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Protein

Glutathione S-transferase A1

Gene

Gsta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9Glutathione1 Publication1
Binding sitei45Glutathione1 Publication1

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: UniProtKB
  • response to bacterium Source: MGI
  • response to stilbenoid Source: UniProtKB

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A1 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 1
Glutathione S-transferase Ya
Glutathione S-transferase Ya1
Cleaved into the following chain:
Gene namesi
Name:Gsta1
Synonyms:Gsta, Gstya
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1095417 Gsta1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232041 – 223Glutathione S-transferase A1Add BLAST223
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00001857882 – 223Glutathione S-transferase A1, N-terminally processedAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Glutathione S-transferase A1, N-terminally processedBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP13745
PaxDbiP13745
PeptideAtlasiP13745
PRIDEiP13745

PTM databases

iPTMnetiP13745
PhosphoSitePlusiP13745

Expressioni

Inductioni

Induced in the liver by beta-naphthoflavone (BNF) and 23-t-butyl-4-hydroxyanisole (BHA).1 Publication

Gene expression databases

BgeeiENSMUSG00000074183
CleanExiMM_GSTA1
GenevisibleiP13745 MM

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi200090, 1 interactor
IntActiP13745, 3 interactors
MINTiP13745
STRINGi10090.ENSMUSP00000096139

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Turni14 – 16Combined sources3
Helixi17 – 25Combined sources9
Beta strandi31 – 35Combined sources5
Helixi38 – 46Combined sources9
Beta strandi57 – 60Combined sources4
Beta strandi63 – 67Combined sources5
Helixi68 – 78Combined sources11
Helixi86 – 108Combined sources23
Helixi109 – 111Combined sources3
Turni114 – 116Combined sources3
Helixi117 – 130Combined sources14
Helixi132 – 143Combined sources12
Beta strandi146 – 149Combined sources4
Helixi155 – 171Combined sources17
Helixi172 – 175Combined sources4
Helixi179 – 189Combined sources11
Helixi192 – 198Combined sources7
Helixi210 – 217Combined sources8

3D structure databases

ProteinModelPortaliP13745
SMRiP13745
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13745

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione binding1 Publication2
Regioni67 – 68Glutathione binding1 Publication2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115734
HOVERGENiHBG053749
InParanoidiP13745
KOiK00799
OMAiNEMIIVL
OrthoDBiEOG091G0O3D
PhylomeDBiP13745
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR003080 GST_alpha
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01266 GSTRNSFRASEA
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKPVLHYF NARGRMECIR WLLAAAGVEF EEKFIQSPED LEKLKKDGNL
60 70 80 90 100
MFDQVPMVEI DGMKLAQTRA ILNYIATKYD LYGKDMKERA LIDMYSEGIL
110 120 130 140 150
DLTEMIGQLV LCPPDQREAK TALAKDRTKN RYLPAFEKVL KSHGQDYLVG
160 170 180 190 200
NRLTRVDIHL LEVLLYVEEF DASLLTPFPL LKAFKSRISS LPNVKKFLQP
210 220
GSQRKPPMDA KQIQEARKAF KIQ
Length:223
Mass (Da):25,608
Last modified:January 23, 2007 - v2
Checksum:iA348A07133FBEC1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19256
, M19251, M19252, M19253, M19254, M19255 Genomic DNA Translation: AAA37750.1 Sequence problems.
BC132572 mRNA Translation: AAI32573.1
BC132576 mRNA Translation: AAI32577.1
CCDSiCCDS23358.1
PIRiA27848
RefSeqiNP_032207.3, NM_008181.3
UniGeneiMm.467426

Genome annotation databases

EnsembliENSMUST00000098537; ENSMUSP00000096139; ENSMUSG00000074183
GeneIDi14857
KEGGimmu:14857
UCSCiuc009qtz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGSTA1_MOUSE
AccessioniPrimary (citable) accession number: P13745
Secondary accession number(s): A2RTN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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