UniProtKB - P13945 (ADRB3_HUMAN)
Protein
Beta-3 adrenergic receptor
Gene
ADRB3
Organism
Homo sapiens (Human)
Status
Functioni
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 117 | Agonist or antagonistBy similarity | 1 | |
Binding sitei | 122 | Agonist or antagonistBy similarity | 1 |
GO - Molecular functioni
- adrenergic receptor activity Source: GO_Central
- beta3-adrenergic receptor activity Source: HGNC-UCL
- beta-adrenergic receptor activity Source: HGNC-UCL
- epinephrine binding Source: GO_Central
- norepinephrine binding Source: GO_Central
- protein homodimerization activity Source: HGNC-UCL
GO - Biological processi
- activation of adenylate cyclase activity Source: HGNC-UCL
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- carbohydrate metabolic process Source: ProtInc
- energy reserve metabolic process Source: ProtInc
- generation of precursor metabolites and energy Source: ProtInc
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: GO_Central
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of MAPK cascade Source: HGNC-UCL
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-390696 Adrenoceptors R-HSA-418555 G alpha (s) signalling events |
SIGNORi | P13945 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-3 adrenergic receptorAlternative name(s): Beta-3 adrenoreceptor Short name: Beta-3 adrenoceptor |
Gene namesi | Name:ADRB3 Synonyms:ADRB3R, B3AR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:288 ADRB3 |
MIMi | 109691 gene |
neXtProti | NX_P13945 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- receptor complex Source: HGNC-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | ExtracellularBy similarityAdd BLAST | 36 | |
Transmembranei | 37 – 63 | Helical; Name=1By similarityAdd BLAST | 27 | |
Topological domaini | 64 – 72 | CytoplasmicBy similarity | 9 | |
Transmembranei | 73 – 91 | Helical; Name=2By similarityAdd BLAST | 19 | |
Topological domaini | 92 – 111 | ExtracellularBy similarityAdd BLAST | 20 | |
Transmembranei | 112 – 133 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 134 – 155 | CytoplasmicBy similarityAdd BLAST | 22 | |
Transmembranei | 156 – 178 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 179 – 203 | ExtracellularBy similarityAdd BLAST | 25 | |
Transmembranei | 204 – 225 | Helical; Name=5By similarityAdd BLAST | 22 | |
Topological domaini | 226 – 292 | CytoplasmicBy similarityAdd BLAST | 67 | |
Transmembranei | 293 – 314 | Helical; Name=6By similarityAdd BLAST | 22 | |
Topological domaini | 315 – 326 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 327 – 347 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 348 – 408 | CytoplasmicBy similarityAdd BLAST | 61 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Keywords - Diseasei
Diabetes mellitus, ObesityOrganism-specific databases
DisGeNETi | 155 |
MalaCardsi | ADRB3 |
OpenTargetsi | ENSG00000188778 |
PharmGKBi | PA24598 |
Miscellaneous databases
Pharosi | P13945 |
Chemistry databases
ChEMBLi | CHEMBL246 |
DrugBanki | DB00866 Alprenolol DB05395 Amibegron DB00182 Amphetamine DB01102 Arbutamine DB00217 Bethanidine DB08807 Bopindolol DB06726 Bufuralol DB08808 Bupranolol DB04846 Celiprolol DB01407 Clenbuterol DB11273 Dihydroergocornine DB13345 Dihydroergocristine DB11278 DL-Methylephedrine DB06262 Droxidopa DB01363 Ephedra sinica root DB01049 Ergoloid mesylate DB01288 Fenoterol DB00983 Formoterol DB01064 Isoprenaline DB01365 Mephentermine DB08893 Mirabegron DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB01580 Oxprenolol DB00960 Pindolol DB00571 Propranolol DB11124 Racepinephrine DB01001 Salbutamol DB00938 Salmeterol DB06190 Solabegron DB00871 Terbutaline DB00726 Trimipramine |
DrugCentrali | P13945 |
GuidetoPHARMACOLOGYi | 30 |
Polymorphism and mutation databases
BioMutai | ADRB3 |
DMDMi | 461604 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069143 | 1 – 408 | Beta-3 adrenergic receptorAdd BLAST | 408 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 196 | PROSITE-ProRule annotation | ||
Disulfide bondi | 189 ↔ 195 | PROSITE-ProRule annotation | ||
Lipidationi | 361 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P13945 |
PRIDEi | P13945 |
ProteomicsDBi | 53011 |
PTM databases
PhosphoSitePlusi | P13945 |
SwissPalmi | P13945 |
Expressioni
Tissue specificityi
Expressed mainly in adipose tissues.
Gene expression databases
Bgeei | ENSG00000188778 Expressed in 36 organ(s), highest expression level in right ovary |
ExpressionAtlasi | P13945 baseline and differential |
Genevisiblei | P13945 HS |
Organism-specific databases
HPAi | HPA061969 |
Interactioni
Subunit structurei
Interacts with ARRDC3.
1 PublicationGO - Molecular functioni
- protein homodimerization activity Source: HGNC-UCL
Protein-protein interaction databases
BioGridi | 106664, 2 interactors |
DIPi | DIP-61451N |
IntActi | P13945, 6 interactors |
STRINGi | 9606.ENSP00000343782 |
Chemistry databases
BindingDBi | P13945 |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 198 – 212 | Agonist and antagonist bindingBy similarityAdd BLAST | 15 | |
Regioni | 305 – 312 | Agonist and antagonist bindingBy similarity | 8 | |
Regioni | 332 – 336 | Agonist and antagonist bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000158663 |
HOGENOMi | HOG000239242 |
InParanoidi | P13945 |
KOi | K04143 |
OMAi | APIMSKW |
OrthoDBi | 1129049at2759 |
PhylomeDBi | P13945 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR002233 ADR_fam IPR000681 ADRB3_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR01103 ADRENERGICR PR00563 ADRENRGCB3AR PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P13945-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA
60 70 80 90 100
TVGGNLLVIV AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT
110 120 130 140 150
GHWPLGATGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT
160 170 180 190 200
KRCARTAVVL VWVVSAAVSF APIMSQWWRV GADAEAQRCH SNPRCCAFAS
210 220 230 240 250
NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG ELGRFPPEES
260 270 280 290 300
PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT
310 320 330 340 350
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP
360 370 380 390 400
DFRSAFRRLL CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL
DGASWGVS
Polymorphismi
The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).1 Publication1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003456 | 64 | W → R5 PublicationsCorresponds to variant dbSNP:rs4994EnsemblClinVar. | 1 | |
Natural variantiVAR_029205 | 249 | E → K. Corresponds to variant dbSNP:rs28364012Ensembl. | 1 | |
Natural variantiVAR_014166 | 265 | T → M1 PublicationCorresponds to variant dbSNP:rs4995Ensembl. | 1 | |
Natural variantiVAR_025102 | 353 | R → C1 PublicationCorresponds to variant dbSNP:rs36031925Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29932 Genomic DNA Translation: AAA35550.1 Different termination. X72861 Genomic DNA Translation: CAA51383.1 X70811 mRNA Translation: CAA50141.1 X70812 Genomic DNA Translation: CAA50142.1 Sequence problems. X70812 Genomic DNA Translation: CAA50143.1 Sequence problems. AY487247 mRNA Translation: AAR37414.1 DQ104441 Genomic DNA Translation: AAY88743.1 BC075017 mRNA Translation: AAH75017.1 S53291 mRNA Translation: AAB24837.1 |
CCDSi | CCDS6099.1 |
PIRi | I57941 S33751 QRHUBE |
RefSeqi | NP_000016.1, NM_000025.2 |
Genome annotation databases
Ensembli | ENST00000345060; ENSP00000343782; ENSG00000188778 |
GeneIDi | 155 |
KEGGi | hsa:155 |
UCSCi | uc003xkr.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29932 Genomic DNA Translation: AAA35550.1 Different termination. X72861 Genomic DNA Translation: CAA51383.1 X70811 mRNA Translation: CAA50141.1 X70812 Genomic DNA Translation: CAA50142.1 Sequence problems. X70812 Genomic DNA Translation: CAA50143.1 Sequence problems. AY487247 mRNA Translation: AAR37414.1 DQ104441 Genomic DNA Translation: AAY88743.1 BC075017 mRNA Translation: AAH75017.1 S53291 mRNA Translation: AAB24837.1 |
CCDSi | CCDS6099.1 |
PIRi | I57941 S33751 QRHUBE |
RefSeqi | NP_000016.1, NM_000025.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CDW | model | - | A | 1-408 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 106664, 2 interactors |
DIPi | DIP-61451N |
IntActi | P13945, 6 interactors |
STRINGi | 9606.ENSP00000343782 |
Chemistry databases
BindingDBi | P13945 |
ChEMBLi | CHEMBL246 |
DrugBanki | DB00866 Alprenolol DB05395 Amibegron DB00182 Amphetamine DB01102 Arbutamine DB00217 Bethanidine DB08807 Bopindolol DB06726 Bufuralol DB08808 Bupranolol DB04846 Celiprolol DB01407 Clenbuterol DB11273 Dihydroergocornine DB13345 Dihydroergocristine DB11278 DL-Methylephedrine DB06262 Droxidopa DB01363 Ephedra sinica root DB01049 Ergoloid mesylate DB01288 Fenoterol DB00983 Formoterol DB01064 Isoprenaline DB01365 Mephentermine DB08893 Mirabegron DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB01580 Oxprenolol DB00960 Pindolol DB00571 Propranolol DB11124 Racepinephrine DB01001 Salbutamol DB00938 Salmeterol DB06190 Solabegron DB00871 Terbutaline DB00726 Trimipramine |
DrugCentrali | P13945 |
GuidetoPHARMACOLOGYi | 30 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | P13945 |
SwissPalmi | P13945 |
Polymorphism and mutation databases
BioMutai | ADRB3 |
DMDMi | 461604 |
Proteomic databases
PaxDbi | P13945 |
PRIDEi | P13945 |
ProteomicsDBi | 53011 |
Genome annotation databases
Ensembli | ENST00000345060; ENSP00000343782; ENSG00000188778 |
GeneIDi | 155 |
KEGGi | hsa:155 |
UCSCi | uc003xkr.3 human |
Organism-specific databases
CTDi | 155 |
DisGeNETi | 155 |
GeneCardsi | ADRB3 |
HGNCi | HGNC:288 ADRB3 |
HPAi | HPA061969 |
MalaCardsi | ADRB3 |
MIMi | 109691 gene |
neXtProti | NX_P13945 |
OpenTargetsi | ENSG00000188778 |
PharmGKBi | PA24598 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000158663 |
HOGENOMi | HOG000239242 |
InParanoidi | P13945 |
KOi | K04143 |
OMAi | APIMSKW |
OrthoDBi | 1129049at2759 |
PhylomeDBi | P13945 |
TreeFami | TF316350 |
Enzyme and pathway databases
Reactomei | R-HSA-390696 Adrenoceptors R-HSA-418555 G alpha (s) signalling events |
SIGNORi | P13945 |
Miscellaneous databases
GeneWikii | Beta-3_adrenergic_receptor |
GenomeRNAii | 155 |
Pharosi | P13945 |
PROi | PR:P13945 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188778 Expressed in 36 organ(s), highest expression level in right ovary |
ExpressionAtlasi | P13945 baseline and differential |
Genevisiblei | P13945 HS |
Family and domain databases
InterProi | View protein in InterPro IPR002233 ADR_fam IPR000681 ADRB3_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR01103 ADRENERGICR PR00563 ADRENRGCB3AR PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADRB3_HUMAN | |
Accessioni | P13945Primary (citable) accession number: P13945 Secondary accession number(s): Q4JFT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | February 1, 1994 | |
Last modified: | November 13, 2019 | |
This is version 201 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references