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Protein

HLA class I histocompatibility antigen, alpha chain E

Gene

HLA-E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.

Caution

The existence of allele E*01:02 (PubMed:3260916) and allele E*01:04 (PubMed:1977695) is uncertain. The alleles could not be confirmed in further studies (PubMed:12445303).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP13747

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain E
Alternative name(s):
MHC class I antigen E
Gene namesi
Name:HLA-E
Synonyms:HLA-6.2, HLAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4962 HLA-E
MIMi143010 gene
neXtProtiNX_P13747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
Transmembranei306 – 329HelicalSequence analysisAdd BLAST24
Topological domaini330 – 358CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3133
PharmGKBiPA35081

Polymorphism and mutation databases

BioMutaiHLA-E
DMDMi34395942

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001888222 – 358HLA class I histocompatibility antigen, alpha chain EAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi122 ↔ 185
Disulfide bondi224 ↔ 280
Modified residuei353PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP13747
PaxDbiP13747
PeptideAtlasiP13747
PRIDEiP13747
ProteomicsDBi52981
TopDownProteomicsiP13747

PTM databases

GlyConnecti1330
iPTMnetiP13747
PhosphoSitePlusiP13747
SwissPalmiP13747

Expressioni

Gene expression databases

CleanExiHS_HLA-E

Organism-specific databases

HPAiHPA031454

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Binary interactionsi

WithEntry#Exp.IntActNotes
HLA-FP305112EBI-726583,EBI-2811134

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109378, 52 interactors
DIPiDIP-32N
IntActiP13747, 21 interactors
STRINGi9606.ENSP00000365817

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13747
SMRiP13747
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13747

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 294Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JD1V Eukaryota
ENOG410YKQA LUCA
HOVERGENiHBG016709
InParanoidiP13747
KOiK06751
OrthoDBiEOG091G09OH
PhylomeDBiP13747

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD
60 70 80 90 100
DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR
110 120 130 140 150
TLRGYYNQSE AGSHTLQWMH GCELGPDRRF LRGYEQFAYD GKDYLTLNED
160 170 180 190 200
LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL
210 220 230 240 250
LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ
310 320 330 340 350
PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA

QGSESHSL
Length:358
Mass (Da):40,157
Last modified:August 29, 2003 - v3
Checksum:i2A211B603591D248
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6DU44Q6DU44_HUMAN
HLA class I histocompatibility anti...
HLA-E
358Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → S in AAA52655 (PubMed:3131426).Curated1

Polymorphismi

The following alleles of E-1 are known: E*01:01, E*01:02, E*01:03 and E*01:04. The sequence shown is that of E*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05951098N → K. Corresponds to variant dbSNP:rs1059510Ensembl.1
Natural variantiVAR_004395104G → R in allele E*01:02. 1
Natural variantiVAR_016651128R → G in allele E*01:03 and allele E*01:04. Corresponds to variant dbSNP:rs1264457Ensembl.1
Natural variantiVAR_016652178R → G in allele E*01:04. Corresponds to variant dbSNP:rs41562314Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20022 mRNA Translation: AAA52655.1
AJ293263 mRNA Translation: CAC07212.1
AJ293264 mRNA Translation: CAC07213.1
AF523274 Genomic DNA Translation: AAM74969.1
AF523275 Genomic DNA Translation: AAM74970.1
AF523276 Genomic DNA Translation: AAM74971.1
AF523277 Genomic DNA Translation: AAM74972.1
AF523278 Genomic DNA Translation: AAM74973.1
AF523279 Genomic DNA Translation: AAM74974.1
AF523280 Genomic DNA Translation: AAM74975.1
AF523281 Genomic DNA Translation: AAM74976.1
AF523282 Genomic DNA Translation: AAM74977.1
AF523283 Genomic DNA Translation: AAM74978.1
BA000025 Genomic DNA Translation: BAB63328.1
BC002578 mRNA Translation: AAH02578.1
BC004297 mRNA Translation: AAH04297.1
M21533 Genomic DNA Translation: AAA59835.1
AY221103 mRNA Translation: AAO34408.1
AY216681 mRNA Translation: AAO37688.1
M32508 Genomic DNA Translation: AAA63225.1
CCDSiCCDS34379.1
PIRiA28834
RefSeqiNP_005507.3, NM_005516.5
UniGeneiHs.650174

Genome annotation databases

EnsembliENST00000383597; ENSP00000373091; ENSG00000206493
ENST00000415289; ENSP00000409910; ENSG00000229252
ENST00000415649; ENSP00000390707; ENSG00000233904
ENST00000427936; ENSP00000397420; ENSG00000230254
GeneIDi3133
KEGGihsa:3133

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20022 mRNA Translation: AAA52655.1
AJ293263 mRNA Translation: CAC07212.1
AJ293264 mRNA Translation: CAC07213.1
AF523274 Genomic DNA Translation: AAM74969.1
AF523275 Genomic DNA Translation: AAM74970.1
AF523276 Genomic DNA Translation: AAM74971.1
AF523277 Genomic DNA Translation: AAM74972.1
AF523278 Genomic DNA Translation: AAM74973.1
AF523279 Genomic DNA Translation: AAM74974.1
AF523280 Genomic DNA Translation: AAM74975.1
AF523281 Genomic DNA Translation: AAM74976.1
AF523282 Genomic DNA Translation: AAM74977.1
AF523283 Genomic DNA Translation: AAM74978.1
BA000025 Genomic DNA Translation: BAB63328.1
BC002578 mRNA Translation: AAH02578.1
BC004297 mRNA Translation: AAH04297.1
M21533 Genomic DNA Translation: AAA59835.1
AY221103 mRNA Translation: AAO34408.1
AY216681 mRNA Translation: AAO37688.1
M32508 Genomic DNA Translation: AAA63225.1
CCDSiCCDS34379.1
PIRiA28834
RefSeqiNP_005507.3, NM_005516.5
UniGeneiHs.650174

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPRX-ray2.80A/C22-295[»]
1KTLX-ray3.10A/C22-295[»]
1MHEX-ray2.85A/C22-295[»]
2ESVX-ray2.60A23-297[»]
3AM8X-ray2.80A/B22-297[»]
3BZEX-ray2.50A/C/E/G23-295[»]
3BZFX-ray2.50A/C22-297[»]
3CDGX-ray3.40A/C23-295[»]
3CIIX-ray4.41A/D23-295[»]
5W1VX-ray3.31A/F/K/P22-299[»]
5W1WX-ray3.10A/F/K/P22-299[»]
ProteinModelPortaliP13747
SMRiP13747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109378, 52 interactors
DIPiDIP-32N
IntActiP13747, 21 interactors
STRINGi9606.ENSP00000365817

PTM databases

GlyConnecti1330
iPTMnetiP13747
PhosphoSitePlusiP13747
SwissPalmiP13747

Polymorphism and mutation databases

BioMutaiHLA-E
DMDMi34395942

Proteomic databases

EPDiP13747
PaxDbiP13747
PeptideAtlasiP13747
PRIDEiP13747
ProteomicsDBi52981
TopDownProteomicsiP13747

Protocols and materials databases

DNASUi3133
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383597; ENSP00000373091; ENSG00000206493
ENST00000415289; ENSP00000409910; ENSG00000229252
ENST00000415649; ENSP00000390707; ENSG00000233904
ENST00000427936; ENSP00000397420; ENSG00000230254
GeneIDi3133
KEGGihsa:3133

Organism-specific databases

CTDi3133
DisGeNETi3133
GeneCardsiHLA-E
HGNCiHGNC:4962 HLA-E
HPAiHPA031454
MIMi143010 gene
neXtProtiNX_P13747
PharmGKBiPA35081
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JD1V Eukaryota
ENOG410YKQA LUCA
HOVERGENiHBG016709
InParanoidiP13747
KOiK06751
OrthoDBiEOG091G09OH
PhylomeDBiP13747

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP13747

Miscellaneous databases

ChiTaRSiHLA-E human
EvolutionaryTraceiP13747
GeneWikiiHLA-E
GenomeRNAii3133
PROiPR:P13747
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-E

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHLAE_HUMAN
AccessioniPrimary (citable) accession number: P13747
Secondary accession number(s): Q30169
, Q9BT83, Q9GIY7, Q9GIY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 29, 2003
Last modified: October 10, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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