UniProtKB - P13866 (SC5A1_HUMAN)
Sodium/glucose cotransporter 1
SLC5A1
Functioni
Electrogenic Na+-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na+ to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump (PubMed:20980548, PubMed:35077764, PubMed:8563765, PubMed:34880492).
Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (PubMed:8563765) (By similarity).
Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity).
Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690).
Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na+ uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
By similarity7 PublicationsCatalytic activityi
- This reaction proceeds in the forward4 Publications direction.
- This reaction proceeds in the forward3 Publications direction.
Activity regulationi
Kineticsi
- KM=1.74 mM for D-glucose1 Publication
- KM=3.12 mM for D-galactose1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 43 | Implicated in sodium couplingBy similarity | 1 | |
Sitei | 300 | Implicated in sodium couplingBy similarity | 1 | |
Binding sitei | 457 | GlucoseBy similarity | 1 | |
Sitei | 460 | Involved in sugar-binding/transport and inhibitor bindingBy similarity | 1 |
GO - Molecular functioni
- alpha-glucoside transmembrane transporter activity Source: ARUK-UCL
- D-glucose transmembrane transporter activity Source: ARUK-UCL
- fucose transmembrane transporter activity Source: ARUK-UCL
- galactose transmembrane transporter activity Source: ARUK-UCL
- glucose:sodium symporter activity Source: UniProtKB
- glucose transmembrane transporter activity Source: ARUK-UCL
- myo-inositol:sodium symporter activity Source: ARUK-UCL
- pentose transmembrane transporter activity Source: ARUK-UCL
- water transmembrane transporter activity Source: ARUK-UCL
GO - Biological processi
- alpha-glucoside transport Source: ARUK-UCL
- fucose transmembrane transport Source: ARUK-UCL
- galactose transmembrane transport Source: ARUK-UCL
- glucose import across plasma membrane Source: ARUK-UCL
- glucose transmembrane transport Source: UniProtKB
- intestinal hexose absorption Source: Reactome
- myo-inositol transport Source: ARUK-UCL
- pentose transmembrane transport Source: ARUK-UCL
- response to inorganic substance Source: ARUK-UCL
- sodium ion import across plasma membrane Source: ARUK-UCL
- sodium ion transport Source: GO_Central
- transepithelial water transport Source: ARUK-UCL
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Biological process | Ion transport, Sodium transport, Sugar transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | P13866 |
Reactomei | R-HSA-189200, Cellular hexose transport R-HSA-5656364, Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) R-HSA-8981373, Intestinal hexose absorption |
SignaLinki | P13866 |
SIGNORi | P13866 |
Protein family/group databases
TCDBi | 2.A.21.3.1, the solute:sodium symporter (sss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/glucose cotransporter 1Short name: Na(+)/glucose cotransporter 11 Publication Alternative name(s): High affinity sodium-glucose cotransporter Solute carrier family 5 member 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11036, SLC5A1 |
MIMi | 182380, gene |
neXtProti | NX_P13866 |
VEuPathDBi | HostDB:ENSG00000100170 |
Subcellular locationi
Plasma membrane
- Apical cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endosome
- early endosome Source: ARUK-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: ARUK-UCL
- brush border membrane Source: ARUK-UCL
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: ARUK-UCL
Other locations
- integral component of membrane Source: GO_Central
- intracellular organelle Source: ARUK-UCL
- intracellular vesicle Source: ARUK-UCL
- perinuclear region of cytoplasm Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 50 – 64 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 105 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 142 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 143 – 163 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 178 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 179 – 201 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 202 – 208 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 209 – 229 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 230 – 277 | ExtracellularSequence analysisAdd BLAST | 48 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 313 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 314 – 334 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 335 – 380 | ExtracellularSequence analysisAdd BLAST | 46 | |
Transmembranei | 381 – 401 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 402 – 423 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 424 – 444 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 445 – 455 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 456 – 476 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 477 – 484 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 485 – 505 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 506 – 526 | ExtracellularSequence analysisAdd BLAST | 21 | |
Intramembranei | 527 – 563 | HelicalSequence analysisAdd BLAST | 37 | |
Topological domaini | 564 – 643 | ExtracellularSequence analysisAdd BLAST | 80 | |
Transmembranei | 644 – 664 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Congenital glucose/galactose malabsorption (GGM)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013630 | 28 | D → G in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912669EnsemblClinVar. | 1 | |
Natural variantiVAR_007168 | 28 | D → N in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912668EnsemblClinVar. | 1 | |
Natural variantiVAR_029147 | 51 | N → S in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683011EnsemblClinVar. | 1 | |
Natural variantiVAR_021502 | 135 | R → W in GGM; loss of activity. 2 Publications | 1 | |
Natural variantiVAR_086053 | 159 | S → P in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086054 | 166 | A → T in GGM; about 90% reduction in activity. 1 Publication | 1 | |
Natural variantiVAR_086055 | 191 – 664 | Missing in GGM; loss of activity. 1 PublicationAdd BLAST | 474 | |
Natural variantiVAR_086056 | 254 – 664 | Missing in GGM. 1 PublicationAdd BLAST | 411 | |
Natural variantiVAR_086057 | 276 | W → L in GGM; about 95% reduction in activity. 1 Publication | 1 | |
Natural variantiVAR_086058 | 292 | C → Y in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086059 | 295 | Q → R in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086060 | 300 | R → S in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086061 | 304 | A → V in GGM; impairs trafficking to the plasma membrane. 1 Publication | 1 | |
Natural variantiVAR_021503 | 318 | G → R in GGM. 1 PublicationCorresponds to variant dbSNP:rs371505974Ensembl. | 1 | |
Natural variantiVAR_086062 | 369 | L → S in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086063 | 379 – 664 | Missing in GGM; loss of activity. 1 PublicationAdd BLAST | 286 | |
Natural variantiVAR_086064 | 379 | R → Q in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086065 | 388 | A → V in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086066 | 405 | F → S in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_029148 | 411 | A → T in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683430EnsemblClinVar. | 1 | |
Natural variantiVAR_086067 | 426 | G → R in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_021504 | 468 | A → V in GGM. 1 PublicationCorresponds to variant dbSNP:rs200406921Ensembl. | 1 | |
Natural variantiVAR_086068 | 470 | V → N in GGM; requires 2 nucleotide substitutions; about 90% reduction in activity. 1 Publication | 1 | |
Natural variantiVAR_086069 | 499 | R → H in GGM; impairs trafficking to the plasma membrane; decreases the sugar affinity. 1 Publication | 1 | |
Natural variantiVAR_086070 | 615 | H → Q in GGM; slightly decreased activity. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 67 | W → A: Strong reduction in D-glucose transporter activity. 1 Publication | 1 | |
Mutagenesisi | 77 | S → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 83 | H → L: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and C-290. 1 Publication | 1 | |
Mutagenesisi | 83 | H → Q: Loss of D-glucose transporter activity. 1 Publication | 1 | |
Mutagenesisi | 204 | D → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 248 | N → Q: Loss of N-glycosylation. 1 Publication | 1 | |
Mutagenesisi | 287 | T → A: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with L-83 and C-290. 1 Publication | 1 | |
Mutagenesisi | 287 | T → N: Loss of D-glucose transporter activity. Has strict selectivity for D-galactose. 2 Publications | 1 | |
Mutagenesisi | 287 | T → S or A: Has normal D-glucose and D-galactose transporter activity. 2 Publications | 1 | |
Mutagenesisi | 290 | Y → C: Loss of D-galactose transporter activity. Has strict selectivity for D-glucose. Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and L-83. 1 Publication | 1 | |
Mutagenesisi | 291 | W → A: Loss of D-glucose transporter activity. 1 Publication | 1 | |
Mutagenesisi | 292 | C → A: Has no effect on water permeability. 1 Publication | 1 | |
Mutagenesisi | 321 | K → Q: Acquires D-mannose and D-allose transporter activity comparable to glucose and galactose. 1 Publication | 1 | |
Mutagenesisi | 363 | N → A: Loss of water permeation. 1 Publication | 1 | |
Mutagenesisi | 396 | S → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 451 | Q → A: Strong reduction in water permeation. 1 Publication | 1 | |
Mutagenesisi | 452 | L → A: Loss of water permeation. 1 Publication | 1 | |
Mutagenesisi | 454 | D → A: Has no effect on water permeation. 1 Publication | 1 | |
Mutagenesisi | 457 | Q → A: Loss of D-glucose transporter activity. 1 Publication | 1 | |
Mutagenesisi | 457 | Q → C: Strong reduction in D-glucose transporter activity. 1 Publication | 1 | |
Mutagenesisi | 460 | T → A: Loss of D-glucose transporter activity. 1 Publication | 1 | |
Mutagenesisi | 641 | W → A: Slightly reduced D-glucose transporter activity. 1 Publication | 1 | |
Mutagenesisi | 660 – 661 | HA → WG: Loss of D-glucose transporter activity. 1 Publication | 2 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6523 |
MalaCardsi | SLC5A1 |
MIMi | 606824, phenotype |
OpenTargetsi | ENSG00000100170 |
Orphaneti | 35710, Glucose-galactose malabsorption |
PharmGKBi | PA308 |
Miscellaneous databases
Pharosi | P13866, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4979 |
DrugBanki | DB00766, Clavulanic acid DB01914, D-glucose DB09341, Dextrose, unspecified form |
DrugCentrali | P13866 |
GuidetoPHARMACOLOGYi | 915 |
Genetic variation databases
BioMutai | SLC5A1 |
DMDMi | 127803 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105366 | 1 – 664 | Sodium/glucose cotransporter 1Add BLAST | 664 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 248 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 255 ↔ 511 | 1 Publication | ||
Disulfide bondi | 345 ↔ 351 | 1 Publication | ||
Disulfide bondi | 355 ↔ 361 | 1 Publication | ||
Disulfide bondi | 517 ↔ 522 | 1 Publication | ||
Modified residuei | 587 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P13866 |
jPOSTi | P13866 |
MassIVEi | P13866 |
MaxQBi | P13866 |
PaxDbi | P13866 |
PeptideAtlasi | P13866 |
PRIDEi | P13866 |
ProteomicsDBi | 52997 [P13866-1] 6623 |
PTM databases
GlyGeni | P13866, 4 sites, 5 O-linked glycans (3 sites) |
iPTMneti | P13866 |
PhosphoSitePlusi | P13866 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000100170, Expressed in duodenum and 126 other tissues |
Genevisiblei | P13866, HS |
Organism-specific databases
HPAi | ENSG00000100170, Tissue enriched (intestine) |
Interactioni
Binary interactionsi
P13866
With | #Exp. | IntAct |
---|---|---|
EGFR [P00533] | 3 | EBI-1772443,EBI-297353 |
Protein-protein interaction databases
BioGRIDi | 112414, 28 interactors |
IntActi | P13866, 1 interactor |
STRINGi | 9606.ENSP00000266088 |
Chemistry databases
BindingDBi | P13866 |
Miscellaneous databases
RNActi | P13866, protein |
Family & Domainsi
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000155844 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | P13866 |
OMAi | AYMTMVT |
OrthoDBi | 243316at2759 |
PhylomeDBi | P13866 |
TreeFami | TF352855 |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSSTWSPKT TAVTRPVETH ELIRNAADIS IIVIYFVVVM AVGLWAMFST
60 70 80 90 100
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAASGIAIGG
110 120 130 140 150
FEWNALVLVV VLGWLFVPIY IKAGVVTMPE YLRKRFGGQR IQVYLSLLSL
160 170 180 190 200
LLYIFTKISA DIFSGAIFIN LALGLNLYLA IFLLLAITAL YTITGGLAAV
210 220 230 240 250
IYTDTLQTVI MLVGSLILTG FAFHEVGGYD AFMEKYMKAI PTIVSDGNTT
260 270 280 290 300
FQEKCYTPRA DSFHIFRDPL TGDLPWPGFI FGMSILTLWY WCTDQVIVQR
310 320 330 340 350
CLSAKNMSHV KGGCILCGYL KLMPMFIMVM PGMISRILYT EKIACVVPSE
360 370 380 390 400
CEKYCGTKVG CTNIAYPTLV VELMPNGLRG LMLSVMLASL MSSLTSIFNS
410 420 430 440 450
ASTLFTMDIY AKVRKRASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG
460 470 480 490 500
QLFDYIQSIT SYLGPPIAAV FLLAIFWKRV NEPGAFWGLI LGLLIGISRM
510 520 530 540 550
ITEFAYGTGS CMEPSNCPTI ICGVHYLYFA IILFAISFIT IVVISLLTKP
560 570 580 590 600
IPDVHLYRLC WSLRNSKEER IDLDAEEENI QEGPKETIEI ETQVPEKKKG
610 620 630 640 650
IFRRAYDLFC GLEQHGAPKM TEEEEKAMKM KMTDTSEKPL WRTVLNVNGI
660
ILVTVAVFCH AYFA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 631 | K → R in BAH14555 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013630 | 28 | D → G in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912669EnsemblClinVar. | 1 | |
Natural variantiVAR_007168 | 28 | D → N in GGM. 2 PublicationsCorresponds to variant dbSNP:rs121912668EnsemblClinVar. | 1 | |
Natural variantiVAR_029147 | 51 | N → S in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683011EnsemblClinVar. | 1 | |
Natural variantiVAR_021502 | 135 | R → W in GGM; loss of activity. 2 Publications | 1 | |
Natural variantiVAR_086053 | 159 | S → P in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086054 | 166 | A → T in GGM; about 90% reduction in activity. 1 Publication | 1 | |
Natural variantiVAR_086055 | 191 – 664 | Missing in GGM; loss of activity. 1 PublicationAdd BLAST | 474 | |
Natural variantiVAR_086056 | 254 – 664 | Missing in GGM. 1 PublicationAdd BLAST | 411 | |
Natural variantiVAR_086057 | 276 | W → L in GGM; about 95% reduction in activity. 1 Publication | 1 | |
Natural variantiVAR_086058 | 292 | C → Y in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086059 | 295 | Q → R in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086060 | 300 | R → S in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086061 | 304 | A → V in GGM; impairs trafficking to the plasma membrane. 1 Publication | 1 | |
Natural variantiVAR_021503 | 318 | G → R in GGM. 1 PublicationCorresponds to variant dbSNP:rs371505974Ensembl. | 1 | |
Natural variantiVAR_086062 | 369 | L → S in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086063 | 379 – 664 | Missing in GGM; loss of activity. 1 PublicationAdd BLAST | 286 | |
Natural variantiVAR_086064 | 379 | R → Q in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086065 | 388 | A → V in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_086066 | 405 | F → S in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_029148 | 411 | A → T in GGM; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs17683430EnsemblClinVar. | 1 | |
Natural variantiVAR_086067 | 426 | G → R in GGM; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_021504 | 468 | A → V in GGM. 1 PublicationCorresponds to variant dbSNP:rs200406921Ensembl. | 1 | |
Natural variantiVAR_086068 | 470 | V → N in GGM; requires 2 nucleotide substitutions; about 90% reduction in activity. 1 Publication | 1 | |
Natural variantiVAR_086069 | 499 | R → H in GGM; impairs trafficking to the plasma membrane; decreases the sugar affinity. 1 Publication | 1 | |
Natural variantiVAR_086070 | 615 | H → Q in GGM; slightly decreased activity. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044782 | 1 – 127 | Missing in isoform 2. 1 PublicationAdd BLAST | 127 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24847 mRNA Translation: AAA60320.1 L29339 , L29328, L29330, L29329, L29331, L29332, L29333, L29334, L29335, L29336, L29337, L29338 Genomic DNA Translation: AAB59448.1 CR456579 mRNA Translation: CAG30465.1 AK297665 mRNA Translation: BAH12645.1 AK312948 mRNA Translation: BAG35789.1 AK316184 mRNA Translation: BAH14555.1 AL022321 Genomic DNA No translation available. Z74021 Genomic DNA No translation available. Z80998 Genomic DNA No translation available. Z83839 Genomic DNA No translation available. Z83849 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60006.1 |
CCDSi | CCDS13902.1 [P13866-1] CCDS58805.1 [P13866-2] |
PIRi | A33545 |
RefSeqi | NP_000334.1, NM_000343.3 [P13866-1] NP_001243243.1, NM_001256314.1 [P13866-2] |
Genome annotation databases
Ensembli | ENST00000266088.9; ENSP00000266088.4; ENSG00000100170.10 ENST00000543737.2; ENSP00000444898.1; ENSG00000100170.10 [P13866-2] |
GeneIDi | 6523 |
KEGGi | hsa:6523 |
MANE-Selecti | ENST00000266088.9; ENSP00000266088.4; NM_000343.4; NP_000334.1 |
UCSCi | uc003amc.4, human [P13866-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24847 mRNA Translation: AAA60320.1 L29339 , L29328, L29330, L29329, L29331, L29332, L29333, L29334, L29335, L29336, L29337, L29338 Genomic DNA Translation: AAB59448.1 CR456579 mRNA Translation: CAG30465.1 AK297665 mRNA Translation: BAH12645.1 AK312948 mRNA Translation: BAG35789.1 AK316184 mRNA Translation: BAH14555.1 AL022321 Genomic DNA No translation available. Z74021 Genomic DNA No translation available. Z80998 Genomic DNA No translation available. Z83839 Genomic DNA No translation available. Z83849 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60006.1 |
CCDSi | CCDS13902.1 [P13866-1] CCDS58805.1 [P13866-2] |
PIRi | A33545 |
RefSeqi | NP_000334.1, NM_000343.3 [P13866-1] NP_001243243.1, NM_001256314.1 [P13866-2] |
3D structure databases
AlphaFoldDBi | P13866 |
SMRi | P13866 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112414, 28 interactors |
IntActi | P13866, 1 interactor |
STRINGi | 9606.ENSP00000266088 |
Chemistry databases
BindingDBi | P13866 |
ChEMBLi | CHEMBL4979 |
DrugBanki | DB00766, Clavulanic acid DB01914, D-glucose DB09341, Dextrose, unspecified form |
DrugCentrali | P13866 |
GuidetoPHARMACOLOGYi | 915 |
Protein family/group databases
TCDBi | 2.A.21.3.1, the solute:sodium symporter (sss) family |
PTM databases
GlyGeni | P13866, 4 sites, 5 O-linked glycans (3 sites) |
iPTMneti | P13866 |
PhosphoSitePlusi | P13866 |
Genetic variation databases
BioMutai | SLC5A1 |
DMDMi | 127803 |
Proteomic databases
EPDi | P13866 |
jPOSTi | P13866 |
MassIVEi | P13866 |
MaxQBi | P13866 |
PaxDbi | P13866 |
PeptideAtlasi | P13866 |
PRIDEi | P13866 |
ProteomicsDBi | 52997 [P13866-1] 6623 |
Protocols and materials databases
Antibodypediai | 25191, 361 antibodies from 34 providers |
DNASUi | 6523 |
Genome annotation databases
Ensembli | ENST00000266088.9; ENSP00000266088.4; ENSG00000100170.10 ENST00000543737.2; ENSP00000444898.1; ENSG00000100170.10 [P13866-2] |
GeneIDi | 6523 |
KEGGi | hsa:6523 |
MANE-Selecti | ENST00000266088.9; ENSP00000266088.4; NM_000343.4; NP_000334.1 |
UCSCi | uc003amc.4, human [P13866-1] |
Organism-specific databases
CTDi | 6523 |
DisGeNETi | 6523 |
GeneCardsi | SLC5A1 |
HGNCi | HGNC:11036, SLC5A1 |
HPAi | ENSG00000100170, Tissue enriched (intestine) |
MalaCardsi | SLC5A1 |
MIMi | 182380, gene 606824, phenotype |
neXtProti | NX_P13866 |
OpenTargetsi | ENSG00000100170 |
Orphaneti | 35710, Glucose-galactose malabsorption |
PharmGKBi | PA308 |
VEuPathDBi | HostDB:ENSG00000100170 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000155844 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | P13866 |
OMAi | AYMTMVT |
OrthoDBi | 243316at2759 |
PhylomeDBi | P13866 |
TreeFami | TF352855 |
Enzyme and pathway databases
PathwayCommonsi | P13866 |
Reactomei | R-HSA-189200, Cellular hexose transport R-HSA-5656364, Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) R-HSA-8981373, Intestinal hexose absorption |
SignaLinki | P13866 |
SIGNORi | P13866 |
Miscellaneous databases
BioGRID-ORCSi | 6523, 12 hits in 1060 CRISPR screens |
ChiTaRSi | SLC5A1, human |
GeneWikii | SLC5A1 |
GenomeRNAii | 6523 |
Pharosi | P13866, Tclin |
PROi | PR:P13866 |
RNActi | P13866, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100170, Expressed in duodenum and 126 other tissues |
Genevisiblei | P13866, HS |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SC5A1_HUMAN | |
Accessioni | P13866Primary (citable) accession number: P13866 Secondary accession number(s): B2R7E2, B7Z4Q9, B7ZA69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families