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UniProtKB - P13721 (SIAT1_RAT)

Entry version 159 (23 Feb 2022)
Sequence version 2 (02 Dec 2020)
Previous versions | rss
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Protein

Beta-galactoside alpha-2,6-sialyltransferase 1

Gene

St6gal1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 35.6 min(-1) for the donor CMP-Neu5Ac (at pH 6.5 and 37 degrees Celsius). kcat is 40.3 min(-1) for the acceptor beta-Gal1,4-GlcNAc (at pH 6.5 and 37 degrees Celsius).
  1. KM=92 µM for donor CMP-Neu5Ac (at pH 6.5 and 37 degrees Celsius)
  2. KM=1.8 mM for acceptor beta-Gal1,4-GlcNAc (at pH 6.5 and 37 degrees Celsius)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei186Substrate; via amide nitrogenBy similarity1
Binding sitei209SubstrateBy similarity1
Binding sitei230SubstrateBy similarity1
Binding sitei350Substrate; via carbonyl oxygenBy similarity1
Binding sitei351SubstrateBy similarity1
Binding sitei362SubstrateBy similarity1
Binding sitei366SubstrateBy similarity1
Binding sitei373SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.4.99.1, 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-4085001, Sialic acid metabolism
R-RNO-975577, N-Glycan antennae elongation
R-RNO-977068, Termination of O-glycan biosynthesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P13721

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT29, Glycosyltransferase Family 29

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 1 (EC:2.4.99.13 Publications)
Short name:
Alpha 2,6-ST 1
Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
ST6Gal I
Short name:
ST6GalI
Sialyltransferase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:St6gal1
Synonyms:Siat1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11
  • UP000234681 Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...RGDi		3676, St6gal1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9Cytoplasmic9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini27 – 403LumenalSequence analysisAdd BLAST377

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi119Y → A: Protein destabilization. 1 Publication1
Mutagenesisi119Y → F: No effect on protein stability, nor on catalytic activity. 1 Publication1
Mutagenesisi180R → A: Small decrease of sialyltransferase activity. 1 Publication1
Mutagenesisi181C → A: Loss of sialyltransferase activity and aberrant subcellular location. 1 Publication1
Mutagenesisi208F → A: Reduced KM/kcat values for CMP-Neu5Ac, no effect on kinetic constants for beta-Gal1,4-GlcNAc. 1 Publication1
Mutagenesisi230N → A: Loss of catalytic activity. 1 Publication1
Mutagenesisi231S → A: Protein destabilization. 1 Publication1
Mutagenesisi232Q → A: Decreased catalytic activity. 1 Publication1
Mutagenesisi271D → A: Decreased catalytic activity. 1 Publication1
Mutagenesisi272Y → A: Strongly decreased catalytic activity. 1 Publication1
Mutagenesisi319S → A: Protein destabilization. 1 Publication1
Mutagenesisi332C → A: Loss of sialyltransferase activity and aberrant subcellular location. 1 Publication1
Mutagenesisi332C → S: Loss of sialyltransferase activity. 1 Publication1
Mutagenesisi333D → A: Small decrease of sialyltransferase activity. 1 Publication1
Mutagenesisi350C → A: Loss of catalytic activity; when associated with A-361. 1 Publication1
Mutagenesisi354Q → A: No effect on catalytic activity. 1 Publication1
Mutagenesisi355K → A: No effect on catalytic activity. 1 Publication1
Mutagenesisi361C → A: Loss of catalytic activity; when associated with A-350. 1 Publication1
Mutagenesisi366Y → A: Loss of catalytic activity. 1 Publication1
Mutagenesisi367H → A: Loss of catalytic activity. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4276

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001492511 – 403Beta-galactoside alpha-2,6-sialyltransferase 1Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi139 ↔ 403Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi146N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi158N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi181 ↔ 332Combined sources2 Publications
Disulfide bondi350 ↔ 361By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei366PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.1 Publication
N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13721

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13721, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13721

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13721

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hepatocytes (at protein level) (PubMed:3121604, PubMed:11278697). Strongly expressed in liver, spleen, lung, kidney and submaxillary gland and weakly in heart and brain (PubMed:1733948, PubMed:2793863).4 Publications
Expressed in liver.1 Publication
Expressed in kidney, but not in liver.2 Publications
Expressed in kidney, but not in liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000001823, Expressed in liver and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). Monomer in its soluble form (PubMed:11278697).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P13721, 1 interactor

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000002499

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P13721

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13721

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 403Catalytic (soluble form)1 PublicationAdd BLAST341
Regioni319 – 321Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2692, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157053

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038334_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13721

Identification of Orthologs from Complete Genome Data

More...OMAi		ICVWKER

Database of Orthologous Groups

More...OrthoDBi		494294at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13721

TreeFam database of animal gene trees

More...TreeFami		TF323961

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.1480.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001675, Glyco_trans_29
IPR038578, GT29-like_sf
IPR012163, Sialyl_trans

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00777, Glyco_transf_29, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005557, Sialyl_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform RLA1 Publication (identifier: P13721-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIHTNLKKKF SLFILVFLLF AVICVWKKGS DYEALTLQAK EFQMPKSQEK 
        60         70         80         90        100
VAMGSASQVV FSNSKQDPKE DIPILSYHRV TAKVKPQPSF QVWDKDSTYS 
       110        120        130        140        150
KLNPRLLKIW RNYLNMNKYK VSYKGPGPGV KFSVEALRCH LRDHVNVSMI 
       160        170        180        190        200
EATDFPFNTT EWEGYLPKEN FRTKVGPWQR CAVVSSAGSL KNSQLGREID 
       210        220        230        240        250
NHDAVLRFNG APTDNFQQDV GSKTTIRLMN SQLVTTEKRF LKDSLYTEGI 
       260        270        280        290        300
LIVWDPSVYH ADIPKWYQKP DYNFFETYKS YRRLNPSQPF YILKPQMPWE 
       310        320        330        340        350
LWDIIQEISA DLIQPNPPSS GMLGIIIMMT LCDQVDIYEF LPSKRKTDVC 
       360        370        380        390        400
YYHQKFFDSA CTMGAYHPLL FEKNMVKHLN EGTDEDIYLF GKATLSGFRN 

IRC
Length:403
Mass (Da):46,754
Last modified:December 2, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF40D7EA6B59355DA
GO
Isoform RKA1 Publication (identifier: P13721-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: MIHTNLKKKF...KTTIRLMNSQ → MRYLLFWYGL...LSLLLLVLGK

Note: Produced by alternative promoter usage. The alternative promoter is active in kidney.1 Publication
Show »
Length:214
Mass (Da):25,210
Checksum:i1C05C601E8B2FA10
GO
Isoform RKB1 Publication (identifier: P13721-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: MIHTNLKKKF...KTTIRLMNSQ → MRYLLFWYGLPHS

Note: Produced by alternative splicing of isoform RKA.1 Publication
Show »
Length:184
Mass (Da):21,896
Checksum:iBC8298805ADF9013
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z3S3F2Z3S3_RAT
Beta-galactoside alpha-2,6-sialyltr...
St6gal1
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti367H → D in AAA41196 (PubMed:3121604).1
Isoform RKA1 Publication (identifier: P13721-2)
Sequence conflicti40V → L in AAB06269 (PubMed:1983783).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0017821 – 232MIHTN…LMNSQ → MRYLLFWYGLPHSYSQCVCH WTPASGIFENEPLLSLLLLV LGK in isoform RKA. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_0017831 – 232MIHTN…LMNSQ → MRYLLFWYGLPHS in isoform RKB. 1 PublicationAdd BLAST232

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M18769 mRNA Translation: AAA41196.1
M73987 mRNA Translation: AAB06269.1
M83143 mRNA Translation: AAB07233.1
AABR07034602 Genomic DNA No translation available.
AABR07034601 Genomic DNA No translation available.
AABR07034600 Genomic DNA No translation available.
CH473999 Genomic DNA Translation: EDL78084.1
CH473999 Genomic DNA Translation: EDL78085.1

Protein sequence database of the Protein Information Resource

More...PIRi		A28451
C42327

NCBI Reference Sequences

More...RefSeqi		NP_001106815.1, NM_001113344.1 [P13721-1]
NP_671738.2, NM_147205.2
XP_006248563.1, XM_006248501.1 [P13721-1]
XP_008767014.1, XM_008768792.2 [P13721-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000002496; ENSRNOP00000002496; ENSRNOG00000001823 [P13721-1]
ENSRNOT00000002499; ENSRNOP00000002499; ENSRNOG00000001823 [P13721-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25197

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:25197

UCSC genome browser

More...UCSCi		RGD:3676, rat [P13721-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18769 mRNA Translation: AAA41196.1
M73987 mRNA Translation: AAB06269.1
M83143 mRNA Translation: AAB07233.1
AABR07034602 Genomic DNA No translation available.
AABR07034601 Genomic DNA No translation available.
AABR07034600 Genomic DNA No translation available.
CH473999 Genomic DNA Translation: EDL78084.1
CH473999 Genomic DNA Translation: EDL78085.1
PIRiA28451
C42327
RefSeqiNP_001106815.1, NM_001113344.1 [P13721-1]
NP_671738.2, NM_147205.2
XP_006248563.1, XM_006248501.1 [P13721-1]
XP_008767014.1, XM_008768792.2 [P13721-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MPSX-ray2.40A/B95-403[»]
SMRiP13721
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP13721, 1 interactor
STRINGi10116.ENSRNOP00000002499

Chemistry databases

BindingDBiP13721
ChEMBLiCHEMBL4276

Protein family/group databases

CAZyiGT29, Glycosyltransferase Family 29

PTM databases

GlyGeniP13721, 2 sites
iPTMnetiP13721
PhosphoSitePlusiP13721

Proteomic databases

PaxDbiP13721

Genome annotation databases

EnsembliENSRNOT00000002496; ENSRNOP00000002496; ENSRNOG00000001823 [P13721-1]
ENSRNOT00000002499; ENSRNOP00000002499; ENSRNOG00000001823 [P13721-1]
GeneIDi25197
KEGGirno:25197
UCSCiRGD:3676, rat [P13721-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6480
RGDi3676, St6gal1

Phylogenomic databases

eggNOGiKOG2692, Eukaryota
GeneTreeiENSGT00940000157053
HOGENOMiCLU_038334_0_0_1
InParanoidiP13721
OMAiICVWKER
OrthoDBi494294at2759
PhylomeDBiP13721
TreeFamiTF323961

Enzyme and pathway databases

UniPathwayiUPA00378
BRENDAi2.4.99.1, 5301
ReactomeiR-RNO-4085001, Sialic acid metabolism
R-RNO-975577, N-Glycan antennae elongation
R-RNO-977068, Termination of O-glycan biosynthesis
SABIO-RKiP13721

Miscellaneous databases

Protein Ontology

More...PROi		PR:P13721

Gene expression databases

BgeeiENSRNOG00000001823, Expressed in liver and 22 other tissues

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675, Glyco_trans_29
IPR038578, GT29-like_sf
IPR012163, Sialyl_trans
PfamiView protein in Pfam
PF00777, Glyco_transf_29, 1 hit
PIRSFiPIRSF005557, Sialyl_trans, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIAT1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13721
Secondary accession number(s): D4ABR2, G3V680
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 2, 2020
Last modified: February 23, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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