Collagen alpha-1(III) chain

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• extracellular matrix structural constituent Source: RGDInferred from sequence orthologyⁱ
  • "Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix."
    Chiodo A.A., Sillence D.O., Cole W.G., Bateman J.F.
    Biochem. J. 311:939-943(1995) [PubMed] [Europe PMC] [Abstract]
  • "Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis."
    Smith L.T., Schwarze U., Goldstein J., Byers P.H.
    J. Invest. Dermatol. 108:241-247(1997) [PubMed] [Europe PMC] [Abstract]
• integrin binding Source: RGDInferred from sequence orthologyⁱ
  • "Simple collagen-like peptides support platelet adhesion under static but not under flow conditions: interaction via alpha2 beta1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces."
    Verkleij M.W., Morton L.F., Knight C.G., de Groot P.G., Barnes M.J., Sixma J.J.
    Blood 91:3808-3816(1998) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• platelet-derived growth factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)."
    Somasundaram R., Schuppan D.
    J. Biol. Chem. 271:26884-26891(1996) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: RGDInferred from sequence orthologyⁱ
  • "MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III."
    Taddese S., Jung M.C., Ihling C., Heinz A., Neubert R.H., Schmelzer C.E.
    Biochim. Biophys. Acta 1804:731-739(2010) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: RGDInferred from sequence orthologyⁱ
  • "Interaction of Smads with collagen types I, III, and V."
    Ellis L.R., Warner D.R., Greene R.M., Pisano M.M.
    Biochem. Biophys. Res. Commun. 310:1117-1123(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• aorta smooth muscle tissue morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome."
    Smith L.B., Hadoke P.W., Dyer E., Denvir M.A., Brownstein D., Miller E., Nelson N., Wells S., Cheeseman M., Greenfield A.
    Cardiovasc. Res. 90:182-190(2011) [PubMed] [Europe PMC] [Abstract]
• blood vessel development Source: RGDInferred from sequence orthologyⁱ
  • "Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development."
    Liu X., Wu H., Byrne M., Krane S., Jaenisch R.
    Proc. Natl. Acad. Sci. U.S.A. 94:1852-1856(1997) [PubMed] [Europe PMC] [Abstract]
• cell-matrix adhesion Source: RGDInferred from sequence orthologyⁱ
  • "A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides."
    Lisman T., Raynal N., Groeneveld D., Maddox B., Peachey A.R., Huizinga E.G., de Groot P.G., Farndale R.W.
    Blood 108:3753-3756(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to amino acid stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice."
    Pogribny I.P., Starlard-Davenport A., Tryndyak V.P., Han T., Ross S.A., Rusyn I., Beland F.A.
    Lab. Invest. 90:1437-1446(2010) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex development Source: UniProtKB
• collagen fibril organization Source: RGDInferred from sequence orthologyⁱ
  • "Myocardial infarction resulting from coronary artery dissection in an adolescent with Ehlers-Danlos syndrome type IV due to a type III collagen mutation."
    Ades L.C., Waltham R.D., Chiodo A.A., Bateman J.F.
    Br Heart J 74:112-116(1995) [PubMed] [Europe PMC] [Abstract]
  • "Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis."
    Smith L.T., Schwarze U., Goldstein J., Byers P.H.
    J. Invest. Dermatol. 108:241-247(1997) [PubMed] [Europe PMC] [Abstract]
  • "Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development."
    Liu X., Wu H., Byrne M., Krane S., Jaenisch R.
    Proc. Natl. Acad. Sci. U.S.A. 94:1852-1856(1997) [PubMed] [Europe PMC] [Abstract]
• digestive tract development Source: RGDInferred from sequence orthologyⁱ
  • "Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development."
    Liu X., Wu H., Byrne M., Krane S., Jaenisch R.
    Proc. Natl. Acad. Sci. U.S.A. 94:1852-1856(1997) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix organization Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• heart development Source: RGDInferred from sequence orthologyⁱ
  • "Myocardial infarction resulting from coronary artery dissection in an adolescent with Ehlers-Danlos syndrome type IV due to a type III collagen mutation."
    Ades L.C., Waltham R.D., Chiodo A.A., Bateman J.F.
    Br Heart J 74:112-116(1995) [PubMed] [Europe PMC] [Abstract]
• integrin-mediated signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin."
    Zoppi N., Gardella R., De Paepe A., Barlati S., Colombi M.
    J. Biol. Chem. 279:18157-18168(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of immune response Source: RGDInferred from sequence orthologyⁱ
  • "Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1."
    Lebbink R.J., de Ruiter T., Adelmeijer J., Brenkman A.B., van Helvoort J.M., Koch M., Farndale R.W., Lisman T., Sonnenberg A., Lenting P.J., Meyaard L.
    J. Exp. Med. 203:1419-1425(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron migration Source: UniProtKB
• peptide cross-linking Source: RGDInferred from sequence orthologyⁱ
  • "Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1."
    Lebbink R.J., de Ruiter T., Adelmeijer J., Brenkman A.B., van Helvoort J.M., Koch M., Farndale R.W., Lisman T., Sonnenberg A., Lenting P.J., Meyaard L.
    J. Exp. Med. 203:1419-1425(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of Rho protein signal transduction Source: UniProtKB
• response to cytokine Source: RGDInferred from sequence orthologyⁱ
  • "Transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells."
    Howard P.S., Kucich U., Coplen D.E., He Y.
    Urology 66:1349-1353(2005) [PubMed] [Europe PMC] [Abstract]
  • "Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms."
    Diaz A., Jimenez S.A.
    Int. J. Biochem. Cell Biol. 29:251-260(1997) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons."
    Sun H.B., Andarawis-Puri N., Li Y., Fung D.T., Lee J.Y., Wang V.M., Basta-Pljakic J., Leong D.J., Sereysky J.B., Ros S.J., Klug R.A., Braman J., Schaffler M.B., Jepsen K.J., Flatow E.L.
    J. Orthop. Res. 28:1380-1386(2010) [PubMed] [Europe PMC] [Abstract]
• response to radiation Source: RGDInferred from sequence orthologyⁱ
  • "The effects of single doses of beta radiation on the wound healing behaviour of human Tenon's capsule fibroblasts."
    Constable P.H., Crowston J.G., Occleston N.L., Khaw P.T.
    Br J Ophthalmol 88:169-173(2004) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: RGDInferred from expression patternⁱ
  • "Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1."
    Marks S.C. Jr., Lundmark C., Wurtz T., Odgren P.R., MacKay C.A., Mason-Savas A., Popoff S.N.
    Dev. Dyn. 215:117-125(1999) [PubMed] [Europe PMC] [Abstract]
• skin development Source: RGDInferred from sequence orthologyⁱ
  • "Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis."
    Smith L.T., Schwarze U., Goldstein J., Byers P.H.
    J. Invest. Dermatol. 108:241-247(1997) [PubMed] [Europe PMC] [Abstract]
• supramolecular fiber organization Source: RGDInferred from sequence orthologyⁱ
  • "Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin."
    Zoppi N., Gardella R., De Paepe A., Barlati S., Colombi M.
    J. Biol. Chem. 279:18157-18168(2004) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells."
    Howard P.S., Kucich U., Coplen D.E., He Y.
    Urology 66:1349-1353(2005) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: RGDInferred from sequence orthologyⁱ
  • "Collagen types I and III propeptides as markers of healing in chronic leg ulcers. A noninvasive method for the determination of procollagen propeptides in wound fluid--influence of growth hormone."
    Rasmussen L.H., Jensen L.T., Avnstorp C., Karlsmark T., Peters K., Horslev-Petersen K.
    Ann. Surg. 216:684-691(1992) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• integrin binding Source: RGDInferred from sequence orthologyⁱ
  • "Simple collagen-like peptides support platelet adhesion under static but not under flow conditions: interaction via alpha2 beta1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces."
    Verkleij M.W., Morton L.F., Knight C.G., de Groot P.G., Barnes M.J., Sixma J.J.
    Blood 91:3808-3816(1998) [PubMed] [Europe PMC] [Abstract]
• platelet-derived growth factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)."
    Somasundaram R., Schuppan D.
    J. Biol. Chem. 271:26884-26891(1996) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: RGDInferred from sequence orthologyⁱ
  • "MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III."
    Taddese S., Jung M.C., Ihling C., Heinz A., Neubert R.H., Schmelzer C.E.
    Biochim. Biophys. Acta 1804:731-739(2010) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: RGDInferred from sequence orthologyⁱ
  • "Interaction of Smads with collagen types I, III, and V."
    Ellis L.R., Warner D.R., Greene R.M., Pisano M.M.
    Biochem. Biophys. Res. Commun. 310:1117-1123(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MMSFVQCGTW FLLTLLHPSL ILAQQSNVDE LGCNYLGQSY ESRDVWKPEP 
        60         70         80         90        100
CQICVCDSGS VLCDDIMCDD EPLDCPNPEI PFGECCAICP QPSTPAPVIP 
       110        120        130        140        150
DGNRPQGPKG DPGPPGIPGR NGDPGLPGQP GLPGPPGSPG ICESCPTGGQ 
       160        170        180        190        200
NYSPQFDSYD VKSGVGGMGG YPGPAGPPGP PGPPGSSGHP GSPGSPGYQG 
       210        220        230        240        250
PPGEPGQAGP AGPPGPPGAI GPSGPAGKDG ESGRPGRPGE RGLPGPPGIK 
       260        270        280        290        300
GPAGIPGFPG MKGHRGFDGR NGEKGETGAP GLKGENGLPG DNGAPGPMGP 
       310        320        330        340        350
RGAPGERGRP GLPGAAGARG NDGARGSDGQ PGPPGPPGTA GFPGSPGAKG 
       360        370        380        390        400
EVGPAGSPGS NGSPGQRGEP GPQGHAGAQG PPGPPGNNGS PGGKGEMGPA 
       410        420        430        440        450
GIPGAPGLLG ARGPPGPAGA NGAPGQRGPS GEPGKNGAKG EPGARGERGE 
       460        470        480        490        500
AGSPGIPGPK GEDGKDGSPG EPGANGVPGN PGERGAPGFR GPAGPNGAPG 
       510        520        530        540        550
EKGPAGERGG PGPAGPRGVA GEPGRDGTPG GPGIRGMPGS PGGPGNDGKP 
       560        570        580        590        600
GPPGSQGESG RPGPPGPSGP RGQPGVMGFP GPKGNDGAPG KNGERGGPGG 
       610        620        630        640        650
PGLPGPAGKN GETGPQGPPG PTGAPGDKGD AGPPGPQGLQ GIPGTSGPPG 
       660        670        680        690        700
ENGKPGEPGP KGEAGAPGVP GGKGDSGAPG ERGPPGTAGT PGLRGGAGPP 
       710        720        730        740        750
GPEGGKGPAG PPGPPGTSGP PGLQGMPGER GGPGSPGPKG EKGEPGGAGA 
       760        770        780        790        800
DGVPGKDGPR GPAGPIGPPG PAGQPGDKGE GGAPGLPGIA GPRGGPGERG 
       810        820        830        840        850
EHGPPGPAGF PGAPGQNGEP GAKGERGAPG EKGEGGPPGA AGPPGGSGPA 
       860        870        880        890        900
GPPGPQGVKG ERGSPGGPGA AGFPGGRGLP GPPGNNGNPG PPGPSGAPGK 
       910        920        930        940        950
DGPPGPAGNS GSPGNPGVAG PKGDAGQPGE KGPPGAQGPP GSPGPLGIAG 
       960        970        980        990       1000
LTGARGLAGP PGMPGPRGSP GPQGIKGESG KPGASGHNGE RGPPGPQGLP 
      1010       1020       1030       1040       1050
GQPGTAGEPG RDGNPGSDGQ PGRDGSPGGK GDRGENGSPG APGAPGHPGP 
      1060       1070       1080       1090       1100
PGPVGPSGKN GDRGETGPAG PSGAPGPAGA RGAPGPQGPR GDKGETGERG 
      1110       1120       1130       1140       1150
SNGIKGHRGF PGNPGPPGSP GAAGHQGAVG SPGPAGPRGP VGPHGPPGKD 
      1160       1170       1180       1190       1200
GSSGHPGPIG PPGPRGNRGE RGSEGSPGHP GQPGPPGPPG APGPCCGGGA 
      1210       1220       1230       1240       1250
AIAGVGGEKS GGFSPYYGDD PMDFKINTEE IMSSLKSVNG QIESLISPDG 
      1260       1270       1280       1290       1300
SRKNPARNCR DLKFCHPELK SGEYWVDPNQ GCKMDAIKVF CNMETGETCI 
      1310       1320       1330       1340       1350
NASPMTVPRK HWWTDAGAEK KHVWFGESMN GGFQFSYGNP DLPEDVLDVQ 
      1360       1370       1380       1390       1400
LAFLRLLSSR ASQNITYHCK NSIAYMDQAN GNVKKSLKLM GSNEGEFKAE 
      1410       1420       1430       1440       1450
GNSKFTYTVL EDGCTKHTGE WSKTVFEYQT RKAMRLPIID IAPYDIGGPD 
      1460 
QEFGVDIGPV CFL                                         

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families