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Protein

Plastin-3

Gene

PLS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi25 – 361PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi65 – 762PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • calcium ion binding Source: InterPro

GO - Biological processi

  • actin filament bundle assembly Source: GO_Central
  • actin filament network formation Source: GO_Central
  • bone development Source: UniProtKB

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-3
Alternative name(s):
T-plastin
Gene namesi
Name:PLS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102024.17
HGNCiHGNC:9091 PLS3
MIMi300131 gene
neXtProtiNX_P13797

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Osteoporosis (OSTEOP)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.
See also OMIM:166710
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070278253A → AN in OSTEOP; associated with disease susceptibility. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5358
MalaCardsiPLS3
MIMi166710 phenotype
300910 phenotype
OpenTargetsiENSG00000102024
Orphaneti391330 X-linked osteoporosis with fractures
PharmGKBiPA33418

Polymorphism and mutation databases

BioMutaiPLS3
DMDMi226694201

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737471 – 630Plastin-3Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268PhosphoserineBy similarity1
Modified residuei293PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei391PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP13797
MaxQBiP13797
PaxDbiP13797
PeptideAtlasiP13797
PRIDEiP13797
ProteomicsDBi52987

PTM databases

iPTMnetiP13797
PhosphoSitePlusiP13797
SwissPalmiP13797

Expressioni

Tissue specificityi

Expressed in a variety of organs, including muscle, brain, uterus and esophagus.

Gene expression databases

BgeeiENSG00000102024 Expressed in 242 organ(s), highest expression level in visceral pleura
CleanExiHS_PLS3
ExpressionAtlasiP13797 baseline and differential
GenevisibleiP13797 HS

Organism-specific databases

HPAiHPA020433
HPA076083

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111372, 61 interactors
IntActiP13797, 18 interactors
MINTiP13797
STRINGi9606.ENSP00000348163

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13797
SMRiP13797
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13797

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini123 – 239Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST117
Domaini267 – 378Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST112
Domaini397 – 506Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST110
Domaini518 – 627Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 382Actin-binding 1Add BLAST274
Regioni383 – 627Actin-binding 2Add BLAST245

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00390000005691
HOGENOMiHOG000213447
HOVERGENiHBG003082
InParanoidiP13797
KOiK17336
OMAiQKEGEPQ
OrthoDBiEOG091G03YP
PhylomeDBiP13797
TreeFamiTF300680

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039956 PLS3
PANTHERiPTHR19961 PTHR19961, 1 hit
PTHR19961:SF32 PTHR19961:SF32, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13797-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG
60 70 80 90 100
YKVREIIQKL MLDGDRNKDG KISFDEFVYI FQEVKSSDIA KTFRKAINRK
110 120 130 140 150
EGICALGGTS ELSSEGTQHS YSEEEKYAFV NWINKALEND PDCRHVIPMN
160 170 180 190 200
PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE RAINKKKLTP FIIQENLNLA
210 220 230 240 250
LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF ADIELSRNEA
260 270 280 290 300
LAALLRDGET LEELMKLSPE ELLLRWANFH LENSGWQKIN NFSADIKDSK
310 320 330 340 350
AYFHLLNQIA PKGQKEGEPR IDINMSGFNE TDDLKRAESM LQQADKLGCR
360 370 380 390 400
QFVTPADVVS GNPKLNLAFV ANLFNKYPAL TKPENQDIDW TLLEGETREE
410 420 430 440 450
RTFRNWMNSL GVNPHVNHLY ADLQDALVIL QLYERIKVPV DWSKVNKPPY
460 470 480 490 500
PKLGANMKKL ENCNYAVELG KHPAKFSLVG IGGQDLNDGN QTLTLALVWQ
510 520 530 540 550
LMRRYTLNVL EDLGDGQKAN DDIIVNWVNR TLSEAGKSTS IQSFKDKTIS
560 570 580 590 600
SSLAVVDLID AIQPGCINYD LVKSGNLTED DKHNNAKYAV SMARRIGARV
610 620 630
YALPEDLVEV KPKMVMTVFA CLMGRGMKRV
Length:630
Mass (Da):70,811
Last modified:April 14, 2009 - v4
Checksum:i631E6F803DC56A56
GO
Isoform 2 (identifier: P13797-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MDEMATTQISKDELDELKEAFAKV → ME
     296-296: I → IKLIDFSNSV

Note: No experimental confirmation available.
Show »
Length:617
Mass (Da):69,350
Checksum:i7DD45809B012DE95
GO
Isoform 3 (identifier: P13797-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,632
Checksum:i9291617EAC62FA5F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQI3U3KQI3_HUMAN
Plastin-3
PLS3
164Annotation score:
F2Z2Z9F2Z2Z9_HUMAN
Plastin-3
PLS3
42Annotation score:
A0A0A0MSQ0A0A0A0MSQ0_HUMAN
Plastin-3
PLS3
617Annotation score:
H7C4N2H7C4N2_HUMAN
Plastin-3
PLS3
190Annotation score:

Polymorphismi

Genetic variations in PLS3 define the bone mineral density quantitative trait locus 18 (BMND18) [MIMi:300910]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070278253A → AN in OSTEOP; associated with disease susceptibility. 1 Publication1
Natural variantiVAR_035462488D → A in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562351 – 45Missing in isoform 3. CuratedAdd BLAST45
Alternative sequenceiVSP_0562361 – 24MDEMA…AFAKV → ME in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_056237296I → IKLIDFSNSV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22299 mRNA Translation: AAB02844.1
M34427 mRNA Translation: AAA36759.1
AK291194 mRNA Translation: BAF83883.1
AK294509 mRNA Translation: BAG57725.1
AK300575 mRNA Translation: BAH13307.1
AK312391 mRNA Translation: BAG35308.1
AC003983 Genomic DNA No translation available.
AC005000 Genomic DNA No translation available.
AL589842 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02614.1
BC039049 mRNA Translation: AAH39049.1
BC056898 mRNA Translation: AAH56898.1
L05491 Genomic DNA Translation: AAA61214.1
CCDSiCCDS14568.1 [P13797-1]
CCDS78499.1 [P13797-2]
PIRiA34789
RefSeqiNP_001129497.1, NM_001136025.4 [P13797-1]
NP_001165806.1, NM_001172335.2
NP_001269266.1, NM_001282337.1 [P13797-2]
NP_001269267.1, NM_001282338.1 [P13797-3]
NP_005023.2, NM_005032.6 [P13797-1]
XP_011535836.1, XM_011537534.1
UniGeneiHs.496622

Genome annotation databases

EnsembliENST00000289290; ENSP00000289290; ENSG00000102024 [P13797-2]
ENST00000355899; ENSP00000348163; ENSG00000102024 [P13797-1]
ENST00000539310; ENSP00000445339; ENSG00000102024 [P13797-1]
GeneIDi5358
KEGGihsa:5358
UCSCiuc004eqd.4 human [P13797-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22299 mRNA Translation: AAB02844.1
M34427 mRNA Translation: AAA36759.1
AK291194 mRNA Translation: BAF83883.1
AK294509 mRNA Translation: BAG57725.1
AK300575 mRNA Translation: BAH13307.1
AK312391 mRNA Translation: BAG35308.1
AC003983 Genomic DNA No translation available.
AC005000 Genomic DNA No translation available.
AL589842 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02614.1
BC039049 mRNA Translation: AAH39049.1
BC056898 mRNA Translation: AAH56898.1
L05491 Genomic DNA Translation: AAA61214.1
CCDSiCCDS14568.1 [P13797-1]
CCDS78499.1 [P13797-2]
PIRiA34789
RefSeqiNP_001129497.1, NM_001136025.4 [P13797-1]
NP_001165806.1, NM_001172335.2
NP_001269266.1, NM_001282337.1 [P13797-2]
NP_001269267.1, NM_001282338.1 [P13797-3]
NP_005023.2, NM_005032.6 [P13797-1]
XP_011535836.1, XM_011537534.1
UniGeneiHs.496622

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOAX-ray2.40A101-375[»]
1WJONMR-A520-630[»]
ProteinModelPortaliP13797
SMRiP13797
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111372, 61 interactors
IntActiP13797, 18 interactors
MINTiP13797
STRINGi9606.ENSP00000348163

PTM databases

iPTMnetiP13797
PhosphoSitePlusiP13797
SwissPalmiP13797

Polymorphism and mutation databases

BioMutaiPLS3
DMDMi226694201

Proteomic databases

EPDiP13797
MaxQBiP13797
PaxDbiP13797
PeptideAtlasiP13797
PRIDEiP13797
ProteomicsDBi52987

Protocols and materials databases

DNASUi5358
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289290; ENSP00000289290; ENSG00000102024 [P13797-2]
ENST00000355899; ENSP00000348163; ENSG00000102024 [P13797-1]
ENST00000539310; ENSP00000445339; ENSG00000102024 [P13797-1]
GeneIDi5358
KEGGihsa:5358
UCSCiuc004eqd.4 human [P13797-1]

Organism-specific databases

CTDi5358
DisGeNETi5358
EuPathDBiHostDB:ENSG00000102024.17
GeneCardsiPLS3
HGNCiHGNC:9091 PLS3
HPAiHPA020433
HPA076083
MalaCardsiPLS3
MIMi166710 phenotype
300131 gene
300910 phenotype
neXtProtiNX_P13797
OpenTargetsiENSG00000102024
Orphaneti391330 X-linked osteoporosis with fractures
PharmGKBiPA33418
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00390000005691
HOGENOMiHOG000213447
HOVERGENiHBG003082
InParanoidiP13797
KOiK17336
OMAiQKEGEPQ
OrthoDBiEOG091G03YP
PhylomeDBiP13797
TreeFamiTF300680

Miscellaneous databases

ChiTaRSiPLS3 human
EvolutionaryTraceiP13797
GeneWikiiPLS3
GenomeRNAii5358
PROiPR:P13797
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102024 Expressed in 242 organ(s), highest expression level in visceral pleura
CleanExiHS_PLS3
ExpressionAtlasiP13797 baseline and differential
GenevisibleiP13797 HS

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039956 PLS3
PANTHERiPTHR19961 PTHR19961, 1 hit
PTHR19961:SF32 PTHR19961:SF32, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPLST_HUMAN
AccessioniPrimary (citable) accession number: P13797
Secondary accession number(s): A8K579
, B1AQ09, B4DGB4, B7Z6M1, Q86YI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 14, 2009
Last modified: November 7, 2018
This is version 203 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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