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Protein

Oncostatin-M

Gene

OSM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).By similarity2 Publications

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • growth factor activity Source: BHF-UCL
  • oncostatin-M receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiP13725
SIGNORiP13725

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M
Short name:
OSM
Gene namesi
Name:OSM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099985.3
HGNCiHGNC:8506 OSM
MIMi165095 gene
neXtProtiNX_P13725

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74C → S: Inactive. 1
Mutagenesisi192C → S: Inactive. 1
Mutagenesisi201F → G: Inactive. 1
Mutagenesisi209F → G: Inactive. 1
Mutagenesisi220R → G: Inhibits propeptide cleavage. 1 Publication1
Mutagenesisi221R → G: Inhibits propeptide cleavage. 1 Publication1

Organism-specific databases

DisGeNETi5008
OpenTargetsiENSG00000099985
PharmGKBiPA32836

Polymorphism and mutation databases

BioMutaiOSM
DMDMi129168

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 252 PublicationsAdd BLAST25
ChainiPRO_000001772026 – 221Oncostatin-M1 PublicationAdd BLAST196
PropeptideiPRO_0000017721222 – 2521 PublicationAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 1521 Publication
Disulfide bondi74 ↔ 1921 Publication
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP13725
PeptideAtlasiP13725
PRIDEiP13725
ProteomicsDBi52975

PTM databases

iPTMnetiP13725
PhosphoSitePlusiP13725

Miscellaneous databases

PMAP-CutDBiP13725

Expressioni

Gene expression databases

BgeeiENSG00000099985 Expressed in 104 organ(s), highest expression level in blood
CleanExiHS_OSM
ExpressionAtlasiP13725 baseline and differential
GenevisibleiP13725 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111049, 11 interactors
DIPiDIP-5785N
IntActiP13725, 5 interactors
MINTiP13725
STRINGi9606.ENSP00000215781

Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13725
SMRiP13725
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13725

Family & Domainsi

Sequence similaritiesi

Belongs to the LIF/OSM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWR2 Eukaryota
ENOG41116AW LUCA
GeneTreeiENSGT00390000004850
HOGENOMiHOG000074128
HOVERGENiHBG007867
InParanoidiP13725
KOiK05418
OMAiLRGYHRF
OrthoDBiEOG091G0TZ1
PhylomeDBiP13725
TreeFamiTF338204

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001581 Leukemia_IF/oncostatin
IPR019827 Leukemia_IF/oncostatin_CS
IPR039578 OSM
PANTHERiPTHR14261 PTHR14261, 1 hit
PfamiView protein in Pfam
PF01291 LIF_OSM, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD023062 PD023062, 1 hit
SMARTiView protein in SMART
SM00080 LIF_OSM, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00590 LIF_OSM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P13725-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVLLTQRTL LSLVLALLFP SMASMAAIGS CSKEYRVLLG QLQKQTDLMQ
60 70 80 90 100
DTSRLLDPYI RIQGLDVPKL REHCRERPGA FPSEETLRGL GRRGFLQTLN
110 120 130 140 150
ATLGCVLHRL ADLEQRLPKA QDLERSGLNI EDLEKLQMAR PNILGLRNNI
160 170 180 190 200
YCMAQLLDNS DTAEPTKAGR GASQPPTPTP ASDAFQRKLE GCRFLHGYHR
210 220 230 240 250
FMHSVGRVFS KWGESPNRSR RHSPHQALRK GVRRTRPSRK GKRLMTRGQL

PR
Length:252
Mass (Da):28,484
Last modified:August 1, 1990 - v2
Checksum:iA5BE281175D101B9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCX1B5MCX1_HUMAN
Oncostatin-M
OSM
231Annotation score:
B5MC70B5MC70_HUMAN
Oncostatin-M
OSM
20Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0497829T → M. Corresponds to variant dbSNP:rs5763919Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27288, M27286, M27287 Genomic DNA Translation: AAA36388.1
CR456534 mRNA Translation: CAG30420.1
CR541703 mRNA Translation: CAG46504.1
AC004264 Genomic DNA Translation: AAC05173.1
CH471095 Genomic DNA Translation: EAW59864.1
BC011589 mRNA Translation: AAH11589.1
CCDSiCCDS13873.1
PIRiA32489
RefSeqiNP_001306037.1, NM_001319108.1
NP_065391.1, NM_020530.5
UniGeneiHs.248156

Genome annotation databases

EnsembliENST00000215781; ENSP00000215781; ENSG00000099985
GeneIDi5008
KEGGihsa:5008
UCSCiuc003ahb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27288, M27286, M27287 Genomic DNA Translation: AAA36388.1
CR456534 mRNA Translation: CAG30420.1
CR541703 mRNA Translation: CAG46504.1
AC004264 Genomic DNA Translation: AAC05173.1
CH471095 Genomic DNA Translation: EAW59864.1
BC011589 mRNA Translation: AAH11589.1
CCDSiCCDS13873.1
PIRiA32489
RefSeqiNP_001306037.1, NM_001319108.1
NP_065391.1, NM_020530.5
UniGeneiHs.248156

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EVSX-ray2.20A26-212[»]
ProteinModelPortaliP13725
SMRiP13725
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111049, 11 interactors
DIPiDIP-5785N
IntActiP13725, 5 interactors
MINTiP13725
STRINGi9606.ENSP00000215781

PTM databases

iPTMnetiP13725
PhosphoSitePlusiP13725

Polymorphism and mutation databases

BioMutaiOSM
DMDMi129168

Proteomic databases

PaxDbiP13725
PeptideAtlasiP13725
PRIDEiP13725
ProteomicsDBi52975

Protocols and materials databases

DNASUi5008
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215781; ENSP00000215781; ENSG00000099985
GeneIDi5008
KEGGihsa:5008
UCSCiuc003ahb.4 human

Organism-specific databases

CTDi5008
DisGeNETi5008
EuPathDBiHostDB:ENSG00000099985.3
GeneCardsiOSM
HGNCiHGNC:8506 OSM
MIMi165095 gene
neXtProtiNX_P13725
OpenTargetsiENSG00000099985
PharmGKBiPA32836
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWR2 Eukaryota
ENOG41116AW LUCA
GeneTreeiENSGT00390000004850
HOGENOMiHOG000074128
HOVERGENiHBG007867
InParanoidiP13725
KOiK05418
OMAiLRGYHRF
OrthoDBiEOG091G0TZ1
PhylomeDBiP13725
TreeFamiTF338204

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiP13725
SIGNORiP13725

Miscellaneous databases

EvolutionaryTraceiP13725
GeneWikiiOncostatin_M
GenomeRNAii5008
PMAP-CutDBiP13725
PROiPR:P13725
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099985 Expressed in 104 organ(s), highest expression level in blood
CleanExiHS_OSM
ExpressionAtlasiP13725 baseline and differential
GenevisibleiP13725 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001581 Leukemia_IF/oncostatin
IPR019827 Leukemia_IF/oncostatin_CS
IPR039578 OSM
PANTHERiPTHR14261 PTHR14261, 1 hit
PfamiView protein in Pfam
PF01291 LIF_OSM, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD023062 PD023062, 1 hit
SMARTiView protein in SMART
SM00080 LIF_OSM, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00590 LIF_OSM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiONCM_HUMAN
AccessioniPrimary (citable) accession number: P13725
Secondary accession number(s): Q6FHP8, Q9UCP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 1, 1990
Last modified: November 7, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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