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Protein

Troponin T, slow skeletal muscle

Gene

TNNT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • tropomyosin binding Source: UniProtKB
  • troponin T binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390522 Striated Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Troponin T, slow skeletal muscle
Short name:
TnTs
Alternative name(s):
Slow skeletal muscle troponin T
Short name:
sTnT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNNT1
Synonyms:TNT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105048.16

Human Gene Nomenclature Database

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HGNCi
HGNC:11948 TNNT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
191041 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P13805

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nemaline myopathy 5 (NEM5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 5 is a severe and progressive form common among Old Order Amish. Affected infants display tremors with hypotonia and mild contractures of the shoulders and hips. Proximal contractures progressively weaken and a pectus carinatum deformity develops before children die of respiratory insufficiency, usually in the second year.
See also OMIM:605355

Keywords - Diseasei

Nemaline myopathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
7138

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TNNT1

MalaCards human disease database

More...
MalaCardsi
TNNT1
MIMi605355 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000105048

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98902 Amish nemaline myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36637

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNNT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1174800

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861681 – 278Troponin T, slow skeletal muscleAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13805

PeptideAtlas

More...
PeptideAtlasi
P13805

PRoteomics IDEntifications database

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PRIDEi
P13805

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52991
52992 [P13805-2]
52993 [P13805-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13805

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13805

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105048 Expressed in 138 organ(s), highest expression level in muscle organ

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNNT1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13805 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13805 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015168
HPA058448

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112992, 61 interactors

Protein interaction database and analysis system

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IntActi
P13805, 61 interactors

Molecular INTeraction database

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MINTi
P13805

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000467176

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P13805

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13805

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3634 Eukaryota
ENOG410XS6A LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160609

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231049

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052790

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13805

KEGG Orthology (KO)

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KOi
K10372

Identification of Orthologs from Complete Genome Data

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OMAi
MYQLESE

Database of Orthologous Groups

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OrthoDBi
EOG091G0U67

Database for complete collections of gene phylogenies

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PhylomeDBi
P13805

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.350, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11521 PTHR11521, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00992 Troponin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13805-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDTEEQEYE EEQPEEEAAE EEEEAPEEPE PVAEPEEERP KPSRPVVPPL
60 70 80 90 100
IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK
110 120 130 140 150
ERIERRRSER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK
160 170 180 190 200
KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKVRILSERK KPLDIDYMGE
210 220 230 240 250
EQLRARSAWL PPSQPSCPAR EKAQELSDWI HQLESEKFDL MAKLKQQKYE
260 270
INVLYNRISH AQKFRKGAGK GRVGGRWK
Length:278
Mass (Da):32,948
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD94DB18BC5804E04
GO
Isoform 2 (identifier: P13805-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-35: Missing.
     205-220: Missing.

Show »
Length:251
Mass (Da):30,096
Checksum:iDA9E80D5F8B5DE19
GO
Isoform 3 (identifier: P13805-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-220: Missing.

Show »
Length:262
Mass (Da):31,242
Checksum:i9CBA4A8DF3884CAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3B759Q3B759_HUMAN
TNNT1 protein
TNNT1
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZU8M0QZU8_HUMAN
Troponin T, slow skeletal muscle
TNNT1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZY5M0QZY5_HUMAN
Troponin T, slow skeletal muscle
TNNT1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQL4K7EQL4_HUMAN
Troponin T, slow skeletal muscle
TNNT1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX01M0QX01_HUMAN
Troponin T, slow skeletal muscle
TNNT1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKM3K7EKM3_HUMAN
Troponin T, slow skeletal muscle
TNNT1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY38M0QY38_HUMAN
Troponin T, slow skeletal muscle
TNNT1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELB0K7ELB0_HUMAN
Troponin T, slow skeletal muscle
TNNT1
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKB5K7EKB5_HUMAN
Troponin T, slow skeletal muscle
TNNT1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH22086 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20E → D in AAA61204 (PubMed:2824479).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00663925 – 35Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_006640205 – 220Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M19308 mRNA Translation: AAA61205.1
M19309 mRNA Translation: AAA61204.1
S69208 mRNA Translation: AAB30272.1
S69209 mRNA Translation: AAB30273.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09750.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09751.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09752.1
BT019630 mRNA Translation: AAV38436.1
BC010963 mRNA Translation: AAH10963.1
BC022086 mRNA Translation: AAH22086.2 Different initiation.
BC034143 mRNA Translation: AAH34143.1
S66057, S66170 Genomic DNA Translation: AAD13978.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12917.1 [P13805-1]
CCDS46185.1 [P13805-2]
CCDS59421.1 [P13805-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A29783 TPHUTW

NCBI Reference Sequences

More...
RefSeqi
NP_001119604.1, NM_001126132.2 [P13805-3]
NP_001119605.1, NM_001126133.2 [P13805-2]
NP_001278703.1, NM_001291774.1 [P13805-2]
NP_003274.3, NM_003283.5 [P13805-1]
XP_016882675.1, XM_017027186.1 [P13805-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.631558

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291901; ENSP00000291901; ENSG00000105048 [P13805-3]
ENST00000356783; ENSP00000349233; ENSG00000105048 [P13805-2]
ENST00000587758; ENSP00000467789; ENSG00000105048 [P13805-2]
ENST00000588981; ENSP00000467176; ENSG00000105048 [P13805-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7138

UCSC genome browser

More...
UCSCi
uc002qjb.5 human [P13805-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19308 mRNA Translation: AAA61205.1
M19309 mRNA Translation: AAA61204.1
S69208 mRNA Translation: AAB30272.1
S69209 mRNA Translation: AAB30273.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09750.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09751.1
AJ011712, AJ011713 Genomic DNA Translation: CAA09752.1
BT019630 mRNA Translation: AAV38436.1
BC010963 mRNA Translation: AAH10963.1
BC022086 mRNA Translation: AAH22086.2 Different initiation.
BC034143 mRNA Translation: AAH34143.1
S66057, S66170 Genomic DNA Translation: AAD13978.1 Sequence problems.
CCDSiCCDS12917.1 [P13805-1]
CCDS46185.1 [P13805-2]
CCDS59421.1 [P13805-3]
PIRiA29783 TPHUTW
RefSeqiNP_001119604.1, NM_001126132.2 [P13805-3]
NP_001119605.1, NM_001126133.2 [P13805-2]
NP_001278703.1, NM_001291774.1 [P13805-2]
NP_003274.3, NM_003283.5 [P13805-1]
XP_016882675.1, XM_017027186.1 [P13805-3]
UniGeneiHs.631558

3D structure databases

ProteinModelPortaliP13805
SMRiP13805
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112992, 61 interactors
IntActiP13805, 61 interactors
MINTiP13805
STRINGi9606.ENSP00000467176

PTM databases

iPTMnetiP13805
PhosphoSitePlusiP13805

Polymorphism and mutation databases

BioMutaiTNNT1
DMDMi1174800

Proteomic databases

PaxDbiP13805
PeptideAtlasiP13805
PRIDEiP13805
ProteomicsDBi52991
52992 [P13805-2]
52993 [P13805-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7138
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291901; ENSP00000291901; ENSG00000105048 [P13805-3]
ENST00000356783; ENSP00000349233; ENSG00000105048 [P13805-2]
ENST00000587758; ENSP00000467789; ENSG00000105048 [P13805-2]
ENST00000588981; ENSP00000467176; ENSG00000105048 [P13805-1]
GeneIDi7138
KEGGihsa:7138
UCSCiuc002qjb.5 human [P13805-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7138
DisGeNETi7138
EuPathDBiHostDB:ENSG00000105048.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TNNT1
GeneReviewsiTNNT1
HGNCiHGNC:11948 TNNT1
HPAiCAB015168
HPA058448
MalaCardsiTNNT1
MIMi191041 gene
605355 phenotype
neXtProtiNX_P13805
OpenTargetsiENSG00000105048
Orphaneti98902 Amish nemaline myopathy
PharmGKBiPA36637

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00940000160609
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiP13805
KOiK10372
OMAiMYQLESE
OrthoDBiEOG091G0U67
PhylomeDBiP13805

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNNT1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNNT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7138

Protein Ontology

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PROi
PR:P13805

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105048 Expressed in 138 organ(s), highest expression level in muscle organ
CleanExiHS_TNNT1
ExpressionAtlasiP13805 baseline and differential
GenevisibleiP13805 HS

Family and domain databases

Gene3Di1.20.5.350, 2 hits
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNNT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13805
Secondary accession number(s): O95472, Q16061, Q5U0E1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 169 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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