Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translationally-controlled tumor protein

Gene

TPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • calcium ion transport Source: UniProtKB
  • cellular calcium ion homeostasis Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • regulation of apoptotic process Source: UniProtKB
  • response to virus Source: UniProtKB

Keywordsi

LigandCalcium

Enzyme and pathway databases

SIGNORiP13693

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Alternative name(s):
Fortilin
Histamine-releasing factor
Short name:
HRF
p23
Gene namesi
Name:TPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000133112.16
HGNCiHGNC:12022 TPT1
MIMi600763 gene
neXtProtiNX_P13693

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi7178
OpenTargetsiENSG00000133112
PharmGKBiPA36701

Protein family/group databases

Allergomei3816 Hom s TCTP

Polymorphism and mutation databases

DMDMi136479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112681 – 172Translationally-controlled tumor proteinAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Phosphoserine; by PLK1Combined sources1 Publication1
Modified residuei53PhosphoserineCombined sources1
Modified residuei64Phosphoserine; by PLK11 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP13693
MaxQBiP13693
PaxDbiP13693
PeptideAtlasiP13693
PRIDEiP13693
ProteomicsDBi52972
TopDownProteomicsiP13693-1 [P13693-1]

2D gel databases

DOSAC-COBS-2DPAGEiP13693
OGPiP13693
REPRODUCTION-2DPAGEiIPI00550900
SWISS-2DPAGEiP13693

PTM databases

iPTMnetiP13693
PhosphoSitePlusiP13693
SwissPalmiP13693

Expressioni

Tissue specificityi

Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.1 Publication

Inductioni

Down-regulated in response to enterovirus 71 (EV71) infection.1 Publication

Gene expression databases

BgeeiENSG00000133112 Expressed in 246 organ(s), highest expression level in pericardium
CleanExiHS_TPT1
ExpressionAtlasiP13693 baseline and differential
GenevisibleiP13693 HS

Organism-specific databases

HPAiCAB008364
HPA039437

Interactioni

Subunit structurei

Interacts with STEAP3.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi113030, 35 interactors
DIPiDIP-40097N
IntActiP13693, 41 interactors
MINTiP13693
STRINGi9606.ENSP00000431872

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13693
SMRiP13693
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13693

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172TCTPPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727 Eukaryota
ENOG4111FVP LUCA
GeneTreeiENSGT00390000006051
HOGENOMiHOG000203361
HOVERGENiHBG002282
InParanoidiP13693
PhylomeDBiP13693
TreeFamiTF300238

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p
PANTHERiPTHR11991 PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838 TCTP, 1 hit
PRINTSiPR01653 TCTPROTEIN
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01002 TCTP_1, 1 hit
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13693-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK
110 120 130 140 150
GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPYM IFFKDGLEME KC
Length:172
Mass (Da):19,595
Last modified:January 1, 1990 - v1
Checksum:iBD31399B71CA62F9
GO
Isoform 2 (identifier: P13693-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:138
Mass (Da):15,597
Checksum:iFD4A670AEFAC61FB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2C3A0A0B4J2C3_HUMAN
Translationally-controlled tumor pr...
TPT1 hCG_32792
197Annotation score:
Q5W0H4Q5W0H4_HUMAN
Translationally-controlled tumor pr...
TPT1
188Annotation score:
J3KPG2J3KPG2_HUMAN
Translationally-controlled tumor pr...
TPT1
160Annotation score:
E9PJF7E9PJF7_HUMAN
Translationally-controlled tumor pr...
TPT1
162Annotation score:
H0YCX0H0YCX0_HUMAN
Translationally-controlled tumor pr...
TPT1
77Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53 – 54SA → YG in AAH12431 (PubMed:15489334).Curated2
Sequence conflicti168E → K in AAQ01550 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052273146V → F. Corresponds to variant dbSNP:rs3087989Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0548381 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16064 mRNA Translation: CAA34200.1
AJ400717 Genomic DNA Translation: CAB87812.1
AY334563 mRNA Translation: AAQ01550.1
AY117678 mRNA Translation: AAM51565.1
CR457036 mRNA Translation: CAG33317.1
AK312951 mRNA Translation: BAG35792.1
AL138963 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08731.1
CH471075 Genomic DNA Translation: EAX08732.1
BC003352 mRNA Translation: AAH03352.1
BC012431 mRNA Translation: AAH12431.1
BC022436 mRNA Translation: AAH22436.1
BC052333 mRNA Translation: AAH52333.1
CCDSiCCDS66538.1 [P13693-2]
CCDS9397.1 [P13693-1]
PIRiS06590
RefSeqiNP_001273202.1, NM_001286273.1 [P13693-2]
NP_003286.1, NM_003295.3 [P13693-1]
UniGeneiHs.374596
Hs.717316

Genome annotation databases

EnsembliENST00000379055; ENSP00000368344; ENSG00000133112 [P13693-2]
ENST00000379056; ENSP00000368345; ENSG00000133112 [P13693-2]
ENST00000530705; ENSP00000431872; ENSG00000133112 [P13693-1]
GeneIDi7178
KEGGihsa:7178
UCSCiuc001uzy.3 human [P13693-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16064 mRNA Translation: CAA34200.1
AJ400717 Genomic DNA Translation: CAB87812.1
AY334563 mRNA Translation: AAQ01550.1
AY117678 mRNA Translation: AAM51565.1
CR457036 mRNA Translation: CAG33317.1
AK312951 mRNA Translation: BAG35792.1
AL138963 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08731.1
CH471075 Genomic DNA Translation: EAX08732.1
BC003352 mRNA Translation: AAH03352.1
BC012431 mRNA Translation: AAH12431.1
BC022436 mRNA Translation: AAH22436.1
BC052333 mRNA Translation: AAH52333.1
CCDSiCCDS66538.1 [P13693-2]
CCDS9397.1 [P13693-1]
PIRiS06590
RefSeqiNP_001273202.1, NM_001286273.1 [P13693-2]
NP_003286.1, NM_003295.3 [P13693-1]
UniGeneiHs.374596
Hs.717316

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZ1X-ray2.00A/B/C/D1-172[»]
2HR9NMR-A1-172[»]
3EBMX-ray2.60A/B/C/D1-172[»]
4Z9VX-ray2.10C/D/E/F/G/H11-31[»]
5O9LX-ray1.75A/B1-172[»]
5O9MX-ray1.40A/B1-172[»]
ProteinModelPortaliP13693
SMRiP13693
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113030, 35 interactors
DIPiDIP-40097N
IntActiP13693, 41 interactors
MINTiP13693
STRINGi9606.ENSP00000431872

Protein family/group databases

Allergomei3816 Hom s TCTP

PTM databases

iPTMnetiP13693
PhosphoSitePlusiP13693
SwissPalmiP13693

Polymorphism and mutation databases

DMDMi136479

2D gel databases

DOSAC-COBS-2DPAGEiP13693
OGPiP13693
REPRODUCTION-2DPAGEiIPI00550900
SWISS-2DPAGEiP13693

Proteomic databases

EPDiP13693
MaxQBiP13693
PaxDbiP13693
PeptideAtlasiP13693
PRIDEiP13693
ProteomicsDBi52972
TopDownProteomicsiP13693-1 [P13693-1]

Protocols and materials databases

DNASUi7178
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379055; ENSP00000368344; ENSG00000133112 [P13693-2]
ENST00000379056; ENSP00000368345; ENSG00000133112 [P13693-2]
ENST00000530705; ENSP00000431872; ENSG00000133112 [P13693-1]
GeneIDi7178
KEGGihsa:7178
UCSCiuc001uzy.3 human [P13693-1]

Organism-specific databases

CTDi7178
DisGeNETi7178
EuPathDBiHostDB:ENSG00000133112.16
GeneCardsiTPT1
HGNCiHGNC:12022 TPT1
HPAiCAB008364
HPA039437
MIMi600763 gene
neXtProtiNX_P13693
OpenTargetsiENSG00000133112
PharmGKBiPA36701
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1727 Eukaryota
ENOG4111FVP LUCA
GeneTreeiENSGT00390000006051
HOGENOMiHOG000203361
HOVERGENiHBG002282
InParanoidiP13693
PhylomeDBiP13693
TreeFamiTF300238

Enzyme and pathway databases

SIGNORiP13693

Miscellaneous databases

ChiTaRSiTPT1 human
EvolutionaryTraceiP13693
GeneWikiiTPT1
Translationally-controlled_tumor_protein
GenomeRNAii7178
PROiPR:P13693
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133112 Expressed in 246 organ(s), highest expression level in pericardium
CleanExiHS_TPT1
ExpressionAtlasiP13693 baseline and differential
GenevisibleiP13693 HS

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p
PANTHERiPTHR11991 PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838 TCTP, 1 hit
PRINTSiPR01653 TCTPROTEIN
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01002 TCTP_1, 1 hit
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCTP_HUMAN
AccessioniPrimary (citable) accession number: P13693
Secondary accession number(s): B2R7E5
, Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 199 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again