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Protein

Beta-3 adrenergic receptor

Gene

ADRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117Agonist or antagonistBy similarity1
Binding sitei122Agonist or antagonistBy similarity1

GO - Molecular functioni

  • beta3-adrenergic receptor activity Source: HGNC
  • beta-3 adrenergic receptor binding Source: Ensembl
  • beta-adrenergic receptor activity Source: HGNC
  • epinephrine binding Source: GO_Central
  • norepinephrine binding Source: Ensembl
  • protein homodimerization activity Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-3 adrenergic receptor
Alternative name(s):
Beta-3 adrenoreceptor
Short name:
Beta-3 adrenoceptor
Gene namesi
Name:ADRB3
Synonyms:ADRB3R, B3AR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000188778.4
HGNCiHGNC:288 ADRB3
MIMi109691 gene
neXtProtiNX_P13945

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularBy similarityAdd BLAST36
Transmembranei37 – 63Helical; Name=1By similarityAdd BLAST27
Topological domaini64 – 72CytoplasmicBy similarity9
Transmembranei73 – 91Helical; Name=2By similarityAdd BLAST19
Topological domaini92 – 111ExtracellularBy similarityAdd BLAST20
Transmembranei112 – 133Helical; Name=3By similarityAdd BLAST22
Topological domaini134 – 155CytoplasmicBy similarityAdd BLAST22
Transmembranei156 – 178Helical; Name=4By similarityAdd BLAST23
Topological domaini179 – 203ExtracellularBy similarityAdd BLAST25
Transmembranei204 – 225Helical; Name=5By similarityAdd BLAST22
Topological domaini226 – 292CytoplasmicBy similarityAdd BLAST67
Transmembranei293 – 314Helical; Name=6By similarityAdd BLAST22
Topological domaini315 – 326ExtracellularBy similarityAdd BLAST12
Transmembranei327 – 347Helical; Name=7By similarityAdd BLAST21
Topological domaini348 – 408CytoplasmicBy similarityAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

DisGeNETi155
MalaCardsiADRB3
OpenTargetsiENSG00000188778
PharmGKBiPA24598

Chemistry databases

ChEMBLiCHEMBL246
DrugBankiDB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB00217 Bethanidine
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB01407 Clenbuterol
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB01288 Fenoterol
DB01064 Isoprenaline
DB01365 Mephentermine
DB08893 Mirabegron
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00571 Propranolol
DB06190 Solabegron
DB05395 SR 58611
DB00726 Trimipramine
GuidetoPHARMACOLOGYi30

Polymorphism and mutation databases

BioMutaiADRB3
DMDMi461604

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691431 – 408Beta-3 adrenergic receptorAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 196PROSITE-ProRule annotation
Disulfide bondi189 ↔ 195PROSITE-ProRule annotation
Lipidationi361S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP13945
PRIDEiP13945
ProteomicsDBi53011

PTM databases

PhosphoSitePlusiP13945

Expressioni

Tissue specificityi

Expressed mainly in adipose tissues.

Gene expression databases

BgeeiENSG00000188778 Expressed in 36 organ(s), highest expression level in right ovary
CleanExiHS_ADRB3
ExpressionAtlasiP13945 baseline and differential
GenevisibleiP13945 HS

Organism-specific databases

HPAiHPA061969

Interactioni

Subunit structurei

Interacts with ARRDC3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106664, 2 interactors
DIPiDIP-61451N
IntActiP13945, 6 interactors
STRINGi9606.ENSP00000343782

Chemistry databases

BindingDBiP13945

Structurei

3D structure databases

ProteinModelPortaliP13945
SMRiP13945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 212Agonist and antagonist bindingBy similarityAdd BLAST15
Regioni305 – 312Agonist and antagonist bindingBy similarity8
Regioni332 – 336Agonist and antagonist bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP13945
KOiK04143
OMAiSNMPYAL
OrthoDBiEOG091G06VI
PhylomeDBiP13945
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000681 ADRB3_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00563 ADRENRGCB3AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P13945-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA
60 70 80 90 100
TVGGNLLVIV AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT
110 120 130 140 150
GHWPLGATGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT
160 170 180 190 200
KRCARTAVVL VWVVSAAVSF APIMSQWWRV GADAEAQRCH SNPRCCAFAS
210 220 230 240 250
NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG ELGRFPPEES
260 270 280 290 300
PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT
310 320 330 340 350
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP
360 370 380 390 400
DFRSAFRRLL CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL

DGASWGVS
Length:408
Mass (Da):43,519
Last modified:February 1, 1994 - v3
Checksum:iE98BD6C130DD977B
GO

Polymorphismi

The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).1 Publication1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00345664W → R5 PublicationsCorresponds to variant dbSNP:rs4994EnsemblClinVar.1
Natural variantiVAR_029205249E → K. Corresponds to variant dbSNP:rs28364012Ensembl.1
Natural variantiVAR_014166265T → M1 PublicationCorresponds to variant dbSNP:rs4995Ensembl.1
Natural variantiVAR_025102353R → C1 PublicationCorresponds to variant dbSNP:rs36031925Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29932 Genomic DNA Translation: AAA35550.1 Different termination.
X72861 Genomic DNA Translation: CAA51383.1
X70811 mRNA Translation: CAA50141.1
X70812 Genomic DNA Translation: CAA50142.1 Sequence problems.
X70812 Genomic DNA Translation: CAA50143.1 Sequence problems.
AY487247 mRNA Translation: AAR37414.1
DQ104441 Genomic DNA Translation: AAY88743.1
BC075017 mRNA Translation: AAH75017.1
S53291 mRNA Translation: AAB24837.1
CCDSiCCDS6099.1
PIRiI57941
S33751 QRHUBE
RefSeqiNP_000016.1, NM_000025.2
UniGeneiHs.2549

Genome annotation databases

EnsembliENST00000345060; ENSP00000343782; ENSG00000188778
GeneIDi155
KEGGihsa:155
UCSCiuc003xkr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29932 Genomic DNA Translation: AAA35550.1 Different termination.
X72861 Genomic DNA Translation: CAA51383.1
X70811 mRNA Translation: CAA50141.1
X70812 Genomic DNA Translation: CAA50142.1 Sequence problems.
X70812 Genomic DNA Translation: CAA50143.1 Sequence problems.
AY487247 mRNA Translation: AAR37414.1
DQ104441 Genomic DNA Translation: AAY88743.1
BC075017 mRNA Translation: AAH75017.1
S53291 mRNA Translation: AAB24837.1
CCDSiCCDS6099.1
PIRiI57941
S33751 QRHUBE
RefSeqiNP_000016.1, NM_000025.2
UniGeneiHs.2549

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CDWmodel-A1-408[»]
ProteinModelPortaliP13945
SMRiP13945
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106664, 2 interactors
DIPiDIP-61451N
IntActiP13945, 6 interactors
STRINGi9606.ENSP00000343782

Chemistry databases

BindingDBiP13945
ChEMBLiCHEMBL246
DrugBankiDB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB00217 Bethanidine
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB01407 Clenbuterol
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB01288 Fenoterol
DB01064 Isoprenaline
DB01365 Mephentermine
DB08893 Mirabegron
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00571 Propranolol
DB06190 Solabegron
DB05395 SR 58611
DB00726 Trimipramine
GuidetoPHARMACOLOGYi30

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP13945

Polymorphism and mutation databases

BioMutaiADRB3
DMDMi461604

Proteomic databases

PaxDbiP13945
PRIDEiP13945
ProteomicsDBi53011

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345060; ENSP00000343782; ENSG00000188778
GeneIDi155
KEGGihsa:155
UCSCiuc003xkr.3 human

Organism-specific databases

CTDi155
DisGeNETi155
EuPathDBiHostDB:ENSG00000188778.4
GeneCardsiADRB3
HGNCiHGNC:288 ADRB3
HPAiHPA061969
MalaCardsiADRB3
MIMi109691 gene
neXtProtiNX_P13945
OpenTargetsiENSG00000188778
PharmGKBiPA24598
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP13945
KOiK04143
OMAiSNMPYAL
OrthoDBiEOG091G06VI
PhylomeDBiP13945
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiiBeta-3_adrenergic_receptor
GenomeRNAii155
PROiPR:P13945
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188778 Expressed in 36 organ(s), highest expression level in right ovary
CleanExiHS_ADRB3
ExpressionAtlasiP13945 baseline and differential
GenevisibleiP13945 HS

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000681 ADRB3_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00563 ADRENRGCB3AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADRB3_HUMAN
AccessioniPrimary (citable) accession number: P13945
Secondary accession number(s): Q4JFT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1994
Last modified: September 12, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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