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UniProtKB - P13928 (ANXA8_HUMAN)

Entry version 197 (23 Feb 2022)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

Annexin A8

Gene

ANXA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi266Calcium; via carbonyl oxygen1
Metal bindingi268Calcium; via carbonyl oxygen1
Metal bindingi270Calcium; via carbonyl oxygen1
Metal bindingi310Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Calcium/phospholipid-binding, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13928

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P13928

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Annexin A8Imported
Alternative name(s):
Annexin VIII1 Publication
Annexin-81 Publication
Vascular anticoagulant-beta1 Publication
Short name:
VAC-beta1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANXA8Imported
Synonyms:ANX8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:546, ANXA8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602396, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13928

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000265190

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		653145
728113

Open Targets

More...OpenTargetsi		ENSG00000265190

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134881914
PA24836

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13928, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANXA8

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274181

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000675031 – 327Annexin A8Add BLAST327

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P13928

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13928

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13928

MaxQB - The MaxQuant DataBase

More...MaxQBi		P13928

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13928

PeptideAtlas

More...PeptideAtlasi		P13928

PRoteomics IDEntifications database

More...PRIDEi		P13928

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5097
52998 [P13928-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13928

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13928

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13928

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000265190, Expressed in zone of skin and 96 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13928, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13928, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000265190, Tissue enhanced (esophagus, skin, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		575558, 43 interactors
608549, 11 interactors

Protein interaction database and analysis system

More...IntActi		P13928, 31 interactors

Molecular INTeraction database

More...MINTi		P13928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13928, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13928

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P13928

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati21 – 92Annexin 1PROSITE-ProRule annotationAdd BLAST72
Repeati93 – 164Annexin 2PROSITE-ProRule annotationAdd BLAST72
Repeati177 – 249Annexin 3PROSITE-ProRule annotationAdd BLAST73
Repeati253 – 324Annexin 4PROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the annexin family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161044

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025300_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13928

Identification of Orthologs from Complete Genome Data

More...OMAi		PRFDFIG

Database of Orthologous Groups

More...OrthoDBi		856254at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13928

TreeFam database of animal gene trees

More...TreeFami		TF105452

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.220.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001464, Annexin
IPR018502, Annexin_repeat
IPR018252, Annexin_repeat_CS
IPR037104, Annexin_sf
IPR009115, ANX8

The PANTHER Classification System

More...PANTHERi		PTHR10502:SF133, PTHR10502:SF133, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00191, Annexin, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00196, ANNEXIN
PR01808, ANNEXINVIII

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00335, ANX, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47874, SSF47874, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00223, ANNEXIN_1, 4 hits
PS51897, ANNEXIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13928-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK 
        60         70         80         90        100
RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK 
       110        120        130        140        150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD 
       160        170        180        190        200
TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK 
       210        220        230        240        250
FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC 
       260        270        280        290        300
TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG 
       310        320 
KTLSSMIMED TSGDYKNALL SLVGSDP
Length:327
Mass (Da):36,881
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DBBDBB6E723C298
GO
Isoform 2 (identifier: P13928-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-141: DYGS → GQQG
     142-327: Missing.

Show »
Length:141
Mass (Da):16,070
Checksum:iD7D3F13E09C28D19
GO
Isoform 3 (identifier: P13928-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-69: Missing.

Show »
Length:265
Mass (Da):30,017
Checksum:iE22DABB4F9AEAE6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTN9A0A087WTN9_HUMAN
Annexin
ANXA8
365Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B765A0A075B765_HUMAN
Annexin
ANXA8
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B748A0A075B748_HUMAN
Annexin A8
ANXA8
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32K → Q in BAG59193 (PubMed:14702039).Curated1
Sequence conflicti32K → Q in CAI12203 (PubMed:15164054).Curated1
Sequence conflicti58Q → T in AAB46383 (PubMed:1313714).Curated1
Sequence conflicti83F → L in AAB46383 (PubMed:1313714).Curated1
Sequence conflicti157R → S in AAB46383 (PubMed:1313714).Curated1
Sequence conflicti313 – 314GD → RY in AAB46383 (PubMed:1313714).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0006046S → A1 PublicationCorresponds to variant dbSNP:rs3870786Ensembl.1
Natural variantiVAR_030630177G → A2 PublicationsCorresponds to variant dbSNP:rs75345346Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0578058 – 69Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_056397138 – 141DYGS → GQQG in isoform 2. 1 Publication4
Alternative sequenceiVSP_056398142 – 327Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X16662 mRNA Translation: CAA34650.1
M81844 mRNA Translation: AAB46383.1
AK296573 mRNA Translation: BAG59193.1
AK300158 mRNA Translation: BAG61941.1
AL391137 Genomic DNA Translation: CAI12203.1
AL591684 Genomic DNA No translation available.
BC004376 mRNA Translation: AAH04376.1
BC073755 mRNA Translation: AAH73755.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73121.1 [P13928-3]
CCDS73122.1 [P13928-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S06476, LUHU8

NCBI Reference Sequences

More...RefSeqi		NP_001035173.1, NM_001040084.2 [P13928-1]
NP_001092315.2, NM_001098845.2
NP_001258631.1, NM_001271702.1
NP_001258632.1, NM_001271703.1 [P13928-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000577813; ENSP00000463244; ENSG00000265190 [P13928-2]
ENST00000583911; ENSP00000463091; ENSG00000265190 [P13928-3]
ENST00000585281; ENSP00000462880; ENSG00000265190

Database of genes from NCBI RefSeq genomes

More...GeneIDi		653145
728113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:653145
hsa:728113

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000585281.6; ENSP00000462880.1; NM_001040084.3; NP_001035173.1

UCSC genome browser

More...UCSCi		uc001jev.5, human [P13928-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16662 mRNA Translation: CAA34650.1
M81844 mRNA Translation: AAB46383.1
AK296573 mRNA Translation: BAG59193.1
AK300158 mRNA Translation: BAG61941.1
AL391137 Genomic DNA Translation: CAI12203.1
AL591684 Genomic DNA No translation available.
BC004376 mRNA Translation: AAH04376.1
BC073755 mRNA Translation: AAH73755.1
CCDSiCCDS73121.1 [P13928-3]
CCDS73122.1 [P13928-1]
PIRiS06476, LUHU8
RefSeqiNP_001035173.1, NM_001040084.2 [P13928-1]
NP_001092315.2, NM_001098845.2
NP_001258631.1, NM_001271702.1
NP_001258632.1, NM_001271703.1 [P13928-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W3WX-ray1.99A1-327[»]
1W45X-ray2.51A/B1-327[»]
SMRiP13928
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi575558, 43 interactors
608549, 11 interactors
IntActiP13928, 31 interactors
MINTiP13928

PTM databases

iPTMnetiP13928
PhosphoSitePlusiP13928
SwissPalmiP13928

Genetic variation databases

BioMutaiANXA8
DMDMi215274181

Proteomic databases

EPDiP13928
jPOSTiP13928
MassIVEiP13928
MaxQBiP13928
PaxDbiP13928
PeptideAtlasiP13928
PRIDEiP13928
ProteomicsDBi5097
52998 [P13928-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72811, 158 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		244

Genome annotation databases

EnsembliENST00000577813; ENSP00000463244; ENSG00000265190 [P13928-2]
ENST00000583911; ENSP00000463091; ENSG00000265190 [P13928-3]
ENST00000585281; ENSP00000462880; ENSG00000265190
GeneIDi653145
728113
KEGGihsa:653145
hsa:728113
MANE-SelectiENST00000585281.6; ENSP00000462880.1; NM_001040084.3; NP_001035173.1
UCSCiuc001jev.5, human [P13928-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		653145
728113
DisGeNETi653145
728113

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANXA8
HGNCiHGNC:546, ANXA8
HPAiENSG00000265190, Tissue enhanced (esophagus, skin, vagina)
MIMi602396, gene
neXtProtiNX_P13928
OpenTargetsiENSG00000265190
PharmGKBiPA134881914
PA24836
VEuPathDBiHostDB:ENSG00000265190

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000161044
HOGENOMiCLU_025300_2_3_1
InParanoidiP13928
OMAiPRFDFIG
OrthoDBi856254at2759
PhylomeDBiP13928
TreeFamiTF105452

Enzyme and pathway databases

PathwayCommonsiP13928
SignaLinkiP13928

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		653145, 4 hits in 942 CRISPR screens
728113, 38 hits in 949 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANXA8, human
EvolutionaryTraceiP13928
PharosiP13928, Tbio

Protein Ontology

More...PROi		PR:P13928
RNActiP13928, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000265190, Expressed in zone of skin and 96 other tissues
ExpressionAtlasiP13928, baseline and differential
GenevisibleiP13928, HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464, Annexin
IPR018502, Annexin_repeat
IPR018252, Annexin_repeat_CS
IPR037104, Annexin_sf
IPR009115, ANX8
PANTHERiPTHR10502:SF133, PTHR10502:SF133, 1 hit
PfamiView protein in Pfam
PF00191, Annexin, 4 hits
PRINTSiPR00196, ANNEXIN
PR01808, ANNEXINVIII
SMARTiView protein in SMART
SM00335, ANX, 4 hits
SUPFAMiSSF47874, SSF47874, 1 hit
PROSITEiView protein in PROSITE
PS00223, ANNEXIN_1, 4 hits
PS51897, ANNEXIN_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANXA8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13928
Secondary accession number(s): A6NDE6
, A6NLM1, B4DKI1, B4DTC9, Q5T2P8, Q5VTM4, Q6GMY3, Q9BT34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 25, 2008
Last modified: February 23, 2022
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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