ETFA

Functionⁱ

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199).1 Publication1 Publication7 Publications

Cofactorⁱ

FAD3 PublicationsNote: Binds 1 FAD per dimer.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	223	FADCombined sources2 Publications	1
Binding siteⁱ	248	FADCombined sources2 Publications	1
Binding siteⁱ	300	FADCombined sources2 Publications	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	263 – 266	FADCombined sources2 Publications	4
Nucleotide bindingⁱ	281 – 286	FADCombined sources2 Publications	6
Nucleotide bindingⁱ	318 – 319	FADCombined sources2 Publications	2

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid beta-oxidation using acyl-CoA dehydrogenase
Source: UniProtKB
Inferred from direct assayⁱ
- 25416781

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Transport
Ligand	FAD, Flavoprotein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport

Reactomeⁱ

R-HSA-611105 Respiratory electron transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Electron transfer flavoprotein subunit alpha, mitochondrial Short name: Alpha-ETF
Gene namesⁱ	Name:ETFA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140374.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3481 ETFA
MIMⁱ	608053 gene
neXtProtⁱ	NX_P13804

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Glutaric aciduria 2A (GA2A)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	249	R → A: Loss of electron transfer activity. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Glutaricaciduria

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2108
MalaCards human disease database More...MalaCardsⁱ	ETFA
MIMⁱ	231680 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000140374
Orphanetⁱ	394532 Multiple acyl-CoA dehydrogenase deficiency, mild type 394529 Multiple acyl-CoA dehydrogenase deficiency, severe neonatal type
PharmGKBⁱ	PA27897

Polymorphism and mutation databases

BioMutaⁱ	ETFA
DMDMⁱ	119636

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 19	MitochondrionSequence analysisCombined sourcesAdd BLAST		19
ChainⁱPRO_0000008650	20 – 333	Electron transfer flavoprotein subunit alpha, mitochondrialAdd BLAST		314

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	59	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	59	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	62	N6-acetyllysineBy similarity	1
Modified residueⁱ	69	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	69	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	75	N6-acetyllysineBy similarity	1
Modified residueⁱ	85	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	85	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	93	PhosphothreonineBy similarity	1
Modified residueⁱ	101	N6-acetyllysineBy similarity	1
Modified residueⁱ	139	N6-acetyllysineBy similarity	1
Modified residueⁱ	140	PhosphoserineCombined sources	1
Modified residueⁱ	158	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	158	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	164	N6-acetyllysineBy similarity	1
Modified residueⁱ	187	N6-succinyllysineBy similarity	1
Modified residueⁱ	203	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	203	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	216	N6-succinyllysineBy similarity	1
Modified residueⁱ	226	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	226	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	232	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	232	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	301	N6-succinyllysineBy similarity	1

Post-translational modificationⁱ

The N-terminus is blocked.

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P13804
PaxDbⁱ	P13804
PeptideAtlas More...PeptideAtlasⁱ	P13804
PRIDEⁱ	P13804
ProteomicsDBⁱ	52989 52990 [P13804-2]
TopDownProteomicsⁱ	P13804-1 [P13804-1] P13804-2 [P13804-2]

2D gel databases

UCD-2DPAGEⁱ	P13804

UCD-2DPAGEⁱ

P13804

PTM databases

CarbonylDBⁱ	P13804
iPTMnetⁱ	P13804
PhosphoSitePlusⁱ	P13804
SwissPalmⁱ	P13804

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000140374 Expressed in 232 organ(s), highest expression level in oocyte
CleanExⁱ	HS_ETFA
ExpressionAtlasⁱ	P13804 baseline and differential
Genevisibleⁱ	P13804 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018990 HPA018993 HPA018996 HPA024089

HPAⁱ

HPA018990
HPA018993
HPA018996
HPA024089

Interactionⁱ

Subunit structureⁱ

Heterodimer composed of ETFA and ETFB (PubMed:8962055, PubMed:15159392, PubMed:15975918, PubMed:9334218). Identified in a complex that contains ETFA, ETFB and ETFRF1 (PubMed:27499296). Interaction with ETFRF1 promotes dissociation of the bound FAD and loss of electron transfer activity (PubMed:27499296).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ETFB	P38117	2	EBI-1052886,EBI-1056543
HSCB	Q8IWL3	3	EBI-1052886,EBI-1805738

Protein-protein interaction databases

BioGridⁱ	108409, 85 interactors
ComplexPortalⁱ	CPX-2731 Electron transfer flavoprotein complex
Database of interacting proteins More...DIPⁱ	DIP-6161N
IntActⁱ	P13804, 44 interactors
Molecular INTeraction database More...MINTⁱ	P13804
STRINGⁱ	9606.ENSP00000452762

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	21 – 25	Combined sources	5
Beta strandⁱ	28 – 31	Combined sources	4
Helixⁱ	36 – 45	Combined sources	10
Beta strandⁱ	49 – 58	Combined sources	10
Helixⁱ	61 – 69	Combined sources	9
Beta strandⁱ	75 – 80	Combined sources	6
Helixⁱ	82 – 84	Combined sources	3
Helixⁱ	89 – 103	Combined sources	15
Beta strandⁱ	106 – 113	Combined sources	8
Helixⁱ	114 – 127	Combined sources	14
Beta strandⁱ	132 – 135	Combined sources	4
Beta strandⁱ	137 – 140	Combined sources	4
Beta strandⁱ	143 – 148	Combined sources	6
Turnⁱ	149 – 152	Combined sources	4
Beta strandⁱ	153 – 159	Combined sources	7
Beta strandⁱ	162 – 168	Combined sources	7
Helixⁱ	170 – 172	Combined sources	3
Beta strandⁱ	178 – 180	Combined sources	3
Beta strandⁱ	184 – 187	Combined sources	4
Beta strandⁱ	196 – 204	Combined sources	9
Helixⁱ	212 – 214	Combined sources	3
Beta strandⁱ	216 – 221	Combined sources	6
Helixⁱ	223 – 225	Combined sources	3
Helixⁱ	229 – 231	Combined sources	3
Helixⁱ	232 – 241	Combined sources	10
Beta strandⁱ	244 – 247	Combined sources	4
Helixⁱ	249 – 253	Combined sources	5
Helixⁱ	259 – 261	Combined sources	3
Beta strandⁱ	262 – 264	Combined sources	3
Beta strandⁱ	273 – 279	Combined sources	7
Helixⁱ	284 – 287	Combined sources	4
Turnⁱ	288 – 292	Combined sources	5
Beta strandⁱ	294 – 301	Combined sources	8
Helixⁱ	306 – 309	Combined sources	4
Beta strandⁱ	312 – 317	Combined sources	6
Helixⁱ	319 – 329	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P13804
SMRⁱ	P13804
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13804

EvolutionaryTraceⁱ

P13804

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	20 – 204	Domain I1 PublicationAdd BLAST		185
Regionⁱ	205 – 333	Domain II1 PublicationAdd BLAST		129

Domainⁱ

Domain I shares an identical polypeptide fold with the beta subunit ETFB though there is no sequence similarity.1 Publication

Sequence similaritiesⁱ

Belongs to the ETF alpha-subunit/FixB family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3954 Eukaryota COG2025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013422
HOGENOMⁱ	HOG000247865
HOVERGENⁱ	HBG002317
InParanoidⁱ	P13804
KEGG Orthology (KO) More...KOⁱ	K03522
OMAⁱ	SQFKFTH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EQM
PhylomeDBⁱ	P13804
TreeFamⁱ	TF105763

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01715 ETF_alpha, 1 hit
Gene3Dⁱ	3.40.50.620, 1 hit
InterProⁱ	View protein in InterPro IPR029035 DHS-like_NAD/FAD-binding_dom IPR014730 ETF_a/b_N IPR001308 ETF_a/FixB IPR033947 ETF_alpha_N IPR014731 ETF_asu_C IPR018206 ETF_asu_C_CS IPR014729 Rossmann-like_a/b/a_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01012 ETF, 1 hit PF00766 ETF_alpha, 1 hit
PIRSFⁱ	PIRSF000089 Electra_flavoP_a, 1 hit
SMARTⁱ	View protein in SMART SM00893 ETF, 1 hit
SUPFAMⁱ	SSF52467 SSF52467, 1 hit
PROSITEⁱ	View protein in PROSITE PS00696 ETF_ALPHA, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P13804-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRAAAPGQL RRAASLLRFQ STLVIAEHAN DSLAPITLNT ITAATRLGGE 
        60         70         80         90        100
VSCLVAGTKC DKVAQDLCKV AGIAKVLVAQ HDVYKGLLPE ELTPLILATQ 
       110        120        130        140        150
KQFNYTHICA GASAFGKNLL PRVAAKLEVA PISDIIAIKS PDTFVRTIYA 
       160        170        180        190        200
GNALCTVKCD EKVKVFSVRG TSFDAAATSG GSASSEKASS TSPVEISEWL 
       210        220        230        240        250
DQKLTKSDRP ELTGAKVVVS GGRGLKSGEN FKLLYDLADQ LHAAVGASRA 
       260        270        280        290        300
AVDAGFVPND MQVGQTGKIV APELYIAVGI SGAIQHLAGM KDSKTIVAIN 
       310        320        330 
KDPEAPIFQV ADYGIVADLF KVVPEMTEIL KKK

Length:333

Mass (Da):35,080

Last modified:January 1, 1990 - v1

Checksum:ⁱ2EC6D1ADE68CBDB5

GO

Isoform 2 (identifier: P13804-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
14-62: Missing.

« Hide

        10         20         30         40         50
MFRAAAPGQL RRAVAQDLCK VAGIAKVLVA QHDVYKGLLP EELTPLILAT 
        60         70         80         90        100
QKQFNYTHIC AGASAFGKNL LPRVAAKLEV APISDIIAIK SPDTFVRTIY 
       110        120        130        140        150
AGNALCTVKC DEKVKVFSVR GTSFDAAATS GGSASSEKAS STSPVEISEW 
       160        170        180        190        200
LDQKLTKSDR PELTGAKVVV SGGRGLKSGE NFKLLYDLAD QLHAAVGASR 
       210        220        230        240        250
AAVDAGFVPN DMQVGQTGKI VAPELYIAVG ISGAIQHLAG MKDSKTIVAI 
       260        270        280 
NKDPEAPIFQ VADYGIVADL FKVVPEMTEI LKKK

Note: No experimental confirmation available.

Show »

Length:284

Mass (Da):30,026

Checksum:ⁱ3AC6D1AA1BE79C6D

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YNX6	H0YNX6_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	254	Annotation score:
H0YLU7	H0YLU7_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	303	Annotation score:
H0YK49	H0YK49_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	229	Annotation score:
H0YL83	H0YL83_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	73	Annotation score:
H0YKF0	H0YKF0_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	289	Annotation score:
H0YL12	H0YL12_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	239	Annotation score:
J3KN60	J3KN60_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	64	Annotation score:
H3BV91	H3BV91_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	46	Annotation score:
H0YM12	H0YM12_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	39	Annotation score:
H0YMU8	H0YMU8_HUMAN	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit alpha, mitochondrial (Electron-transfer-flavoprotein alpha polypeptide isoform 2)	ETFA	45	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_002366	116	G → R in GA2A; impaired protein stability and loss of electron transfer activity. 2 PublicationsCorresponds to variant dbSNP:rs119458971EnsemblClinVar.	1
Natural variantⁱVAR_002367	157	V → G in GA2A. 1 PublicationCorresponds to variant dbSNP:rs119458969EnsemblClinVar.	1
Natural variantⁱVAR_008547	171	T → I Decreased protein stability. 1 PublicationCorresponds to variant dbSNP:rs1801591EnsemblClinVar.	1
Natural variantⁱVAR_002368	266	T → M in GA2A; decreased electron transfer activity. 2 PublicationsCorresponds to variant dbSNP:rs119458970EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043246	14 – 62	Missing in isoform 2. 1 PublicationAdd BLAST		49

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04058 mRNA Translation: AAA52406.1 S55815 mRNA No translation available. S55816 mRNA No translation available. AJ224002 Genomic DNA Translation: CAA11802.1 AF436657 AF436656 Genomic DNA Translation: AAN03712.1 BT009796 mRNA Translation: AAP88798.1 AK292979 mRNA Translation: BAF85668.1 AK300044 mRNA Translation: BAG61855.1 AC027243 Genomic DNA No translation available. AC091100 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99221.1 BC015526 mRNA Translation: AAH15526.1 BC095457 mRNA Translation: AAH95457.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32299.1 [P13804-1] CCDS45311.1 [P13804-2]
PIRⁱ	A31998
NCBI Reference Sequences More...RefSeqⁱ	NP_000117.1, NM_000126.3 [P13804-1] NP_001121188.1, NM_001127716.1 [P13804-2]
UniGeneⁱ	Hs.39925

Genome annotation databases

Ensemblⁱ	ENST00000433983; ENSP00000399273; ENSG00000140374 [P13804-2] ENST00000557943; ENSP00000452762; ENSG00000140374 [P13804-1]
GeneIDⁱ	2108
KEGGⁱ	hsa:2108
UCSC genome browser More...UCSCⁱ	uc002bbt.3 human [P13804-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13804	Electron-transfer-flavoprotein alpha polypeptide isoform 1 (Fragment)		HUMAN		333	UniRef100_P13804

Protein	Similar proteins		Species	Score	Length	Source
P13804	Electron transfer flavoprotein subunit alpha, mitochondrial		BOVIN		333	UniRef90_P13804
Electron transfer flavoprotein subunit alpha, mitochondrial		MACFA		333
Electron transfer flavoprotein subunit alpha, mitochondrial		MOUSE		333
Electron transfer flavoprotein subunit alpha, mitochondrial		PONAB		333
Electron transfer flavoprotein subunit alpha, mitochondrial		RAT		333
+65
P13804-2	ETFA isoform 2		PANTR		284	UniRef90_P13804-2
Uncharacterized protein		PANPA		284
Uncharacterized protein		MACMU		284
Uncharacterized protein		PAPAN		284
Uncharacterized protein		MACFA		284
+15

Protein	Similar proteins		Species	Score	Length	Source
P13804	Electron transfer flavoprotein subunit alpha, mitochondrial		MOUSE		333	UniRef50_P13804
Electron transfer flavoprotein subunit alpha, mitochondrial		MACFA		333
Electron transfer flavoprotein subunit alpha, mitochondrial		RAT		333
Electron transfer flavoprotein subunit alpha, mitochondrial		BOVIN		333
Electron transfer flavoprotein subunit alpha, mitochondrial		PONAB		333
+407

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04058 mRNA Translation: AAA52406.1 S55815 mRNA No translation available. S55816 mRNA No translation available. AJ224002 Genomic DNA Translation: CAA11802.1 AF436657 AF436656 Genomic DNA Translation: AAN03712.1 BT009796 mRNA Translation: AAP88798.1 AK292979 mRNA Translation: BAF85668.1 AK300044 mRNA Translation: BAG61855.1 AC027243 Genomic DNA No translation available. AC091100 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99221.1 BC015526 mRNA Translation: AAH15526.1 BC095457 mRNA Translation: AAH95457.1
CCDSⁱ	CCDS32299.1 [P13804-1] CCDS45311.1 [P13804-2]
PIRⁱ	A31998
RefSeqⁱ	NP_000117.1, NM_000126.3 [P13804-1] NP_001121188.1, NM_001127716.1 [P13804-2]
UniGeneⁱ	Hs.39925

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1EFV	X-ray	2.10	A	20-333	[»]
	1T9G	X-ray	2.90	R	1-333	[»]
	2A1T	X-ray	2.80	R	1-333	[»]
	2A1U	X-ray	2.11	A	1-333	[»]
ProteinModelPortalⁱ	P13804
SMRⁱ	P13804
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108409, 85 interactors
ComplexPortalⁱ	CPX-2731 Electron transfer flavoprotein complex
DIPⁱ	DIP-6161N
IntActⁱ	P13804, 44 interactors
MINTⁱ	P13804
STRINGⁱ	9606.ENSP00000452762

PTM databases

CarbonylDBⁱ	P13804
iPTMnetⁱ	P13804
PhosphoSitePlusⁱ	P13804
SwissPalmⁱ	P13804

Polymorphism and mutation databases

BioMutaⁱ	ETFA
DMDMⁱ	119636

2D gel databases

UCD-2DPAGEⁱ	P13804

UCD-2DPAGEⁱ

P13804

Proteomic databases

EPDⁱ	P13804
PaxDbⁱ	P13804
PeptideAtlasⁱ	P13804
PRIDEⁱ	P13804
ProteomicsDBⁱ	52989 52990 [P13804-2]
TopDownProteomicsⁱ	P13804-1 [P13804-1] P13804-2 [P13804-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2108
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000433983; ENSP00000399273; ENSG00000140374 [P13804-2] ENST00000557943; ENSP00000452762; ENSG00000140374 [P13804-1]
GeneIDⁱ	2108
KEGGⁱ	hsa:2108
UCSCⁱ	uc002bbt.3 human [P13804-1]

Organism-specific databases

CTDⁱ	2108
DisGeNETⁱ	2108
EuPathDBⁱ	HostDB:ENSG00000140374.15
GeneCardsⁱ	ETFA
HGNCⁱ	HGNC:3481 ETFA
HPAⁱ	HPA018990 HPA018993 HPA018996 HPA024089
MalaCardsⁱ	ETFA
MIMⁱ	231680 phenotype 608053 gene
neXtProtⁱ	NX_P13804
OpenTargetsⁱ	ENSG00000140374
Orphanetⁱ	394532 Multiple acyl-CoA dehydrogenase deficiency, mild type 394529 Multiple acyl-CoA dehydrogenase deficiency, severe neonatal type
PharmGKBⁱ	PA27897
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3954 Eukaryota COG2025 LUCA
GeneTreeⁱ	ENSGT00390000013422
HOGENOMⁱ	HOG000247865
HOVERGENⁱ	HBG002317
InParanoidⁱ	P13804
KOⁱ	K03522
OMAⁱ	SQFKFTH
OrthoDBⁱ	EOG091G0EQM
PhylomeDBⁱ	P13804
TreeFamⁱ	TF105763

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport

Reactomeⁱ

R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSⁱ	ETFA human
EvolutionaryTraceⁱ	P13804
GeneWikiⁱ	ETFA
GenomeRNAiⁱ	2108
Protein Ontology More...PROⁱ	PR:P13804
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140374 Expressed in 232 organ(s), highest expression level in oocyte
CleanExⁱ	HS_ETFA
ExpressionAtlasⁱ	P13804 baseline and differential
Genevisibleⁱ	P13804 HS

Family and domain databases

CDDⁱ	cd01715 ETF_alpha, 1 hit
Gene3Dⁱ	3.40.50.620, 1 hit
InterProⁱ	View protein in InterPro IPR029035 DHS-like_NAD/FAD-binding_dom IPR014730 ETF_a/b_N IPR001308 ETF_a/FixB IPR033947 ETF_alpha_N IPR014731 ETF_asu_C IPR018206 ETF_asu_C_CS IPR014729 Rossmann-like_a/b/a_fold
Pfamⁱ	View protein in Pfam PF01012 ETF, 1 hit PF00766 ETF_alpha, 1 hit
PIRSFⁱ	PIRSF000089 Electra_flavoP_a, 1 hit
SMARTⁱ	View protein in SMART SM00893 ETF, 1 hit
SUPFAMⁱ	SSF52467 SSF52467, 1 hit
PROSITEⁱ	View protein in PROSITE PS00696 ETF_ALPHA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ETFA_HUMAN
Accessionⁱ	P13804Primary (citable) accession number: P13804 Secondary accession number(s): B4DT43, Q53XN3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	November 7, 2018
	This is version 202 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P13804 (ETFA_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Electron transfer flavoprotein subunit alpha, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ