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Entry version 155 (10 Feb 2021)
Sequence version 2 (02 Dec 2020)
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Protein

Beta-galactoside alpha-2,6-sialyltransferase 1

Gene

St6gal1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 35.6 min(-1) for the donor CMP-Neu5Ac (at pH 6.5 and 37 degrees Celsius). kcat is 40.3 min(-1) for the acceptor beta-Gal1,4-GlcNAc (at pH 6.5 and 37 degrees Celsius).
  1. KM=92 µM for donor CMP-Neu5Ac (at pH 6.5 and 37 degrees Celsius)
  2. KM=1.8 mM for acceptor beta-Gal1,4-GlcNAc (at pH 6.5 and 37 degrees Celsius)

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei186Substrate; via amide nitrogenBy similarity1
    Binding sitei209SubstrateBy similarity1
    Binding sitei230SubstrateBy similarity1
    Binding sitei350Substrate; via carbonyl oxygenBy similarity1
    Binding sitei351SubstrateBy similarity1
    Binding sitei362SubstrateBy similarity1
    Binding sitei366SubstrateBy similarity1
    Binding sitei373SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.99.1, 5301

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-RNO-4085001, Sialic acid metabolism
    R-RNO-975577, N-Glycan antennae elongation
    R-RNO-977068, Termination of O-glycan biosynthesis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00378

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT29, Glycosyltransferase Family 29

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 1 (EC:2.4.99.13 Publications)
    Short name:
    Alpha 2,6-ST 1
    Alternative name(s):
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
    ST6Gal I
    Short name:
    ST6GalI
    Sialyltransferase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:St6gal1
    Synonyms:Siat1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11
    • UP000234681 Componentsi: Chromosome 11, Unassembled WGS sequence

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    3676, St6gal1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9Cytoplasmic9
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
    Topological domaini27 – 403LumenalSequence analysisAdd BLAST377

    Keywords - Cellular componenti

    Golgi apparatus, Membrane, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi119Y → A: Protein destabilization. 1 Publication1
    Mutagenesisi119Y → F: No effect on protein stability, nor on catalytic activity. 1 Publication1
    Mutagenesisi180R → A: Small decrease of sialyltransferase activity. 1 Publication1
    Mutagenesisi181C → A: Loss of sialyltransferase activity and aberrant subcellular location. 1 Publication1
    Mutagenesisi208F → A: Reduced KM/Kcat values for CMP-Neu5Ac, no effect on kinetic constants for beta-Gal1,4-GlcNAc. 1 Publication1
    Mutagenesisi230N → A: Loss of catalytic activity. 1 Publication1
    Mutagenesisi231S → A: Protein destabilization. 1 Publication1
    Mutagenesisi232Q → A: Decreased catalytic activity. 1 Publication1
    Mutagenesisi271D → A: Decreased catalytic activity. 1 Publication1
    Mutagenesisi272Y → A: Strongly decreased catalytic activity. 1 Publication1
    Mutagenesisi319S → A: Protein destabilization. 1 Publication1
    Mutagenesisi332C → A: Loss of sialyltransferase activity and aberrant subcellular location. 1 Publication1
    Mutagenesisi332C → S: Loss of sialyltransferase activity. 1 Publication1
    Mutagenesisi333D → A: Small decrease of sialyltransferase activity. 1 Publication1
    Mutagenesisi350C → A: Loss of catalytic activity; when associated with A-361. 1 Publication1
    Mutagenesisi354Q → A: No effect on catalytic activity. 1 Publication1
    Mutagenesisi355K → A: No effect on catalytic activity. 1 Publication1
    Mutagenesisi361C → A: Loss of catalytic activity; when associated with A-350. 1 Publication1
    Mutagenesisi366Y → A: Loss of catalytic activity. 1 Publication1
    Mutagenesisi367H → A: Loss of catalytic activity. 1 Publication1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4276

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001492511 – 403Beta-galactoside alpha-2,6-sialyltransferase 1Add BLAST403

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi139 ↔ 403Combined sources1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi146N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Glycosylationi158N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Disulfide bondi181 ↔ 332Combined sources2 Publications
    Disulfide bondi350 ↔ 361By similarity
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei366PhosphotyrosineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    The soluble form derives from the membrane form by proteolytic processing.1 Publication
    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P13721

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P13721

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    P13721, 2 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P13721

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P13721

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in hepatocytes (at protein level) (PubMed:3121604, PubMed:11278697). Strongly expressed in liver, spleen, lung, kidney and submaxillary gland and weakly in heart and brain (PubMed:1733948, PubMed:2793863).4 Publications
    Expressed in liver.1 Publication
    Expressed in kidney, but not in liver.2 Publications
    Expressed in kidney, but not in liver.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSRNOG00000001823, Expressed in liver and 22 other tissues

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (By similarity). Monomer in its soluble form (PubMed:11278697).

    By similarity1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    P13721, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000002499

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P13721

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P13721

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 403Catalytic (soluble form)1 PublicationAdd BLAST341
    Regioni319 – 321Substrate bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2692, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_038334_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P13721

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ALHCHLR

    Database of Orthologous Groups

    More...
    OrthoDBi
    494294at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P13721

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323961

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.1480.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf
    IPR012163, Sialyl_trans

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00777, Glyco_transf_29, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF005557, Sialyl_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform RLA1 Publication (identifier: P13721-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MIHTNLKKKF SLFILVFLLF AVICVWKKGS DYEALTLQAK EFQMPKSQEK
    60 70 80 90 100
    VAMGSASQVV FSNSKQDPKE DIPILSYHRV TAKVKPQPSF QVWDKDSTYS
    110 120 130 140 150
    KLNPRLLKIW RNYLNMNKYK VSYKGPGPGV KFSVEALRCH LRDHVNVSMI
    160 170 180 190 200
    EATDFPFNTT EWEGYLPKEN FRTKVGPWQR CAVVSSAGSL KNSQLGREID
    210 220 230 240 250
    NHDAVLRFNG APTDNFQQDV GSKTTIRLMN SQLVTTEKRF LKDSLYTEGI
    260 270 280 290 300
    LIVWDPSVYH ADIPKWYQKP DYNFFETYKS YRRLNPSQPF YILKPQMPWE
    310 320 330 340 350
    LWDIIQEISA DLIQPNPPSS GMLGIIIMMT LCDQVDIYEF LPSKRKTDVC
    360 370 380 390 400
    YYHQKFFDSA CTMGAYHPLL FEKNMVKHLN EGTDEDIYLF GKATLSGFRN

    IRC
    Length:403
    Mass (Da):46,754
    Last modified:December 2, 2020 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF40D7EA6B59355DA
    GO
    Isoform RKA1 Publication (identifier: P13721-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-232: MIHTNLKKKF...KTTIRLMNSQ → MRYLLFWYGL...LSLLLLVLGK

    Note: Produced by alternative promoter usage. The alternative promoter is active in kidney.1 Publication
    Show »
    Length:214
    Mass (Da):25,210
    Checksum:i1C05C601E8B2FA10
    GO
    Isoform RKB1 Publication (identifier: P13721-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-232: MIHTNLKKKF...KTTIRLMNSQ → MRYLLFWYGLPHS

    Note: Produced by alternative splicing of isoform RKA.1 Publication
    Show »
    Length:184
    Mass (Da):21,896
    Checksum:iBC8298805ADF9013
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F2Z3S3F2Z3S3_RAT
    Beta-galactoside alpha-2,6-sialyltr...
    St6gal1
    214Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti367H → D in AAA41196 (PubMed:3121604).1
    Isoform RKA1 Publication (identifier: P13721-2)
    Sequence conflicti40V → L in AAB06269 (PubMed:1983783).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0017821 – 232MIHTN…LMNSQ → MRYLLFWYGLPHSYSQCVCH WTPASGIFENEPLLSLLLLV LGK in isoform RKA. 1 PublicationAdd BLAST232
    Alternative sequenceiVSP_0017831 – 232MIHTN…LMNSQ → MRYLLFWYGLPHS in isoform RKB. 1 PublicationAdd BLAST232

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

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    EMBLi

    GenBank nucleotide sequence database

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    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

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    DDBJi
    Links Updated
    M18769 mRNA Translation: AAA41196.1
    M73987 mRNA Translation: AAB06269.1
    M83143 mRNA Translation: AAB07233.1
    AABR07034602 Genomic DNA No translation available.
    AABR07034601 Genomic DNA No translation available.
    AABR07034600 Genomic DNA No translation available.
    CH473999 Genomic DNA Translation: EDL78084.1
    CH473999 Genomic DNA Translation: EDL78085.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A28451
    C42327

    NCBI Reference Sequences

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    RefSeqi
    NP_001106815.1, NM_001113344.1 [P13721-1]
    NP_671738.2, NM_147205.2
    XP_006248563.1, XM_006248501.1 [P13721-1]
    XP_008767014.1, XM_008768792.2 [P13721-3]

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    25197

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    rno:25197

    UCSC genome browser

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    UCSCi
    RGD:3676, rat [P13721-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M18769 mRNA Translation: AAA41196.1
    M73987 mRNA Translation: AAB06269.1
    M83143 mRNA Translation: AAB07233.1
    AABR07034602 Genomic DNA No translation available.
    AABR07034601 Genomic DNA No translation available.
    AABR07034600 Genomic DNA No translation available.
    CH473999 Genomic DNA Translation: EDL78084.1
    CH473999 Genomic DNA Translation: EDL78085.1
    PIRiA28451
    C42327
    RefSeqiNP_001106815.1, NM_001113344.1 [P13721-1]
    NP_671738.2, NM_147205.2
    XP_006248563.1, XM_006248501.1 [P13721-1]
    XP_008767014.1, XM_008768792.2 [P13721-3]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4MPSX-ray2.40A/B95-403[»]
    SMRiP13721
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    IntActiP13721, 1 interactor
    STRINGi10116.ENSRNOP00000002499

    Chemistry databases

    BindingDBiP13721
    ChEMBLiCHEMBL4276

    Protein family/group databases

    CAZyiGT29, Glycosyltransferase Family 29

    PTM databases

    GlyGeniP13721, 2 sites
    iPTMnetiP13721
    PhosphoSitePlusiP13721

    Proteomic databases

    PaxDbiP13721
    PRIDEiP13721

    Genome annotation databases

    GeneIDi25197
    KEGGirno:25197
    UCSCiRGD:3676, rat [P13721-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6480
    RGDi3676, St6gal1

    Phylogenomic databases

    eggNOGiKOG2692, Eukaryota
    HOGENOMiCLU_038334_0_0_1
    InParanoidiP13721
    OMAiALHCHLR
    OrthoDBi494294at2759
    PhylomeDBiP13721
    TreeFamiTF323961

    Enzyme and pathway databases

    UniPathwayiUPA00378
    BRENDAi2.4.99.1, 5301
    ReactomeiR-RNO-4085001, Sialic acid metabolism
    R-RNO-975577, N-Glycan antennae elongation
    R-RNO-977068, Termination of O-glycan biosynthesis

    Miscellaneous databases

    Protein Ontology

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    PROi
    PR:P13721

    Gene expression databases

    BgeeiENSRNOG00000001823, Expressed in liver and 22 other tissues

    Family and domain databases

    Gene3Di3.90.1480.20, 1 hit
    InterProiView protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf
    IPR012163, Sialyl_trans
    PfamiView protein in Pfam
    PF00777, Glyco_transf_29, 1 hit
    PIRSFiPIRSF005557, Sialyl_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIAT1_RAT
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13721
    Secondary accession number(s): D4ABR2, G3V680
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: December 2, 2020
    Last modified: February 10, 2021
    This is version 155 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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