UniProtKB - P13856 (RSR1_YEAST)
Protein
Ras-related protein RSR1
Gene
RSR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Ras-related protein which binds GDP/GTP and possesses intrinsic GTPase activity (PubMed:1910037). Involved in development of cell polarity during the cell division cycle, and essential for bud emergence (PubMed:2690082).2 Publications
Catalytic activityi
- EC:3.6.5.21 Publication
Activity regulationi
Alternates between an inactive form bound to GDP and an active form bound to GTP (PubMed:1910037). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP) (PubMed:1910037).1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 17 | GTPBy similarity | 8 | |
Nucleotide bindingi | 57 – 61 | GTPBy similarity | 5 | |
Nucleotide bindingi | 116 – 119 | GTPBy similarity | 4 |
GO - Molecular functioni
- GDP binding Source: GO_Central
- GTPase activity Source: SGD
- GTP binding Source: GO_Central
GO - Biological processi
- axial cellular bud site selection Source: SGD
- bipolar cellular bud site selection Source: SGD
- cytogamy Source: SGD
- establishment of protein localization Source: SGD
- maintenance of protein location in cell Source: SGD
- positive regulation of Rho guanyl-nucleotide exchange factor activity Source: SGD
- positive regulation of Rho protein signal transduction Source: SGD
- regulation of establishment of cell polarity Source: SGD
- small GTPase mediated signal transduction Source: SGD
Keywordsi
Molecular function | Hydrolase |
Biological process | Cell cycle, Cell division |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-354192, Integrin signaling R-SCE-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-SCE-392517, Rap1 signalling R-SCE-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RSR1 Synonyms:BUD1 Ordered Locus Names:YGR152C ORF Names:G6658 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YGR152C |
SGDi | S000003384, RSR1 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Plasma Membrane
- plasma membrane Source: SGD
Vacuole
- vacuolar membrane Source: SGD
Other locations
- cell division site Source: SGD
- cell periphery Source: SGD
- cellular bud neck Source: SGD
- incipient cellular bud site Source: SGD
- site of polarized growth Source: SGD
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 12 | G → V: Loss of GAP-induced GTPase activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082691 | 1 – 269 | Ras-related protein RSR1Add BLAST | 269 | |
PropeptideiPRO_0000281342 | 270 – 272 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 269 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 269 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, PrenylationProteomic databases
MaxQBi | P13856 |
PaxDbi | P13856 |
PRIDEi | P13856 |
PTM databases
iPTMneti | P13856 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33400, 62 interactors |
DIPi | DIP-2230N |
IntActi | P13856, 25 interactors |
MINTi | P13856 |
STRINGi | 4932.YGR152C |
Miscellaneous databases
RNActi | P13856, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 32 – 40 | Effector regionSequence analysis | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000173447 |
HOGENOMi | CLU_041217_9_0_1 |
InParanoidi | P13856 |
OMAi | QREYHIA |
Family and domain databases
CDDi | cd04177, RSR1, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041841, Rsr1 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P13856-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRDYKLVVLG AGGVGKSCLT VQFVQGVYLD TYDPTIEDSY RKTIEIDNKV
60 70 80 90 100
FDLEILDTAG IAQFTAMREL YIKSGMGFLL VYSVTDRQSL EELMELREQV
110 120 130 140 150
LRIKDSDRVP MVLIGNKADL INERVISVEE GIEVSSKWGR VPFYETSALL
160 170 180 190 200
RSNVDEVFVD LVRQIIRNEM ESVAVKDARN QSQQFSKIES PSTRLPSSAK
210 220 230 240 250
QDTKQSNNKQ SSKGLYNKSS QGQAKVKQST PVNEKHKPSH AVPKSGSSNR
260 270
TGISATSQQK KKKKNASTCT IL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26928 Genomic DNA Translation: AAA35013.1 X85807 Genomic DNA Translation: CAA59809.1 Z72936 Genomic DNA Translation: CAA97166.1 BK006941 Genomic DNA Translation: DAA08243.1 |
PIRi | A34511 |
RefSeqi | NP_011668.3, NM_001181281.3 |
Genome annotation databases
EnsemblFungii | YGR152C_mRNA; YGR152C; YGR152C |
GeneIDi | 853056 |
KEGGi | sce:YGR152C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26928 Genomic DNA Translation: AAA35013.1 X85807 Genomic DNA Translation: CAA59809.1 Z72936 Genomic DNA Translation: CAA97166.1 BK006941 Genomic DNA Translation: DAA08243.1 |
PIRi | A34511 |
RefSeqi | NP_011668.3, NM_001181281.3 |
3D structure databases
SMRi | P13856 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33400, 62 interactors |
DIPi | DIP-2230N |
IntActi | P13856, 25 interactors |
MINTi | P13856 |
STRINGi | 4932.YGR152C |
PTM databases
iPTMneti | P13856 |
Proteomic databases
MaxQBi | P13856 |
PaxDbi | P13856 |
PRIDEi | P13856 |
Genome annotation databases
EnsemblFungii | YGR152C_mRNA; YGR152C; YGR152C |
GeneIDi | 853056 |
KEGGi | sce:YGR152C |
Organism-specific databases
EuPathDBi | FungiDB:YGR152C |
SGDi | S000003384, RSR1 |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000173447 |
HOGENOMi | CLU_041217_9_0_1 |
InParanoidi | P13856 |
OMAi | QREYHIA |
Enzyme and pathway databases
Reactomei | R-SCE-354192, Integrin signaling R-SCE-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-SCE-392517, Rap1 signalling R-SCE-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:P13856 |
RNActi | P13856, protein |
Family and domain databases
CDDi | cd04177, RSR1, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041841, Rsr1 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSR1_YEAST | |
Accessioni | P13856Primary (citable) accession number: P13856 Secondary accession number(s): D6VUT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names