UniProtKB - P13808 (B3A2_MOUSE)
Anion exchange protein 2
Slc4a2
Functioni
GO - Molecular functioni
- anion:anion antiporter activity Source: GO_Central
- chloride transmembrane transporter activity Source: UniProtKB
- enzyme binding Source: MGI
- inorganic anion exchanger activity Source: InterPro
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- bicarbonate transport Source: GO_Central
- chloride transport Source: UniProtKB
- ion homeostasis Source: GO_Central
- regulation of intracellular pH Source: MGI
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Anion exchange, Antiport, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-425381, Bicarbonate transporters |
Names & Taxonomyi
Protein namesi | Recommended name: Anion exchange protein 2Short name: AE 2 Short name: Anion exchanger 2 Alternative name(s): Band 3-related protein Short name: B3RP Non-erythroid band 3-like protein Solute carrier family 4 member 2 |
Gene namesi | Name:Slc4a2 Synonyms:Ae2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109351, Slc4a2 |
Subcellular locationi
Other locations
Plasma Membrane
- apical plasma membrane Source: MGI
- basolateral plasma membrane Source: MGI
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 703 | CytoplasmicSequence analysisAdd BLAST | 703 | |
Transmembranei | 704 – 727 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 733 – 770 | HelicalSequence analysisAdd BLAST | 38 | |
Transmembranei | 790 – 812 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 822 – 843 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 844 – 896 | ExtracellularSequence analysisAdd BLAST | 53 | |
Transmembranei | 897 – 914 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 915 – 929 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 930 – 950 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 984 – 1006 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1032 – 1053 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1087 – 1132 | HelicalSequence analysisAdd BLAST | 46 | |
Transmembranei | 1159 – 1195 | HelicalSequence analysisAdd BLAST | 37 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079216 | 1 – 1237 | Anion exchange protein 2Add BLAST | 1237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 112 | PhosphoserineBy similarity | 1 | |
Modified residuei | 131 | PhosphoserineBy similarity | 1 | |
Modified residuei | 144 | PhosphoserineCombined sources | 1 | |
Modified residuei | 170 | PhosphoserineCombined sources | 1 | |
Modified residuei | 172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 239 | PhosphoserineBy similarity | 1 | |
Modified residuei | 253 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 270 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 855 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 866 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 878 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1169 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, Methylation, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P13808 |
MaxQBi | P13808 |
PaxDbi | P13808 |
PeptideAtlasi | P13808 |
PRIDEi | P13808 |
PTM databases
GlyGeni | P13808, 3 sites |
iPTMneti | P13808 |
PhosphoSitePlusi | P13808 |
Expressioni
Tissue specificityi
Interactioni
GO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203314, 4 interactors |
IntActi | P13808, 1 interactor |
MINTi | P13808 |
STRINGi | 10090.ENSMUSP00000078972 |
Miscellaneous databases
RNActi | P13808, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 704 – 1237 | Membrane (anion exchange)Add BLAST | 534 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 5 – 316 | Pro-richAdd BLAST | 312 | |
Compositional biasi | 73 – 87 | His-richAdd BLAST | 15 | |
Compositional biasi | 861 – 865 | Poly-Ser | 5 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1172, Eukaryota |
InParanoidi | P13808 |
OrthoDBi | 265068at2759 |
PhylomeDBi | P13808 |
TreeFami | TF313630 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL
60 70 80 90 100
QEAGSRGGEE PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG
110 120 130 140 150
PGRKPRRRPG ASPTGETPTI EEGEEDEEEA SEAEGFRAPP QQPSPATTPS
160 170 180 190 200
AVQFFLQEDE GAERKPERTS PSPPTQTPHQ EAAPRASKGA QTGTLVEEMV
210 220 230 240 250
AVASATAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM TGVEQALLPR
260 270 280 290 300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR
310 320 330 340 350
EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE
360 370 380 390 400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ
410 420 430 440 450
MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH
460 470 480 490 500
HAQGTESDPH VTEPLIGGVP ETRLEVDRER ELPPPAPPAG ITRSKSKHEL
510 520 530 540 550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR
560 570 580 590 600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA
610 620 630 640 650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS
660 670 680 690 700
AQDKALLQMV EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL
710 720 730 740 750
DPQCLAAVIF IYFAALSPAI TFGGLLGEKT KDLIGVSELI MSTALQGVVF
760 770 780 790 800
CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NELEYLVGRV WIGFWLVFLA
810 820 830 840 850
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG
860 870 880 890 900
CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS
910 920 930 940 950
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI
960 970 980 990 1000
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV
1010 1020 1030 1040 1050
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL
1060 1070 1080 1090 1100
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSM
1110 1120 1130 1140 1150
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY
1160 1170 1180 1190 1200
VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL
1210 1220 1230
TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV
The sequence of this isoform differs from the canonical sequence as follows:
1-17: MSSAPRRPASGADSLHT → MTQ
The sequence of this isoform differs from the canonical sequence as follows:
1-17: MSSAPRRPASGADSLHT → MDFLLRPQ
The sequence of this isoform differs from the canonical sequence as follows:
1-198: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-166: Missing.
167-193: ERTSPSPPTQTPHQEAAPRASKGAQTG → MPAFQEWKSGGLREEAVFGAHGCSVCR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J101 | A0A0R4J101_MOUSE | Anion exchange protein | Slc4a2 | 1,237 | Annotation score: | ||
A0A0R4J1K4 | A0A0R4J1K4_MOUSE | Anion exchange protein | Slc4a2 | 1,223 | Annotation score: | ||
A0A0R4J1K9 | A0A0R4J1K9_MOUSE | Anion exchange protein | Slc4a2 | 1,228 | Annotation score: | ||
D3YUF1 | D3YUF1_MOUSE | Anion exchange protein 2 | Slc4a2 | 121 | Annotation score: | ||
D3Z5G3 | D3Z5G3_MOUSE | Anion exchange protein 2 | Slc4a2 | 131 | Annotation score: | ||
A0A1C7ZN01 | A0A1C7ZN01_MOUSE | Anion exchange protein 2 | Slc4a2 | 9 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 205 | A → G in AAG23154 (PubMed:11006093).Curated | 1 | |
Sequence conflicti | 205 | A → G in AAG23155 (PubMed:11006093).Curated | 1 | |
Sequence conflicti | 205 | A → G in AAG23156 (PubMed:11006093).Curated | 1 | |
Sequence conflicti | 205 | A → G in AAG23158 (PubMed:11006093).Curated | 1 | |
Sequence conflicti | 205 | A → G in AAG23157 (PubMed:11006093).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000460 | 1 – 198 | Missing in isoform C1. CuratedAdd BLAST | 198 | |
Alternative sequenceiVSP_000459 | 1 – 166 | Missing in isoform C2. CuratedAdd BLAST | 166 | |
Alternative sequenceiVSP_000458 | 1 – 17 | MSSAP…DSLHT → MTQ in isoform B1. CuratedAdd BLAST | 17 | |
Alternative sequenceiVSP_000457 | 1 – 17 | MSSAP…DSLHT → MDFLLRPQ in isoform B2. CuratedAdd BLAST | 17 | |
Alternative sequenceiVSP_000461 | 167 – 193 | ERTSP…GAQTG → MPAFQEWKSGGLREEAVFGA HGCSVCR in isoform C2. CuratedAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04036 mRNA Translation: AAA65505.1 AF255774 Genomic DNA Translation: AAG23154.1 AF255774 Genomic DNA Translation: AAG23155.1 AF255774 Genomic DNA Translation: AAG23156.1 AF255774 Genomic DNA Translation: AAG23158.1 AF255774 Genomic DNA Translation: AAG23157.1 |
CCDSi | CCDS19119.1 [P13808-1] |
PIRi | A31789 |
RefSeqi | NP_001240821.1, NM_001253892.1 NP_033233.2, NM_009207.3 XP_006535713.1, XM_006535650.1 XP_006535714.1, XM_006535651.3 XP_006535718.1, XM_006535655.3 XP_006535719.1, XM_006535656.3 |
Genome annotation databases
GeneIDi | 20535 |
KEGGi | mmu:20535 |
UCSCi | uc008wrm.2, mouse [P13808-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04036 mRNA Translation: AAA65505.1 AF255774 Genomic DNA Translation: AAG23154.1 AF255774 Genomic DNA Translation: AAG23155.1 AF255774 Genomic DNA Translation: AAG23156.1 AF255774 Genomic DNA Translation: AAG23158.1 AF255774 Genomic DNA Translation: AAG23157.1 |
CCDSi | CCDS19119.1 [P13808-1] |
PIRi | A31789 |
RefSeqi | NP_001240821.1, NM_001253892.1 NP_033233.2, NM_009207.3 XP_006535713.1, XM_006535650.1 XP_006535714.1, XM_006535651.3 XP_006535718.1, XM_006535655.3 XP_006535719.1, XM_006535656.3 |
3D structure databases
SMRi | P13808 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203314, 4 interactors |
IntActi | P13808, 1 interactor |
MINTi | P13808 |
STRINGi | 10090.ENSMUSP00000078972 |
PTM databases
GlyGeni | P13808, 3 sites |
iPTMneti | P13808 |
PhosphoSitePlusi | P13808 |
Proteomic databases
jPOSTi | P13808 |
MaxQBi | P13808 |
PaxDbi | P13808 |
PeptideAtlasi | P13808 |
PRIDEi | P13808 |
Genome annotation databases
GeneIDi | 20535 |
KEGGi | mmu:20535 |
UCSCi | uc008wrm.2, mouse [P13808-1] |
Organism-specific databases
CTDi | 6522 |
MGIi | MGI:109351, Slc4a2 |
Phylogenomic databases
eggNOGi | KOG1172, Eukaryota |
InParanoidi | P13808 |
OrthoDBi | 265068at2759 |
PhylomeDBi | P13808 |
TreeFami | TF313630 |
Enzyme and pathway databases
Reactomei | R-MMU-425381, Bicarbonate transporters |
Miscellaneous databases
BioGRID-ORCSi | 20535, 2 hits in 17 CRISPR screens |
ChiTaRSi | Slc4a2, mouse |
PROi | PR:P13808 |
RNActi | P13808, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3A2_MOUSE | |
Accessioni | P13808Primary (citable) accession number: P13808 Secondary accession number(s): Q9ES09 Q9ES13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families