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Protein

HLA class I histocompatibility antigen, alpha chain E

Gene

HLA-E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334).9 Publications
(Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei28Pathogen-derived peptide antigen1 Publication1
Binding sitei98Self-peptide antigen1 Publication1
Binding sitei105Self-peptide antigen1 Publication1
Binding sitei164Self- and pathogen-derived peptide antigen2 Publications1
Binding sitei167Self- and pathogen-derived peptide antigen2 Publications1
Binding sitei177Self-peptide antigen1 Publication1
Binding sitei180Self- and pathogen-derived peptide antigen2 Publications1
Binding sitei192Self- and pathogen-derived peptide antigen2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SIGNOR Signaling Network Open Resource

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SIGNORi
P13747

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain E
Alternative name(s):
MHC class I antigen E
Cleaved into the following chain:
Soluble HLA class I histocompatibility antigen, alpha chain E
Short name:
sHLA-E1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-E1 PublicationImported
Synonyms:HLA-6.2, HLAE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204592.8

Human Gene Nomenclature Database

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HGNCi
HGNC:4962 HLA-E

Online Mendelian Inheritance in Man (OMIM)

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MIMi
143010 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13747

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei306 – 329HelicalSequence analysisAdd BLAST24
Topological domaini330 – 358CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, MHC I, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi83R → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi86R → A: Reduces the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi90D → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi93Q → A: Impairs the recognition by KLRD1-KLRC1. 1 Publication1
Mutagenesisi96R → A: Abolishes the recognition by KLRD1-KLRC1. 1 Publication1
Mutagenesisi97V → A: Impairs the recognition by KLRD1-KLRC1. 1 Publication1
Mutagenesisi100R → A: Reduces the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi110E → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi129R → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi167K → A: Impairs folding. 1 Publication1
Mutagenesisi170D → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi173E → A: Impairs the recognition by KLRD1-KLRC1. 1 Publication1
Mutagenesisi175E → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi176H → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi183D → A: Impairs the recognition by KLRD1-KLRC1. 1 Publication1
Mutagenesisi187E → A: Reduces the affinity for KLRD1-KLRC1. 1 Publication1
Mutagenesisi235T → A: Has no impact on the affinity for KLRD1-KLRC1. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
3133

Open Targets

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OpenTargetsi
ENSG00000204592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35081

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HLA-E

Domain mapping of disease mutations (DMDM)

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DMDMi
34395942

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001888222 – 358HLA class I histocompatibility antigen, alpha chain EAdd BLAST337
ChainiPRO_000044575722 – ?Soluble HLA class I histocompatibility antigen, alpha chain E

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi122 ↔ 1852 Publications
Disulfide bondi224 ↔ 2802 Publications
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei353PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
The soluble form (sHLA-E) can be partly produced by proteolytic cleavage at the cell surface (shedding) by a matrix metalloproteinase. Alternative splicing is also suggested as a mechanism for generation of sHLA-E, although it remains to be proved.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P13747

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P13747

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13747

PeptideAtlas

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PeptideAtlasi
P13747

PRoteomics IDEntifications database

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PRIDEi
P13747

ProteomicsDB human proteome resource

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ProteomicsDBi
52981

Consortium for Top Down Proteomics

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TopDownProteomicsi
P13747

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1330

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13747

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13747

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13747

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in extravillous trophoblast (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Proinflammatory cytokines including TNF, IL1B and IFNG up-regulate membrane bound HLA-E expression on endothelial and NK cells and induce the release of soluble HLA-E (sHLA-E) in the extracellular compartment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204592 Expressed in 235 organ(s), highest expression level in right lung

CleanEx database of gene expression profiles

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CleanExi
HS_HLA-E

Organism-specific databases

Human Protein Atlas

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HPAi
HPA031454

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterotrimer with B2M and a self- or a pathogen-derived peptide (peptide-bound HLA-E-B2M) (PubMed:18339401, PubMed:30087334). Similarly to MHC class Ia assembly, HLA-E-B2M heterodimer interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for peptide loading and translocation to the cell surface (PubMed:9427624). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9427624). The optimum binding peptide is a nonamer (VL9) that is primarily derived from amino-acid residues 3-11 of the signal sequences of most HLA-A, -B, -C and -G molecules (PubMed:9754572, PubMed:18083576, PubMed:9660937, PubMed:18339401). The VL9 peptide anchors to five main sites in the peptide-binding groove of HLA-E (PubMed:18339401). Peptide-bound HLA-E-B2M complex interacts with KLRD1-KLRC1 receptor on NK cells (PubMed:9486650, PubMed:18083576). Binds with lower affinity to activating KLRD1-KLRC2 (PubMed:18083576, PubMed:23335510). The common subunit KLRC1 plays a prominent role in directly interacting with HLA-E (PubMed:18083576). Peptide-bound HLA-E-B2M interacts with the alpha-beta TCR on unconventional CD8+ T cells (PubMed:16474394). Peptide-free HLA-E interacts with HLA-F-B2M complex; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I OCs.10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HLA-FP305112EBI-726583,EBI-2811134

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109378, 52 interactors

Database of interacting proteins

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DIPi
DIP-32N

Protein interaction database and analysis system

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IntActi
P13747, 21 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365817

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPRX-ray2.80A/C22-295[»]
1KTLX-ray3.10A/C22-295[»]
1MHEX-ray2.85A/C22-295[»]
2ESVX-ray2.60A23-297[»]
3AM8X-ray2.80A/B22-297[»]
3BZEX-ray2.50A/C/E/G23-295[»]
3BZFX-ray2.50A/C22-297[»]
3CDGX-ray3.40A/C23-295[»]
3CIIX-ray4.41A/D23-295[»]
5W1VX-ray3.31A/F/K/P22-299[»]
5W1WX-ray3.10A/F/K/P22-299[»]
6GGMX-ray2.73A/C22-295[»]
6GH1X-ray2.10A/C/E/G22-295[»]
6GH4X-ray2.16A/C/E/G22-295[»]
6GL1X-ray2.62A/C/E/G22-295[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13747

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13747

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P13747

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 294Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410JD1V Eukaryota
ENOG410YKQA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153382

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG016709

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13747

KEGG Orthology (KO)

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KOi
K06751

Identification of Orthologs from Complete Genome Data

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OMAi
SALTKTW

Database of Orthologous Groups

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OrthoDBi
912212at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P13747

TreeFam database of animal gene trees

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TreeFami
TF336617

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C

Pfam protein domain database

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Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01638 MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P13747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD
60 70 80 90 100
DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR
110 120 130 140 150
TLRGYYNQSE AGSHTLQWMH GCELGPDGRF LRGYEQFAYD GKDYLTLNED
160 170 180 190 200
LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL
210 220 230 240 250
LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ
310 320 330 340 350
PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA

QGSESHSL
Length:358
Mass (Da):40,058
Last modified:December 5, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B3001CA9F3B7FE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10L → S in AAA52655 (PubMed:3131426).Curated1
Sequence conflicti104G → R in AAA59835 (PubMed:3260916).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles are known: E*01:01 and E*01:03 (PubMed:3131426, PubMed:10064069, PubMed:16702430, PubMed:16570139, PubMed:28127896). The frequency of E*01:01 and E*01:03 alleles in the population is about equal suggesting balanced selection in diverse populations. Evolutionary studies suggest that E*01:03 is the original allele (PubMed:12445303). Two other alleles has been described E*01:02 and E*01:04 (PubMed:3260916, PubMed:1977695). Allele E*01:02 was found to be identical to HLA E*01:01 (PubMed:3260916, PubMed:22665232). The existence of allele E*01:04 is uncertain as it could not be confirmed in further studies (PubMed:1977695, PubMed:12445303). The sequence shown is that of E*01:03 (PubMed:10064069, PubMed:16702430, PubMed:16570139, PubMed:28127896).9 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05951098N → K. Corresponds to variant dbSNP:rs1059510Ensembl.1
Natural variantiVAR_016651128G → R in allele E*01:01. 1 PublicationCorresponds to variant dbSNP:rs1264457Ensembl.1
Natural variantiVAR_016652178R → G in allele E*01:04. Corresponds to variant dbSNP:rs41562314Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M20022 mRNA Translation: AAA52655.1
AJ293263 mRNA Translation: CAC07212.1
AJ293264 mRNA Translation: CAC07213.1
M21533 Genomic DNA Translation: AAA59835.1
M32508 Genomic DNA Translation: AAA63225.1
AB103600 Genomic DNA Translation: BAF31260.1
AF523274 Genomic DNA Translation: AAM74969.1
AF523275 Genomic DNA Translation: AAM74970.1
AF523276 Genomic DNA Translation: AAM74971.1
AF523277 Genomic DNA Translation: AAM74972.1
AF523278 Genomic DNA Translation: AAM74973.1
AF523279 Genomic DNA Translation: AAM74974.1
AF523280 Genomic DNA Translation: AAM74975.1
AF523281 Genomic DNA Translation: AAM74976.1
AF523282 Genomic DNA Translation: AAM74977.1
AF523283 Genomic DNA Translation: AAM74978.1
AY645727 Genomic DNA Translation: AAT73210.1
AY645731 Genomic DNA Translation: AAT73214.1
AY645733 Genomic DNA Translation: AAT73216.1
AY645736 Genomic DNA Translation: AAT73219.1
AY645737 Genomic DNA Translation: AAT73220.1
AY645738 Genomic DNA Translation: AAT73221.1
AY645740 Genomic DNA Translation: AAT73223.1
AY645741 Genomic DNA Translation: AAT73224.1
LM654512 Genomic DNA Translation: CDX10595.1
LT618796 Genomic DNA Translation: SCQ83612.1
AY221103 mRNA Translation: AAO34408.1
AY216681 mRNA Translation: AAO37688.1
KX709624 Genomic DNA Translation: ASU09661.1
HM231277 Genomic DNA Translation: ADN38247.1
BA000025 Genomic DNA Translation: BAB63328.1
BC002578 mRNA Translation: AAH02578.1
BC040479 mRNA Translation: AAH40479.1
BC004297 mRNA Translation: AAH04297.1
AL662873 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34379.1

Protein sequence database of the Protein Information Resource

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PIRi
A28834

NCBI Reference Sequences

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RefSeqi
NP_005507.3, NM_005516.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.650174

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376630; ENSP00000365817; ENSG00000204592
ENST00000383597; ENSP00000373091; ENSG00000206493
ENST00000415289; ENSP00000409910; ENSG00000229252
ENST00000415649; ENSP00000390707; ENSG00000233904
ENST00000425603; ENSP00000402694; ENSG00000236632
ENST00000427936; ENSP00000397420; ENSG00000230254
ENST00000444683; ENSP00000400458; ENSG00000225201

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3133

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20022 mRNA Translation: AAA52655.1
AJ293263 mRNA Translation: CAC07212.1
AJ293264 mRNA Translation: CAC07213.1
M21533 Genomic DNA Translation: AAA59835.1
M32508 Genomic DNA Translation: AAA63225.1
AB103600 Genomic DNA Translation: BAF31260.1
AF523274 Genomic DNA Translation: AAM74969.1
AF523275 Genomic DNA Translation: AAM74970.1
AF523276 Genomic DNA Translation: AAM74971.1
AF523277 Genomic DNA Translation: AAM74972.1
AF523278 Genomic DNA Translation: AAM74973.1
AF523279 Genomic DNA Translation: AAM74974.1
AF523280 Genomic DNA Translation: AAM74975.1
AF523281 Genomic DNA Translation: AAM74976.1
AF523282 Genomic DNA Translation: AAM74977.1
AF523283 Genomic DNA Translation: AAM74978.1
AY645727 Genomic DNA Translation: AAT73210.1
AY645731 Genomic DNA Translation: AAT73214.1
AY645733 Genomic DNA Translation: AAT73216.1
AY645736 Genomic DNA Translation: AAT73219.1
AY645737 Genomic DNA Translation: AAT73220.1
AY645738 Genomic DNA Translation: AAT73221.1
AY645740 Genomic DNA Translation: AAT73223.1
AY645741 Genomic DNA Translation: AAT73224.1
LM654512 Genomic DNA Translation: CDX10595.1
LT618796 Genomic DNA Translation: SCQ83612.1
AY221103 mRNA Translation: AAO34408.1
AY216681 mRNA Translation: AAO37688.1
KX709624 Genomic DNA Translation: ASU09661.1
HM231277 Genomic DNA Translation: ADN38247.1
BA000025 Genomic DNA Translation: BAB63328.1
BC002578 mRNA Translation: AAH02578.1
BC040479 mRNA Translation: AAH40479.1
BC004297 mRNA Translation: AAH04297.1
AL662873 Genomic DNA No translation available.
CCDSiCCDS34379.1
PIRiA28834
RefSeqiNP_005507.3, NM_005516.5
UniGeneiHs.650174

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPRX-ray2.80A/C22-295[»]
1KTLX-ray3.10A/C22-295[»]
1MHEX-ray2.85A/C22-295[»]
2ESVX-ray2.60A23-297[»]
3AM8X-ray2.80A/B22-297[»]
3BZEX-ray2.50A/C/E/G23-295[»]
3BZFX-ray2.50A/C22-297[»]
3CDGX-ray3.40A/C23-295[»]
3CIIX-ray4.41A/D23-295[»]
5W1VX-ray3.31A/F/K/P22-299[»]
5W1WX-ray3.10A/F/K/P22-299[»]
6GGMX-ray2.73A/C22-295[»]
6GH1X-ray2.10A/C/E/G22-295[»]
6GH4X-ray2.16A/C/E/G22-295[»]
6GL1X-ray2.62A/C/E/G22-295[»]
ProteinModelPortaliP13747
SMRiP13747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109378, 52 interactors
DIPiDIP-32N
IntActiP13747, 21 interactors
STRINGi9606.ENSP00000365817

PTM databases

GlyConnecti1330
iPTMnetiP13747
PhosphoSitePlusiP13747
SwissPalmiP13747

Polymorphism and mutation databases

BioMutaiHLA-E
DMDMi34395942

Proteomic databases

EPDiP13747
jPOSTiP13747
PaxDbiP13747
PeptideAtlasiP13747
PRIDEiP13747
ProteomicsDBi52981
TopDownProteomicsiP13747

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3133
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376630; ENSP00000365817; ENSG00000204592
ENST00000383597; ENSP00000373091; ENSG00000206493
ENST00000415289; ENSP00000409910; ENSG00000229252
ENST00000415649; ENSP00000390707; ENSG00000233904
ENST00000425603; ENSP00000402694; ENSG00000236632
ENST00000427936; ENSP00000397420; ENSG00000230254
ENST00000444683; ENSP00000400458; ENSG00000225201
GeneIDi3133
KEGGihsa:3133

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3133
DisGeNETi3133
EuPathDBiHostDB:ENSG00000204592.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-E
HGNCiHGNC:4962 HLA-E
HPAiHPA031454
MIMi143010 gene
neXtProtiNX_P13747
OpenTargetsiENSG00000204592
PharmGKBiPA35081

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JD1V Eukaryota
ENOG410YKQA LUCA
GeneTreeiENSGT00940000153382
HOVERGENiHBG016709
InParanoidiP13747
KOiK06751
OMAiSALTKTW
OrthoDBi912212at2759
PhylomeDBiP13747
TreeFamiTF336617

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP13747

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-E human
EvolutionaryTraceiP13747

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HLA-E

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3133

Protein Ontology

More...
PROi
PR:P13747

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204592 Expressed in 235 organ(s), highest expression level in right lung
CleanExiHS_HLA-E

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHLAE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13747
Secondary accession number(s): E2G051
, Q30169, Q6DU44, Q9BT83, Q9GIY7, Q9GIY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 5, 2018
Last modified: January 16, 2019
This is version 190 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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