UniProtKB - P13808 (B3A2_MOUSE)

BLAST

>sp|P13808|B3A2_MOUSE Anion exchange protein 2 OS=Mus musculus OX=10090 GN=Slc4a2 PE=1 SV=1
MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEDELRTLGVERFEEILQEAGSRGGEE
PGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTI
EEGEEDEEEASEAEGFRAPPQQPSPATTPSAVQFFLQEDEGAERKPERTSPSPPTQTPHQ
EAAPRASKGAQTGTLVEEMVAVASATAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSM
TGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGR
EPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPH
VASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALL
LKHSHPSDEKEFSFPRNISAGSLGSLLGHHHAQGTESDPHVTEPLIGGVPETRLEVDRER
ELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELD
AVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINA
FLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMV
EVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAI
TFGGLLGEKTKDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSS
NELEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLI
KIFQEHPLHGCSGSNDSEAGSSSSSNMTWATTILVPDNSSASGQSGQEKPRGQPNTALLS
LVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSV
PSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKER
MLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQ
EVKEQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLM
PPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVL
TRIFTEREMKCLDANEAEPVFDECEGVDEYNEMPMPV

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History
Entry version 157 (07 Nov 2018)
Sequence version 1 (01 Jan 1990)
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Protein

Anion exchange protein 2

Gene

Slc4a2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functionⁱ

anion:anion antiporter activity Source: UniProtKB-KW
chloride transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17690150
enzyme binding Source: MGI
inorganic anion exchanger activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bicarbonate transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chloride transport
Source: UniProtKB
Inferred from direct assayⁱ
- 17690150
regulation of intracellular pH Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Anion exchange, Antiport, Ion transport, Transport

Biological process

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Anion exchange protein 2 Short name: AE 2 Short name: Anion exchanger 2 Alternative name(s): Band 3-related protein Short name: B3RP Non-erythroid band 3-like protein Solute carrier family 4 member 2
Gene namesⁱ	Name:Slc4a2 Synonyms:Ae2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:109351 Slc4a2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 703	CytoplasmicSequence analysisAdd BLAST	703
Transmembraneⁱ	704 – 727	HelicalSequence analysisAdd BLAST	24
Transmembraneⁱ	733 – 770	HelicalSequence analysisAdd BLAST	38
Transmembraneⁱ	790 – 812	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	822 – 843	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	844 – 896	ExtracellularSequence analysisAdd BLAST	53
Transmembraneⁱ	897 – 914	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	915 – 929	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	930 – 950	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	984 – 1006	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	1032 – 1053	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	1087 – 1132	HelicalSequence analysisAdd BLAST	46
Transmembraneⁱ	1159 – 1195	HelicalSequence analysisAdd BLAST	37

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079216	1 – 1237	Anion exchange protein 2Add BLAST		1237

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	112	PhosphoserineBy similarity	1
Modified residueⁱ	131	PhosphoserineBy similarity	1
Modified residueⁱ	144	PhosphoserineCombined sources	1
Modified residueⁱ	170	PhosphoserineCombined sources	1
Modified residueⁱ	172	PhosphoserineCombined sources	1
Modified residueⁱ	239	PhosphoserineBy similarity	1
Modified residueⁱ	253	PhosphothreonineCombined sources	1
Modified residueⁱ	270	N6-methyllysineBy similarity	1
Modified residueⁱ	439	PhosphoserineBy similarity	1
Glycosylationⁱ	855	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	866	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	878	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	1169	S-palmitoyl cysteineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13808
PaxDbⁱ	P13808
PeptideAtlas More...PeptideAtlasⁱ	P13808
PRIDEⁱ	P13808

PTM databases

iPTMnetⁱ	P13808
PhosphoSitePlusⁱ	P13808

Expressionⁱ

Tissue specificityⁱ

Isoform a is widely expressed at similar levels in all tissues examined. Isoforms B1 and B2 are predominantly expressed in stomach although they are also detected at lower levels in other tissues. Isoform C1 is stomach-specific. Isoform C2 is expressed at slightly higher levels in lung and stomach than in other tissues.1 Publication

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P13808, 1 interactor
Molecular INTeraction database More...MINTⁱ	P13808
STRINGⁱ	10090.ENSMUSP00000078972

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13808
SMRⁱ	P13808
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	704 – 1237	Membrane (anion exchange)Add BLAST		534

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	5 – 316	Pro-richAdd BLAST	312
Compositional biasⁱ	73 – 87	His-richAdd BLAST	15
Compositional biasⁱ	861 – 865	Poly-Ser	5

Sequence similaritiesⁱ

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1172 Eukaryota ENOG410XPHD LUCA
HOGENOMⁱ	HOG000280683
HOVERGENⁱ	HBG004326
InParanoidⁱ	P13808
KEGG Orthology (KO) More...KOⁱ	K13855
PhylomeDBⁱ	P13808
TreeFamⁱ	TF313630

Family and domain databases

Gene3Dⁱ	3.40.930.10, 1 hit
InterProⁱ	View protein in InterPro IPR001717 Anion_exchange IPR002978 Anion_exchange_2 IPR018241 Anion_exchange_CS IPR013769 Band3_cytoplasmic_dom IPR011531 HCO3_transpt_C IPR003020 HCO3_transpt_euk IPR016152 PTrfase/Anion_transptr
PANTHERⁱ	PTHR11453 PTHR11453, 1 hit PTHR11453:SF14 PTHR11453:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07565 Band_3_cyto, 1 hit PF00955 HCO3_cotransp, 1 hit
PRINTSⁱ	PR00165 ANIONEXCHNGR PR01188 ANIONEXHNGR2 PR01231 HCO3TRNSPORT
SUPFAMⁱ	SSF55804 SSF55804, 1 hit
TIGRFAMsⁱ	TIGR00834 ae, 1 hit
PROSITEⁱ	View protein in PROSITE PS00219 ANION_EXCHANGER_1, 1 hit PS00220 ANION_EXCHANGER_2, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform A (identifier: P13808-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL 
        60         70         80         90        100
QEAGSRGGEE PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG 
       110        120        130        140        150
PGRKPRRRPG ASPTGETPTI EEGEEDEEEA SEAEGFRAPP QQPSPATTPS 
       160        170        180        190        200
AVQFFLQEDE GAERKPERTS PSPPTQTPHQ EAAPRASKGA QTGTLVEEMV 
       210        220        230        240        250
AVASATAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM TGVEQALLPR 
       260        270        280        290        300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR 
       310        320        330        340        350
EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE 
       360        370        380        390        400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ 
       410        420        430        440        450
MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH 
       460        470        480        490        500
HAQGTESDPH VTEPLIGGVP ETRLEVDRER ELPPPAPPAG ITRSKSKHEL 
       510        520        530        540        550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR 
       560        570        580        590        600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA 
       610        620        630        640        650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS 
       660        670        680        690        700
AQDKALLQMV EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL 
       710        720        730        740        750
DPQCLAAVIF IYFAALSPAI TFGGLLGEKT KDLIGVSELI MSTALQGVVF 
       760        770        780        790        800
CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NELEYLVGRV WIGFWLVFLA 
       810        820        830        840        850
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG 
       860        870        880        890        900
CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS 
       910        920        930        940        950
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI 
       960        970        980        990       1000
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV 
      1010       1020       1030       1040       1050
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL 
      1060       1070       1080       1090       1100
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSM 
      1110       1120       1130       1140       1150
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY 
      1160       1170       1180       1190       1200
VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL 
      1210       1220       1230 
TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV

Length:1,237

Mass (Da):136,814

Last modified:January 1, 1990 - v1

Checksum:ⁱ1A0782C0071782EE

Isoform B1 (identifier: P13808-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-17: MSSAPRRPASGADSLHT → MTQ

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        10         20         30         40         50
MTQPEPESLS PGTPGFPEQE EDELRTLGVE RFEEILQEAG SRGGEEPGRS 
        60         70         80         90        100
YGEEDFEYHR QSSHHIHHPL STHLPPDARR RKTPQGPGRK PRRRPGASPT 
       110        120        130        140        150
GETPTIEEGE EDEEEASEAE GFRAPPQQPS PATTPSAVQF FLQEDEGAER 
       160        170        180        190        200
KPERTSPSPP TQTPHQEAAP RASKGAQTGT LVEEMVAVAS ATAGGDDGGA 
       210        220        230        240        250
AGRPLTKAQP GHRSYNLQER RRIGSMTGVE QALLPRVPTD ESEAQTLATA 
       260        270        280        290        300
DLDLMKSHRF EDVPGVRRHL VRKNAKGSTQ AAREGREPGP TPRARPRAPH 
       310        320        330        340        350
KPHEVFVELN ELLLDKNQEP QWRETARWIK FEEDVEEETE RWGKPHVASL 
       360        370        380        390        400
SFRSLLELRR TLAHGAVLLD LDQQTLPGVA HQVVEQMVIS DQIKAEDRAN 
       410        420        430        440        450
VLRALLLKHS HPSDEKEFSF PRNISAGSLG SLLGHHHAQG TESDPHVTEP 
       460        470        480        490        500
LIGGVPETRL EVDRERELPP PAPPAGITRS KSKHELKLLE KIPENAEATV 
       510        520        530        540        550
VLVGCVEFLS RPTMAFVRLR EAVELDAVLE VPVPVRFLFL LLGPSSANMD 
       560        570        580        590        600
YHEIGRSIST LMSDKQFHEA AYLADERDDL LTAINAFLDC SVVLPPSEVQ 
       610        620        630        640        650
GEELLRSVAH FQRQMLKKRE EQGRLLPPGA GLEPKSAQDK ALLQMVEVAG 
       660        670        680        690        700
AAEDDPLRRT GRPFGGLIRD VRRRYPHYLS DFRDALDPQC LAAVIFIYFA 
       710        720        730        740        750
ALSPAITFGG LLGEKTKDLI GVSELIMSTA LQGVVFCLLG AQPLLVIGFS 
       760        770        780        790        800
GPLLVFEEAF FSFCSSNELE YLVGRVWIGF WLVFLALLMV ALEGSFLVRF 
       810        820        830        840        850
VSRFTQEIFA FLISLIFIYE TFYKLIKIFQ EHPLHGCSGS NDSEAGSSSS 
       860        870        880        890        900
SNMTWATTIL VPDNSSASGQ SGQEKPRGQP NTALLSLVLM AGTFFIAFFL 
       910        920        930        940        950
RKFKNSRFFP GRIRRVIGDF GVPIAILIMV LVDYSIEDTY TQKLSVPSGF 
       960        970        980        990       1000
SVTAPDKRGW VINPLGEKTP FPVWMMVASL LPAVLVFILI FMETQITTLI 
      1010       1020       1030       1040       1050
ISKKERMLQK GSGFHLDLLL IVAMGGICAL FGLPWLAAAT VRSVTHANAL 
      1060       1070       1080       1090       1100
TVMSKAVAPG DKPKIQEVKE QRVTGLLVAL LVGLSMVIGD LLRQIPLAVL 
      1110       1120       1130       1140       1150
FGIFLYMGVT SLNGIQFYER LHLLLMPPKH HPDVTYVKKV RTMRMHLFTA 
      1160       1170       1180       1190       1200
LQLLCLALLW AVMSTAASLA FPFILILTVP LRMVVLTRIF TEREMKCLDA 
      1210       1220 
NEAEPVFDEC EGVDEYNEMP MPV

Show »

Length:1,223

Mass (Da):135,452

Checksum:ⁱE03B373EAAA48119

Isoform B2 (identifier: P13808-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-17: MSSAPRRPASGADSLHT → MDFLLRPQ

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        10         20         30         40         50
MDFLLRPQPE PESLSPGTPG FPEQEEDELR TLGVERFEEI LQEAGSRGGE 
        60         70         80         90        100
EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP 
       110        120        130        140        150
GASPTGETPT IEEGEEDEEE ASEAEGFRAP PQQPSPATTP SAVQFFLQED 
       160        170        180        190        200
EGAERKPERT SPSPPTQTPH QEAAPRASKG AQTGTLVEEM VAVASATAGG 
       210        220        230        240        250
DDGGAAGRPL TKAQPGHRSY NLQERRRIGS MTGVEQALLP RVPTDESEAQ 
       260        270        280        290        300
TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQAAREG REPGPTPRAR 
       310        320        330        340        350
PRAPHKPHEV FVELNELLLD KNQEPQWRET ARWIKFEEDV EEETERWGKP 
       360        370        380        390        400
HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE QMVISDQIKA 
       410        420        430        440        450
EDRANVLRAL LLKHSHPSDE KEFSFPRNIS AGSLGSLLGH HHAQGTESDP 
       460        470        480        490        500
HVTEPLIGGV PETRLEVDRE RELPPPAPPA GITRSKSKHE LKLLEKIPEN 
       510        520        530        540        550
AEATVVLVGC VEFLSRPTMA FVRLREAVEL DAVLEVPVPV RFLFLLLGPS 
       560        570        580        590        600
SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN AFLDCSVVLP 
       610        620        630        640        650
PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPPGAGLEPK SAQDKALLQM 
       660        670        680        690        700
VEVAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA LDPQCLAAVI 
       710        720        730        740        750
FIYFAALSPA ITFGGLLGEK TKDLIGVSEL IMSTALQGVV FCLLGAQPLL 
       760        770        780        790        800
VIGFSGPLLV FEEAFFSFCS SNELEYLVGR VWIGFWLVFL ALLMVALEGS 
       810        820        830        840        850
FLVRFVSRFT QEIFAFLISL IFIYETFYKL IKIFQEHPLH GCSGSNDSEA 
       860        870        880        890        900
GSSSSSNMTW ATTILVPDNS SASGQSGQEK PRGQPNTALL SLVLMAGTFF 
       910        920        930        940        950
IAFFLRKFKN SRFFPGRIRR VIGDFGVPIA ILIMVLVDYS IEDTYTQKLS 
       960        970        980        990       1000
VPSGFSVTAP DKRGWVINPL GEKTPFPVWM MVASLLPAVL VFILIFMETQ 
      1010       1020       1030       1040       1050
ITTLIISKKE RMLQKGSGFH LDLLLIVAMG GICALFGLPW LAAATVRSVT 
      1060       1070       1080       1090       1100
HANALTVMSK AVAPGDKPKI QEVKEQRVTG LLVALLVGLS MVIGDLLRQI 
      1110       1120       1130       1140       1150
PLAVLFGIFL YMGVTSLNGI QFYERLHLLL MPPKHHPDVT YVKKVRTMRM 
      1160       1170       1180       1190       1200
HLFTALQLLC LALLWAVMST AASLAFPFIL ILTVPLRMVV LTRIFTEREM 
      1210       1220 
KCLDANEAEP VFDECEGVDE YNEMPMPV

Show »

Length:1,228

Mass (Da):136,092

Checksum:ⁱ8EC77B1EF4AF52A2

Isoform C1 (identifier: P13808-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-198: Missing.

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        10         20         30         40         50
MVAVASATAG GDDGGAAGRP LTKAQPGHRS YNLQERRRIG SMTGVEQALL 
        60         70         80         90        100
PRVPTDESEA QTLATADLDL MKSHRFEDVP GVRRHLVRKN AKGSTQAARE 
       110        120        130        140        150
GREPGPTPRA RPRAPHKPHE VFVELNELLL DKNQEPQWRE TARWIKFEED 
       160        170        180        190        200
VEEETERWGK PHVASLSFRS LLELRRTLAH GAVLLDLDQQ TLPGVAHQVV 
       210        220        230        240        250
EQMVISDQIK AEDRANVLRA LLLKHSHPSD EKEFSFPRNI SAGSLGSLLG 
       260        270        280        290        300
HHHAQGTESD PHVTEPLIGG VPETRLEVDR ERELPPPAPP AGITRSKSKH 
       310        320        330        340        350
ELKLLEKIPE NAEATVVLVG CVEFLSRPTM AFVRLREAVE LDAVLEVPVP 
       360        370        380        390        400
VRFLFLLLGP SSANMDYHEI GRSISTLMSD KQFHEAAYLA DERDDLLTAI 
       410        420        430        440        450
NAFLDCSVVL PPSEVQGEEL LRSVAHFQRQ MLKKREEQGR LLPPGAGLEP 
       460        470        480        490        500
KSAQDKALLQ MVEVAGAAED DPLRRTGRPF GGLIRDVRRR YPHYLSDFRD 
       510        520        530        540        550
ALDPQCLAAV IFIYFAALSP AITFGGLLGE KTKDLIGVSE LIMSTALQGV 
       560        570        580        590        600
VFCLLGAQPL LVIGFSGPLL VFEEAFFSFC SSNELEYLVG RVWIGFWLVF 
       610        620        630        640        650
LALLMVALEG SFLVRFVSRF TQEIFAFLIS LIFIYETFYK LIKIFQEHPL 
       660        670        680        690        700
HGCSGSNDSE AGSSSSSNMT WATTILVPDN SSASGQSGQE KPRGQPNTAL 
       710        720        730        740        750
LSLVLMAGTF FIAFFLRKFK NSRFFPGRIR RVIGDFGVPI AILIMVLVDY 
       760        770        780        790        800
SIEDTYTQKL SVPSGFSVTA PDKRGWVINP LGEKTPFPVW MMVASLLPAV 
       810        820        830        840        850
LVFILIFMET QITTLIISKK ERMLQKGSGF HLDLLLIVAM GGICALFGLP 
       860        870        880        890        900
WLAAATVRSV THANALTVMS KAVAPGDKPK IQEVKEQRVT GLLVALLVGL 
       910        920        930        940        950
SMVIGDLLRQ IPLAVLFGIF LYMGVTSLNG IQFYERLHLL LMPPKHHPDV 
       960        970        980        990       1000
TYVKKVRTMR MHLFTALQLL CLALLWAVMS TAASLAFPFI LILTVPLRMV 
      1010       1020       1030 
VLTRIFTERE MKCLDANEAE PVFDECEGVD EYNEMPMPV

Show »

Length:1,039

Mass (Da):115,198

Checksum:ⁱ5F6C9A0FC1FECBC6

Isoform C2 (identifier: P13808-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-166: Missing.
167-193: ERTSPSPPTQTPHQEAAPRASKGAQTG → MPAFQEWKSGGLREEAVFGAHGCSVCR

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        10         20         30         40         50
MPAFQEWKSG GLREEAVFGA HGCSVCRTLV EEMVAVASAT AGGDDGGAAG 
        60         70         80         90        100
RPLTKAQPGH RSYNLQERRR IGSMTGVEQA LLPRVPTDES EAQTLATADL 
       110        120        130        140        150
DLMKSHRFED VPGVRRHLVR KNAKGSTQAA REGREPGPTP RARPRAPHKP 
       160        170        180        190        200
HEVFVELNEL LLDKNQEPQW RETARWIKFE EDVEEETERW GKPHVASLSF 
       210        220        230        240        250
RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ VVEQMVISDQ IKAEDRANVL 
       260        270        280        290        300
RALLLKHSHP SDEKEFSFPR NISAGSLGSL LGHHHAQGTE SDPHVTEPLI 
       310        320        330        340        350
GGVPETRLEV DRERELPPPA PPAGITRSKS KHELKLLEKI PENAEATVVL 
       360        370        380        390        400
VGCVEFLSRP TMAFVRLREA VELDAVLEVP VPVRFLFLLL GPSSANMDYH 
       410        420        430        440        450
EIGRSISTLM SDKQFHEAAY LADERDDLLT AINAFLDCSV VLPPSEVQGE 
       460        470        480        490        500
ELLRSVAHFQ RQMLKKREEQ GRLLPPGAGL EPKSAQDKAL LQMVEVAGAA 
       510        520        530        540        550
EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF RDALDPQCLA AVIFIYFAAL 
       560        570        580        590        600
SPAITFGGLL GEKTKDLIGV SELIMSTALQ GVVFCLLGAQ PLLVIGFSGP 
       610        620        630        640        650
LLVFEEAFFS FCSSNELEYL VGRVWIGFWL VFLALLMVAL EGSFLVRFVS 
       660        670        680        690        700
RFTQEIFAFL ISLIFIYETF YKLIKIFQEH PLHGCSGSND SEAGSSSSSN 
       710        720        730        740        750
MTWATTILVP DNSSASGQSG QEKPRGQPNT ALLSLVLMAG TFFIAFFLRK 
       760        770        780        790        800
FKNSRFFPGR IRRVIGDFGV PIAILIMVLV DYSIEDTYTQ KLSVPSGFSV 
       810        820        830        840        850
TAPDKRGWVI NPLGEKTPFP VWMMVASLLP AVLVFILIFM ETQITTLIIS 
       860        870        880        890        900
KKERMLQKGS GFHLDLLLIV AMGGICALFG LPWLAAATVR SVTHANALTV 
       910        920        930        940        950
MSKAVAPGDK PKIQEVKEQR VTGLLVALLV GLSMVIGDLL RQIPLAVLFG 
       960        970        980        990       1000
IFLYMGVTSL NGIQFYERLH LLLMPPKHHP DVTYVKKVRT MRMHLFTALQ 
      1010       1020       1030       1040       1050
LLCLALLWAV MSTAASLAFP FILILTVPLR MVVLTRIFTE REMKCLDANE 
      1060       1070 
AEPVFDECEG VDEYNEMPMP V

Show »

Length:1,071

Mass (Da):118,705

Checksum:ⁱ9BED064CDDEAB4E4

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0R4J101	A0A0R4J101_MOUSE	Anion exchange protein Anion exchange protein	Slc4a2 mCG_121457	1,237	Annotation score:
A0A0R4J1K4	A0A0R4J1K4_MOUSE	Anion exchange protein Anion exchange protein	Slc4a2	1,223	Annotation score:
A0A0R4J1K9	A0A0R4J1K9_MOUSE	Anion exchange protein Anion exchange protein	Slc4a2 mCG_121457	1,228	Annotation score:
D3YUF1	D3YUF1_MOUSE	Anion exchange protein 2 Anion exchange protein 2	Slc4a2	121	Annotation score:
D3Z5G3	D3Z5G3_MOUSE	Anion exchange protein 2 Anion exchange protein 2	Slc4a2	131	Annotation score:
A0A1C7ZN01	A0A1C7ZN01_MOUSE	Anion exchange protein 2 Anion exchange protein 2	Slc4a2	9	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	205	A → G in AAG23154 (PubMed:11006093).Curated	1
Sequence conflictⁱ	205	A → G in AAG23155 (PubMed:11006093).Curated	1
Sequence conflictⁱ	205	A → G in AAG23156 (PubMed:11006093).Curated	1
Sequence conflictⁱ	205	A → G in AAG23158 (PubMed:11006093).Curated	1
Sequence conflictⁱ	205	A → G in AAG23157 (PubMed:11006093).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000460	1 – 198	Missing in isoform C1. CuratedAdd BLAST	198
Alternative sequenceⁱVSP_000459	1 – 166	Missing in isoform C2. CuratedAdd BLAST	166
Alternative sequenceⁱVSP_000458	1 – 17	MSSAP…DSLHT → MTQ in isoform B1. CuratedAdd BLAST	17
Alternative sequenceⁱVSP_000457	1 – 17	MSSAP…DSLHT → MDFLLRPQ in isoform B2. CuratedAdd BLAST	17
Alternative sequenceⁱVSP_000461	167 – 193	ERTSP…GAQTG → MPAFQEWKSGGLREEAVFGA HGCSVCR in isoform C2. CuratedAdd BLAST	27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04036 mRNA Translation: AAA65505.1 AF255774 Genomic DNA Translation: AAG23154.1 AF255774 Genomic DNA Translation: AAG23155.1 AF255774 Genomic DNA Translation: AAG23156.1 AF255774 Genomic DNA Translation: AAG23158.1 AF255774 Genomic DNA Translation: AAG23157.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19119.1 [P13808-1]
PIRⁱ	A31789
NCBI Reference Sequences More...RefSeqⁱ	NP_001240821.1, NM_001253892.1 NP_033233.2, NM_009207.3 XP_006535713.1, XM_006535650.1 XP_006535714.1, XM_006535651.3 XP_006535718.1, XM_006535655.3 XP_006535719.1, XM_006535656.3
UniGeneⁱ	Mm.4580

Genome annotation databases

GeneIDⁱ	20535
KEGGⁱ	mmu:20535
UCSC genome browser More...UCSCⁱ	uc008wrm.2 mouse [P13808-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13808	Isoform C1 of Anion exchange protein 2		MOUSE		1039	UniRef100_P13808
Anion exchange protein (Fragment)		MOUSE		466

Protein	Similar proteins		Species	Score	Length	Source
P13808	Anion exchange protein 2		CAVPO		1238	UniRef90_P13808
Anion exchange protein 2		RAT		1234
Isoform C1 of Anion exchange protein 2		MOUSE		1039
Anion exchange protein		AOTNA		1255
Anion exchange protein 2-like protein (Fragment)		CALJA		184
+99

Protein	Similar proteins		Species	Score	Length	Source
P13808	Anion exchange protein 2		CAVPO		1238	UniRef50_P13808
Anion exchange protein 2		RAT		1234
Anion exchange protein 3		RABIT		1233
Anion exchange protein 3		HUMAN		1232
Anion exchange protein 3		PLEMO		1232
+741

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04036 mRNA Translation: AAA65505.1 AF255774 Genomic DNA Translation: AAG23154.1 AF255774 Genomic DNA Translation: AAG23155.1 AF255774 Genomic DNA Translation: AAG23156.1 AF255774 Genomic DNA Translation: AAG23158.1 AF255774 Genomic DNA Translation: AAG23157.1
CCDSⁱ	CCDS19119.1 [P13808-1]
PIRⁱ	A31789
RefSeqⁱ	NP_001240821.1, NM_001253892.1 NP_033233.2, NM_009207.3 XP_006535713.1, XM_006535650.1 XP_006535714.1, XM_006535651.3 XP_006535718.1, XM_006535655.3 XP_006535719.1, XM_006535656.3
UniGeneⁱ	Mm.4580

3D structure databases

ProteinModelPortalⁱ	P13808
SMRⁱ	P13808
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P13808, 1 interactor
MINTⁱ	P13808
STRINGⁱ	10090.ENSMUSP00000078972

PTM databases

iPTMnetⁱ	P13808
PhosphoSitePlusⁱ	P13808

Proteomic databases

MaxQBⁱ	P13808
PaxDbⁱ	P13808
PeptideAtlasⁱ	P13808
PRIDEⁱ	P13808

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	20535
KEGGⁱ	mmu:20535
UCSCⁱ	uc008wrm.2 mouse [P13808-1]

Organism-specific databases

CTDⁱ	6522
MGIⁱ	MGI:109351 Slc4a2

Phylogenomic databases

eggNOGⁱ	KOG1172 Eukaryota ENOG410XPHD LUCA
HOGENOMⁱ	HOG000280683
HOVERGENⁱ	HBG004326
InParanoidⁱ	P13808
KOⁱ	K13855
PhylomeDBⁱ	P13808
TreeFamⁱ	TF313630

Miscellaneous databases

ChiTaRSⁱ	Slc4a2 mouse
Protein Ontology More...PROⁱ	PR:P13808
SOURCEⁱ	Search...

Family and domain databases

Gene3Dⁱ	3.40.930.10, 1 hit
InterProⁱ	View protein in InterPro IPR001717 Anion_exchange IPR002978 Anion_exchange_2 IPR018241 Anion_exchange_CS IPR013769 Band3_cytoplasmic_dom IPR011531 HCO3_transpt_C IPR003020 HCO3_transpt_euk IPR016152 PTrfase/Anion_transptr
PANTHERⁱ	PTHR11453 PTHR11453, 1 hit PTHR11453:SF14 PTHR11453:SF14, 1 hit
Pfamⁱ	View protein in Pfam PF07565 Band_3_cyto, 1 hit PF00955 HCO3_cotransp, 1 hit
PRINTSⁱ	PR00165 ANIONEXCHNGR PR01188 ANIONEXHNGR2 PR01231 HCO3TRNSPORT
SUPFAMⁱ	SSF55804 SSF55804, 1 hit
TIGRFAMsⁱ	TIGR00834 ae, 1 hit
PROSITEⁱ	View protein in PROSITE PS00219 ANION_EXCHANGER_1, 1 hit PS00220 ANION_EXCHANGER_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B3A2_MOUSE
Accessionⁱ	P13808Primary (citable) accession number: P13808 Secondary accession number(s): Q9ES09 , Q9ES10, Q9ES11, Q9ES12, Q9ES13
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P13808 (B3A2_MOUSE)

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Anion exchange protein 2

Slc4a2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

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Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ