ANXA8

Functionⁱ

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	266	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	268	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	270	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	310	Calcium	1

GO - Molecular functionⁱ

actin filament binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16638567
calcium-dependent phospholipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16638567
- 2530088
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15644210
phosphatidylinositol-3,4,5-trisphosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16638567
phosphatidylinositol-3,4-bisphosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16638567
phosphatidylinositol-4,5-bisphosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16638567

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: UniProtKB-KW
endosomal transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18923148
endosome organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18923148
negative regulation of phospholipase A2 activity
Source: UniProtKB
Inferred from direct assayⁱ
- 2530088
negative regulation of serine-type endopeptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 2530088

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Blood coagulation, Hemostasis
Ligand	Calcium, Calcium/phospholipid-binding, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Annexin A8Imported Alternative name(s): Annexin VIII1 Publication Annexin-81 Publication Vascular anticoagulant-beta1 Publication Short name: VAC-beta1 Publication
Gene namesⁱ	Name:ANXA8Imported Synonyms:ANX8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000265190.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:546 ANXA8
MIMⁱ	602396 gene
neXtProtⁱ	NX_P13928

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	653145 728113
Open Targets More...OpenTargetsⁱ	ENSG00000265190
PharmGKBⁱ	PA134881914 PA24836

Polymorphism and mutation databases

BioMutaⁱ	ANXA8
DMDMⁱ	215274181

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000067503	1 – 327	Annexin A8Add BLAST		327

Proteomic databases

EPDⁱ	P13928
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13928
PaxDbⁱ	P13928
PeptideAtlas More...PeptideAtlasⁱ	P13928
PRIDEⁱ	P13928
ProteomicsDBⁱ	52998 64350

PTM databases

iPTMnetⁱ	P13928
PhosphoSitePlusⁱ	P13928

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000265190 Expressed in 77 organ(s), highest expression level in vagina
CleanExⁱ	HS_ANXA8
ExpressionAtlasⁱ	P13928 baseline and differential
Genevisibleⁱ	P13928 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045246 HPA047451

HPAⁱ

HPA045246
HPA047451

Interactionⁱ

GO - Molecular functionⁱ

actin filament binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16638567

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	575558, 9 interactors 608549, 9 interactors
IntActⁱ	P13928, 7 interactors
Molecular INTeraction database More...MINTⁱ	P13928
STRINGⁱ	9606.ENSP00000341674

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	24 – 34	Combined sources	11
Beta strandⁱ	35 – 38	Combined sources	4
Helixⁱ	41 – 48	Combined sources	8
Helixⁱ	53 – 67	Combined sources	15
Helixⁱ	71 – 78	Combined sources	8
Helixⁱ	81 – 91	Combined sources	11
Helixⁱ	96 – 107	Combined sources	12
Beta strandⁱ	108 – 110	Combined sources	3
Helixⁱ	113 – 122	Combined sources	10
Helixⁱ	125 – 139	Combined sources	15
Helixⁱ	143 – 150	Combined sources	8
Helixⁱ	153 – 163	Combined sources	11
Beta strandⁱ	167 – 170	Combined sources	4
Helixⁱ	176 – 191	Combined sources	16
Beta strandⁱ	193 – 195	Combined sources	3
Helixⁱ	198 – 207	Combined sources	10
Helixⁱ	210 – 224	Combined sources	15
Helixⁱ	228 – 235	Combined sources	8
Helixⁱ	238 – 252	Combined sources	15
Helixⁱ	254 – 266	Combined sources	13
Beta strandⁱ	267 – 270	Combined sources	4
Helixⁱ	273 – 283	Combined sources	11
Turnⁱ	284 – 286	Combined sources	3
Helixⁱ	288 – 299	Combined sources	12
Helixⁱ	303 – 310	Combined sources	8
Helixⁱ	313 – 323	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P13928
SMRⁱ	P13928
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13928

EvolutionaryTraceⁱ

P13928

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	30 – 90	Annexin 1Add BLAST	61
Repeatⁱ	102 – 162	Annexin 2Add BLAST	61
Repeatⁱ	187 – 247	Annexin 3Add BLAST	61
Repeatⁱ	262 – 322	Annexin 4Add BLAST	61

Domainⁱ

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesⁱ

Belongs to the annexin family.Curated

Keywords - Domainⁱ

Annexin, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118972
HOGENOMⁱ	HOG000158803
HOVERGENⁱ	HBG061815
InParanoidⁱ	P13928
KEGG Orthology (KO) More...KOⁱ	K17096
PhylomeDBⁱ	P13928
TreeFamⁱ	TF105452

Family and domain databases

Gene3Dⁱ	1.10.220.10, 4 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR009115 ANX8
PANTHERⁱ	PTHR10502:SF133 PTHR10502:SF133, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00191 Annexin, 4 hits
PRINTSⁱ	PR00196 ANNEXIN PR01808 ANNEXINVIII
SMARTⁱ	View protein in SMART SM00335 ANX, 4 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 4 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P13928-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK 
        60         70         80         90        100
RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK 
       110        120        130        140        150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD 
       160        170        180        190        200
TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK 
       210        220        230        240        250
FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC 
       260        270        280        290        300
TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG 
       310        320 
KTLSSMIMED TSGDYKNALL SLVGSDP

Length:327

Mass (Da):36,881

Last modified:November 25, 2008 - v3

Checksum:ⁱ5DBBDBB6E723C298

GO

Isoform 2 (identifier: P13928-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
138-141: DYGS → GQQG
142-327: Missing.

« Hide

        10         20         30         40         50
MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK 
        60         70         80         90        100
RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK 
       110        120        130        140 
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEGQQ G

Note: No experimental confirmation available.

Show »

Length:141

Mass (Da):16,070

Checksum:ⁱD7D3F13E09C28D19

GO

Isoform 3 (identifier: P13928-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
8-69: Missing.

« Hide

        10         20         30         40         50
MAWWKSWDLT ETLKSELSGK FERLIVALMY PPYRYEAKEL HDAMKGLGTK 
        60         70         80         90        100
EGVIIEILAS RTKNQLREIM KAYEEDYGSS LEEDIQADTS GYLERILVCL 
       110        120        130        140        150
LQGSRDDVSS FVDPGLALQD AQDLYAAGEK IRGTDEMKFI TILCTRSATH 
       160        170        180        190        200
LLRVFEEYEK IANKSIEDSI KSETHGSLEE AMLTVVKCTQ NLHSYFAERL 
       210        220        230        240        250
YYAMKGAGTR DGTLIRNIVS RSEIDLNLIK CHFKKMYGKT LSSMIMEDTS 
       260 
GDYKNALLSL VGSDP

Note: No experimental confirmation available.

Show »

Length:265

Mass (Da):30,017

Checksum:ⁱE22DABB4F9AEAE6C

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WTN9	A0A087WTN9_HUMAN	Annexin Annexin	ANXA8	365	Annotation score:
A0A075B765	A0A075B765_HUMAN	Annexin Annexin	ANXA8	276	Annotation score:
A0A075B748	A0A075B748_HUMAN	Annexin A8 Annexin A8	ANXA8	21	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	32	K → Q in BAG59193 (PubMed:14702039).Curated	1
Sequence conflictⁱ	32	K → Q in CAI12203 (PubMed:15164054).Curated	1
Sequence conflictⁱ	58	Q → T in AAB46383 (PubMed:1313714).Curated	1
Sequence conflictⁱ	83	F → L in AAB46383 (PubMed:1313714).Curated	1
Sequence conflictⁱ	157	R → S in AAB46383 (PubMed:1313714).Curated	1
Sequence conflictⁱ	313 – 314	GD → RY in AAB46383 (PubMed:1313714).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_000604	6	S → A1 PublicationCorresponds to variant dbSNP:rs3870786Ensembl.		1
Natural variantⁱVAR_030630	177	G → A2 PublicationsCorresponds to variant dbSNP:rs3013886Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_057805	8 – 69	Missing in isoform 3. 1 PublicationAdd BLAST	62
Alternative sequenceⁱVSP_056397	138 – 141	DYGS → GQQG in isoform 2. 1 Publication	4
Alternative sequenceⁱVSP_056398	142 – 327	Missing in isoform 2. 1 PublicationAdd BLAST	186

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16662 mRNA Translation: CAA34650.1 M81844 mRNA Translation: AAB46383.1 AK296573 mRNA Translation: BAG59193.1 AK300158 mRNA Translation: BAG61941.1 AL391137 Genomic DNA Translation: CAI12203.1 AL591684 Genomic DNA No translation available. BC004376 mRNA Translation: AAH04376.1 BC073755 mRNA Translation: AAH73755.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73121.1 [P13928-3] CCDS73122.1 [P13928-1]
PIRⁱ	S06476 LUHU8
NCBI Reference Sequences More...RefSeqⁱ	NP_001035173.1, NM_001040084.2 [P13928-1] NP_001092315.2, NM_001098845.2 NP_001258631.1, NM_001271702.1 NP_001258632.1, NM_001271703.1 [P13928-3]
UniGeneⁱ	Hs.535306 Hs.705389 Hs.744068

Genome annotation databases

Ensemblⁱ	ENST00000577813; ENSP00000463244; ENSG00000265190 [P13928-2] ENST00000583911; ENSP00000463091; ENSG00000265190 [P13928-3] ENST00000585281; ENSP00000462880; ENSG00000265190 [P13928-1]
GeneIDⁱ	653145 728113
KEGGⁱ	hsa:653145 hsa:728113
UCSC genome browser More...UCSCⁱ	uc001jev.5 human [P13928-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P13928	Annexin		HUMAN		393	UniRef90_P13928
UPI0005D0371D		HUMAN		448
UPI0005D01F2A		HUMAN		387
P13928-2	Annexin		PONAB		141	UniRef90_P13928-2
P13928-3	Annexin		LIPVE		266	UniRef90_P13928-3
Annexin		HUMAN		265
Annexin		SAIBB		265
Annexin		PROCO		265
Annexin		MACMU		265
+26

Protein	Similar proteins		Species	Score	Length	Source
P13928	Annexin A8		PANTR		327	UniRef50_P13928
Annexin A8-like protein 1		HUMAN		327
Annexin		OTOGA		327
annexin A8		URSMA		374
Annexin		ICTTR		329
+86
P13928-2	Annexin		PONAB		141	UniRef50_P13928-2
Annexin		PETMA		175
Annexin (Fragment)		blackstripe livebearer		151
Annexin		blackstripe livebearer		140
P13928-3	Annexin		LIPVE		266	UniRef50_P13928-3
Annexin		TARSY		265
Annexin		AOTNA		265
Annexin		GORGO		265
Annexin		SAIBB		265
+37

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16662 mRNA Translation: CAA34650.1 M81844 mRNA Translation: AAB46383.1 AK296573 mRNA Translation: BAG59193.1 AK300158 mRNA Translation: BAG61941.1 AL391137 Genomic DNA Translation: CAI12203.1 AL591684 Genomic DNA No translation available. BC004376 mRNA Translation: AAH04376.1 BC073755 mRNA Translation: AAH73755.1
CCDSⁱ	CCDS73121.1 [P13928-3] CCDS73122.1 [P13928-1]
PIRⁱ	S06476 LUHU8
RefSeqⁱ	NP_001035173.1, NM_001040084.2 [P13928-1] NP_001092315.2, NM_001098845.2 NP_001258631.1, NM_001271702.1 NP_001258632.1, NM_001271703.1 [P13928-3]
UniGeneⁱ	Hs.535306 Hs.705389 Hs.744068

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1W3W	X-ray	1.99	A	1-327	[»]
	1W45	X-ray	2.51	A/B	1-327	[»]
ProteinModelPortalⁱ	P13928
SMRⁱ	P13928
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	575558, 9 interactors 608549, 9 interactors
IntActⁱ	P13928, 7 interactors
MINTⁱ	P13928
STRINGⁱ	9606.ENSP00000341674

PTM databases

iPTMnetⁱ	P13928
PhosphoSitePlusⁱ	P13928

Polymorphism and mutation databases

BioMutaⁱ	ANXA8
DMDMⁱ	215274181

Proteomic databases

EPDⁱ	P13928
MaxQBⁱ	P13928
PaxDbⁱ	P13928
PeptideAtlasⁱ	P13928
PRIDEⁱ	P13928
ProteomicsDBⁱ	52998 64350

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	244
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000577813; ENSP00000463244; ENSG00000265190 [P13928-2] ENST00000583911; ENSP00000463091; ENSG00000265190 [P13928-3] ENST00000585281; ENSP00000462880; ENSG00000265190 [P13928-1]
GeneIDⁱ	653145 728113
KEGGⁱ	hsa:653145 hsa:728113
UCSCⁱ	uc001jev.5 human [P13928-1]

Organism-specific databases

CTDⁱ	653145 728113
DisGeNETⁱ	653145 728113
EuPathDBⁱ	HostDB:ENSG00000265190.6
GeneCardsⁱ	ANXA8
HGNCⁱ	HGNC:546 ANXA8
HPAⁱ	HPA045246 HPA047451
MIMⁱ	602396 gene
neXtProtⁱ	NX_P13928
OpenTargetsⁱ	ENSG00000265190
PharmGKBⁱ	PA134881914 PA24836
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
GeneTreeⁱ	ENSGT00760000118972
HOGENOMⁱ	HOG000158803
HOVERGENⁱ	HBG061815
InParanoidⁱ	P13928
KOⁱ	K17096
PhylomeDBⁱ	P13928
TreeFamⁱ	TF105452

Miscellaneous databases

ChiTaRSⁱ	ANXA8 human
EvolutionaryTraceⁱ	P13928
Protein Ontology More...PROⁱ	PR:P13928
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000265190 Expressed in 77 organ(s), highest expression level in vagina
CleanExⁱ	HS_ANXA8
ExpressionAtlasⁱ	P13928 baseline and differential
Genevisibleⁱ	P13928 HS

Family and domain databases

Gene3Dⁱ	1.10.220.10, 4 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR009115 ANX8
PANTHERⁱ	PTHR10502:SF133 PTHR10502:SF133, 1 hit
Pfamⁱ	View protein in Pfam PF00191 Annexin, 4 hits
PRINTSⁱ	PR00196 ANNEXIN PR01808 ANNEXINVIII
SMARTⁱ	View protein in SMART SM00335 ANX, 4 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANXA8_HUMAN
Accessionⁱ	P13928Primary (citable) accession number: P13928 Secondary accession number(s): A6NDE6 Q9BT34
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	November 25, 2008
	Last modified:	October 10, 2018
	This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - P13928 (ANXA8_HUMAN)

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Annexin A8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Endosome

Extracellular region or secreted

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ