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UniProtKB - P13945 (ADRB3_HUMAN)

Entry version 210 (07 Apr 2021)
Sequence version 3 (01 Feb 1994)
Previous versions | rss
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Protein

Beta-3 adrenergic receptor

Gene

ADRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117Agonist or antagonistBy similarity1
Binding sitei122Agonist or antagonistBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13945

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390696, Adrenoceptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SIGNOR Signaling Network Open Resource

More...SIGNORi		P13945

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-3 adrenergic receptor
Alternative name(s):
Beta-3 adrenoreceptor
Short name:
Beta-3 adrenoceptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRB3
Synonyms:ADRB3R, B3AR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:288, ADRB3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		109691, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13945

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188778.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36ExtracellularBy similarityAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 63Helical; Name=1By similarityAdd BLAST27
Topological domaini64 – 72CytoplasmicBy similarity9
Transmembranei73 – 91Helical; Name=2By similarityAdd BLAST19
Topological domaini92 – 111ExtracellularBy similarityAdd BLAST20
Transmembranei112 – 133Helical; Name=3By similarityAdd BLAST22
Topological domaini134 – 155CytoplasmicBy similarityAdd BLAST22
Transmembranei156 – 178Helical; Name=4By similarityAdd BLAST23
Topological domaini179 – 203ExtracellularBy similarityAdd BLAST25
Transmembranei204 – 225Helical; Name=5By similarityAdd BLAST22
Topological domaini226 – 292CytoplasmicBy similarityAdd BLAST67
Transmembranei293 – 314Helical; Name=6By similarityAdd BLAST22
Topological domaini315 – 326ExtracellularBy similarityAdd BLAST12
Transmembranei327 – 347Helical; Name=7By similarityAdd BLAST21
Topological domaini348 – 408CytoplasmicBy similarityAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

DisGeNET

More...DisGeNETi		155

MalaCards human disease database

More...MalaCardsi		ADRB3

Open Targets

More...OpenTargetsi		ENSG00000188778

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13945, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL246

Drug and drug target database

More...DrugBanki		DB00866, Alprenolol
DB05395, Amibegron
DB01118, Amiodarone
DB00182, Amphetamine
DB01102, Arbutamine
DB00217, Bethanidine
DB08807, Bopindolol
DB06726, Bufuralol
DB08808, Bupranolol
DB04846, Celiprolol
DB01407, Clenbuterol
DB00785, Cryptenamine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB11278, DL-Methylephedrine
DB06262, Droxidopa
DB01363, Ephedra sinica root
DB01049, Ergoloid mesylate
DB01288, Fenoterol
DB00983, Formoterol
DB01064, Isoprenaline
DB01365, Mephentermine
DB08893, Mirabegron
DB04861, Nebivolol
DB00368, Norepinephrine
DB00540, Nortriptyline
DB00334, Olanzapine
DB01580, Oxprenolol
DB00715, Paroxetine
DB00960, Pindolol
DB00571, Propranolol
DB11124, Racepinephrine
DB01001, Salbutamol
DB00938, Salmeterol
DB06190, Solabegron
DB00871, Terbutaline
DB00726, Trimipramine
DB14895, Vibegron

DrugCentral

More...DrugCentrali		P13945

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		30

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADRB3

Domain mapping of disease mutations (DMDM)

More...DMDMi		461604

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000691431 – 408Beta-3 adrenergic receptorAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 196PROSITE-ProRule annotation
Disulfide bondi189 ↔ 195PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi361S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13945

PRoteomics IDEntifications database

More...PRIDEi		P13945

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53011

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13945, 2 sites

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13945

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13945

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in adipose tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188778, Expressed in right ovary and 58 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13945, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13945, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188778, Tissue enhanced (gallbladder, ovary, smooth muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARRDC3.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106664, 2 interactors

Database of interacting proteins

More...DIPi		DIP-61451N

Protein interaction database and analysis system

More...IntActi		P13945, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343782

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P13945

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13945, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13945

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni198 – 212Agonist and antagonist bindingBy similarityAdd BLAST15
Regioni305 – 312Agonist and antagonist bindingBy similarity8
Regioni332 – 336Agonist and antagonist bindingBy similarity5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158663

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13945

Identification of Orthologs from Complete Genome Data

More...OMAi		APIMSKW

Database of Orthologous Groups

More...OrthoDBi		614199at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13945

TreeFam database of animal gene trees

More...TreeFami		TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002233, ADR_fam
IPR000681, ADRB3_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01103, ADRENERGICR
PR00563, ADRENRGCB3AR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P13945-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA 
        60         70         80         90        100
TVGGNLLVIV AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT 
       110        120        130        140        150
GHWPLGATGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT 
       160        170        180        190        200
KRCARTAVVL VWVVSAAVSF APIMSQWWRV GADAEAQRCH SNPRCCAFAS 
       210        220        230        240        250
NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG ELGRFPPEES 
       260        270        280        290        300
PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT 
       310        320        330        340        350
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP 
       360        370        380        390        400
DFRSAFRRLL CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL 

DGASWGVS
Length:408
Mass (Da):43,519
Last modified:February 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE98BD6C130DD977B
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).1 Publication1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00345664W → R5 PublicationsCorresponds to variant dbSNP:rs4994EnsemblClinVar.1
Natural variantiVAR_029205249E → K. Corresponds to variant dbSNP:rs28364012Ensembl.1
Natural variantiVAR_014166265T → M1 PublicationCorresponds to variant dbSNP:rs4995Ensembl.1
Natural variantiVAR_025102353R → C1 PublicationCorresponds to variant dbSNP:rs36031925EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M29932 Genomic DNA Translation: AAA35550.1 Different termination.
X72861 Genomic DNA Translation: CAA51383.1
X70811 mRNA Translation: CAA50141.1
X70812 Genomic DNA Translation: CAA50142.1 Sequence problems.
X70812 Genomic DNA Translation: CAA50143.1 Sequence problems.
AY487247 mRNA Translation: AAR37414.1
DQ104441 Genomic DNA Translation: AAY88743.1
BC075017 mRNA Translation: AAH75017.1
S53291 mRNA Translation: AAB24837.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6099.1

Protein sequence database of the Protein Information Resource

More...PIRi		I57941
S33751, QRHUBE

NCBI Reference Sequences

More...RefSeqi		NP_000016.1, NM_000025.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000345060; ENSP00000343782; ENSG00000188778

Database of genes from NCBI RefSeq genomes

More...GeneIDi		155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:155

UCSC genome browser

More...UCSCi		uc003xkr.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29932 Genomic DNA Translation: AAA35550.1 Different termination.
X72861 Genomic DNA Translation: CAA51383.1
X70811 mRNA Translation: CAA50141.1
X70812 Genomic DNA Translation: CAA50142.1 Sequence problems.
X70812 Genomic DNA Translation: CAA50143.1 Sequence problems.
AY487247 mRNA Translation: AAR37414.1
DQ104441 Genomic DNA Translation: AAY88743.1
BC075017 mRNA Translation: AAH75017.1
S53291 mRNA Translation: AAB24837.1
CCDSiCCDS6099.1
PIRiI57941
S33751, QRHUBE
RefSeqiNP_000016.1, NM_000025.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CDWmodel-A1-408[»]
SMRiP13945
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106664, 2 interactors
DIPiDIP-61451N
IntActiP13945, 6 interactors
STRINGi9606.ENSP00000343782

Chemistry databases

BindingDBiP13945
ChEMBLiCHEMBL246
DrugBankiDB00866, Alprenolol
DB05395, Amibegron
DB01118, Amiodarone
DB00182, Amphetamine
DB01102, Arbutamine
DB00217, Bethanidine
DB08807, Bopindolol
DB06726, Bufuralol
DB08808, Bupranolol
DB04846, Celiprolol
DB01407, Clenbuterol
DB00785, Cryptenamine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB11278, DL-Methylephedrine
DB06262, Droxidopa
DB01363, Ephedra sinica root
DB01049, Ergoloid mesylate
DB01288, Fenoterol
DB00983, Formoterol
DB01064, Isoprenaline
DB01365, Mephentermine
DB08893, Mirabegron
DB04861, Nebivolol
DB00368, Norepinephrine
DB00540, Nortriptyline
DB00334, Olanzapine
DB01580, Oxprenolol
DB00715, Paroxetine
DB00960, Pindolol
DB00571, Propranolol
DB11124, Racepinephrine
DB01001, Salbutamol
DB00938, Salmeterol
DB06190, Solabegron
DB00871, Terbutaline
DB00726, Trimipramine
DB14895, Vibegron
DrugCentraliP13945
GuidetoPHARMACOLOGYi30

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP13945, 2 sites
PhosphoSitePlusiP13945
SwissPalmiP13945

Genetic variation databases

BioMutaiADRB3
DMDMi461604

Proteomic databases

PaxDbiP13945
PRIDEiP13945
ProteomicsDBi53011

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10846, 406 antibodies

Genome annotation databases

EnsembliENST00000345060; ENSP00000343782; ENSG00000188778
GeneIDi155
KEGGihsa:155
UCSCiuc003xkr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		155
DisGeNETi155

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADRB3
HGNCiHGNC:288, ADRB3
HPAiENSG00000188778, Tissue enhanced (gallbladder, ovary, smooth muscle)
MalaCardsiADRB3
MIMi109691, gene
neXtProtiNX_P13945
OpenTargetsiENSG00000188778
PharmGKBiPA24598
VEuPathDBiHostDB:ENSG00000188778.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000158663
HOGENOMiCLU_009579_11_0_1
InParanoidiP13945
OMAiAPIMSKW
OrthoDBi614199at2759
PhylomeDBiP13945
TreeFamiTF316350

Enzyme and pathway databases

PathwayCommonsiP13945
ReactomeiR-HSA-390696, Adrenoceptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SIGNORiP13945

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		155, 3 hits in 993 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Beta-3_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		155
PharosiP13945, Tclin

Protein Ontology

More...PROi		PR:P13945
RNActiP13945, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188778, Expressed in right ovary and 58 other tissues
ExpressionAtlasiP13945, baseline and differential
GenevisibleiP13945, HS

Family and domain databases

InterProiView protein in InterPro
IPR002233, ADR_fam
IPR000681, ADRB3_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR01103, ADRENERGICR
PR00563, ADRENRGCB3AR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADRB3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13945
Secondary accession number(s): Q4JFT4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1994
Last modified: April 7, 2021
This is version 210 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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