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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Gene

Gpd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41NADBy similarity1
Binding sitei97NADBy similarity1
Binding sitei120SubstrateBy similarity1
Binding sitei153NAD; via amide nitrogenBy similarity1
Active sitei204Proton acceptorSequence analysis1
Binding sitei269NADBy similarity1
Binding sitei296NAD; via amide nitrogenBy similarity1
Binding sitei298NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA
SABIO-RKiP13707

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:Gpd1
Synonyms:Gdc-1, Gdc1, Kiaa4010
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:95679 Gpd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380801 – 349Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154PhosphoserineBy similarity1
Modified residuei289N6-succinyllysineCombined sources1
Modified residuei326PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP13707
PaxDbiP13707
PeptideAtlasiP13707
PRIDEiP13707

2D gel databases

REPRODUCTION-2DPAGEiIPI00230185
P13707
SWISS-2DPAGEiP13707

PTM databases

iPTMnetiP13707
PhosphoSitePlusiP13707
SwissPalmiP13707

Expressioni

Gene expression databases

BgeeiENSMUSG00000023019 Expressed in 255 organ(s), highest expression level in brown adipose tissue
CleanExiMM_GPD1
ExpressionAtlasiP13707 baseline and differential
GenevisibleiP13707 MM

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP13707, 7 interactors
MINTiP13707
STRINGi10090.ENSMUSP00000023760

Structurei

3D structure databases

ProteinModelPortaliP13707
SMRiP13707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni269 – 270Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2711 Eukaryota
COG0240 LUCA
GeneTreeiENSGT00390000003114
HOGENOMiHOG000246855
HOVERGENiHBG003669
InParanoidiP13707
KOiK00006
OMAiWLCKGFE
OrthoDBiEOG091G0DO6
PhylomeDBiP13707
TreeFamiTF300836

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13707-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKKVCIVG SGNWGSAIAK IVGSNAGRLA HFDPRVTMWV FEEDIGGRKL
60 70 80 90 100
TEIINTQHEN VKYLPGHKLP PNVVAIPDVV QAATGADILV FVVPHQFIGK
110 120 130 140 150
ICDQLKGHLK ANTIGISLIK GVDEGPNGLK LISEVIGERL GIPMSVLMGA
160 170 180 190 200
NIASEVAEEK FCETTIGCKD PAQGQLLKDL MQTPNFRITV VQEVDTVEIC
210 220 230 240 250
GALKNIVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGTVSSA
260 270 280 290 300
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE MLNGQKLQGP
310 320 330 340
QTARELHSIL QHKGLVDKFP LFTAVYKVCY EGQPVGEFIR CLQNHPEHM
Length:349
Mass (Da):37,573
Last modified:January 23, 2007 - v3
Checksum:iF2C572DADFEA1B99
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXN5E0CXN5_MOUSE
Glycerol-3-phosphate dehydrogenase ...
Gpd1
326Annotation score:

Sequence cautioni

The sequence BAD90479 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218G → R AA sequence (Ref. 7) Curated1
Sequence conflicti246T → I in AAA37726 (PubMed:3755721).Curated1
Sequence conflicti246T → I in AAA37727 (PubMed:3755721).Curated1
Sequence conflicti246T → I in BAD90479 (Ref. 4) Curated1
Sequence conflicti318K → R in BAE23246 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02655 mRNA Translation: AAA37728.1
M25558 Genomic DNA Translation: AAA37726.1
M13366 Genomic DNA Translation: AAA37727.1
AK220445 mRNA Translation: BAD90479.1 Different initiation.
AK137134 mRNA Translation: BAE23246.1
AK004565 mRNA Translation: BAB23376.1
AK018733 mRNA Translation: BAB31376.1
BC005756 mRNA Translation: AAH05756.1
BC019391 mRNA Translation: AAH19391.1
CCDSiCCDS27828.1
PIRiA25952
RefSeqiNP_034401.1, NM_010271.2
UniGeneiMm.252391

Genome annotation databases

EnsembliENSMUST00000023760; ENSMUSP00000023760; ENSMUSG00000023019
GeneIDi14555
KEGGimmu:14555
UCSCiuc007xqd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02655 mRNA Translation: AAA37728.1
M25558 Genomic DNA Translation: AAA37726.1
M13366 Genomic DNA Translation: AAA37727.1
AK220445 mRNA Translation: BAD90479.1 Different initiation.
AK137134 mRNA Translation: BAE23246.1
AK004565 mRNA Translation: BAB23376.1
AK018733 mRNA Translation: BAB31376.1
BC005756 mRNA Translation: AAH05756.1
BC019391 mRNA Translation: AAH19391.1
CCDSiCCDS27828.1
PIRiA25952
RefSeqiNP_034401.1, NM_010271.2
UniGeneiMm.252391

3D structure databases

ProteinModelPortaliP13707
SMRiP13707
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP13707, 7 interactors
MINTiP13707
STRINGi10090.ENSMUSP00000023760

Chemistry databases

ChEMBLiCHEMBL1075171

PTM databases

iPTMnetiP13707
PhosphoSitePlusiP13707
SwissPalmiP13707

2D gel databases

REPRODUCTION-2DPAGEiIPI00230185
P13707
SWISS-2DPAGEiP13707

Proteomic databases

MaxQBiP13707
PaxDbiP13707
PeptideAtlasiP13707
PRIDEiP13707

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023760; ENSMUSP00000023760; ENSMUSG00000023019
GeneIDi14555
KEGGimmu:14555
UCSCiuc007xqd.1 mouse

Organism-specific databases

CTDi2819
MGIiMGI:95679 Gpd1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2711 Eukaryota
COG0240 LUCA
GeneTreeiENSGT00390000003114
HOGENOMiHOG000246855
HOVERGENiHBG003669
InParanoidiP13707
KOiK00006
OMAiWLCKGFE
OrthoDBiEOG091G0DO6
PhylomeDBiP13707
TreeFamiTF300836

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA
SABIO-RKiP13707

Miscellaneous databases

ChiTaRSiGpd1 mouse
PROiPR:P13707
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023019 Expressed in 255 organ(s), highest expression level in brown adipose tissue
CleanExiMM_GPD1
ExpressionAtlasiP13707 baseline and differential
GenevisibleiP13707 MM

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPDA_MOUSE
AccessioniPrimary (citable) accession number: P13707
Secondary accession number(s): Q3UVM3, Q5DTS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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