UniProtKB - P13875 (PB2_INBAC)
Polymerase basic protein 2
PB2
Functioni
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
UniRule annotationGO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-UniRule
GO - Biological processi
- 7-methylguanosine mRNA capping Source: UniProtKB-UniRule
- cap snatching Source: UniProtKB-UniRule
- suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity Source: UniProtKB-UniRule
- transcription, DNA-templated Source: UniProtKB-UniRule
- viral RNA genome replication Source: InterPro
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Polymerase basic protein 2UniRule annotationAlternative name(s): RNA-directed RNA polymerase subunit P3UniRule annotation |
Gene namesi | Name:PB2UniRule annotation |
Organismi | Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted]) |
Taxonomic identifieri | 11522 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Insthoviricetes › Articulavirales › Orthomyxoviridae › Betainfluenzavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
Keywords - Cellular componenti
Host nucleus, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078844 | 1 – 770 | Polymerase basic protein 2Add BLAST | 770 |
Interactioni
Subunit structurei
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.
Interacts (via N-terminus) with PB1 (via C-terminus).
Interacts with nucleoprotein NP (via N-terminus).
UniRule annotationFamily & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 740 – 743 | Nuclear localization signalUniRule annotation | 4 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.30.30.90, 1 hit |
HAMAPi | MF_04062, INV_PB2, 1 hit |
InterProi | View protein in InterPro IPR001591, INV_PB2 IPR037258, PDB2_C |
Pfami | View protein in Pfam PF00604, Flu_PB2, 1 hit |
SUPFAMi | SSF160453, SSF160453, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTLAKIELLK QLLRDNEAKT VLKQTTVDQY NIIRKFNTSR IERNPSLRMK
60 70 80 90 100
WAMCSNFPLA LTKGDMANRI PLEYKGIQLK TNAEDIGTKG QMCSIAAVTW
110 120 130 140 150
WNTYGPIGDT EGFEKVYESF FLRKMRLDNA TWGRITFGPV ERVRKRVLLN
160 170 180 190 200
PLTKEMPPDE ASNVIMEILF PKEAGIPRES TWIHRELIKE KREKLKGTMI
210 220 230 240 250
TPIVLAYMLE RELVARRRFL PVAGATSAEF IEMLHCLQGE NWRQIYHPGG
260 270 280 290 300
NKLTESRSQS MIVACRKIIR RSIVASNPLE LAVEIANKTV IDTEPLKSCL
310 320 330 340 350
AAIDGGDVAC DIIRAALGLK IRQRQRFGRL ELKRISGRGF KNDEEILIGN
360 370 380 390 400
GTIQKIGIWD GEEEFHVRCG ECRGILKKSK MRMEKLLINS AKKEDMKDLI
410 420 430 440 450
ILCMVFSQDT RMFQGVRGEI NFLNRAGQLL SPMYQLQRYF LNRSNDLFDQ
460 470 480 490 500
WGYEEPPKAS ELHGINELMN ASDYTLKGVV VTKNVIDDFS STETEKVSIT
510 520 530 540 550
KNLSLIKRTG EVIMGANDVS ELESQAQLMI TYDTPKMWEM GTTKELVQNT
560 570 580 590 600
YQWVLKNLVT LKAQFLLGKE DMFQWDAFEA FESIIPQKMA GQYSGFARAV
610 620 630 640 650
LKQMRDQEVM KTDQFIKLLP FCFSPPKLRR NGEPYQFLRL MLKGGGENFI
660 670 680 690 700
EVRKGSPLFS YNPQTEVLTI CGRMMSLKGK IEDEERNRSM GNAVLAGFLV
710 720 730 740 750
SGKYDPDLGD FKTIEELEKL KPGEKANILL YQGKPVKVVK RKRYSALSND
760 770
ISQGIKRQRM TVESMGWALS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20163 Genomic RNA Translation: AAA43762.1 |
PIRi | A28604, P3IVBC |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20163 Genomic RNA Translation: AAA43762.1 |
PIRi | A28604, P3IVBC |
3D structure databases
SMRi | P13875 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.30.30.90, 1 hit |
HAMAPi | MF_04062, INV_PB2, 1 hit |
InterProi | View protein in InterPro IPR001591, INV_PB2 IPR037258, PDB2_C |
Pfami | View protein in Pfam PF00604, Flu_PB2, 1 hit |
SUPFAMi | SSF160453, SSF160453, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PB2_INBAC | |
Accessioni | P13875Primary (citable) accession number: P13875 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |