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Protein

Plastin-2

Gene

LCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi22 – 331PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi62 – 732PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • GTPase binding Source: UniProtKB
  • identical protein binding Source: Ensembl
  • integrin binding Source: ARUK-UCL

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP13796

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-2
Alternative name(s):
L-plastin
LC64P
Lymphocyte cytosolic protein 1
Short name:
LCP-1
Gene namesi
Name:LCP1
Synonyms:PLS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000136167.13
HGNCiHGNC:6528 LCP1
MIMi153430 gene
neXtProtiNX_P13796

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6.1 Publication
Defects in LCP1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5S → A: Abolishes phosphorylation and reduces the cell surface expression of CD69 and IL2RA. Reduces association with the actin cytoskeleton. 2 Publications1
Mutagenesisi5S → E: Promotes association with the actin cytoskeleton. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3936
OpenTargetsiENSG00000136167
PharmGKBiPA30312

Polymorphism and mutation databases

BioMutaiLCP1
DMDMi308153685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000737432 – 627Plastin-2Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei5PhosphoserineCombined sources2 Publications1
Modified residuei7PhosphoserineCombined sources1
Modified residuei28PhosphotyrosineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei76N6-acetyllysineCombined sources1
Modified residuei88N6-acetyllysineCombined sources1
Modified residuei124PhosphotyrosineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei291PhosphothreonineCombined sources1
Modified residuei294N6-acetyllysineCombined sources1
Modified residuei297N6-acetyllysineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei353PhosphothreonineCombined sources1
Modified residuei361N6-acetyllysineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei472N6-acetyllysineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei542N6-acetyllysineCombined sources1
Modified residuei579N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP13796
MaxQBiP13796
PaxDbiP13796
PeptideAtlasiP13796
PRIDEiP13796
ProteomicsDBi52986

PTM databases

iPTMnetiP13796
PhosphoSitePlusiP13796
SwissPalmiP13796

Expressioni

Tissue specificityi

Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.1 Publication

Gene expression databases

BgeeiENSG00000136167 Expressed in 176 organ(s), highest expression level in blood
CleanExiHS_LCP1
ExpressionAtlasiP13796 baseline and differential
GenevisibleiP13796 HS

Organism-specific databases

HPAiCAB020673
HPA019493

Interactioni

Subunit structurei

Monomer. Interacts with AIF1 (By similarity). Interacts with actin (PubMed:28493397).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110128, 23 interactors
DIPiDIP-34767N
ELMiP13796
IntActiP13796, 9 interactors
MINTiP13796
STRINGi9606.ENSP00000315757

Structurei

Secondary structure

1627
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13796
SMRiP13796
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13796

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini120 – 236Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST117
Domaini264 – 375Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST112
Domaini394 – 503Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST110
Domaini515 – 624Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 379Actin-binding 1Add BLAST274
Regioni380 – 624Actin-binding 2Add BLAST245

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00390000005691
HOGENOMiHOG000213447
HOVERGENiHBG003082
InParanoidiP13796
KOiK17276
OMAiNAFQMTE
OrthoDBiEOG091G03YP
PhylomeDBiP13796
TreeFamiTF300680

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039953 LCP-1
PANTHERiPTHR19961 PTHR19961, 1 hit
PTHR19961:SF35 PTHR19961:SF35, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13796-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARGSVSDEE MMELREAFAK VDTDGNGYIS FNELNDLFKA ACLPLPGYRV
60 70 80 90 100
REITENLMAT GDLDQDGRIS FDEFIKIFHG LKSTDVAKTF RKAINKKEGI
110 120 130 140 150
CAIGGTSEQS SVGTQHSYSE EEKYAFVNWI NKALENDPDC RHVIPMNPNT
160 170 180 190 200
NDLFNAVGDG IVLCKMINLS VPDTIDERTI NKKKLTPFTI QENLNLALNS
210 220 230 240 250
ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI ELSRNEALIA
260 270 280 290 300
LLREGESLED LMKLSPEELL LRWANYHLEN AGCNKIGNFS TDIKDSKAYY
310 320 330 340 350
HLLEQVAPKG DEEGVPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV
360 370 380 390 400
TATDVVRGNP KLNLAFIANL FNRYPALHKP ENQDIDWGAL EGETREERTF
410 420 430 440 450
RNWMNSLGVN PRVNHLYSDL SDALVIFQLY EKIKVPVDWN RVNKPPYPKL
460 470 480 490 500
GGNMKKLENC NYAVELGKNQ AKFSLVGIGG QDLNEGNRTL TLALIWQLMR
510 520 530 540 550
RYTLNILEEI GGGQKVNDDI IVNWVNETLR EAKKSSSISS FKDPKISTSL
560 570 580 590 600
PVLDLIDAIQ PGSINYDLLK TENLNDDEKL NNAKYAISMA RKIGARVYAL
610 620
PEDLVEVNPK MVMTVFACLM GKGMKRV
Length:627
Mass (Da):70,288
Last modified:October 5, 2010 - v6
Checksum:i668E4AA6A3FC7B58
GO
Isoform 2 (identifier: P13796-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MARGSVSDEEMMELREAFAKVDTDG → MCAEDGDSKFSMSISMNSPFLEILH
     26-456: Missing.

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):21,792
Checksum:i06D5580FBCC9F5E9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TBN3Q5TBN3_HUMAN
Plastin-2
LCP1
246Annotation score:
Q5TBN5Q5TBN5_HUMAN
Plastin-2
LCP1
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti611M → T AA sequence (PubMed:3261603).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00137124D → E. 1
Natural variantiVAR_024398533K → E5 PublicationsCorresponds to variant dbSNP:rs4941543Ensembl.1
Natural variantiVAR_030826544P → A. Corresponds to variant dbSNP:rs17067725Ensembl.1
Natural variantiVAR_079850608N → S Found in a patient with isolated coloboma; increases interaction with actin. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564501 – 25MARGS…VDTDG → MCAEDGDSKFSMSISMNSPF LEILH in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_05645126 – 456Missing in isoform 2. 1 PublicationAdd BLAST431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02923 mRNA Translation: AAA63236.1
AK300556 mRNA Translation: BAG62262.1
AK312393 mRNA Translation: BAG35310.1
AL137141 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08757.1
BC007673 mRNA Translation: AAH07673.1
BC010271 mRNA Translation: AAH10271.1
M22300 mRNA Translation: AAB02845.1
AH002870 Genomic DNA Translation: AAA59529.1
M34426 mRNA Translation: AAA36184.1
CCDSiCCDS9403.1 [P13796-1]
PIRiA35836
RefSeqiNP_002289.2, NM_002298.4 [P13796-1]
XP_005266431.1, XM_005266374.1 [P13796-1]
UniGeneiHs.381099
Hs.658408

Genome annotation databases

EnsembliENST00000323076; ENSP00000315757; ENSG00000136167 [P13796-1]
ENST00000398576; ENSP00000381581; ENSG00000136167 [P13796-1]
GeneIDi3936
KEGGihsa:3936
UCSCiuc001vba.5 human [P13796-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02923 mRNA Translation: AAA63236.1
AK300556 mRNA Translation: BAG62262.1
AK312393 mRNA Translation: BAG35310.1
AL137141 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08757.1
BC007673 mRNA Translation: AAH07673.1
BC010271 mRNA Translation: AAH10271.1
M22300 mRNA Translation: AAB02845.1
AH002870 Genomic DNA Translation: AAA59529.1
M34426 mRNA Translation: AAA36184.1
CCDSiCCDS9403.1 [P13796-1]
PIRiA35836
RefSeqiNP_002289.2, NM_002298.4 [P13796-1]
XP_005266431.1, XM_005266374.1 [P13796-1]
UniGeneiHs.381099
Hs.658408

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D85NMR-A517-627[»]
5JOJNMR-A1-97[»]
5JOLNMR-A1-82[»]
ProteinModelPortaliP13796
SMRiP13796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110128, 23 interactors
DIPiDIP-34767N
ELMiP13796
IntActiP13796, 9 interactors
MINTiP13796
STRINGi9606.ENSP00000315757

PTM databases

iPTMnetiP13796
PhosphoSitePlusiP13796
SwissPalmiP13796

Polymorphism and mutation databases

BioMutaiLCP1
DMDMi308153685

Proteomic databases

EPDiP13796
MaxQBiP13796
PaxDbiP13796
PeptideAtlasiP13796
PRIDEiP13796
ProteomicsDBi52986

Protocols and materials databases

DNASUi3936
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323076; ENSP00000315757; ENSG00000136167 [P13796-1]
ENST00000398576; ENSP00000381581; ENSG00000136167 [P13796-1]
GeneIDi3936
KEGGihsa:3936
UCSCiuc001vba.5 human [P13796-1]

Organism-specific databases

CTDi3936
DisGeNETi3936
EuPathDBiHostDB:ENSG00000136167.13
GeneCardsiLCP1
H-InvDBiHIX0130592
HGNCiHGNC:6528 LCP1
HPAiCAB020673
HPA019493
MIMi153430 gene
neXtProtiNX_P13796
OpenTargetsiENSG00000136167
PharmGKBiPA30312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00390000005691
HOGENOMiHOG000213447
HOVERGENiHBG003082
InParanoidiP13796
KOiK17276
OMAiNAFQMTE
OrthoDBiEOG091G03YP
PhylomeDBiP13796
TreeFamiTF300680

Enzyme and pathway databases

ReactomeiR-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP13796

Miscellaneous databases

ChiTaRSiLCP1 human
EvolutionaryTraceiP13796
GeneWikiiLCP1
GenomeRNAii3936
PROiPR:P13796
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136167 Expressed in 176 organ(s), highest expression level in blood
CleanExiHS_LCP1
ExpressionAtlasiP13796 baseline and differential
GenevisibleiP13796 HS

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039953 LCP-1
PANTHERiPTHR19961 PTHR19961, 1 hit
PTHR19961:SF35 PTHR19961:SF35, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPLSL_HUMAN
AccessioniPrimary (citable) accession number: P13796
Secondary accession number(s): B2R613, B4DUA0, Q5TBN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 213 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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