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Entry version 198 (26 Feb 2020)
Sequence version 2 (15 Dec 2009)
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Protein

Bone marrow proteoglycan

Gene

PRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.1 Publication

Miscellaneous

Binds heparin. Does not bind calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Heparin-binding
Biological processImmunity
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I63.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bone marrow proteoglycan
Short name:
BMPG
Alternative name(s):
Proteoglycan 2
Cleaved into the following chain:
Eosinophil granule major basic protein
Short name:
EMBP
Short name:
MBP
Alternative name(s):
Pregnancy-associated major basic protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRG2
Synonyms:MBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9362 PRG2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605601 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13727

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5553

Open Targets

More...
OpenTargetsi
ENSG00000186652

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33734

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P13727 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB06752 Chymopapain
DB00020 Sargramostim

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
281185479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 163 PublicationsAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025992317 – 222Bone marrow proteoglycanAdd BLAST206
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001738517 – 105Acidic2 PublicationsAdd BLAST89
ChainiPRO_0000017386106 – 222Eosinophil granule major basic proteinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23O-linked (GalNAc...) threonine; partial1 Publication1
Glycosylationi24O-linked (GalNAc...) serine2 Publications1
Glycosylationi25O-linked (GalNAc...) threonine2 Publications1
Glycosylationi34O-linked (GalNAc...) threonine; partial1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51Interchain (with C-461 in PAPPA)PROSITE-ProRule annotation1 Publication
Glycosylationi62O-linked (Xyl...) (chondroitin sulfate) serine2 Publications1
Glycosylationi86N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi125 ↔ 220PROSITE-ProRule annotation1 Publication
Disulfide bondi169Interchain (with C-732 in PAPPA)PROSITE-ProRule annotation1 Publication
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Nitrated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13727

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P13727

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P13727

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13727

PeptideAtlas

More...
PeptideAtlasi
P13727

PRoteomics IDEntifications database

More...
PRIDEi
P13727

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1773
52978 [P13727-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P13727-1 [P13727-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13727

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13727

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Levels of the proform increase in serum and placenta during pregnancy.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186652 Expressed in placenta and 71 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13727 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038515

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.

5 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111544, 67 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P13727

Protein interaction database and analysis system

More...
IntActi
P13727, 45 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312134

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P13727 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P13727

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P13727

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 222C-type lectinPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000039859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_107200_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P13727

KEGG Orthology (KO)

More...
KOi
K10786

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIQCSVS

Database of Orthologous Groups

More...
OrthoDBi
1328472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13727

TreeFam database of animal gene trees

More...
TreeFami
TF336281

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03598 CLECT_EMBP_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR033816 EMBP_CTLD
IPR002352 Eosinophil_major_basic

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059 Lectin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00770 EMAJORBASICP

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P13727-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLPLLLALL FGAVSALHLR SETSTFETPL GAKTLPEDEE TPEQEMEETP
60 70 80 90 100
CRELEEEEEW GSGSEDASKK DGAVESISVP DMVDKNLTCP EEEDTVKVVG
110 120 130 140 150
IPGCQTCRYL LVRSLQTFSQ AWFTCRRCYR GNLVSIHNFN INYRIQCSVS
160 170 180 190 200
ALNQGQVWIG GRITGSGRCR RFQWVDGSRW NFAYWAAHQP WSRGGHCVAL
210 220
CTRGGHWRRA HCLRRLPFIC SY
Length:222
Mass (Da):25,206
Last modified:December 15, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDD545642555E2D0
GO
Isoform 2 (identifier: P13727-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-122: Missing.

Show »
Length:211
Mass (Da):23,901
Checksum:i56CDF739284A3DE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84D → H in AAA36203 (PubMed:3171483).Curated1
Sequence conflicti190P → L in BAG35128 (PubMed:14702039).Curated1
Sequence conflicti192S → T in CAA81207 (PubMed:7531438).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036401179R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs142359007Ensembl.1
Natural variantiVAR_060729206H → Y8 PublicationsCorresponds to variant dbSNP:rs536455Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056735112 – 122Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00809 mRNA Translation: CAA68751.1
M36805 mRNA Translation: AAA36203.1
M34462 Genomic DNA Translation: AAA35796.1
M35670 mRNA Translation: AAA35965.1
X14088 mRNA Translation: CAA32250.1
X65787 mRNA Translation: CAA46670.1
Z26248 mRNA Translation: CAA81207.1
AK312195 mRNA Translation: BAG35128.1
CR450311 mRNA Translation: CAG29307.1
DQ846874 mRNA Translation: ABI63361.1
AP000781 Genomic DNA No translation available.
BC005929 mRNA Translation: AAH05929.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58133.1 [P13727-2]
CCDS7955.1 [P13727-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I54055 JL0085

NCBI Reference Sequences

More...
RefSeqi
NP_001230174.1, NM_001243245.2 [P13727-2]
NP_001289855.1, NM_001302926.1 [P13727-1]
NP_001289856.1, NM_001302927.1 [P13727-1]
NP_002719.3, NM_002728.5 [P13727-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311862; ENSP00000312134; ENSG00000186652 [P13727-1]
ENST00000525955; ENSP00000433016; ENSG00000186652 [P13727-1]
ENST00000533605; ENSP00000433231; ENSG00000186652 [P13727-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5553

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5553

UCSC genome browser

More...
UCSCi
uc001nkc.4 human [P13727-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Major basic protein entry

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00809 mRNA Translation: CAA68751.1
M36805 mRNA Translation: AAA36203.1
M34462 Genomic DNA Translation: AAA35796.1
M35670 mRNA Translation: AAA35965.1
X14088 mRNA Translation: CAA32250.1
X65787 mRNA Translation: CAA46670.1
Z26248 mRNA Translation: CAA81207.1
AK312195 mRNA Translation: BAG35128.1
CR450311 mRNA Translation: CAG29307.1
DQ846874 mRNA Translation: ABI63361.1
AP000781 Genomic DNA No translation available.
BC005929 mRNA Translation: AAH05929.1
CCDSiCCDS58133.1 [P13727-2]
CCDS7955.1 [P13727-1]
PIRiI54055 JL0085
RefSeqiNP_001230174.1, NM_001243245.2 [P13727-2]
NP_001289855.1, NM_001302926.1 [P13727-1]
NP_001289856.1, NM_001302927.1 [P13727-1]
NP_002719.3, NM_002728.5 [P13727-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8UX-ray1.80A/B106-222[»]
2BRSX-ray2.20A/B106-222[»]
4QXXX-ray1.45Z131-135[»]
SMRiP13727
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111544, 67 interactors
CORUMiP13727
IntActiP13727, 45 interactors
STRINGi9606.ENSP00000312134

Chemistry databases

DrugBankiDB06752 Chymopapain
DB00020 Sargramostim

Protein family/group databases

MEROPSiI63.001

PTM databases

iPTMnetiP13727
PhosphoSitePlusiP13727

Polymorphism and mutation databases

BioMutaiPRG2
DMDMi281185479

Proteomic databases

EPDiP13727
jPOSTiP13727
MassIVEiP13727
PaxDbiP13727
PeptideAtlasiP13727
PRIDEiP13727
ProteomicsDBi1773
52978 [P13727-1]
TopDownProteomicsiP13727-1 [P13727-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5553

Genome annotation databases

EnsembliENST00000311862; ENSP00000312134; ENSG00000186652 [P13727-1]
ENST00000525955; ENSP00000433016; ENSG00000186652 [P13727-1]
ENST00000533605; ENSP00000433231; ENSG00000186652 [P13727-2]
GeneIDi5553
KEGGihsa:5553
UCSCiuc001nkc.4 human [P13727-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5553
DisGeNETi5553

GeneCards: human genes, protein and diseases

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GeneCardsi
PRG2
HGNCiHGNC:9362 PRG2
HPAiHPA038515
MIMi605601 gene
neXtProtiNX_P13727
OpenTargetsiENSG00000186652
PharmGKBiPA33734

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00440000039859
HOGENOMiCLU_107200_1_0_1
InParanoidiP13727
KOiK10786
OMAiRIQCSVS
OrthoDBi1328472at2759
PhylomeDBiP13727
TreeFamiTF336281

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PRG2 human
EvolutionaryTraceiP13727

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Major_basic_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5553
PharosiP13727 Tbio

Protein Ontology

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PROi
PR:P13727
RNActiP13727 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186652 Expressed in placenta and 71 other tissues
GenevisibleiP13727 HS

Family and domain databases

CDDicd03598 CLECT_EMBP_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR033816 EMBP_CTLD
IPR002352 Eosinophil_major_basic
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PRINTSiPR00770 EMAJORBASICP
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13727
Secondary accession number(s): A6XMW0
, B2R5I1, P81448, Q14227, Q6ICT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 15, 2009
Last modified: February 26, 2020
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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