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Protein

Sodium/glucose cotransporter 1

Gene

SLC5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei43Implicated in sodium couplingBy similarity1
Sitei300Implicated in sodium couplingBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei457GlucoseBy similarity1
Sitei460Involved in sugar-binding/transport and inhibitor bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glucose:sodium symporter activity Source: UniProtKB

GO - Biological processi

  • glucose transmembrane transport Source: UniProtKB
  • intestinal hexose absorption Source: Reactome
  • sodium ion transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Sugar transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189200 Cellular hexose transport
R-HSA-5656364 Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
R-HSA-8981373 Intestinal hexose absorption

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P13866

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.21.3.1 the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/glucose cotransporter 1
Short name:
Na(+)/glucose cotransporter 1
Alternative name(s):
High affinity sodium-glucose cotransporter
Solute carrier family 5 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC5A1
Synonyms:NAGT, SGLT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100170.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11036 SLC5A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182380 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13866

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 64CytoplasmicSequence analysisAdd BLAST15
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105ExtracellularSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 142CytoplasmicSequence analysisAdd BLAST16
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 178ExtracellularSequence analysisAdd BLAST15
Transmembranei179 – 201HelicalSequence analysisAdd BLAST23
Topological domaini202 – 208CytoplasmicSequence analysis7
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 277ExtracellularSequence analysisAdd BLAST48
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 313CytoplasmicSequence analysisAdd BLAST15
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 380ExtracellularSequence analysisAdd BLAST46
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 423CytoplasmicSequence analysisAdd BLAST22
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 455ExtracellularSequence analysisAdd BLAST11
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 484CytoplasmicSequence analysis8
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 526ExtracellularSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei527 – 563HelicalSequence analysisAdd BLAST37
Topological domaini564 – 643ExtracellularSequence analysisAdd BLAST80
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital glucose/galactose malabsorption (GGM)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionIntestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.
See also OMIM:606824
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01363028D → G in GGM. 1 PublicationCorresponds to variant dbSNP:rs121912669EnsemblClinVar.1
Natural variantiVAR_00716828D → N in GGM. 1 PublicationCorresponds to variant dbSNP:rs121912668EnsemblClinVar.1
Natural variantiVAR_021502135R → W in GGM; loss of activity. 1 Publication1
Natural variantiVAR_021503318G → R in GGM. 1 PublicationCorresponds to variant dbSNP:rs371505974Ensembl.1
Natural variantiVAR_021504468A → V in GGM. 1 PublicationCorresponds to variant dbSNP:rs200406921Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi248N → Q: Loss of N-glycosylation. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6523

MalaCards human disease database

More...
MalaCardsi
SLC5A1
MIMi606824 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100170

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
35710 Glucose-galactose malabsorption

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA308

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4979

Drug and drug target database

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DrugBanki
DB08907 Canagliflozin

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
915

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC5A1

Domain mapping of disease mutations (DMDM)

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DMDMi
127803

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001053661 – 664Sodium/glucose cotransporter 1Add BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi248N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi255 ↔ 610By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei587PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is not necessary for the cotransporter function.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P13866

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P13866

MaxQB - The MaxQuant DataBase

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MaxQBi
P13866

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13866

PeptideAtlas

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PeptideAtlasi
P13866

PRoteomics IDEntifications database

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PRIDEi
P13866

ProteomicsDB human proteome resource

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ProteomicsDBi
52997

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13866

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13866

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in intestine and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100170 Expressed in 111 organ(s), highest expression level in duodenum

CleanEx database of gene expression profiles

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CleanExi
HS_SLC5A1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13866 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015467
HPA051805
HPA055106

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005333EBI-1772443,EBI-297353

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112414, 2 interactors

Protein interaction database and analysis system

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IntActi
P13866, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000266088

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P13866

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13866

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP49 Eukaryota
COG4146 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155844

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052859

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13866

KEGG Orthology (KO)

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KOi
K14158

Identification of Orthologs from Complete Genome Data

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OMAi
CWTDLIQ

Database of Orthologous Groups

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OrthoDBi
243316at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P13866

TreeFam database of animal gene trees

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TreeFami
TF352855

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00474 SSF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00813 sss, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P13866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSSTWSPKT TAVTRPVETH ELIRNAADIS IIVIYFVVVM AVGLWAMFST
60 70 80 90 100
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAASGIAIGG
110 120 130 140 150
FEWNALVLVV VLGWLFVPIY IKAGVVTMPE YLRKRFGGQR IQVYLSLLSL
160 170 180 190 200
LLYIFTKISA DIFSGAIFIN LALGLNLYLA IFLLLAITAL YTITGGLAAV
210 220 230 240 250
IYTDTLQTVI MLVGSLILTG FAFHEVGGYD AFMEKYMKAI PTIVSDGNTT
260 270 280 290 300
FQEKCYTPRA DSFHIFRDPL TGDLPWPGFI FGMSILTLWY WCTDQVIVQR
310 320 330 340 350
CLSAKNMSHV KGGCILCGYL KLMPMFIMVM PGMISRILYT EKIACVVPSE
360 370 380 390 400
CEKYCGTKVG CTNIAYPTLV VELMPNGLRG LMLSVMLASL MSSLTSIFNS
410 420 430 440 450
ASTLFTMDIY AKVRKRASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG
460 470 480 490 500
QLFDYIQSIT SYLGPPIAAV FLLAIFWKRV NEPGAFWGLI LGLLIGISRM
510 520 530 540 550
ITEFAYGTGS CMEPSNCPTI ICGVHYLYFA IILFAISFIT IVVISLLTKP
560 570 580 590 600
IPDVHLYRLC WSLRNSKEER IDLDAEEENI QEGPKETIEI ETQVPEKKKG
610 620 630 640 650
IFRRAYDLFC GLEQHGAPKM TEEEEKAMKM KMTDTSEKPL WRTVLNVNGI
660
ILVTVAVFCH AYFA
Length:664
Mass (Da):73,498
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B403376595EAB74
GO
Isoform 2 (identifier: P13866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.
Show »
Length:537
Mass (Da):60,097
Checksum:iF7B5A898E54C9476
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti631K → R in BAH14555 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01363028D → G in GGM. 1 PublicationCorresponds to variant dbSNP:rs121912669EnsemblClinVar.1
Natural variantiVAR_00716828D → N in GGM. 1 PublicationCorresponds to variant dbSNP:rs121912668EnsemblClinVar.1
Natural variantiVAR_02914751N → S. Corresponds to variant dbSNP:rs17683011EnsemblClinVar.1
Natural variantiVAR_021502135R → W in GGM; loss of activity. 1 Publication1
Natural variantiVAR_021503318G → R in GGM. 1 PublicationCorresponds to variant dbSNP:rs371505974Ensembl.1
Natural variantiVAR_029148411A → T. Corresponds to variant dbSNP:rs17683430EnsemblClinVar.1
Natural variantiVAR_021504468A → V in GGM. 1 PublicationCorresponds to variant dbSNP:rs200406921Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0447821 – 127Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M24847 mRNA Translation: AAA60320.1
L29339
, L29328, L29330, L29329, L29331, L29332, L29333, L29334, L29335, L29336, L29337, L29338 Genomic DNA Translation: AAB59448.1
CR456579 mRNA Translation: CAG30465.1
AK297665 mRNA Translation: BAH12645.1
AK312948 mRNA Translation: BAG35789.1
AK316184 mRNA Translation: BAH14555.1
AL022321 Genomic DNA No translation available.
Z74021 Genomic DNA No translation available.
Z80998 Genomic DNA No translation available.
Z83839 Genomic DNA No translation available.
Z83849 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60006.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13902.1 [P13866-1]
CCDS58805.1 [P13866-2]

Protein sequence database of the Protein Information Resource

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PIRi
A33545

NCBI Reference Sequences

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RefSeqi
NP_000334.1, NM_000343.3 [P13866-1]
NP_001243243.1, NM_001256314.1 [P13866-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.1964

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000266088; ENSP00000266088; ENSG00000100170 [P13866-1]
ENST00000543737; ENSP00000444898; ENSG00000100170 [P13866-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6523

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6523

UCSC genome browser

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UCSCi
uc003amc.4 human [P13866-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24847 mRNA Translation: AAA60320.1
L29339
, L29328, L29330, L29329, L29331, L29332, L29333, L29334, L29335, L29336, L29337, L29338 Genomic DNA Translation: AAB59448.1
CR456579 mRNA Translation: CAG30465.1
AK297665 mRNA Translation: BAH12645.1
AK312948 mRNA Translation: BAG35789.1
AK316184 mRNA Translation: BAH14555.1
AL022321 Genomic DNA No translation available.
Z74021 Genomic DNA No translation available.
Z80998 Genomic DNA No translation available.
Z83839 Genomic DNA No translation available.
Z83849 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60006.1
CCDSiCCDS13902.1 [P13866-1]
CCDS58805.1 [P13866-2]
PIRiA33545
RefSeqiNP_000334.1, NM_000343.3 [P13866-1]
NP_001243243.1, NM_001256314.1 [P13866-2]
UniGeneiHs.1964

3D structure databases

ProteinModelPortaliP13866
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112414, 2 interactors
IntActiP13866, 1 interactor
STRINGi9606.ENSP00000266088

Chemistry databases

BindingDBiP13866
ChEMBLiCHEMBL4979
DrugBankiDB08907 Canagliflozin
GuidetoPHARMACOLOGYi915

Protein family/group databases

TCDBi2.A.21.3.1 the solute:sodium symporter (sss) family

PTM databases

iPTMnetiP13866
PhosphoSitePlusiP13866

Polymorphism and mutation databases

BioMutaiSLC5A1
DMDMi127803

Proteomic databases

EPDiP13866
jPOSTiP13866
MaxQBiP13866
PaxDbiP13866
PeptideAtlasiP13866
PRIDEiP13866
ProteomicsDBi52997

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6523
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266088; ENSP00000266088; ENSG00000100170 [P13866-1]
ENST00000543737; ENSP00000444898; ENSG00000100170 [P13866-2]
GeneIDi6523
KEGGihsa:6523
UCSCiuc003amc.4 human [P13866-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6523
DisGeNETi6523
EuPathDBiHostDB:ENSG00000100170.9

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC5A1
HGNCiHGNC:11036 SLC5A1
HPAiCAB015467
HPA051805
HPA055106
MalaCardsiSLC5A1
MIMi182380 gene
606824 phenotype
neXtProtiNX_P13866
OpenTargetsiENSG00000100170
Orphaneti35710 Glucose-galactose malabsorption
PharmGKBiPA308

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00940000155844
HOVERGENiHBG052859
InParanoidiP13866
KOiK14158
OMAiCWTDLIQ
OrthoDBi243316at2759
PhylomeDBiP13866
TreeFamiTF352855

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-5656364 Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
R-HSA-8981373 Intestinal hexose absorption
SIGNORiP13866

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC5A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC5A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6523

Protein Ontology

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PROi
PR:P13866

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100170 Expressed in 111 organ(s), highest expression level in duodenum
CleanExiHS_SLC5A1
GenevisibleiP13866 HS

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC5A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13866
Secondary accession number(s): B2R7E2, B7Z4Q9, B7ZA69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 16, 2019
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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