PRKAR2A

Functionⁱ

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	208	cAMP 1	1
Binding siteⁱ	217	cAMP 1	1
Binding siteⁱ	338	cAMP 2	1
Binding siteⁱ	347	cAMP 2	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	139 – 260	cAMP 1Add BLAST		122
Nucleotide bindingⁱ	261 – 404	cAMP 2Add BLAST		144

GO - Molecular functionⁱ

cAMP binding Source: UniProtKB-KW
cAMP-dependent protein kinase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- "The testis-specific C?2 subunit of PKA is kinetically indistinguishable from the common C?1 subunit of PKA."
  Vetter M.M., Zenn H.-M., Mendez E., van den Boom H., Herberg F.W., Skaalhegg B.S.
  BMC Biochem. 12:40-40(2011) [PubMed] [Europe PMC] [Abstract]
cAMP-dependent protein kinase regulator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- "The testis-specific C?2 subunit of PKA is kinetically indistinguishable from the common C?1 subunit of PKA."
  Vetter M.M., Zenn H.-M., Mendez E., van den Boom H., Herberg F.W., Skaalhegg B.S.
  BMC Biochem. 12:40-40(2011) [PubMed] [Europe PMC] [Abstract]
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- "A systematic evaluation of protein kinase A-A-Kinase anchoring protein interaction motifs."
  Burgers P.P., van der Heyden M.A., Kok B., Heck A.J., Scholten A.
  Biochemistry 54:11-21(2015) [PubMed] [Europe PMC] [Abstract]
protein kinase A catalytic subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- "Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin."
  Ruppelt A., Mosenden R., Gronholm M., Aandahl E.M., Tobin D., Carlson C.R., Abrahamsen H., Herberg F.W., Carpen O., Tasken K.
  J. Immunol. 179:5159-5168(2007) [PubMed] [Europe PMC] [Abstract]
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.22
  "Control of PKA stability and signalling by the RING ligase praja2."
  Lignitto L., Carlucci A., Sepe M., Stefan E., Cuomo O., Nistico R., Scorziello A., Savoia C., Garbi C., Annunziato L., Feliciello A.
  Nat. Cell Biol. 13:412-422(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PJA2.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	cAMP, cAMP-binding, Nucleotide-binding

Ligand

cAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	P13861
Reactomeⁱ	R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-180024, DARPP-32 events R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-5610787, Hedgehog 'off' state R-HSA-9010642, ROBO receptors bind AKAP5 R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	P13861
SIGNORⁱ	P13861

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene namesⁱ	Name:PRKAR2A Synonyms:PKR2, PRKAR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114302.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9391, PRKAR2A
MIMⁱ	176910, gene
neXtProtⁱ	NX_P13861

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5576
Open Targets More...OpenTargetsⁱ	ENSG00000114302
PharmGKBⁱ	PA33757

Miscellaneous databases

Pharosⁱ	P13861, Tbio

Pharosⁱ

P13861, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL2221
Drug and drug target database More...DrugBankⁱ	DB05798, GEM-231
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1474

Polymorphism and mutation databases

BioMutaⁱ	PRKAR2A
DMDMⁱ	125198

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000205385	2 – 404	cAMP-dependent protein kinase type II-alpha regulatory subunitAdd BLAST		403

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	48	PhosphoserineCombined sources	1
Modified residueⁱ	54	PhosphothreonineCombined sources	1
Modified residueⁱ	58	PhosphoserineCombined sources	1
Modified residueⁱ	78	PhosphoserineCombined sources	1
Modified residueⁱ	80	PhosphoserineCombined sources	1
Modified residueⁱ	99	Phosphoserine; by PKACombined sources	1
Modified residueⁱ	215	Phosphothreonine; by PDPK1By similarity	1
Modified residueⁱ	350	PhosphoserineCombined sources	1
Modified residueⁱ	395	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by the activated catalytic chain.

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P13861
jPOSTⁱ	P13861
MassIVEⁱ	P13861
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13861
PaxDbⁱ	P13861
PeptideAtlas More...PeptideAtlasⁱ	P13861
PRIDEⁱ	P13861
ProteomicsDBⁱ	52996 [P13861-1] 79069

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P13861

OGPⁱ

P13861

PTM databases

iPTMnetⁱ	P13861
PhosphoSitePlusⁱ	P13861
SwissPalmⁱ	P13861

Expressionⁱ

Tissue specificityⁱ

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Gene expression databases

Bgeeⁱ	ENSG00000114302, Expressed in buccal mucosa cell and 255 other tissues
ExpressionAtlasⁱ	P13861, baseline and differential
Genevisibleⁱ	P13861, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000114302, Tissue enhanced (testis)

HPAⁱ

ENSG00000114302, Tissue enhanced (testis)

Interactionⁱ

Subunit structureⁱ

The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules.

Interacts with AKAP4 and CBFA2T3.

Interacts with the phosphorylated form of PJA2.

Interacts with MYRIP. This interaction may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).

Forms a complex composed of PRKAR2A, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (PubMed:27484798).

Interacts with ADCY8; inhibits adenylate cyclase activity through PKA phosphorylation (PubMed:22976297).

By similarity2 Publications

Binary interactionsⁱ

Hide details

P13861

With	#Exp.	IntAct
AKAP1 [Q92667]	4	EBI-2556122,EBI-2119593
AKAP3 [O75969]	2	EBI-2556122,EBI-9033101
AKAP5 [P24588]	5	EBI-2556122,EBI-703640
AKAP8 [O43823]	3	EBI-2556122,EBI-1237481
Isoform Early E1A 26 kDa protein [P03259-2] from Human adenovirus A serotype 12.	5	EBI-2556122,EBI-7225021

Isoform 2 [P13861-2]

With	#Exp.	IntAct
AKAP14 [Q86UN6]	3	EBI-11752137,EBI-2119626
AKAP7 - isoform Alpha [O43687-2]	5	EBI-11752137,EBI-10185182
LRIF1 [Q5T3J3]	3	EBI-11752137,EBI-473196

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111562, 92 interactors
CORUMⁱ	P13861
Database of interacting proteins More...DIPⁱ	DIP-552N
IntActⁱ	P13861, 86 interactors
Molecular INTeraction database More...MINTⁱ	P13861
STRINGⁱ	9606.ENSP00000265563

Miscellaneous databases

RNActⁱ	P13861, protein

RNActⁱ

P13861, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	10 – 24	Combined sources		15
Helixⁱ	29 – 43	Combined sources		15

Show more details

3D structure databases

BMRBⁱ	P13861
SMRⁱ	P13861
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13861

EvolutionaryTraceⁱ

P13861

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 138	Dimerization and phosphorylationAdd BLAST		137

Sequence similaritiesⁱ

Belongs to the cAMP-dependent kinase regulatory chain family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG1113, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154836
HOGENOMⁱ	CLU_018310_2_0_1
InParanoidⁱ	P13861
KEGG Orthology (KO) More...KOⁱ	K04739
OMAⁱ	IARCHRG
PhylomeDBⁱ	P13861
TreeFamⁱ	TF314920

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00038, CAP_ED, 2 hits
Database of protein disorder More...DisProtⁱ	DP02333
Gene3Dⁱ	2.60.120.10, 2 hits
IDEALⁱ	IID00411
InterProⁱ	View protein in InterPro IPR012198, cAMP_dep_PK_reg_su IPR003117, cAMP_dep_PK_reg_su_I/II_a/b IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR014710, RmlC-like_jellyroll
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00027, cNMP_binding, 2 hits PF02197, RIIa, 1 hit
PIRSFⁱ	PIRSF000548, PK_regulatory, 1 hit
SMARTⁱ	View protein in SMART SM00100, cNMP, 2 hits SM00394, RIIa, 1 hit
SUPFAMⁱ	SSF51206, SSF51206, 2 hits
PROSITEⁱ	View protein in PROSITE PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P13861-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL 
        60         70         80         90        100
PAATPRQSLG HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV 
       110        120        130        140        150
CAETYNPDEE EEDTDPRVIH PKTDEQRCRL QEACKDILLF KNLDQEQLSQ 
       160        170        180        190        200
VLDAMFERIV KADEHVIDQG DDGDNFYVIE RGTYDILVTK DNQTRSVGQY 
       210        220        230        240        250
DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI IVKNNAKKRK 
       260        270        280        290        300
MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI 
       310        320        330        340        350
IESGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS 
       360        370        380        390        400
AYAVGDVKCL VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG 

NLGQ

Length:404

Mass (Da):45,518

Last modified:January 23, 2007 - v2

Checksum:ⁱC7D6E8E476E1DB65

GO

Isoform 2 (identifier: P13861-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
292-313: Missing.

« Hide

        10         20         30         40         50
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL 
        60         70         80         90        100
PAATPRQSLG HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV 
       110        120        130        140        150
CAETYNPDEE EEDTDPRVIH PKTDEQRCRL QEACKDILLF KNLDQEQLSQ 
       160        170        180        190        200
VLDAMFERIV KADEHVIDQG DDGDNFYVIE RGTYDILVTK DNQTRSVGQY 
       210        220        230        240        250
DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI IVKNNAKKRK 
       260        270        280        290        300
MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QTKSNKDGGN 
       310        320        330        340        350
QEVEIARCHK GQYFGELALV TNKPRAASAY AVGDVKCLVM DVQAFERLLG 
       360        370        380 
PCMDIMKRNI SHYEEQLVKM FGSSVDLGNL GQ

Show »

Length:382

Mass (Da):43,067

Checksum:ⁱ87D6AC1A5CE9E300

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J830	C9J830_HUMAN	cAMP-dependent protein kinase type ... cAMP-dependent protein kinase type II-alpha regulatory subunit	PRKAR2A	114	Annotation score:
H7C1L0	H7C1L0_HUMAN	cAMP-dependent protein kinase type ... cAMP-dependent protein kinase type II-alpha regulatory subunit	PRKAR2A	200	Annotation score:
H7C330	H7C330_HUMAN	cAMP-dependent protein kinase type ... cAMP-dependent protein kinase type II-alpha regulatory subunit	PRKAR2A	92	Annotation score:
H7C4A9	H7C4A9_HUMAN	cAMP-dependent protein kinase type ... cAMP-dependent protein kinase type II-alpha regulatory subunit	PRKAR2A	99	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056821	292 – 313	Missing in isoform 2. 2 PublicationsAdd BLAST		22

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14968 mRNA Translation: CAA33094.1 BT007225 mRNA Translation: AAP35889.1 AC141002 Genomic DNA No translation available. AC144546 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64926.1 CH471055 Genomic DNA Translation: EAW64927.1 BC002763 mRNA Translation: AAH02763.1 X99455 Genomic DNA Translation: CAA67817.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2778.1 [P13861-1] CCDS82771.1 [P13861-2]
PIRⁱ	S03885, OKHU2R
NCBI Reference Sequences More...RefSeqⁱ	NP_001308911.1, NM_001321982.1 [P13861-1] NP_001308912.1, NM_001321983.1 [P13861-2] NP_004148.1, NM_004157.3 [P13861-1] XP_011532244.1, XM_011533942.2 [P13861-1] XP_016862304.1, XM_017006815.1

Genome annotation databases

Ensemblⁱ	ENST00000265563; ENSP00000265563; ENSG00000114302 [P13861-1] ENST00000296446; ENSP00000296446; ENSG00000114302 [P13861-2] ENST00000454963; ENSP00000394041; ENSG00000114302 [P13861-1]
GeneIDⁱ	5576
KEGGⁱ	hsa:5576
UCSC genome browser More...UCSCⁱ	uc003cux.2, human [P13861-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13861	Protein kinase cAMP-dependent regulatory type II alpha isoform 2 (Fragment)		HUMAN		404	UniRef100_P13861
PRKAR2A isoform 1 (Fragment)		PONAB		91
PRKAR2A isoform 8 (Fragment)		PANTR		91
P13861-2	Protein kinase cAMP-dependent regulatory type II alpha isoform 1 (Fragment)		HUMAN		382	UniRef100_P13861-2

Protein	Similar proteins		Species	Score	Length	Source
P13861	Protein kinase cAMP-dependent regulatory type II alpha isoform 2 (Fragment)		HUMAN		404	UniRef90_P13861
PRKAR2A isoform 1 (Fragment)		PONAB		91
PRKAR2A isoform 8 (Fragment)		PANTR		91
Protein kinase cAMP-dependent type II regulatory subunit alpha		GORGO		411
Protein kinase cAMP-dependent type II regulatory subunit alpha		NOMLE		404
+14
P13861-2	Protein kinase cAMP-dependent regulatory type II alpha isoform 1 (Fragment)		HUMAN		382	UniRef90_P13861-2
Uncharacterized protein		AOTNA		404
Uncharacterized protein		Cebus capucinus imitator		404
cAMP-dependent protein kinase type II-alpha regulatory subunit		SAPAP		404
Uncharacterized protein		MACFA		392
+29

Protein	Similar proteins		Species	Score	Length	Source
P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	)	BOVIN		401	UniRef50_P13861
cAMP-dependent protein kinase type II-alpha regulatory subunit	)	MOUSE		401
cAMP-dependent protein kinase type II-alpha regulatory subunit	)	RAT		401
Protein kinase cAMP-dependent regulatory type II alpha isoform 2 (Fragment)		HUMAN		404
PRKAR2A isoform 1 (Fragment)		PONAB		91
+516
P13861-2	Protein kinase cAMP-dependent regulatory type II alpha isoform 1 (Fragment)		HUMAN		382	UniRef50_P13861-2
Uncharacterized protein		AOTNA		404
cAMP-dependent protein kinase type II-alpha regulatory subunit		SAPAP		404
Uncharacterized protein		Cebus capucinus imitator		404
Uncharacterized protein		MACFA		392
+298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14968 mRNA Translation: CAA33094.1 BT007225 mRNA Translation: AAP35889.1 AC141002 Genomic DNA No translation available. AC144546 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64926.1 CH471055 Genomic DNA Translation: EAW64927.1 BC002763 mRNA Translation: AAH02763.1 X99455 Genomic DNA Translation: CAA67817.1
CCDSⁱ	CCDS2778.1 [P13861-1] CCDS82771.1 [P13861-2]
PIRⁱ	S03885, OKHU2R
RefSeqⁱ	NP_001308911.1, NM_001321982.1 [P13861-1] NP_001308912.1, NM_001321983.1 [P13861-2] NP_004148.1, NM_004157.3 [P13861-1] XP_011532244.1, XM_011533942.2 [P13861-1] XP_016862304.1, XM_017006815.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2IZX	X-ray	1.30	A/B	4-44	[»]
	2KYG	NMR	-	A/B	1-45	[»]
	4ZP3	X-ray	2.63	A/B/C/D/E/F/G/H/I/J/K/L	2-44	[»]
	5H78	X-ray	2.00	A/B	5-49	[»]
	5XBY	X-ray	3.25	A/B/C/D	5-44	[»]
BMRBⁱ	P13861
SMRⁱ	P13861
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111562, 92 interactors
CORUMⁱ	P13861
DIPⁱ	DIP-552N
IntActⁱ	P13861, 86 interactors
MINTⁱ	P13861
STRINGⁱ	9606.ENSP00000265563

Chemistry databases

ChEMBLⁱ	CHEMBL2221
DrugBankⁱ	DB05798, GEM-231
GuidetoPHARMACOLOGYⁱ	1474

PTM databases

iPTMnetⁱ	P13861
PhosphoSitePlusⁱ	P13861
SwissPalmⁱ	P13861

Polymorphism and mutation databases

BioMutaⁱ	PRKAR2A
DMDMⁱ	125198

2D gel databases

OGPⁱ	P13861

OGPⁱ

P13861

Proteomic databases

EPDⁱ	P13861
jPOSTⁱ	P13861
MassIVEⁱ	P13861
MaxQBⁱ	P13861
PaxDbⁱ	P13861
PeptideAtlasⁱ	P13861
PRIDEⁱ	P13861
ProteomicsDBⁱ	52996 [P13861-1] 79069

Protocols and materials databases

Antibodypediaⁱ	3555, 439 antibodies
The DNASU plasmid repository More...DNASUⁱ	5576

Genome annotation databases

Ensemblⁱ	ENST00000265563; ENSP00000265563; ENSG00000114302 [P13861-1] ENST00000296446; ENSP00000296446; ENSG00000114302 [P13861-2] ENST00000454963; ENSP00000394041; ENSG00000114302 [P13861-1]
GeneIDⁱ	5576
KEGGⁱ	hsa:5576
UCSCⁱ	uc003cux.2, human [P13861-1]

Organism-specific databases

CTDⁱ	5576
DisGeNETⁱ	5576
EuPathDBⁱ	HostDB:ENSG00000114302.15
GeneCardsⁱ	PRKAR2A
HGNCⁱ	HGNC:9391, PRKAR2A
HPAⁱ	ENSG00000114302, Tissue enhanced (testis)
MIMⁱ	176910, gene
neXtProtⁱ	NX_P13861
OpenTargetsⁱ	ENSG00000114302
PharmGKBⁱ	PA33757
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1113, Eukaryota
GeneTreeⁱ	ENSGT00940000154836
HOGENOMⁱ	CLU_018310_2_0_1
InParanoidⁱ	P13861
KOⁱ	K04739
OMAⁱ	IARCHRG
PhylomeDBⁱ	P13861
TreeFamⁱ	TF314920

Enzyme and pathway databases

PathwayCommonsⁱ	P13861
Reactomeⁱ	R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-180024, DARPP-32 events R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-5610787, Hedgehog 'off' state R-HSA-9010642, ROBO receptors bind AKAP5 R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	P13861
SIGNORⁱ	P13861

Miscellaneous databases

BioGRID-ORCSⁱ	5576, 34 hits in 872 CRISPR screens
ChiTaRSⁱ	PRKAR2A, human
EvolutionaryTraceⁱ	P13861
GeneWikiⁱ	PRKAR2A
GenomeRNAiⁱ	5576
Pharosⁱ	P13861, Tbio
Protein Ontology More...PROⁱ	PR:P13861
RNActⁱ	P13861, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114302, Expressed in buccal mucosa cell and 255 other tissues
ExpressionAtlasⁱ	P13861, baseline and differential
Genevisibleⁱ	P13861, HS

Family and domain databases

CDDⁱ	cd00038, CAP_ED, 2 hits
DisProtⁱ	DP02333
Gene3Dⁱ	2.60.120.10, 2 hits
IDEALⁱ	IID00411
InterProⁱ	View protein in InterPro IPR012198, cAMP_dep_PK_reg_su IPR003117, cAMP_dep_PK_reg_su_I/II_a/b IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR014710, RmlC-like_jellyroll
Pfamⁱ	View protein in Pfam PF00027, cNMP_binding, 2 hits PF02197, RIIa, 1 hit
PIRSFⁱ	PIRSF000548, PK_regulatory, 1 hit
SMARTⁱ	View protein in SMART SM00100, cNMP, 2 hits SM00394, RIIa, 1 hit
SUPFAMⁱ	SSF51206, SSF51206, 2 hits
PROSITEⁱ	View protein in PROSITE PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KAP2_HUMAN
Accessionⁱ	P13861Primary (citable) accession number: P13861 Secondary accession number(s): Q16823, Q9BUB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 23, 2007
	Last modified:	October 7, 2020
	This is version 209 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM

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UniProtKB - P13861 (KAP2_HUMAN)

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cAMP-dependent protein kinase type II-alpha regulatory subunit

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P13861

Isoform 2 [P13861-2]

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ