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Entry version 174 (17 Jun 2020)
Sequence version 2 (21 Jun 2005)
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Protein

Homeotic protein female sterile

Gene

fs(1)h

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8951936 RUNX3 regulates p14-ARF

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeotic protein female sterile
Alternative name(s):
Fragile-chorion membrane protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fs(1)h
Synonyms:fsh
ORF Names:CG2252
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004656 fs(1)h

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Transmembranei750 – 770HelicalSequence analysisAdd BLAST21
Transmembranei790 – 810HelicalSequence analysisAdd BLAST21
Transmembranei816 – 830HelicalSequence analysisAdd BLAST15
Transmembranei874 – 894HelicalSequence analysisAdd BLAST21
Transmembranei1731 – 1751HelicalSequence analysisAdd BLAST21
Transmembranei1939 – 1959HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111941 – 2038Homeotic protein female sterileAdd BLAST2038

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei452Phosphoserine1 Publication1
Modified residuei943Phosphoserine1 Publication1
Modified residuei1653Phosphoserine1 Publication1
Modified residuei1980Phosphoserine1 Publication1
Modified residuei1988Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13709

PRoteomics IDEntifications database

More...
PRIDEi
P13709

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13709

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004656 Expressed in female gonad and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13709 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13709 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58193, 26 interactors

Database of interacting proteins

More...
DIPi
DIP-19376N

Protein interaction database and analysis system

More...
IntActi
P13709, 29 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305499

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P13709

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 123Bromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini495 – 567Bromo 2PROSITE-ProRule annotationAdd BLAST73
Domaini942 – 1024NETPROSITE-ProRule annotationAdd BLAST83

Keywords - Domaini

Bromodomain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1474 Eukaryota
COG5076 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001499_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P13709

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGETGPM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13709

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.220, 1 hit
1.20.920.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031354 BRD4_CDT
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027353 NET_dom
IPR038336 NET_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17035 BET, 1 hit
PF17105 BRD4_CDT, 1 hit
PF00439 Bromodomain, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
PS51525 NET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P13709-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSEPPPRY EPPVEPVNGI VQPPVIPPAE RPGRNTNQLQ YLIKTVMKVI
60 70 80 90 100
WKHHFSWPFQ QPVDAKKLNL PDYHKIIKQP MDMGTIKKRL ENNYYWSAKE
110 120 130 140 150
TIQDFNTMFN NCYVYNKPGE DVVVMAQTLE KVFLQKIESM PKEELELEPV
160 170 180 190 200
TAKGGKKKQR APATPKSSSG GAGASTGSGT SSAAVTSGPG SGSTKVSVAA
210 220 230 240 250
SSAQQSGLQG ATGAGGGSSS TPGTQPGSGA GGAIAARPVS AMGGTVSSTA
260 270 280 290 300
GGAPSIPPIS TMPPHTVPGS TNTTTTAMAG GVGGPGAAGA NPNAAALMAS
310 320 330 340 350
LLNAGQTGAY PGAPGQTAVN SSSLLDGSTA AVAAAAAAAA AAAAAAGGAA
360 370 380 390 400
GAAGGAGTIP AVAVNAANAV QAYVNAGVSV GVDAVIPPQQ PAKIKKGVKR
410 420 430 440 450
KADTTTPTAN AFESPYTQMD SKSAKIATRR ESNRQDLTFQ GSGYNMSPLG
460 470 480 490 500
VSGVPGLGGL VAGGVAGVAV AKNKEKLSDA LKSCNEILKE LFSKKHSGYA
510 520 530 540 550
WPFYKPVDAE MLGLHDYHDI IKKPMDLGTV KRKMDNREYK SAPEFAADVR
560 570 580 590 600
LIFTNCYKYN PPDHDVVAMG RKLQDVFEMR YANIPDEPVA NAAHHHGHGH
610 620 630 640 650
GHGHGHGHGH GHGHGHGHGH GYGGSSSLKH DASDSSSEDS SDTENESNSD
660 670 680 690 700
EERSARLKML ESKLLGLQEE IRKLSEEASA KKKAKKKLKE KKKSIGGGSG
710 720 730 740 750
SGSASHHCHA TGGGANAGGA GGPGSGGHGS VSVPGGVGSL GPGGAGGANL
760 770 780 790 800
NALLGGSLVG HGGAAVAGGV PNVGALHSQV HDVAMAFSQM AGGGAAAGAG
810 820 830 840 850
FGAGVTAAGA SSGGKAGTLA GALAAGAAAG AGGTTAGSGS SKGAKSKGGR
860 870 880 890 900
GAKGSGAGGV GASNNAAAGN AAGGAAGAAA GAGSVGGVGG AGAAGGGNAS
910 920 930 940 950
KRAKGSSSAG AGGGVGGANA SAGGAGARGS SKKKPSQVMN FDSEEEDTAK
960 970 980 990 1000
PMSYDEKRQL SLDINKLPGD KLGRVVHIIQ NREPSLRDSN PDEIEIDFET
1010 1020 1030 1040 1050
LKPSTLRELE SYVASCLRKK THKKPSGKSK DEQMAEKKQE LEKRLQDVTG
1060 1070 1080 1090 1100
QLGASKKTAK KDESASSKVE AVQPANPVSS SSSSSDSSSS SSSDSSSSDS
1110 1120 1130 1140 1150
SDSEAGDGDE RPPRKKKSRD SNGSNVNNPS INVVMGGNLP SGALSPTTML
1160 1170 1180 1190 1200
MGLDHVVNSN TPTSQMSNML GNANPLTAAA MLNNNNKTSL PGSNFGGAPA
1210 1220 1230 1240 1250
PGNMMHAGAG VPVAGAAVSA STGQQHNKNG PNDLSKVQPG GPINAALPPH
1260 1270 1280 1290 1300
SFAGGTATVA TSQSSGGIRI ASNLHKPSGL GGGDLGEHHA ALAAALTSGI
1310 1320 1330 1340 1350
NSTGTAGGGI NNNGGSNNNA NPLGGSHGDA MVNASLASLA SGLKQIPQFD
1360 1370 1380 1390 1400
DPVEQSLASL EFSAGSTGKS GLTDNFLMQQ HLMQPAGPQQ QQQQQQQQPF
1410 1420 1430 1440 1450
GHQQQQQQQQ QQQQQQQQHM DYVTELLSKG AENVGGMNGN HLLNFNLDMA
1460 1470 1480 1490 1500
AAYQQKHPQQ QQQQAHNNGF NVADFGMAGF DGLNMTAASF LDLEPSLQQQ
1510 1520 1530 1540 1550
QMQQMQLQQQ HHQQQQQQTH QQQQQHQQQH HQQQQQQQLT QQQLQQQQQQ
1560 1570 1580 1590 1600
QQQQQHLQQQ QHQQQHHQAA NKLLIIPKPI ESMMPSPPDK QQLQQHQKVL
1610 1620 1630 1640 1650
PPQQSPSDMK LHPNAAAAAA VASAQAKLVQ TFKANEQNLK NASSWSSLAS
1660 1670 1680 1690 1700
ANSPQSHTSS SSSSSKAKPA MDSFQQFRNK AKERDRLKLL EAAEKEKKNQ
1710 1720 1730 1740 1750
KEAAEKEQQR KHHKSSSSSL TSAAVAQAAA IAAATAAAAV TLGAAAAAAL
1760 1770 1780 1790 1800
ASSASNPSGG SSSGGAGSTS QQAITGDRDR DRDRERERER SGSGGGQSGN
1810 1820 1830 1840 1850
GNNSSNSANS NGPGSAGSGG SGGGGGSGPA SAGGPNSGGG GTANSNSGGG
1860 1870 1880 1890 1900
GGGGGPALLN AGSNSNSGVG SGGAASSNSN SSVGGIVGSG GPGSNSQGSS
1910 1920 1930 1940 1950
GGGGGGPASG GGMGSGAIDY GQQVAVLTQV AANAQAQHVA AAVAAQAILA
1960 1970 1980 1990 2000
ASPLGAMESG RKSVHDAQPQ ISRVEDIKAS PGGQGQSSPA QQSPQDRAAA
2010 2020 2030
KRAEQRRAEQ ERRRREALAG QIDMNMQSDL MAAFEETL
Length:2,038
Mass (Da):205,345
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC4A1A7B1266191E
GO
Isoform A (identifier: P13709-2) [UniParc]FASTAAdd to basket
Also known as: C, D, E

The sequence of this isoform differs from the canonical sequence as follows:
     1022-1022: H → RKPYY
     1107-2038: Missing.

Show »
Length:1,110
Mass (Da):110,620
Checksum:i9E60DC63BB2DC524
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PJC7M9PJC7_DROME
Female sterile (1) homeotic, isofor...
fs(1)h 26A, anon-EST:fe1G2, anon-EST:Liang-1.81, clone 1.81, Dmel\CG2252
2,046Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJJ8E1JJJ8_DROME
Female sterile (1) homeotic, isofor...
fs(1)h 26A, anon-EST:fe1G2, anon-EST:Liang-1.81, clone 1.81, Dmel\CG2252
1,110Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PE02M9PE02_DROME
Female sterile (1) homeotic, isofor...
fs(1)h 26A, anon-EST:fe1G2, anon-EST:Liang-1.81, clone 1.81, Dmel\CG2252
1,105Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGM8M9PGM8_DROME
Female sterile (1) homeotic, isofor...
fs(1)h 26A, anon-EST:fe1G2, anon-EST:Liang-1.81, clone 1.81, Dmel\CG2252
1,115Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti909A → G in AAA28540 (PubMed:2567251).Curated1
Sequence conflicti1403Q → QQ in AAA28540 (PubMed:2567251).Curated1
Sequence conflicti1532Missing in AAA28540 (PubMed:2567251).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0141481022H → RKPYY in isoform A. 2 Publications1
Alternative sequenceiVSP_0141491107 – 2038Missing in isoform A. 2 PublicationsAdd BLAST932

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23221 mRNA Translation: AAA28540.1
M23222 mRNA Translation: AAA28541.1
AE014298 Genomic DNA Translation: AAF46312.3
AE014298 Genomic DNA Translation: AAN09226.1
AE014298 Genomic DNA Translation: AAS65277.1
AE014298 Genomic DNA Translation: AAS65278.1
AE014298 Genomic DNA Translation: AAS65279.1
BT015270 mRNA Translation: AAT94499.1
M15762 Genomic DNA Translation: AAA70424.1
M15763 mRNA Translation: AAA70423.1
M15764 mRNA Translation: AAA70422.1

Protein sequence database of the Protein Information Resource

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PIRi
A43742

NCBI Reference Sequences

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RefSeqi
NP_001162699.1, NM_001169228.2 [P13709-2]
NP_511078.2, NM_078523.3 [P13709-1]
NP_727228.1, NM_167144.4 [P13709-2]
NP_996368.1, NM_206645.4 [P13709-2]
NP_996369.1, NM_206646.4 [P13709-2]
NP_996370.1, NM_206647.3 [P13709-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071118; FBpp0071073; FBgn0004656 [P13709-2]
FBtr0071119; FBpp0071074; FBgn0004656 [P13709-1]
FBtr0071120; FBpp0089297; FBgn0004656 [P13709-2]
FBtr0071121; FBpp0089298; FBgn0004656 [P13709-2]
FBtr0071122; FBpp0089299; FBgn0004656 [P13709-2]
FBtr0301309; FBpp0290524; FBgn0004656 [P13709-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
31722

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2252

UCSC genome browser

More...
UCSCi
CG2252-RC d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23221 mRNA Translation: AAA28540.1
M23222 mRNA Translation: AAA28541.1
AE014298 Genomic DNA Translation: AAF46312.3
AE014298 Genomic DNA Translation: AAN09226.1
AE014298 Genomic DNA Translation: AAS65277.1
AE014298 Genomic DNA Translation: AAS65278.1
AE014298 Genomic DNA Translation: AAS65279.1
BT015270 mRNA Translation: AAT94499.1
M15762 Genomic DNA Translation: AAA70424.1
M15763 mRNA Translation: AAA70423.1
M15764 mRNA Translation: AAA70422.1
PIRiA43742
RefSeqiNP_001162699.1, NM_001169228.2 [P13709-2]
NP_511078.2, NM_078523.3 [P13709-1]
NP_727228.1, NM_167144.4 [P13709-2]
NP_996368.1, NM_206645.4 [P13709-2]
NP_996369.1, NM_206646.4 [P13709-2]
NP_996370.1, NM_206647.3 [P13709-2]

3D structure databases

SMRiP13709
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58193, 26 interactors
DIPiDIP-19376N
IntActiP13709, 29 interactors
STRINGi7227.FBpp0305499

PTM databases

iPTMnetiP13709

Proteomic databases

PaxDbiP13709
PRIDEiP13709

Genome annotation databases

EnsemblMetazoaiFBtr0071118; FBpp0071073; FBgn0004656 [P13709-2]
FBtr0071119; FBpp0071074; FBgn0004656 [P13709-1]
FBtr0071120; FBpp0089297; FBgn0004656 [P13709-2]
FBtr0071121; FBpp0089298; FBgn0004656 [P13709-2]
FBtr0071122; FBpp0089299; FBgn0004656 [P13709-2]
FBtr0301309; FBpp0290524; FBgn0004656 [P13709-2]
GeneIDi31722
KEGGidme:Dmel_CG2252
UCSCiCG2252-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31722
FlyBaseiFBgn0004656 fs(1)h

Phylogenomic databases

eggNOGiKOG1474 Eukaryota
COG5076 LUCA
HOGENOMiCLU_001499_3_0_1
InParanoidiP13709
OMAiDGETGPM
PhylomeDBiP13709

Enzyme and pathway databases

ReactomeiR-DME-8951936 RUNX3 regulates p14-ARF

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
31722 1 hit in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
fs(1)h fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31722

Protein Ontology

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PROi
PR:P13709

Gene expression databases

BgeeiFBgn0004656 Expressed in female gonad and 35 other tissues
ExpressionAtlasiP13709 baseline and differential
GenevisibleiP13709 DM

Family and domain databases

Gene3Di1.20.1270.220, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR031354 BRD4_CDT
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027353 NET_dom
IPR038336 NET_sf
PfamiView protein in Pfam
PF17035 BET, 1 hit
PF17105 BRD4_CDT, 1 hit
PF00439 Bromodomain, 2 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
PS51525 NET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSH_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13709
Secondary accession number(s): A4V442
, P13710, Q8IRN6, Q9W3L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 21, 2005
Last modified: June 17, 2020
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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