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Entry version 205 (13 Feb 2019)
Sequence version 1 (01 Jan 1990)
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Protein

Tissue factor

Gene

F3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine receptor activity Source: GO_Central
  • phospholipid binding Source: BHF-UCL
  • protease binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation

SIGNOR Signaling Network Open Resource

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SIGNORi
P13726

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tissue factor
Short name:
TF
Alternative name(s):
Coagulation factor III
Thromboplastin
CD_antigen: CD142
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117525.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3541 F3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
134390 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13726

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 251ExtracellularSequence analysisAdd BLAST219
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei252 – 274HelicalSequence analysisAdd BLAST23
Topological domaini275 – 295CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2152

Open Targets

More...
OpenTargetsi
ENSG00000117525

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA158

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4081

Drug and drug target database

More...
DrugBanki
DB07207 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB13150 Coagulation factor VII human
DB00036 Coagulation factor VIIa Recombinant Human

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
F3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
135666

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Add BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003363833 – 295Tissue factorAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi81 ↔ 891 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 2411 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi277S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13726

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P13726

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P13726

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13726

PeptideAtlas

More...
PeptideAtlasi
P13726

PRoteomics IDEntifications database

More...
PRIDEi
P13726

ProteomicsDB human proteome resource

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ProteomicsDBi
52976
52977 [P13726-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1811

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13726

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13726

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13726

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Lung, placenta and pancreas.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000117525 Expressed in 222 organ(s), highest expression level in nasal cavity epithelium

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13726 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009438
HPA049292
HPA069132

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108451, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2808 Factor VII - TF complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P13726

Database of interacting proteins

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DIPi
DIP-6136N

Protein interaction database and analysis system

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IntActi
P13726, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000334145

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P13726

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00C/F33-251[»]
1BOYX-ray2.20A33-251[»]
1DANX-ray2.00T37-116[»]
U122-242[»]
1FAKX-ray2.10T37-242[»]
1J9CX-ray2.90T33-242[»]
1JPSX-ray1.85T33-251[»]
1NL8model-T33-242[»]
1O5DX-ray2.05T34-251[»]
1TFHX-ray2.40A/B33-251[»]
1UJ3X-ray2.10C38-242[»]
1W0YX-ray2.50T33-242[»]
1W2KX-ray3.00T33-242[»]
1WQVX-ray2.50T33-250[»]
1WSSX-ray2.60T33-250[»]
1WTGX-ray2.20T33-250[»]
1WUNX-ray2.40T33-250[»]
1WV7X-ray2.70T33-250[»]
1Z6JX-ray2.00T33-243[»]
2A2QX-ray1.80T38-242[»]
2AEIX-ray2.52T33-243[»]
2AERX-ray1.87T38-242[»]
2B7DX-ray2.24T34-251[»]
2B8OX-ray2.80T38-242[»]
2C4FX-ray1.72T38-112[»]
U123-242[»]
2CEFNMR-A277-295[»]
2CEHNMR-A277-295[»]
2CEZNMR-A277-295[»]
2CFJNMR-A277-295[»]
2EC9X-ray2.00T38-112[»]
U123-242[»]
2F9BX-ray2.54T34-251[»]
2FIRX-ray2.00T38-242[»]
2FLBX-ray1.95T34-251[»]
2FLRX-ray2.35T34-251[»]
2HFTX-ray1.69A33-243[»]
2PUQX-ray2.05T38-241[»]
2ZP0X-ray2.70T33-250[»]
2ZWLX-ray2.20T33-250[»]
2ZZUX-ray2.50T33-250[»]
3ELAX-ray2.20T33-241[»]
3TH2X-ray1.72T38-242[»]
3TH3X-ray2.70T38-242[»]
3TH4X-ray1.80T38-242[»]
4IBLX-ray1.80T33-251[»]
4M7LX-ray3.40T37-245[»]
4YLQX-ray1.40T33-251[»]
4Z6AX-ray2.25T36-242[»]
4ZMAX-ray2.30T33-251[»]
5W06X-ray2.60T37-245[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13726

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13726

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P13726

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi46 – 48WKS motif3
Motifi77 – 79WKS motif3
Motifi190 – 192WKS motif3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tissue factor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYA1 Eukaryota
ENOG4111MW4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012668

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043076

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054376

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13726

KEGG Orthology (KO)

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KOi
K03901

Identification of Orthologs from Complete Genome Data

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OMAi
YYWKASS

Database of Orthologous Groups

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OrthoDBi
1000890at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P13726

TreeFam database of animal gene trees

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TreeFami
TF352627

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR001187 Tissue_factor
IPR030472 Tissue_Factor_CS

The PANTHER Classification System

More...
PANTHERi
PTHR20859:SF22 PTHR20859:SF22, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002498 Tissue_factor_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00346 TISSUEFACTOR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00621 TISSUE_FACTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms may exist.
Isoform 1 (identifier: P13726-1) [UniParc]FASTAAdd to basket
Also known as: flTF

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN
60 70 80 90 100
FKTILEWEPK PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK
110 120 130 140 150
QTYLARVFSY PAGNVESTGS AGEPLYENSP EFTPYLETNL GQPTIQSFEQ
160 170 180 190 200
VGTKVNVTVE DERTLVRRNN TFLSLRDVFG KDLIYTLYYW KSSSSGKKTA
210 220 230 240 250
KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE CMGQEKGEFR
260 270 280 290
EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS
Length:295
Mass (Da):33,068
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3486C713ED8EAD0
GO
Isoform 2 (identifier: P13726-2) [UniParc]FASTAAdd to basket
Also known as: asHTF

The sequence of this isoform differs from the canonical sequence as follows:
     199-238: TAKTNTNEFL...TVNRKSTDSP → YSTSLELWYL...WGRAGRRTPH
     239-295: Missing.

Show »
Length:238
Mass (Da):27,145
Checksum:i5021EDB85C12B48C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti260V → A in AAA61151 (PubMed:2823875).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01429836T → A1 PublicationCorresponds to variant dbSNP:rs3917604Ensembl.1
Natural variantiVAR_014299145I → V1 PublicationCorresponds to variant dbSNP:rs3917627Ensembl.1
Natural variantiVAR_012008163R → W. Corresponds to variant dbSNP:rs5901Ensembl.1
Natural variantiVAR_052280281G → E. Corresponds to variant dbSNP:rs3789683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041896199 – 238TAKTN…STDSP → YSTSLELWYLWSSSLSSSWL YLYTSVERQEWGRAGRRTPH in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_041897239 – 295Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M16553 mRNA Translation: AAA61151.1
J02931 mRNA Translation: AAA61150.1
M27436 mRNA Translation: AAA36734.1
J02846 Genomic DNA Translation: AAA61152.1
BT019808 mRNA Translation: AAV38611.1
CR541792 mRNA Translation: CAG46591.1
AF487337 mRNA Translation: AAO61150.1
AF540377 Genomic DNA Translation: AAN01236.1
AC093117 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73044.1
CH471097 Genomic DNA Translation: EAW73045.1
BC011029 mRNA Translation: AAH11029.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53345.1 [P13726-2]
CCDS750.1 [P13726-1]

Protein sequence database of the Protein Information Resource

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PIRi
A43645 KFHU3

NCBI Reference Sequences

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RefSeqi
NP_001171567.1, NM_001178096.1 [P13726-2]
NP_001984.1, NM_001993.4 [P13726-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.62192

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000334047; ENSP00000334145; ENSG00000117525 [P13726-1]
ENST00000370207; ENSP00000359226; ENSG00000117525 [P13726-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2152

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2152

UCSC genome browser

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UCSCi
uc001dqr.4 human [P13726-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Tissue factor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16553 mRNA Translation: AAA61151.1
J02931 mRNA Translation: AAA61150.1
M27436 mRNA Translation: AAA36734.1
J02846 Genomic DNA Translation: AAA61152.1
BT019808 mRNA Translation: AAV38611.1
CR541792 mRNA Translation: CAG46591.1
AF487337 mRNA Translation: AAO61150.1
AF540377 Genomic DNA Translation: AAN01236.1
AC093117 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73044.1
CH471097 Genomic DNA Translation: EAW73045.1
BC011029 mRNA Translation: AAH11029.1
CCDSiCCDS53345.1 [P13726-2]
CCDS750.1 [P13726-1]
PIRiA43645 KFHU3
RefSeqiNP_001171567.1, NM_001178096.1 [P13726-2]
NP_001984.1, NM_001993.4 [P13726-1]
UniGeneiHs.62192

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00C/F33-251[»]
1BOYX-ray2.20A33-251[»]
1DANX-ray2.00T37-116[»]
U122-242[»]
1FAKX-ray2.10T37-242[»]
1J9CX-ray2.90T33-242[»]
1JPSX-ray1.85T33-251[»]
1NL8model-T33-242[»]
1O5DX-ray2.05T34-251[»]
1TFHX-ray2.40A/B33-251[»]
1UJ3X-ray2.10C38-242[»]
1W0YX-ray2.50T33-242[»]
1W2KX-ray3.00T33-242[»]
1WQVX-ray2.50T33-250[»]
1WSSX-ray2.60T33-250[»]
1WTGX-ray2.20T33-250[»]
1WUNX-ray2.40T33-250[»]
1WV7X-ray2.70T33-250[»]
1Z6JX-ray2.00T33-243[»]
2A2QX-ray1.80T38-242[»]
2AEIX-ray2.52T33-243[»]
2AERX-ray1.87T38-242[»]
2B7DX-ray2.24T34-251[»]
2B8OX-ray2.80T38-242[»]
2C4FX-ray1.72T38-112[»]
U123-242[»]
2CEFNMR-A277-295[»]
2CEHNMR-A277-295[»]
2CEZNMR-A277-295[»]
2CFJNMR-A277-295[»]
2EC9X-ray2.00T38-112[»]
U123-242[»]
2F9BX-ray2.54T34-251[»]
2FIRX-ray2.00T38-242[»]
2FLBX-ray1.95T34-251[»]
2FLRX-ray2.35T34-251[»]
2HFTX-ray1.69A33-243[»]
2PUQX-ray2.05T38-241[»]
2ZP0X-ray2.70T33-250[»]
2ZWLX-ray2.20T33-250[»]
2ZZUX-ray2.50T33-250[»]
3ELAX-ray2.20T33-241[»]
3TH2X-ray1.72T38-242[»]
3TH3X-ray2.70T38-242[»]
3TH4X-ray1.80T38-242[»]
4IBLX-ray1.80T33-251[»]
4M7LX-ray3.40T37-245[»]
4YLQX-ray1.40T33-251[»]
4Z6AX-ray2.25T36-242[»]
4ZMAX-ray2.30T33-251[»]
5W06X-ray2.60T37-245[»]
ProteinModelPortaliP13726
SMRiP13726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108451, 11 interactors
ComplexPortaliCPX-2808 Factor VII - TF complex
CORUMiP13726
DIPiDIP-6136N
IntActiP13726, 4 interactors
STRINGi9606.ENSP00000334145

Chemistry databases

BindingDBiP13726
ChEMBLiCHEMBL4081
DrugBankiDB07207 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB13150 Coagulation factor VII human
DB00036 Coagulation factor VIIa Recombinant Human

PTM databases

GlyConnecti1811
iPTMnetiP13726
PhosphoSitePlusiP13726
SwissPalmiP13726

Polymorphism and mutation databases

BioMutaiF3
DMDMi135666

Proteomic databases

EPDiP13726
jPOSTiP13726
MaxQBiP13726
PaxDbiP13726
PeptideAtlasiP13726
PRIDEiP13726
ProteomicsDBi52976
52977 [P13726-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2152
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334047; ENSP00000334145; ENSG00000117525 [P13726-1]
ENST00000370207; ENSP00000359226; ENSG00000117525 [P13726-2]
GeneIDi2152
KEGGihsa:2152
UCSCiuc001dqr.4 human [P13726-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2152
DisGeNETi2152
EuPathDBiHostDB:ENSG00000117525.13

GeneCards: human genes, protein and diseases

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GeneCardsi
F3
HGNCiHGNC:3541 F3
HPAiCAB009438
HPA049292
HPA069132
MIMi134390 gene
neXtProtiNX_P13726
OpenTargetsiENSG00000117525
PharmGKBiPA158

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYA1 Eukaryota
ENOG4111MW4 LUCA
GeneTreeiENSGT00390000012668
HOGENOMiHOG000043076
HOVERGENiHBG054376
InParanoidiP13726
KOiK03901
OMAiYYWKASS
OrthoDBi1000890at2759
PhylomeDBiP13726
TreeFamiTF352627

Enzyme and pathway databases

ReactomeiR-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation
SIGNORiP13726

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
F3 human
EvolutionaryTraceiP13726

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Tissue_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2152

Protein Ontology

More...
PROi
PR:P13726

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117525 Expressed in 222 organ(s), highest expression level in nasal cavity epithelium
GenevisibleiP13726 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR001187 Tissue_factor
IPR030472 Tissue_Factor_CS
PANTHERiPTHR20859:SF22 PTHR20859:SF22, 1 hit
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF002498 Tissue_factor_3, 1 hit
PRINTSiPR00346 TISSUEFACTOR
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS00621 TISSUE_FACTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13726
Secondary accession number(s): D3DT47, Q6FHG2, Q86WH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: February 13, 2019
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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