; ENSP00000343782; ENSG00000188778
GeneIDⁱ	155
KEGGⁱ	hsa:155
UCSCⁱ	uc003xkr.3 human

Organism-specific databases

CTDⁱ	155
DisGeNETⁱ	155
EuPathDBⁱ	HostDB:ENSG00000188778.4
GeneCardsⁱ	ADRB3
HGNCⁱ	HGNC:288 ADRB3
HPAⁱ	HPA061969
MalaCardsⁱ	ADRB3
MIMⁱ	109691 gene
neXtProtⁱ	NX_P13945
OpenTargetsⁱ	ENSG00000188778
PharmGKBⁱ	PA24598
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P13945
KOⁱ	K04143
OMAⁱ	SNMPYAL
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P13945
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiⁱ	Beta-3_adrenergic_receptor
GenomeRNAiⁱ	155
Protein Ontology More...PROⁱ	PR:P13945
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188778 Expressed in 36 organ(s), highest expression level in right ovary
CleanExⁱ	HS_ADRB3
ExpressionAtlasⁱ	P13945 baseline and differential
Genevisibleⁱ	P13945 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000681 ADRB3_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00563 ADRENRGCB3AR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADRB3_HUMAN
Accessionⁱ	P13945Primary (citable) accession number: P13945 Secondary accession number(s): Q4JFT4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	February 1, 1994
	Last modified:	September 12, 2018
	This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

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Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P13945 (ADRB3_HUMAN)

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Beta-3 adrenergic receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ