UniProtKB - P13871 (RDRP_INBAC)
RNA-directed RNA polymerase catalytic subunit
PB1
Functioni
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
UniRule annotationCatalytic activityi
- EC:2.7.7.48UniRule annotation
GO - Molecular functioni
- nucleotide binding Source: UniProtKB-UniRule
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-UniRule
GO - Biological processi
- suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity Source: UniProtKB-UniRule
- transcription, DNA-templated Source: UniProtKB-UniRule
- viral RNA genome replication Source: UniProtKB-UniRule
- viral transcription Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: RNA-directed RNA polymerase catalytic subunitUniRule annotation (EC:2.7.7.48UniRule annotation)Alternative name(s): Polymerase basic protein 1UniRule annotation Short name: PB1UniRule annotation RNA-directed RNA polymerase subunit P1UniRule annotation |
Gene namesi | Name:PB1UniRule annotation |
Organismi | Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted]) |
Taxonomic identifieri | 11522 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Insthoviricetes › Articulavirales › Orthomyxoviridae › Betainfluenzavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Subcellular locationi
- Host nucleus UniRule annotation
- Host cytoplasm UniRule annotation
Keywords - Cellular componenti
Host cytoplasm, Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078772 | 1 – 752 | RNA-directed RNA polymerase catalytic subunitAdd BLAST | 752 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.
Interacts (via N-terminus) with PA (via C-terminus).
Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 286 – 482 | RdRp catalyticUniRule annotationAdd BLAST | 197 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 249 – 256 | Promoter-binding siteUniRule annotation | 8 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 187 – 195 | Nuclear localization signalUniRule annotation | 9 | |
Motifi | 203 – 216 | Nuclear localization signalUniRule annotationAdd BLAST | 14 |
Sequence similaritiesi
Family and domain databases
HAMAPi | MF_04065, INFV_RDRP, 1 hit |
InterProi | View protein in InterPro IPR007099, RNA-dir_pol_NSvirus IPR001407, RNA_pol_PB1_influenza |
Pfami | View protein in Pfam PF00602, Flu_PB1, 1 hit |
PIRSFi | PIRSF000827, RdRPol_OMV, 1 hit |
PROSITEi | View protein in PROSITE PS50525, RDRP_SSRNA_NEG_SEG, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MNINPYFLFI DVPIQAAIST TFPYTGVPPY SHGTGTGYTI DTVIRTHEYS
60 70 80 90 100
NKGKQYISDV TGCAMVDPTN GPLPEDNEPS AYAQLDCVLE ALDRMDEEHP
110 120 130 140 150
GLFQAASQNA MEALMVTTVD KLTQGRQTFD WTVCRNQPAA TALNTTITSF
160 170 180 190 200
RLNDLNGADK GGLVPFCQDI IDSLDKPEMT FFSVKNIKKK LPAKNRKGFL
210 220 230 240 250
IKRIPMKVKD RITRVEYIKR ALSLNTMTKD AERGKLKRRA IATAGIQIRG
260 270 280 290 300
FVLVVENLAK NICENLEQSG LPVGGNEKKA KLSNAVAKML SNCPPGGISM
310 320 330 340 350
TVTGDNTKWN ECLNPRIFLA MTERITRDSP IWFRDFCSIA PVLFSNKIAR
360 370 380 390 400
LGKGFMITSK TKRLKAQIPC PDLFNIPLER YNEETRAKLK KLKPFFNEEG
410 420 430 440 450
TASLSPGMMM GMFNMLSTVL GVAALGIKNI GNKEYLWDGL QSSDDFALFV
460 470 480 490 500
NAKDEETCME GINDFYRTCK LLGINMSKKK SYCNETGMFE FTSMFYRDGF
510 520 530 540 550
VSNFAMELPS FGVAGVNESA DMAIGMTIIK NNMINNGMGP ATAQTAIQLF
560 570 580 590 600
IADYRYTYKC HRGDSKVEGK RMKIIKELWE NTKGRDGLLV ADGGPNIYNL
610 620 630 640 650
RNLHIPEIVL KYNLMDPEYK GRLLHPQNPF VGHLSIEGIK EADITPAHGP
660 670 680 690 700
VKKMDYDAVS GTHSWRTKRN RSILNTDQRN MILEEQCYAK CCNLFEACFN
710 720 730 740 750
SASYRKPVGQ HSMLEAMAHR LRMDARLDYE SGRMSKDDFE KAMAHLGEIG
YI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20169 Genomic RNA Translation: AAA43769.1 Sequence problems. |
PIRi | C28604, P1IVBC |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20169 Genomic RNA Translation: AAA43769.1 Sequence problems. |
PIRi | C28604, P1IVBC |
3D structure databases
SMRi | P13871 |
ModBasei | Search... |
Family and domain databases
HAMAPi | MF_04065, INFV_RDRP, 1 hit |
InterProi | View protein in InterPro IPR007099, RNA-dir_pol_NSvirus IPR001407, RNA_pol_PB1_influenza |
Pfami | View protein in Pfam PF00602, Flu_PB1, 1 hit |
PIRSFi | PIRSF000827, RdRPol_OMV, 1 hit |
PROSITEi | View protein in PROSITE PS50525, RDRP_SSRNA_NEG_SEG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_INBAC | |
Accessioni | P13871Primary (citable) accession number: P13871 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |