UniProtKB - P13928 (ANXA8_HUMAN)
Protein
Annexin A8
Gene
ANXA8
Organism
Homo sapiens (Human)
Status
Functioni
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 266 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 268 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 270 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 310 | Calcium | 1 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- calcium-dependent phospholipid binding Source: UniProtKB
- calcium ion binding Source: UniProtKB
- phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
- phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
- endosomal transport Source: UniProtKB
- endosome organization Source: UniProtKB
- negative regulation of phospholipase A2 activity Source: UniProtKB
- negative regulation of serine-type endopeptidase activity Source: UniProtKB
Keywordsi
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium, Calcium/phospholipid-binding, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P13928 |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A8ImportedAlternative name(s): Annexin VIII1 Publication Annexin-81 Publication Vascular anticoagulant-beta1 Publication Short name: VAC-beta1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:546, ANXA8 |
MIMi | 602396, gene |
neXtProti | NX_P13928 |
VEuPathDBi | HostDB:ENSG00000265190.6 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Endosome
- late endosome membrane Source: UniProtKB
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 653145 728113 |
OpenTargetsi | ENSG00000265190 |
PharmGKBi | PA134881914 PA24836 |
Miscellaneous databases
Pharosi | P13928, Tbio |
Genetic variation databases
BioMutai | ANXA8 |
DMDMi | 215274181 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067503 | 1 – 327 | Annexin A8Add BLAST | 327 |
Proteomic databases
EPDi | P13928 |
jPOSTi | P13928 |
MassIVEi | P13928 |
MaxQBi | P13928 |
PaxDbi | P13928 |
PeptideAtlasi | P13928 |
PRIDEi | P13928 |
ProteomicsDBi | 5097 52998 [P13928-1] 64350 |
PTM databases
iPTMneti | P13928 |
PhosphoSitePlusi | P13928 |
SwissPalmi | P13928 |
Expressioni
Gene expression databases
Bgeei | ENSG00000265190, Expressed in zone of skin and 95 other tissues |
ExpressionAtlasi | P13928, baseline and differential |
Genevisiblei | P13928, HS |
Organism-specific databases
HPAi | ENSG00000265190, Group enriched (esophagus, skin) |
Interactioni
Binary interactionsi
Hide detailsP13928
GO - Molecular functioni
- actin filament binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 575558, 9 interactors 608549, 11 interactors |
IntActi | P13928, 30 interactors |
MINTi | P13928 |
Miscellaneous databases
RNActi | P13928, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P13928 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P13928 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 21 – 92 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 93 – 164 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 177 – 249 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 253 – 324 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
GeneTreei | ENSGT00940000161044 |
HOGENOMi | CLU_025300_2_3_1 |
InParanoidi | P13928 |
OrthoDBi | 856254at2759 |
PhylomeDBi | P13928 |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR009115, ANX8 |
PANTHERi | PTHR10502:SF133, PTHR10502:SF133, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01808, ANNEXINVIII |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P13928-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK
60 70 80 90 100
RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK
110 120 130 140 150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD
160 170 180 190 200
TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK
210 220 230 240 250
FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC
260 270 280 290 300
TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG
310 320
KTLSSMIMED TSGDYKNALL SLVGSDP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WTN9 | A0A087WTN9_HUMAN | Annexin | ANXA8 | 365 | Annotation score: | ||
A0A075B765 | A0A075B765_HUMAN | Annexin | ANXA8 | 276 | Annotation score: | ||
A0A075B748 | A0A075B748_HUMAN | Annexin A8 | ANXA8 | 21 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | K → Q in BAG59193 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 32 | K → Q in CAI12203 (PubMed:15164054).Curated | 1 | |
Sequence conflicti | 58 | Q → T in AAB46383 (PubMed:1313714).Curated | 1 | |
Sequence conflicti | 83 | F → L in AAB46383 (PubMed:1313714).Curated | 1 | |
Sequence conflicti | 157 | R → S in AAB46383 (PubMed:1313714).Curated | 1 | |
Sequence conflicti | 313 – 314 | GD → RY in AAB46383 (PubMed:1313714).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_000604 | 6 | S → A1 PublicationCorresponds to variant dbSNP:rs3870786Ensembl. | 1 | |
Natural variantiVAR_030630 | 177 | G → A2 PublicationsCorresponds to variant dbSNP:rs3013886Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057805 | 8 – 69 | Missing in isoform 3. 1 PublicationAdd BLAST | 62 | |
Alternative sequenceiVSP_056397 | 138 – 141 | DYGS → GQQG in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_056398 | 142 – 327 | Missing in isoform 2. 1 PublicationAdd BLAST | 186 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16662 mRNA Translation: CAA34650.1 M81844 mRNA Translation: AAB46383.1 AK296573 mRNA Translation: BAG59193.1 AK300158 mRNA Translation: BAG61941.1 AL391137 Genomic DNA Translation: CAI12203.1 AL591684 Genomic DNA No translation available. BC004376 mRNA Translation: AAH04376.1 BC073755 mRNA Translation: AAH73755.1 |
CCDSi | CCDS73121.1 [P13928-3] CCDS73122.1 [P13928-1] |
PIRi | S06476, LUHU8 |
RefSeqi | NP_001035173.1, NM_001040084.2 [P13928-1] NP_001092315.2, NM_001098845.2 NP_001258631.1, NM_001271702.1 NP_001258632.1, NM_001271703.1 [P13928-3] |
Genome annotation databases
Ensembli | ENST00000577813; ENSP00000463244; ENSG00000265190 [P13928-2] ENST00000583911; ENSP00000463091; ENSG00000265190 [P13928-3] ENST00000585281; ENSP00000462880; ENSG00000265190 [P13928-1] |
GeneIDi | 653145 728113 |
KEGGi | hsa:653145 hsa:728113 |
UCSCi | uc001jev.5, human [P13928-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16662 mRNA Translation: CAA34650.1 M81844 mRNA Translation: AAB46383.1 AK296573 mRNA Translation: BAG59193.1 AK300158 mRNA Translation: BAG61941.1 AL391137 Genomic DNA Translation: CAI12203.1 AL591684 Genomic DNA No translation available. BC004376 mRNA Translation: AAH04376.1 BC073755 mRNA Translation: AAH73755.1 |
CCDSi | CCDS73121.1 [P13928-3] CCDS73122.1 [P13928-1] |
PIRi | S06476, LUHU8 |
RefSeqi | NP_001035173.1, NM_001040084.2 [P13928-1] NP_001092315.2, NM_001098845.2 NP_001258631.1, NM_001271702.1 NP_001258632.1, NM_001271703.1 [P13928-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1W3W | X-ray | 1.99 | A | 1-327 | [»] | |
1W45 | X-ray | 2.51 | A/B | 1-327 | [»] | |
SMRi | P13928 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 575558, 9 interactors 608549, 11 interactors |
IntActi | P13928, 30 interactors |
MINTi | P13928 |
PTM databases
iPTMneti | P13928 |
PhosphoSitePlusi | P13928 |
SwissPalmi | P13928 |
Genetic variation databases
BioMutai | ANXA8 |
DMDMi | 215274181 |
Proteomic databases
EPDi | P13928 |
jPOSTi | P13928 |
MassIVEi | P13928 |
MaxQBi | P13928 |
PaxDbi | P13928 |
PeptideAtlasi | P13928 |
PRIDEi | P13928 |
ProteomicsDBi | 5097 52998 [P13928-1] 64350 |
Protocols and materials databases
Antibodypediai | 72811, 152 antibodies |
DNASUi | 244 |
Genome annotation databases
Ensembli | ENST00000577813; ENSP00000463244; ENSG00000265190 [P13928-2] ENST00000583911; ENSP00000463091; ENSG00000265190 [P13928-3] ENST00000585281; ENSP00000462880; ENSG00000265190 [P13928-1] |
GeneIDi | 653145 728113 |
KEGGi | hsa:653145 hsa:728113 |
UCSCi | uc001jev.5, human [P13928-1] |
Organism-specific databases
CTDi | 653145 728113 |
DisGeNETi | 653145 728113 |
GeneCardsi | ANXA8 |
HGNCi | HGNC:546, ANXA8 |
HPAi | ENSG00000265190, Group enriched (esophagus, skin) |
MIMi | 602396, gene |
neXtProti | NX_P13928 |
OpenTargetsi | ENSG00000265190 |
PharmGKBi | PA134881914 PA24836 |
VEuPathDBi | HostDB:ENSG00000265190.6 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161044 |
HOGENOMi | CLU_025300_2_3_1 |
InParanoidi | P13928 |
OrthoDBi | 856254at2759 |
PhylomeDBi | P13928 |
TreeFami | TF105452 |
Enzyme and pathway databases
PathwayCommonsi | P13928 |
Miscellaneous databases
BioGRID-ORCSi | 653145, 1 hit in 833 CRISPR screens 728113, 33 hits in 836 CRISPR screens |
ChiTaRSi | ANXA8, human |
EvolutionaryTracei | P13928 |
Pharosi | P13928, Tbio |
PROi | PR:P13928 |
RNActi | P13928, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000265190, Expressed in zone of skin and 95 other tissues |
ExpressionAtlasi | P13928, baseline and differential |
Genevisiblei | P13928, HS |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR009115, ANX8 |
PANTHERi | PTHR10502:SF133, PTHR10502:SF133, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01808, ANNEXINVIII |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANXA8_HUMAN | |
Accessioni | P13928Primary (citable) accession number: P13928 Secondary accession number(s): A6NDE6 Q9BT34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families