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Protein

Plastin-3

Gene

PLS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi25 – 361PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi65 – 762PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • calcium ion binding Source: InterPro

GO - Biological processi

  • actin filament bundle assembly Source: GO_Central
  • actin filament network formation Source: GO_Central
  • bone development Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plastin-3
Alternative name(s):
T-plastin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102024.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9091 PLS3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300131 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13797

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Osteoporosis (OSTEOP)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.
See also OMIM:166710
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070278253A → AN in OSTEOP; associated with disease susceptibility. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5358

MalaCards human disease database

More...
MalaCardsi
PLS3
MIMi166710 phenotype
300910 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000102024

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391330 X-linked osteoporosis with fractures

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33418

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLS3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226694201

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000737471 – 630Plastin-3Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei268PhosphoserineBy similarity1
Modified residuei293PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei391PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13797

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P13797

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P13797

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13797

PeptideAtlas

More...
PeptideAtlasi
P13797

PRoteomics IDEntifications database

More...
PRIDEi
P13797

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52987

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13797

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13797

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13797

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of organs, including muscle, brain, uterus and esophagus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102024 Expressed in 242 organ(s), highest expression level in visceral pleura

CleanEx database of gene expression profiles

More...
CleanExi
HS_PLS3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13797 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13797 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020433
HPA076083

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111372, 61 interactors

Protein interaction database and analysis system

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IntActi
P13797, 18 interactors

Molecular INTeraction database

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MINTi
P13797

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348163

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOAX-ray2.40A101-375[»]
1WJONMR-A520-630[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13797

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13797

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P13797

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini123 – 239Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST117
Domaini267 – 378Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST112
Domaini397 – 506Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST110
Domaini518 – 627Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni109 – 382Actin-binding 1Add BLAST274
Regioni383 – 627Actin-binding 2Add BLAST245

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0046 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153719

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000213447

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003082

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P13797

KEGG Orthology (KO)

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KOi
K17336

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKEGEPQ

Database of Orthologous Groups

More...
OrthoDBi
312506at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13797

TreeFam database of animal gene trees

More...
TreeFami
TF300680

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039956 PLS3

The PANTHER Classification System

More...
PANTHERi
PTHR19961 PTHR19961, 1 hit
PTHR19961:SF32 PTHR19961:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13797-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG
60 70 80 90 100
YKVREIIQKL MLDGDRNKDG KISFDEFVYI FQEVKSSDIA KTFRKAINRK
110 120 130 140 150
EGICALGGTS ELSSEGTQHS YSEEEKYAFV NWINKALEND PDCRHVIPMN
160 170 180 190 200
PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE RAINKKKLTP FIIQENLNLA
210 220 230 240 250
LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF ADIELSRNEA
260 270 280 290 300
LAALLRDGET LEELMKLSPE ELLLRWANFH LENSGWQKIN NFSADIKDSK
310 320 330 340 350
AYFHLLNQIA PKGQKEGEPR IDINMSGFNE TDDLKRAESM LQQADKLGCR
360 370 380 390 400
QFVTPADVVS GNPKLNLAFV ANLFNKYPAL TKPENQDIDW TLLEGETREE
410 420 430 440 450
RTFRNWMNSL GVNPHVNHLY ADLQDALVIL QLYERIKVPV DWSKVNKPPY
460 470 480 490 500
PKLGANMKKL ENCNYAVELG KHPAKFSLVG IGGQDLNDGN QTLTLALVWQ
510 520 530 540 550
LMRRYTLNVL EDLGDGQKAN DDIIVNWVNR TLSEAGKSTS IQSFKDKTIS
560 570 580 590 600
SSLAVVDLID AIQPGCINYD LVKSGNLTED DKHNNAKYAV SMARRIGARV
610 620 630
YALPEDLVEV KPKMVMTVFA CLMGRGMKRV
Length:630
Mass (Da):70,811
Last modified:April 14, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i631E6F803DC56A56
GO
Isoform 2 (identifier: P13797-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MDEMATTQISKDELDELKEAFAKV → ME
     296-296: I → IKLIDFSNSV

Note: No experimental confirmation available.
Show »
Length:617
Mass (Da):69,350
Checksum:i7DD45809B012DE95
GO
Isoform 3 (identifier: P13797-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,632
Checksum:i9291617EAC62FA5F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQI3U3KQI3_HUMAN
Plastin-3
PLS3
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2Z9F2Z2Z9_HUMAN
Plastin-3
PLS3
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSQ0A0A0A0MSQ0_HUMAN
Plastin-3
PLS3
617Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4N2H7C4N2_HUMAN
Plastin-3
PLS3
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in PLS3 define the bone mineral density quantitative trait locus 18 (BMND18) [MIMi:300910]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070278253A → AN in OSTEOP; associated with disease susceptibility. 1 Publication1
Natural variantiVAR_035462488D → A in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0562351 – 45Missing in isoform 3. CuratedAdd BLAST45
Alternative sequenceiVSP_0562361 – 24MDEMA…AFAKV → ME in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_056237296I → IKLIDFSNSV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M22299 mRNA Translation: AAB02844.1
M34427 mRNA Translation: AAA36759.1
AK291194 mRNA Translation: BAF83883.1
AK294509 mRNA Translation: BAG57725.1
AK300575 mRNA Translation: BAH13307.1
AK312391 mRNA Translation: BAG35308.1
AC003983 Genomic DNA No translation available.
AC005000 Genomic DNA No translation available.
AL589842 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02614.1
BC039049 mRNA Translation: AAH39049.1
BC056898 mRNA Translation: AAH56898.1
L05491 Genomic DNA Translation: AAA61214.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14568.1 [P13797-1]
CCDS78499.1 [P13797-2]

Protein sequence database of the Protein Information Resource

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PIRi
A34789

NCBI Reference Sequences

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RefSeqi
NP_001129497.1, NM_001136025.4 [P13797-1]
NP_001165806.1, NM_001172335.2
NP_001269266.1, NM_001282337.1 [P13797-2]
NP_001269267.1, NM_001282338.1 [P13797-3]
NP_005023.2, NM_005032.6 [P13797-1]
XP_011535836.1, XM_011537534.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.496622

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000289290; ENSP00000289290; ENSG00000102024 [P13797-2]
ENST00000355899; ENSP00000348163; ENSG00000102024 [P13797-1]
ENST00000539310; ENSP00000445339; ENSG00000102024 [P13797-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5358

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5358

UCSC genome browser

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UCSCi
uc004eqd.4 human [P13797-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22299 mRNA Translation: AAB02844.1
M34427 mRNA Translation: AAA36759.1
AK291194 mRNA Translation: BAF83883.1
AK294509 mRNA Translation: BAG57725.1
AK300575 mRNA Translation: BAH13307.1
AK312391 mRNA Translation: BAG35308.1
AC003983 Genomic DNA No translation available.
AC005000 Genomic DNA No translation available.
AL589842 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02614.1
BC039049 mRNA Translation: AAH39049.1
BC056898 mRNA Translation: AAH56898.1
L05491 Genomic DNA Translation: AAA61214.1
CCDSiCCDS14568.1 [P13797-1]
CCDS78499.1 [P13797-2]
PIRiA34789
RefSeqiNP_001129497.1, NM_001136025.4 [P13797-1]
NP_001165806.1, NM_001172335.2
NP_001269266.1, NM_001282337.1 [P13797-2]
NP_001269267.1, NM_001282338.1 [P13797-3]
NP_005023.2, NM_005032.6 [P13797-1]
XP_011535836.1, XM_011537534.1
UniGeneiHs.496622

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOAX-ray2.40A101-375[»]
1WJONMR-A520-630[»]
ProteinModelPortaliP13797
SMRiP13797
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111372, 61 interactors
IntActiP13797, 18 interactors
MINTiP13797
STRINGi9606.ENSP00000348163

PTM databases

iPTMnetiP13797
PhosphoSitePlusiP13797
SwissPalmiP13797

Polymorphism and mutation databases

BioMutaiPLS3
DMDMi226694201

Proteomic databases

EPDiP13797
jPOSTiP13797
MaxQBiP13797
PaxDbiP13797
PeptideAtlasiP13797
PRIDEiP13797
ProteomicsDBi52987

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5358
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289290; ENSP00000289290; ENSG00000102024 [P13797-2]
ENST00000355899; ENSP00000348163; ENSG00000102024 [P13797-1]
ENST00000539310; ENSP00000445339; ENSG00000102024 [P13797-1]
GeneIDi5358
KEGGihsa:5358
UCSCiuc004eqd.4 human [P13797-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5358
DisGeNETi5358
EuPathDBiHostDB:ENSG00000102024.17

GeneCards: human genes, protein and diseases

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GeneCardsi
PLS3
HGNCiHGNC:9091 PLS3
HPAiHPA020433
HPA076083
MalaCardsiPLS3
MIMi166710 phenotype
300131 gene
300910 phenotype
neXtProtiNX_P13797
OpenTargetsiENSG00000102024
Orphaneti391330 X-linked osteoporosis with fractures
PharmGKBiPA33418

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000153719
HOGENOMiHOG000213447
HOVERGENiHBG003082
InParanoidiP13797
KOiK17336
OMAiQKEGEPQ
OrthoDBi312506at2759
PhylomeDBiP13797
TreeFamiTF300680

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLS3 human
EvolutionaryTraceiP13797

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PLS3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5358

Protein Ontology

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PROi
PR:P13797

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102024 Expressed in 242 organ(s), highest expression level in visceral pleura
CleanExiHS_PLS3
ExpressionAtlasiP13797 baseline and differential
GenevisibleiP13797 HS

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039956 PLS3
PANTHERiPTHR19961 PTHR19961, 1 hit
PTHR19961:SF32 PTHR19961:SF32, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLST_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13797
Secondary accession number(s): A8K579
, B1AQ09, B4DGB4, B7Z6M1, Q86YI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 14, 2009
Last modified: January 16, 2019
This is version 205 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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