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UniProtKB - P13866 (SC5A1_HUMAN)

Entry version 208 (25 May 2022)
Sequence version 1 (01 Jan 1990)
Previous versions | rss
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Protein

Sodium/glucose cotransporter 1

Gene

SLC5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Electrogenic Na+-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na+ to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump (PubMed:20980548, PubMed:35077764, PubMed:8563765, PubMed:34880492).

Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (PubMed:8563765) (By similarity).

Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity).

Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690).

Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na+ uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.

By similarity7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by phlorizin (PubMed:20980548, PubMed:34880492). Possibly modulated by cholesterol binding (PubMed:34880492).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.74 mM for D-glucose1 Publication
  2. KM=3.12 mM for D-galactose1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei43Implicated in sodium couplingBy similarity1
Sitei300Implicated in sodium couplingBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei457GlucoseBy similarity1
Sitei460Involved in sugar-binding/transport and inhibitor bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Sugar transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13866

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-189200, Cellular hexose transport
R-HSA-5656364, Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
R-HSA-8981373, Intestinal hexose absorption

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P13866

SIGNOR Signaling Network Open Resource

More...SIGNORi		P13866

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.21.3.1, the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/glucose cotransporter 1
Short name:
Na(+)/glucose cotransporter 11 Publication
Alternative name(s):
High affinity sodium-glucose cotransporter
Solute carrier family 5 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC5A11 PublicationImported
Synonyms:NAGT, SGLT11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11036, SLC5A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182380, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13866

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100170

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 64CytoplasmicSequence analysisAdd BLAST15
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105ExtracellularSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 142CytoplasmicSequence analysisAdd BLAST16
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 178ExtracellularSequence analysisAdd BLAST15
Transmembranei179 – 201HelicalSequence analysisAdd BLAST23
Topological domaini202 – 208CytoplasmicSequence analysis7
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 277ExtracellularSequence analysisAdd BLAST48
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 313CytoplasmicSequence analysisAdd BLAST15
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 380ExtracellularSequence analysisAdd BLAST46
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 423CytoplasmicSequence analysisAdd BLAST22
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 455ExtracellularSequence analysisAdd BLAST11
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 484CytoplasmicSequence analysis8
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 526ExtracellularSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei527 – 563HelicalSequence analysisAdd BLAST37
Topological domaini564 – 643ExtracellularSequence analysisAdd BLAST80
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital glucose/galactose malabsorption (GGM)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionIntestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01363028D → G in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912669EnsemblClinVar.1
Natural variantiVAR_00716828D → N in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912668EnsemblClinVar.1
Natural variantiVAR_02914751N → S in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683011EnsemblClinVar.1
Natural variantiVAR_021502135R → W in GGM; loss of activity. 2 Publications1
Natural variantiVAR_086053159S → P in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086054166A → T in GGM; about 90% reduction in activity. 1 Publication1
Natural variantiVAR_086055191 – 664Missing in GGM; loss of activity. 1 PublicationAdd BLAST474
Natural variantiVAR_086056254 – 664Missing in GGM. 1 PublicationAdd BLAST411
Natural variantiVAR_086057276W → L in GGM; about 95% reduction in activity. 1 Publication1
Natural variantiVAR_086058292C → Y in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086059295Q → R in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086060300R → S in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086061304A → V in GGM; impairs trafficking to the plasma membrane. 1 Publication1
Natural variantiVAR_021503318G → R in GGM. 1 PublicationCorresponds to variant dbSNP:rs371505974Ensembl.1
Natural variantiVAR_086062369L → S in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086063379 – 664Missing in GGM; loss of activity. 1 PublicationAdd BLAST286
Natural variantiVAR_086064379R → Q in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086065388A → V in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086066405F → S in GGM; loss of activity. 1 Publication1
Natural variantiVAR_029148411A → T in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683430EnsemblClinVar.1
Natural variantiVAR_086067426G → R in GGM; loss of activity. 1 Publication1
Natural variantiVAR_021504468A → V in GGM. 1 PublicationCorresponds to variant dbSNP:rs200406921Ensembl.1
Natural variantiVAR_086068470V → N in GGM; requires 2 nucleotide substitutions; about 90% reduction in activity. 1 Publication1
Natural variantiVAR_086069499R → H in GGM; impairs trafficking to the plasma membrane; decreases the sugar affinity. 1 Publication1
Natural variantiVAR_086070615H → Q in GGM; slightly decreased activity. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67W → A: Strong reduction in D-glucose transporter activity. 1 Publication1
Mutagenesisi77S → A: Loss of activity. 1 Publication1
Mutagenesisi83H → L: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and C-290. 1 Publication1
Mutagenesisi83H → Q: Loss of D-glucose transporter activity. 1 Publication1
Mutagenesisi204D → A: Loss of activity. 1 Publication1
Mutagenesisi248N → Q: Loss of N-glycosylation. 1 Publication1
Mutagenesisi287T → A: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with L-83 and C-290. 1 Publication1
Mutagenesisi287T → N: Loss of D-glucose transporter activity. Has strict selectivity for D-galactose. 2 Publications1
Mutagenesisi287T → S or A: Has normal D-glucose and D-galactose transporter activity. 2 Publications1
Mutagenesisi290Y → C: Loss of D-galactose transporter activity. Has strict selectivity for D-glucose. Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and L-83. 1 Publication1
Mutagenesisi291W → A: Loss of D-glucose transporter activity. 1 Publication1
Mutagenesisi292C → A: Has no effect on water permeability. 1 Publication1
Mutagenesisi321K → Q: Acquires D-mannose and D-allose transporter activity comparable to glucose and galactose. 1 Publication1
Mutagenesisi363N → A: Loss of water permeation. 1 Publication1
Mutagenesisi396S → A: Loss of activity. 1 Publication1
Mutagenesisi451Q → A: Strong reduction in water permeation. 1 Publication1
Mutagenesisi452L → A: Loss of water permeation. 1 Publication1
Mutagenesisi454D → A: Has no effect on water permeation. 1 Publication1
Mutagenesisi457Q → A: Loss of D-glucose transporter activity. 1 Publication1
Mutagenesisi457Q → C: Strong reduction in D-glucose transporter activity. 1 Publication1
Mutagenesisi460T → A: Loss of D-glucose transporter activity. 1 Publication1
Mutagenesisi641W → A: Slightly reduced D-glucose transporter activity. 1 Publication1
Mutagenesisi660 – 661HA → WG: Loss of D-glucose transporter activity. 1 Publication2

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		6523

MalaCards human disease database

More...MalaCardsi		SLC5A1
MIMi606824, phenotype

Open Targets

More...OpenTargetsi		ENSG00000100170

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		35710, Glucose-galactose malabsorption

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA308

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13866, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4979

Drug and drug target database

More...DrugBanki		DB00766, Clavulanic acid
DB01914, D-glucose
DB09341, Dextrose, unspecified form

DrugCentral

More...DrugCentrali		P13866

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		915

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC5A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		127803

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001053661 – 664Sodium/glucose cotransporter 1Add BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi248N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi255 ↔ 5111 Publication
Disulfide bondi345 ↔ 3511 Publication
Disulfide bondi355 ↔ 3611 Publication
Disulfide bondi517 ↔ 5221 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei587PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is not necessary for the cotransporter function.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P13866

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13866

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13866

MaxQB - The MaxQuant DataBase

More...MaxQBi		P13866

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13866

PeptideAtlas

More...PeptideAtlasi		P13866

PRoteomics IDEntifications database

More...PRIDEi		P13866

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52997 [P13866-1]
6623

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13866, 4 sites, 5 O-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13866

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13866

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in intestine (PubMed:2490366). Expressed in endometrial cells (PubMed:28974690).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated upon transition of the endometrium from the non-receptive early secretory phase to the receptive mid-secretory phase of the cycle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100170, Expressed in duodenum and 126 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13866, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100170, Tissue enriched (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112414, 28 interactors

Protein interaction database and analysis system

More...IntActi		P13866, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000266088

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P13866

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13866, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P13866

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13866

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cholesterol-binding site is formed by transmembrane helices TM1, TM7 and TM13.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2349, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155844

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018808_9_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13866

Identification of Orthologs from Complete Genome Data

More...OMAi		AYMTMVT

Database of Orthologous Groups

More...OrthoDBi		243316at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13866

TreeFam database of animal gene trees

More...TreeFami		TF352855

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR018212, Na/solute_symporter_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00474, SSF, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00813, sss, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00456, NA_SOLUT_SYMP_1, 1 hit
PS00457, NA_SOLUT_SYMP_2, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P13866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSSTWSPKT TAVTRPVETH ELIRNAADIS IIVIYFVVVM AVGLWAMFST 
        60         70         80         90        100
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAASGIAIGG 
       110        120        130        140        150
FEWNALVLVV VLGWLFVPIY IKAGVVTMPE YLRKRFGGQR IQVYLSLLSL 
       160        170        180        190        200
LLYIFTKISA DIFSGAIFIN LALGLNLYLA IFLLLAITAL YTITGGLAAV 
       210        220        230        240        250
IYTDTLQTVI MLVGSLILTG FAFHEVGGYD AFMEKYMKAI PTIVSDGNTT 
       260        270        280        290        300
FQEKCYTPRA DSFHIFRDPL TGDLPWPGFI FGMSILTLWY WCTDQVIVQR 
       310        320        330        340        350
CLSAKNMSHV KGGCILCGYL KLMPMFIMVM PGMISRILYT EKIACVVPSE 
       360        370        380        390        400
CEKYCGTKVG CTNIAYPTLV VELMPNGLRG LMLSVMLASL MSSLTSIFNS 
       410        420        430        440        450
ASTLFTMDIY AKVRKRASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG 
       460        470        480        490        500
QLFDYIQSIT SYLGPPIAAV FLLAIFWKRV NEPGAFWGLI LGLLIGISRM 
       510        520        530        540        550
ITEFAYGTGS CMEPSNCPTI ICGVHYLYFA IILFAISFIT IVVISLLTKP 
       560        570        580        590        600
IPDVHLYRLC WSLRNSKEER IDLDAEEENI QEGPKETIEI ETQVPEKKKG 
       610        620        630        640        650
IFRRAYDLFC GLEQHGAPKM TEEEEKAMKM KMTDTSEKPL WRTVLNVNGI 
       660 
ILVTVAVFCH AYFA
Length:664
Mass (Da):73,498
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B403376595EAB74
GO
Isoform 2 (identifier: P13866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Show »
Length:537
Mass (Da):60,097
Checksum:iF7B5A898E54C9476
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti631K → R in BAH14555 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01363028D → G in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912669EnsemblClinVar.1
Natural variantiVAR_00716828D → N in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912668EnsemblClinVar.1
Natural variantiVAR_02914751N → S in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683011EnsemblClinVar.1
Natural variantiVAR_021502135R → W in GGM; loss of activity. 2 Publications1
Natural variantiVAR_086053159S → P in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086054166A → T in GGM; about 90% reduction in activity. 1 Publication1
Natural variantiVAR_086055191 – 664Missing in GGM; loss of activity. 1 PublicationAdd BLAST474
Natural variantiVAR_086056254 – 664Missing in GGM. 1 PublicationAdd BLAST411
Natural variantiVAR_086057276W → L in GGM; about 95% reduction in activity. 1 Publication1
Natural variantiVAR_086058292C → Y in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086059295Q → R in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086060300R → S in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086061304A → V in GGM; impairs trafficking to the plasma membrane. 1 Publication1
Natural variantiVAR_021503318G → R in GGM. 1 PublicationCorresponds to variant dbSNP:rs371505974Ensembl.1
Natural variantiVAR_086062369L → S in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086063379 – 664Missing in GGM; loss of activity. 1 PublicationAdd BLAST286
Natural variantiVAR_086064379R → Q in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086065388A → V in GGM; loss of activity. 1 Publication1
Natural variantiVAR_086066405F → S in GGM; loss of activity. 1 Publication1
Natural variantiVAR_029148411A → T in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683430EnsemblClinVar.1
Natural variantiVAR_086067426G → R in GGM; loss of activity. 1 Publication1
Natural variantiVAR_021504468A → V in GGM. 1 PublicationCorresponds to variant dbSNP:rs200406921Ensembl.1
Natural variantiVAR_086068470V → N in GGM; requires 2 nucleotide substitutions; about 90% reduction in activity. 1 Publication1
Natural variantiVAR_086069499R → H in GGM; impairs trafficking to the plasma membrane; decreases the sugar affinity. 1 Publication1
Natural variantiVAR_086070615H → Q in GGM; slightly decreased activity. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0447821 – 127Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M24847 mRNA Translation: AAA60320.1
L29339 L29338 Genomic DNA Translation: AAB59448.1
CR456579 mRNA Translation: CAG30465.1
AK297665 mRNA Translation: BAH12645.1
AK312948 mRNA Translation: BAG35789.1
AK316184 mRNA Translation: BAH14555.1
AL022321 Genomic DNA No translation available.
Z74021 Genomic DNA No translation available.
Z80998 Genomic DNA No translation available.
Z83839 Genomic DNA No translation available.
Z83849 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60006.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13902.1 [P13866-1]
CCDS58805.1 [P13866-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A33545

NCBI Reference Sequences

More...RefSeqi		NP_000334.1, NM_000343.3 [P13866-1]
NP_001243243.1, NM_001256314.1 [P13866-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000266088.9; ENSP00000266088.4; ENSG00000100170.10
ENST00000543737.2; ENSP00000444898.1; ENSG00000100170.10 [P13866-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6523

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6523

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000266088.9; ENSP00000266088.4; NM_000343.4; NP_000334.1

UCSC genome browser

More...UCSCi		uc003amc.4, human [P13866-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24847 mRNA Translation: AAA60320.1
L29339 L29338 Genomic DNA Translation: AAB59448.1
CR456579 mRNA Translation: CAG30465.1
AK297665 mRNA Translation: BAH12645.1
AK312948 mRNA Translation: BAG35789.1
AK316184 mRNA Translation: BAH14555.1
AL022321 Genomic DNA No translation available.
Z74021 Genomic DNA No translation available.
Z80998 Genomic DNA No translation available.
Z83839 Genomic DNA No translation available.
Z83849 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60006.1
CCDSiCCDS13902.1 [P13866-1]
CCDS58805.1 [P13866-2]
PIRiA33545
RefSeqiNP_000334.1, NM_000343.3 [P13866-1]
NP_001243243.1, NM_001256314.1 [P13866-2]

3D structure databases

AlphaFoldDBiP13866
SMRiP13866
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112414, 28 interactors
IntActiP13866, 1 interactor
STRINGi9606.ENSP00000266088

Chemistry databases

BindingDBiP13866
ChEMBLiCHEMBL4979
DrugBankiDB00766, Clavulanic acid
DB01914, D-glucose
DB09341, Dextrose, unspecified form
DrugCentraliP13866
GuidetoPHARMACOLOGYi915

Protein family/group databases

TCDBi2.A.21.3.1, the solute:sodium symporter (sss) family

PTM databases

GlyGeniP13866, 4 sites, 5 O-linked glycans (3 sites)
iPTMnetiP13866
PhosphoSitePlusiP13866

Genetic variation databases

BioMutaiSLC5A1
DMDMi127803

Proteomic databases

EPDiP13866
jPOSTiP13866
MassIVEiP13866
MaxQBiP13866
PaxDbiP13866
PeptideAtlasiP13866
PRIDEiP13866
ProteomicsDBi52997 [P13866-1]
6623

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25191, 361 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		6523

Genome annotation databases

EnsembliENST00000266088.9; ENSP00000266088.4; ENSG00000100170.10
ENST00000543737.2; ENSP00000444898.1; ENSG00000100170.10 [P13866-2]
GeneIDi6523
KEGGihsa:6523
MANE-SelectiENST00000266088.9; ENSP00000266088.4; NM_000343.4; NP_000334.1
UCSCiuc003amc.4, human [P13866-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6523
DisGeNETi6523

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC5A1
HGNCiHGNC:11036, SLC5A1
HPAiENSG00000100170, Tissue enriched (intestine)
MalaCardsiSLC5A1
MIMi182380, gene
606824, phenotype
neXtProtiNX_P13866
OpenTargetsiENSG00000100170
Orphaneti35710, Glucose-galactose malabsorption
PharmGKBiPA308
VEuPathDBiHostDB:ENSG00000100170

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2349, Eukaryota
GeneTreeiENSGT00940000155844
HOGENOMiCLU_018808_9_2_1
InParanoidiP13866
OMAiAYMTMVT
OrthoDBi243316at2759
PhylomeDBiP13866
TreeFamiTF352855

Enzyme and pathway databases

PathwayCommonsiP13866
ReactomeiR-HSA-189200, Cellular hexose transport
R-HSA-5656364, Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
R-HSA-8981373, Intestinal hexose absorption
SignaLinkiP13866
SIGNORiP13866

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6523, 12 hits in 1060 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC5A1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC5A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6523
PharosiP13866, Tclin

Protein Ontology

More...PROi		PR:P13866
RNActiP13866, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100170, Expressed in duodenum and 126 other tissues
GenevisibleiP13866, HS

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR018212, Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474, SSF, 1 hit
TIGRFAMsiTIGR00813, sss, 1 hit
PROSITEiView protein in PROSITE
PS00456, NA_SOLUT_SYMP_1, 1 hit
PS00457, NA_SOLUT_SYMP_2, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC5A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13866
Secondary accession number(s): B2R7E2, B7Z4Q9, B7ZA69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 25, 2022
This is version 208 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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