Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bone marrow proteoglycan

Gene

PRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.1 Publication

Miscellaneous

Binds heparin. Does not bind calcium.

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Heparin-binding
Biological processImmunity
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI63.001

Names & Taxonomyi

Protein namesi
Recommended name:
Bone marrow proteoglycan
Short name:
BMPG
Alternative name(s):
Proteoglycan 2
Cleaved into the following chain:
Eosinophil granule major basic protein
Short name:
EMBP
Short name:
MBP
Alternative name(s):
Pregnancy-associated major basic protein
Gene namesi
Name:PRG2
Synonyms:MBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000186652.9
HGNCiHGNC:9362 PRG2
MIMi605601 gene
neXtProtiNX_P13727

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5553
OpenTargetsiENSG00000186652
PharmGKBiPA33734

Chemistry databases

DrugBankiDB00020 Sargramostim

Polymorphism and mutation databases

BioMutaiPRG2
DMDMi281185479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 163 PublicationsAdd BLAST16
ChainiPRO_000025992317 – 222Bone marrow proteoglycanAdd BLAST206
PropeptideiPRO_000001738517 – 105Acidic2 PublicationsAdd BLAST89
ChainiPRO_0000017386106 – 222Eosinophil granule major basic proteinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonine; partial1 Publication1
Glycosylationi24O-linked (GalNAc...) serine2 Publications1
Glycosylationi25O-linked (GalNAc...) threonine2 Publications1
Glycosylationi34O-linked (GalNAc...) threonine; partial1 Publication1
Disulfide bondi51Interchain (with C-461 in PAPPA)PROSITE-ProRule annotation1 Publication
Glycosylationi62O-linked (Xyl...) (chondroitin sulfate) serine2 Publications1
Glycosylationi86N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi125 ↔ 220PROSITE-ProRule annotation1 Publication
Disulfide bondi169Interchain (with C-732 in PAPPA)PROSITE-ProRule annotation1 Publication
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Nitrated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration, Proteoglycan

Proteomic databases

EPDiP13727
PaxDbiP13727
PeptideAtlasiP13727
PRIDEiP13727
ProteomicsDBi52978
TopDownProteomicsiP13727-1 [P13727-1]

PTM databases

iPTMnetiP13727
PhosphoSitePlusiP13727

Expressioni

Tissue specificityi

High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.2 Publications

Developmental stagei

Levels of the proform increase in serum and placenta during pregnancy.2 Publications

Gene expression databases

BgeeiENSG00000186652 Expressed in 72 organ(s), highest expression level in placenta
CleanExiHS_MBP
HS_PRG2
GenevisibleiP13727 HS

Organism-specific databases

HPAiHPA038515

Interactioni

Subunit structurei

In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.5 Publications

Protein-protein interaction databases

BioGridi111544, 66 interactors
CORUMiP13727
IntActiP13727, 2 interactors
STRINGi9606.ENSP00000312134

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13727
SMRiP13727
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13727

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 222C-type lectinPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00440000039859
HOGENOMiHOG000261603
HOVERGENiHBG005583
InParanoidiP13727
KOiK10786
OMAiGHWRRAH
OrthoDBiEOG091G0LK4
PhylomeDBiP13727
TreeFamiTF336281

Family and domain databases

CDDicd03598 CLECT_EMBP_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR033816 EMBP_CTLD
IPR002352 Eosinophil_major_basic
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PRINTSiPR00770 EMAJORBASICP
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P13727-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLPLLLALL FGAVSALHLR SETSTFETPL GAKTLPEDEE TPEQEMEETP
60 70 80 90 100
CRELEEEEEW GSGSEDASKK DGAVESISVP DMVDKNLTCP EEEDTVKVVG
110 120 130 140 150
IPGCQTCRYL LVRSLQTFSQ AWFTCRRCYR GNLVSIHNFN INYRIQCSVS
160 170 180 190 200
ALNQGQVWIG GRITGSGRCR RFQWVDGSRW NFAYWAAHQP WSRGGHCVAL
210 220
CTRGGHWRRA HCLRRLPFIC SY
Length:222
Mass (Da):25,206
Last modified:December 15, 2009 - v2
Checksum:iCDD545642555E2D0
GO
Isoform 2 (identifier: P13727-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-122: Missing.

Show »
Length:211
Mass (Da):23,901
Checksum:i56CDF739284A3DE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84D → H in AAA36203 (PubMed:3171483).Curated1
Sequence conflicti190P → L in BAG35128 (PubMed:14702039).Curated1
Sequence conflicti192S → T in CAA81207 (PubMed:7531438).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036401179R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs142359007Ensembl.1
Natural variantiVAR_060729206H → Y8 PublicationsCorresponds to variant dbSNP:rs536455Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056735112 – 122Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00809 mRNA Translation: CAA68751.1
M36805 mRNA Translation: AAA36203.1
M34462 Genomic DNA Translation: AAA35796.1
M35670 mRNA Translation: AAA35965.1
X14088 mRNA Translation: CAA32250.1
X65787 mRNA Translation: CAA46670.1
Z26248 mRNA Translation: CAA81207.1
AK312195 mRNA Translation: BAG35128.1
CR450311 mRNA Translation: CAG29307.1
DQ846874 mRNA Translation: ABI63361.1
AP000781 Genomic DNA No translation available.
BC005929 mRNA Translation: AAH05929.1
CCDSiCCDS58133.1 [P13727-2]
CCDS7955.1 [P13727-1]
PIRiI54055 JL0085
RefSeqiNP_001230174.1, NM_001243245.2 [P13727-2]
NP_001289855.1, NM_001302926.1 [P13727-1]
NP_001289856.1, NM_001302927.1 [P13727-1]
NP_002719.3, NM_002728.5 [P13727-1]
UniGeneiHs.512633

Genome annotation databases

EnsembliENST00000311862; ENSP00000312134; ENSG00000186652 [P13727-1]
ENST00000525955; ENSP00000433016; ENSG00000186652 [P13727-1]
ENST00000533605; ENSP00000433231; ENSG00000186652 [P13727-2]
GeneIDi5553
KEGGihsa:5553
UCSCiuc001nkc.4 human [P13727-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Major basic protein entry

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00809 mRNA Translation: CAA68751.1
M36805 mRNA Translation: AAA36203.1
M34462 Genomic DNA Translation: AAA35796.1
M35670 mRNA Translation: AAA35965.1
X14088 mRNA Translation: CAA32250.1
X65787 mRNA Translation: CAA46670.1
Z26248 mRNA Translation: CAA81207.1
AK312195 mRNA Translation: BAG35128.1
CR450311 mRNA Translation: CAG29307.1
DQ846874 mRNA Translation: ABI63361.1
AP000781 Genomic DNA No translation available.
BC005929 mRNA Translation: AAH05929.1
CCDSiCCDS58133.1 [P13727-2]
CCDS7955.1 [P13727-1]
PIRiI54055 JL0085
RefSeqiNP_001230174.1, NM_001243245.2 [P13727-2]
NP_001289855.1, NM_001302926.1 [P13727-1]
NP_001289856.1, NM_001302927.1 [P13727-1]
NP_002719.3, NM_002728.5 [P13727-1]
UniGeneiHs.512633

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8UX-ray1.80A/B106-222[»]
2BRSX-ray2.20A/B106-222[»]
4QXXX-ray1.45Z131-135[»]
ProteinModelPortaliP13727
SMRiP13727
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111544, 66 interactors
CORUMiP13727
IntActiP13727, 2 interactors
STRINGi9606.ENSP00000312134

Chemistry databases

DrugBankiDB00020 Sargramostim

Protein family/group databases

MEROPSiI63.001

PTM databases

iPTMnetiP13727
PhosphoSitePlusiP13727

Polymorphism and mutation databases

BioMutaiPRG2
DMDMi281185479

Proteomic databases

EPDiP13727
PaxDbiP13727
PeptideAtlasiP13727
PRIDEiP13727
ProteomicsDBi52978
TopDownProteomicsiP13727-1 [P13727-1]

Protocols and materials databases

DNASUi5553
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311862; ENSP00000312134; ENSG00000186652 [P13727-1]
ENST00000525955; ENSP00000433016; ENSG00000186652 [P13727-1]
ENST00000533605; ENSP00000433231; ENSG00000186652 [P13727-2]
GeneIDi5553
KEGGihsa:5553
UCSCiuc001nkc.4 human [P13727-1]

Organism-specific databases

CTDi5553
DisGeNETi5553
EuPathDBiHostDB:ENSG00000186652.9
GeneCardsiPRG2
H-InvDBiHIX0009634
HGNCiHGNC:9362 PRG2
HPAiHPA038515
MIMi605601 gene
neXtProtiNX_P13727
OpenTargetsiENSG00000186652
PharmGKBiPA33734
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00440000039859
HOGENOMiHOG000261603
HOVERGENiHBG005583
InParanoidiP13727
KOiK10786
OMAiGHWRRAH
OrthoDBiEOG091G0LK4
PhylomeDBiP13727
TreeFamiTF336281

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiPRG2 human
EvolutionaryTraceiP13727
GeneWikiiMajor_basic_protein
GenomeRNAii5553
PROiPR:P13727
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186652 Expressed in 72 organ(s), highest expression level in placenta
CleanExiHS_MBP
HS_PRG2
GenevisibleiP13727 HS

Family and domain databases

CDDicd03598 CLECT_EMBP_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR033816 EMBP_CTLD
IPR002352 Eosinophil_major_basic
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PRINTSiPR00770 EMAJORBASICP
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRG2_HUMAN
AccessioniPrimary (citable) accession number: P13727
Secondary accession number(s): A6XMW0
, B2R5I1, P81448, Q14227, Q6ICT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 15, 2009
Last modified: September 12, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again