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Protein

HLA class II histocompatibility antigen, DO beta chain

Gene

HLA-DOB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
SIGNORiP13765

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DO beta chain
Alternative name(s):
MHC class II antigen DOB
Gene namesi
Name:HLA-DOB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000241106.6
HGNCiHGNC:4937 HLA-DOB
MIMi142920 gene
600629 gene
neXtProtiNX_P13765

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 224ExtracellularSequence analysisAdd BLAST198
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 273CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3112
OpenTargetsiENSG00000241106
PharmGKBiPA35061

Polymorphism and mutation databases

BioMutaiHLA-DOB
DMDMi122261

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001896327 – 273HLA class II histocompatibility antigen, DO beta chainAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 105PROSITE-ProRule annotation
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP13765
PeptideAtlasiP13765
PRIDEiP13765
ProteomicsDBi52985

PTM databases

iPTMnetiP13765
PhosphoSitePlusiP13765

Expressioni

Gene expression databases

BgeeiENSG00000241106
CleanExiHS_HLA-DOB
ExpressionAtlasiP13765 baseline and differential
GenevisibleiP13765 HS

Organism-specific databases

HPAiHPA013846

Interactioni

Subunit structurei

Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

Protein-protein interaction databases

BioGridi109357, 3 interactors
DIPiDIP-60117N
IntActiP13765, 3 interactors
STRINGi9606.ENSP00000390020

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 44Combined sources11
Turni45 – 48Combined sources4
Beta strandi49 – 58Combined sources10
Beta strandi61 – 67Combined sources7
Turni68 – 70Combined sources3
Beta strandi72 – 75Combined sources4
Helixi78 – 80Combined sources3
Helixi81 – 89Combined sources9
Helixi91 – 103Combined sources13
Helixi105 – 112Combined sources8
Helixi113 – 115Combined sources3
Turni116 – 118Combined sources3
Beta strandi124 – 131Combined sources8
Beta strandi139 – 151Combined sources13
Beta strandi154 – 159Combined sources6
Beta strandi166 – 169Combined sources4
Beta strandi177 – 179Combined sources3
Beta strandi181 – 189Combined sources9
Beta strandi197 – 202Combined sources6
Beta strandi210 – 214Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20D/H30-218[»]
ProteinModelPortaliP13765
SMRiP13765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 213Ig-like C1-typeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 120Beta-1Add BLAST94
Regioni121 – 214Beta-2Add BLAST94
Regioni215 – 224Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
GeneTreeiENSGT00900000140849
HOGENOMiHOG000100909
HOVERGENiHBG012730
InParanoidiP13765
KOiK06752
OMAiWNNRPDI
OrthoDBiEOG09370LQE
PhylomeDBiP13765
TreeFamiTF336626

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGWVPWVV ALLVNLTRLD SSMTQGTDSP EDFVIQAKAD CYFTNGTEKV
60 70 80 90 100
QFVVRFIFNL EEYVRFDSDV GMFVALTKLG QPDAEQWNSR LDLLERSRQA
110 120 130 140 150
VDGVCRHNYR LGAPFTVGRK VQPEVTVYPE RTPLLHQHNL LHCSVTGFYP
160 170 180 190 200
GDIKIKWFLN GQEERAGVMS TGPIRNGDWT FQTVVMLEMT PELGHVYTCL
210 220 230 240 250
VDHSSLLSPV SVEWRAQSEY SWRKMLSGIA AFLLGLIFLL VGIVIQLRAQ
260 270
KGYVRTQMSG NEVSRAVLLP QSC
Length:273
Mass (Da):30,822
Last modified:January 1, 1990 - v1
Checksum:iC06A1360DCC4AD26
GO

Polymorphismi

The following alleles of DOB are known: DOB*01:01, DOB*01:02, DOB*01:03 and DOB*01:04. The sequence shown is that of DOB*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01674318R → Q in allele DOB*01:02. Corresponds to variant dbSNP:rs2071554Ensembl.1
Natural variantiVAR_050363210V → I2 PublicationsCorresponds to variant dbSNP:rs11575907Ensembl.1
Natural variantiVAR_016745234L → F in allele DOB*01:04. Corresponds to variant dbSNP:rs2070121Ensembl.1
Natural variantiVAR_016744244V → I in allele DOB*01:03. Corresponds to variant dbSNP:rs2621330Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03066 mRNA Translation: CAA26870.1
M26040 mRNA Translation: AAA59718.1
X66401 Genomic DNA Translation: CAA47028.1
CR541832 mRNA Translation: CAG46631.1
CR788227 Genomic DNA No translation available.
BC006097 mRNA Translation: AAH06097.1
L29472 Genomic DNA Translation: AAA59717.1
X87344 Genomic DNA Translation: CAA60789.1
AB035252 Genomic DNA No translation available.
CCDSiCCDS4754.1
PIRiS27335 A24669
RefSeqiNP_002111.1, NM_002120.3
UniGeneiHs.1802

Genome annotation databases

EnsembliENST00000426644; ENSP00000395780; ENSG00000243612
ENST00000438763; ENSP00000390020; ENSG00000241106
ENST00000447178; ENSP00000405108; ENSG00000241386
ENST00000454286; ENSP00000397268; ENSG00000243496
ENST00000454969; ENSP00000410390; ENSG00000241910
ENST00000456406; ENSP00000394783; ENSG00000239457
GeneIDi3112
KEGGihsa:3112
UCSCiuc011gkh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDOB_HUMAN
AccessioniPrimary (citable) accession number: P13765
Secondary accession number(s): B0V0Y0
, Q29746, Q29825, Q6FHC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 20, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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