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Protein

Translationally-controlled tumor protein

Gene

TPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in calcium binding and microtubule stabilization.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • calcium ion transport Source: UniProtKB
  • cellular calcium ion homeostasis Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • regulation of apoptotic process Source: UniProtKB
  • response to virus Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P13693

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Alternative name(s):
Fortilin
Histamine-releasing factor
Short name:
HRF
p23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000133112.16

Human Gene Nomenclature Database

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HGNCi
HGNC:12022 TPT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600763 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13693

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7178

Open Targets

More...
OpenTargetsi
ENSG00000133112

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36701

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3816 Hom s TCTP

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
136479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112681 – 172Translationally-controlled tumor proteinAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei46Phosphoserine; by PLK1Combined sources1 Publication1
Modified residuei53PhosphoserineCombined sources1
Modified residuei64Phosphoserine; by PLK11 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13693

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P13693

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13693

PeptideAtlas

More...
PeptideAtlasi
P13693

PRoteomics IDEntifications database

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PRIDEi
P13693

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52972

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P13693-1 [P13693-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P13693

USC-OGP 2-DE database

More...
OGPi
P13693

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00550900

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P13693

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13693

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13693

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13693

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in response to enterovirus 71 (EV71) infection.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133112 Expressed in 246 organ(s), highest expression level in pericardium

CleanEx database of gene expression profiles

More...
CleanExi
HS_TPT1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13693 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13693 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008364
HPA039437

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STEAP3.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113030, 35 interactors

Database of interacting proteins

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DIPi
DIP-40097N

Protein interaction database and analysis system

More...
IntActi
P13693, 41 interactors

Molecular INTeraction database

More...
MINTi
P13693

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000431872

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13693

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13693

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P13693

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 172TCTPPROSITE-ProRule annotationAdd BLAST172

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1727 Eukaryota
ENOG4111FVP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000203361

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002282

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13693

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13693

TreeFam database of animal gene trees

More...
TreeFami
TF300238

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p

The PANTHER Classification System

More...
PANTHERi
PTHR11991 PTHR11991, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00838 TCTP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01653 TCTPROTEIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51316 SSF51316, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01002 TCTP_1, 1 hit
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13693-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK
110 120 130 140 150
GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPYM IFFKDGLEME KC
Length:172
Mass (Da):19,595
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD31399B71CA62F9
GO
Isoform 2 (identifier: P13693-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:138
Mass (Da):15,597
Checksum:iFD4A670AEFAC61FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2C3A0A0B4J2C3_HUMAN
Translationally-controlled tumor pr...
TPT1 hCG_32792
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5W0H4Q5W0H4_HUMAN
Translationally-controlled tumor pr...
TPT1
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPG2J3KPG2_HUMAN
Translationally-controlled tumor pr...
TPT1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJF7E9PJF7_HUMAN
Translationally-controlled tumor pr...
TPT1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCX0H0YCX0_HUMAN
Translationally-controlled tumor pr...
TPT1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53 – 54SA → YG in AAH12431 (PubMed:15489334).Curated2
Sequence conflicti168E → K in AAQ01550 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052273146V → F. Corresponds to variant dbSNP:rs3087989Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548381 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16064 mRNA Translation: CAA34200.1
AJ400717 Genomic DNA Translation: CAB87812.1
AY334563 mRNA Translation: AAQ01550.1
AY117678 mRNA Translation: AAM51565.1
CR457036 mRNA Translation: CAG33317.1
AK312951 mRNA Translation: BAG35792.1
AL138963 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08731.1
CH471075 Genomic DNA Translation: EAX08732.1
BC003352 mRNA Translation: AAH03352.1
BC012431 mRNA Translation: AAH12431.1
BC022436 mRNA Translation: AAH22436.1
BC052333 mRNA Translation: AAH52333.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66538.1 [P13693-2]
CCDS9397.1 [P13693-1]

Protein sequence database of the Protein Information Resource

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PIRi
S06590

NCBI Reference Sequences

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RefSeqi
NP_001273202.1, NM_001286273.1 [P13693-2]
NP_003286.1, NM_003295.3 [P13693-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.374596
Hs.717316

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379055; ENSP00000368344; ENSG00000133112 [P13693-2]
ENST00000379056; ENSP00000368345; ENSG00000133112 [P13693-2]
ENST00000530705; ENSP00000431872; ENSG00000133112 [P13693-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7178

UCSC genome browser

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UCSCi
uc001uzy.3 human [P13693-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16064 mRNA Translation: CAA34200.1
AJ400717 Genomic DNA Translation: CAB87812.1
AY334563 mRNA Translation: AAQ01550.1
AY117678 mRNA Translation: AAM51565.1
CR457036 mRNA Translation: CAG33317.1
AK312951 mRNA Translation: BAG35792.1
AL138963 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08731.1
CH471075 Genomic DNA Translation: EAX08732.1
BC003352 mRNA Translation: AAH03352.1
BC012431 mRNA Translation: AAH12431.1
BC022436 mRNA Translation: AAH22436.1
BC052333 mRNA Translation: AAH52333.1
CCDSiCCDS66538.1 [P13693-2]
CCDS9397.1 [P13693-1]
PIRiS06590
RefSeqiNP_001273202.1, NM_001286273.1 [P13693-2]
NP_003286.1, NM_003295.3 [P13693-1]
UniGeneiHs.374596
Hs.717316

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZ1X-ray2.00A/B/C/D1-172[»]
2HR9NMR-A1-172[»]
3EBMX-ray2.60A/B/C/D1-172[»]
4Z9VX-ray2.10C/D/E/F/G/H11-31[»]
5O9LX-ray1.75A/B1-172[»]
5O9MX-ray1.40A/B1-172[»]
ProteinModelPortaliP13693
SMRiP13693
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113030, 35 interactors
DIPiDIP-40097N
IntActiP13693, 41 interactors
MINTiP13693
STRINGi9606.ENSP00000431872

Protein family/group databases

Allergomei3816 Hom s TCTP

PTM databases

iPTMnetiP13693
PhosphoSitePlusiP13693
SwissPalmiP13693

Polymorphism and mutation databases

DMDMi136479

2D gel databases

DOSAC-COBS-2DPAGEiP13693
OGPiP13693
REPRODUCTION-2DPAGEiIPI00550900
SWISS-2DPAGEiP13693

Proteomic databases

EPDiP13693
MaxQBiP13693
PaxDbiP13693
PeptideAtlasiP13693
PRIDEiP13693
ProteomicsDBi52972
TopDownProteomicsiP13693-1 [P13693-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7178
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379055; ENSP00000368344; ENSG00000133112 [P13693-2]
ENST00000379056; ENSP00000368345; ENSG00000133112 [P13693-2]
ENST00000530705; ENSP00000431872; ENSG00000133112 [P13693-1]
GeneIDi7178
KEGGihsa:7178
UCSCiuc001uzy.3 human [P13693-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7178
DisGeNETi7178
EuPathDBiHostDB:ENSG00000133112.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TPT1
HGNCiHGNC:12022 TPT1
HPAiCAB008364
HPA039437
MIMi600763 gene
neXtProtiNX_P13693
OpenTargetsiENSG00000133112
PharmGKBiPA36701

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1727 Eukaryota
ENOG4111FVP LUCA
GeneTreeiENSGT00390000006051
HOGENOMiHOG000203361
HOVERGENiHBG002282
InParanoidiP13693
PhylomeDBiP13693
TreeFamiTF300238

Enzyme and pathway databases

SIGNORiP13693

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TPT1 human
EvolutionaryTraceiP13693

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TPT1
Translationally-controlled_tumor_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7178

Protein Ontology

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PROi
PR:P13693

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133112 Expressed in 246 organ(s), highest expression level in pericardium
CleanExiHS_TPT1
ExpressionAtlasiP13693 baseline and differential
GenevisibleiP13693 HS

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p
PANTHERiPTHR11991 PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838 TCTP, 1 hit
PRINTSiPR01653 TCTPROTEIN
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01002 TCTP_1, 1 hit
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCTP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13693
Secondary accession number(s): B2R7E5
, Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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