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UniProtKB - P13804 (ETFA_HUMAN)

Entry version 221 (02 Jun 2021)
Sequence version 1 (01 Jan 1990)
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Protein

Electron transfer flavoprotein subunit alpha, mitochondrial

Gene

ETFA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313).

It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218).

Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199).

1 Publication1 Publication7 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD3 PublicationsNote: Binds 1 FAD per dimer.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei223FADCombined sources2 Publications1
Binding sitei248FADCombined sources2 Publications1
Binding sitei300FADCombined sources2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi263 – 266FADCombined sources2 Publications4
Nucleotide bindingi281 – 286FADCombined sources2 Publications6
Nucleotide bindingi318 – 319FADCombined sources2 Publications2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport
LigandFAD, Flavoprotein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13804

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-611105, Respiratory electron transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electron transfer flavoprotein subunit alpha, mitochondrial
Short name:
Alpha-ETF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ETFA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3481, ETFA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608053, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13804

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140374.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glutaric aciduria 2A (GA2A)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_002366116G → R in GA2A; impaired protein stability and loss of electron transfer activity. 2 PublicationsCorresponds to variant dbSNP:rs119458971EnsemblClinVar.1
Natural variantiVAR_002367157V → G in GA2A. 1 PublicationCorresponds to variant dbSNP:rs119458969EnsemblClinVar.1
Natural variantiVAR_002368266T → M in GA2A; decreased electron transfer activity. 2 PublicationsCorresponds to variant dbSNP:rs119458970EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi249R → A: Loss of electron transfer activity. 1 Publication1

Keywords - Diseasei

Disease variant, Glutaricaciduria

Organism-specific databases

DisGeNET

More...DisGeNETi		2108

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		ETFA

MalaCards human disease database

More...MalaCardsi		ETFA
MIMi231680, phenotype

Open Targets

More...OpenTargetsi		ENSG00000140374

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		394532, Multiple acyl-CoA dehydrogenase deficiency, mild type
394529, Multiple acyl-CoA dehydrogenase deficiency, severe neonatal type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27897

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13804, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ETFA

Domain mapping of disease mutations (DMDM)

More...DMDMi		119636

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 19MitochondrionSequence analysisCombined sourcesAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000865020 – 333Electron transfer flavoprotein subunit alpha, mitochondrialAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59N6-acetyllysine; alternateBy similarity1
Modified residuei59N6-succinyllysine; alternateBy similarity1
Modified residuei62N6-acetyllysineBy similarity1
Modified residuei69N6-acetyllysine; alternateBy similarity1
Modified residuei69N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei85N6-acetyllysine; alternateBy similarity1
Modified residuei85N6-succinyllysine; alternateBy similarity1
Modified residuei93PhosphothreonineBy similarity1
Modified residuei101N6-acetyllysineBy similarity1
Modified residuei139N6-acetyllysineBy similarity1
Modified residuei140PhosphoserineCombined sources1
Modified residuei158N6-acetyllysine; alternateBy similarity1
Modified residuei158N6-succinyllysine; alternateBy similarity1
Modified residuei164N6-acetyllysineBy similarity1
Modified residuei187N6-succinyllysineBy similarity1
Modified residuei203N6-acetyllysine; alternateBy similarity1
Modified residuei203N6-succinyllysine; alternateBy similarity1
Modified residuei216N6-succinyllysineBy similarity1
Modified residuei226N6-acetyllysine; alternateBy similarity1
Modified residuei226N6-succinyllysine; alternateBy similarity1
Modified residuei232N6-acetyllysine; alternateBy similarity1
Modified residuei232N6-succinyllysine; alternateBy similarity1
Modified residuei301N6-succinyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-365
CPTAC-366

Encyclopedia of Proteome Dynamics

More...EPDi		P13804

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13804

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13804

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13804

PeptideAtlas

More...PeptideAtlasi		P13804

PRoteomics IDEntifications database

More...PRIDEi		P13804

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52989 [P13804-1]
52990 [P13804-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P13804-1 [P13804-1]
P13804-2 [P13804-2]

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P13804

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P13804

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13804

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P13804

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13804

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13804

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140374, Expressed in oocyte and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13804, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13804, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140374, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of ETFA and ETFB (PubMed:8962055, PubMed:15159392, PubMed:15975918, PubMed:9334218).

Identified in a complex that contains ETFA, ETFB and ETFRF1 (PubMed:27499296). Interaction with ETFRF1 promotes dissociation of the bound FAD and loss of electron transfer activity (PubMed:27499296).

Interacts with TASOR (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108409, 208 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2731, Mitochondrial electron transfer flavoprotein complex

Database of interacting proteins

More...DIPi		DIP-6161N

Protein interaction database and analysis system

More...IntActi		P13804, 64 interactors

Molecular INTeraction database

More...MINTi		P13804

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000452762

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13804, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13804

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P13804

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 204Domain I1 PublicationAdd BLAST185
Regioni205 – 333Domain II1 PublicationAdd BLAST129

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Domain I shares an identical polypeptide fold with the beta subunit ETFB though there is no sequence similarity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETF alpha-subunit/FixB family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3954, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013422

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034178_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13804

Identification of Orthologs from Complete Genome Data

More...OMAi		WRPHSEH

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13804

TreeFam database of animal gene trees

More...TreeFami		TF105763

Family and domain databases

Conserved Domains Database

More...CDDi		cd01715, ETF_alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR014730, ETF_a/b_N
IPR001308, ETF_a/FixB
IPR033947, ETF_alpha_N
IPR014731, ETF_asu_C
IPR018206, ETF_asu_C_CS
IPR014729, Rossmann-like_a/b/a_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01012, ETF, 1 hit
PF00766, ETF_alpha, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000089, Electra_flavoP_a, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00893, ETF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52467, SSF52467, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00696, ETF_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRAAAPGQL RRAASLLRFQ STLVIAEHAN DSLAPITLNT ITAATRLGGE 
        60         70         80         90        100
VSCLVAGTKC DKVAQDLCKV AGIAKVLVAQ HDVYKGLLPE ELTPLILATQ 
       110        120        130        140        150
KQFNYTHICA GASAFGKNLL PRVAAKLEVA PISDIIAIKS PDTFVRTIYA 
       160        170        180        190        200
GNALCTVKCD EKVKVFSVRG TSFDAAATSG GSASSEKASS TSPVEISEWL 
       210        220        230        240        250
DQKLTKSDRP ELTGAKVVVS GGRGLKSGEN FKLLYDLADQ LHAAVGASRA 
       260        270        280        290        300
AVDAGFVPND MQVGQTGKIV APELYIAVGI SGAIQHLAGM KDSKTIVAIN 
       310        320        330 
KDPEAPIFQV ADYGIVADLF KVVPEMTEIL KKK
Length:333
Mass (Da):35,080
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EC6D1ADE68CBDB5
GO
Isoform 2 (identifier: P13804-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-62: Missing.

Show »
Length:284
Mass (Da):30,026
Checksum:i3AC6D1AA1BE79C6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YK49H0YK49_HUMAN
Electron transfer flavoprotein subu...
ETFA
229Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLU7H0YLU7_HUMAN
Electron transfer flavoprotein subu...
ETFA
303Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNX6H0YNX6_HUMAN
Electron transfer flavoprotein subu...
ETFA
254Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKF0H0YKF0_HUMAN
Electron transfer flavoprotein subu...
ETFA
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL83H0YL83_HUMAN
Electron transfer flavoprotein subu...
ETFA
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL12H0YL12_HUMAN
Electron transfer flavoprotein subu...
ETFA
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KN60J3KN60_HUMAN
Electron transfer flavoprotein subu...
ETFA
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM12H0YM12_HUMAN
Electron transfer flavoprotein subu...
ETFA
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV91H3BV91_HUMAN
Electron transfer flavoprotein subu...
ETFA
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMU8H0YMU8_HUMAN
Electron transfer flavoprotein subu...
ETFA
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002366116G → R in GA2A; impaired protein stability and loss of electron transfer activity. 2 PublicationsCorresponds to variant dbSNP:rs119458971EnsemblClinVar.1
Natural variantiVAR_002367157V → G in GA2A. 1 PublicationCorresponds to variant dbSNP:rs119458969EnsemblClinVar.1
Natural variantiVAR_008547171T → I Decreased protein stability. 1 PublicationCorresponds to variant dbSNP:rs1801591EnsemblClinVar.1
Natural variantiVAR_002368266T → M in GA2A; decreased electron transfer activity. 2 PublicationsCorresponds to variant dbSNP:rs119458970EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04324614 – 62Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04058 mRNA Translation: AAA52406.1
S55815 mRNA No translation available.
S55816 mRNA No translation available.
AJ224002 Genomic DNA Translation: CAA11802.1
AF436657 AF436656 Genomic DNA Translation: AAN03712.1
BT009796 mRNA Translation: AAP88798.1
AK292979 mRNA Translation: BAF85668.1
AK300044 mRNA Translation: BAG61855.1
AC027243 Genomic DNA No translation available.
AC091100 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99221.1
BC015526 mRNA Translation: AAH15526.1
BC095457 mRNA Translation: AAH95457.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32299.1 [P13804-1]
CCDS45311.1 [P13804-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A31998

NCBI Reference Sequences

More...RefSeqi		NP_000117.1, NM_000126.3 [P13804-1]
NP_001121188.1, NM_001127716.1 [P13804-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000433983; ENSP00000399273; ENSG00000140374 [P13804-2]
ENST00000557943; ENSP00000452762; ENSG00000140374 [P13804-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2108

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2108

UCSC genome browser

More...UCSCi		uc002bbt.3, human [P13804-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04058 mRNA Translation: AAA52406.1
S55815 mRNA No translation available.
S55816 mRNA No translation available.
AJ224002 Genomic DNA Translation: CAA11802.1
AF436657 AF436656 Genomic DNA Translation: AAN03712.1
BT009796 mRNA Translation: AAP88798.1
AK292979 mRNA Translation: BAF85668.1
AK300044 mRNA Translation: BAG61855.1
AC027243 Genomic DNA No translation available.
AC091100 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99221.1
BC015526 mRNA Translation: AAH15526.1
BC095457 mRNA Translation: AAH95457.1
CCDSiCCDS32299.1 [P13804-1]
CCDS45311.1 [P13804-2]
PIRiA31998
RefSeqiNP_000117.1, NM_000126.3 [P13804-1]
NP_001121188.1, NM_001127716.1 [P13804-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EFVX-ray2.10A20-333[»]
1T9GX-ray2.90R1-333[»]
2A1TX-ray2.80R1-333[»]
2A1UX-ray2.11A1-333[»]
SMRiP13804
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108409, 208 interactors
ComplexPortaliCPX-2731, Mitochondrial electron transfer flavoprotein complex
DIPiDIP-6161N
IntActiP13804, 64 interactors
MINTiP13804
STRINGi9606.ENSP00000452762

PTM databases

CarbonylDBiP13804
iPTMnetiP13804
MetOSiteiP13804
PhosphoSitePlusiP13804
SwissPalmiP13804

Genetic variation databases

BioMutaiETFA
DMDMi119636

2D gel databases

UCD-2DPAGEiP13804

Proteomic databases

CPTACiCPTAC-365
CPTAC-366
EPDiP13804
jPOSTiP13804
MassIVEiP13804
PaxDbiP13804
PeptideAtlasiP13804
PRIDEiP13804
ProteomicsDBi52989 [P13804-1]
52990 [P13804-2]
TopDownProteomicsiP13804-1 [P13804-1]
P13804-2 [P13804-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14895, 364 antibodies

The DNASU plasmid repository

More...DNASUi		2108

Genome annotation databases

EnsembliENST00000433983; ENSP00000399273; ENSG00000140374 [P13804-2]
ENST00000557943; ENSP00000452762; ENSG00000140374 [P13804-1]
GeneIDi2108
KEGGihsa:2108
UCSCiuc002bbt.3, human [P13804-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2108
DisGeNETi2108

GeneCards: human genes, protein and diseases

More...GeneCardsi		ETFA
GeneReviewsiETFA
HGNCiHGNC:3481, ETFA
HPAiENSG00000140374, Low tissue specificity
MalaCardsiETFA
MIMi231680, phenotype
608053, gene
neXtProtiNX_P13804
OpenTargetsiENSG00000140374
Orphaneti394532, Multiple acyl-CoA dehydrogenase deficiency, mild type
394529, Multiple acyl-CoA dehydrogenase deficiency, severe neonatal type
PharmGKBiPA27897
VEuPathDBiHostDB:ENSG00000140374.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3954, Eukaryota
GeneTreeiENSGT00390000013422
HOGENOMiCLU_034178_0_0_1
InParanoidiP13804
OMAiWRPHSEH
PhylomeDBiP13804
TreeFamiTF105763

Enzyme and pathway databases

PathwayCommonsiP13804
ReactomeiR-HSA-611105, Respiratory electron transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2108, 4 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ETFA, human
EvolutionaryTraceiP13804

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ETFA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2108
PharosiP13804, Tbio

Protein Ontology

More...PROi		PR:P13804
RNActiP13804, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140374, Expressed in oocyte and 246 other tissues
ExpressionAtlasiP13804, baseline and differential
GenevisibleiP13804, HS

Family and domain databases

CDDicd01715, ETF_alpha, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR014730, ETF_a/b_N
IPR001308, ETF_a/FixB
IPR033947, ETF_alpha_N
IPR014731, ETF_asu_C
IPR018206, ETF_asu_C_CS
IPR014729, Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01012, ETF, 1 hit
PF00766, ETF_alpha, 1 hit
PIRSFiPIRSF000089, Electra_flavoP_a, 1 hit
SMARTiView protein in SMART
SM00893, ETF, 1 hit
SUPFAMiSSF52467, SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS00696, ETF_ALPHA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETFA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13804
Secondary accession number(s): B4DT43, Q53XN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 2, 2021
This is version 221 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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