CEACAM1

Functionⁱ

Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity).

Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763).

Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226).

Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730).

Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763).

Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226).

Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity).

Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity).

Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity).

Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity).

Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity).

Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity).

Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724).

Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity).

Negatively regulates osteoclastogenesis (By similarity).

By similarity4 Publications

Isoform 8:

Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity).

Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity).

By similarity

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

PathwayCommonsⁱ	P13688
Reactomeⁱ	R-HSA-1566977, Fibronectin matrix formation R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-6798695, Neutrophil degranulation
SignaLinkⁱ	P13688
SIGNORⁱ	P13688

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Carcinoembryonic antigen-related cell adhesion molecule 11 Publication Alternative name(s): Biliary glycoprotein 11 Publication Short name: BGP-1 CD_antigen: CD66a
Gene namesⁱ	Name:CEACAM1Imported Synonyms:BGP1 Publication, BGP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1814, CEACAM1
MIMⁱ	109770, gene
neXtProtⁱ	NX_P13688
VEuPathDBⁱ	HostDB:ENSG00000079385

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	35 – 428	ExtracellularSequence analysisAdd BLAST	394
Transmembraneⁱ	429 – 452	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	453 – 526	CytoplasmicSequence analysisAdd BLAST	74

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	76	N → A: Impairs interaction with HAVCR2. 1 Publication	1
Mutagenesisⁱ	77 – 78	RQ → GL: Doesn't affect cell surface expression. Impairs phosphorylation. 1 Publication	2
Mutagenesisⁱ	81	G → A: Impairs interaction with HAVCR2. 1 Publication	1
Mutagenesisⁱ	457	T → D: Decreases the binding to ANXA2. 1 Publication	1
Mutagenesisⁱ	493	Y → F: Impairs phosphorylation; when associated with F-520. 1 Publication	1
Mutagenesisⁱ	520	Y → F: Impairs phosphorylation; when associated with F-493. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	634
Open Targets More...OpenTargetsⁱ	ENSG00000079385
PharmGKBⁱ	PA26358

Miscellaneous databases

Pharosⁱ	P13688, Tbio

Pharosⁱ

P13688, Tbio

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00113, Technetium Tc-99m arcitumomab

DrugBankⁱ

DB00113, Technetium Tc-99m arcitumomab

Genetic variation databases

BioMutaⁱ	CEACAM1
DMDMⁱ	399116

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 34	Add BLAST		34
ChainⁱPRO_0000014562	35 – 526	Carcinoembryonic antigen-related cell adhesion molecule 1Add BLAST		492

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	35	Pyrrolidone carboxylic acid1 Publication	1
Glycosylationⁱ	104	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	111	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	115	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	152	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Disulfide bondⁱ	167 ↔ 215	PROSITE-ProRule annotation
Glycosylationⁱ	182	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	197	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	208	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	224	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	232	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	254	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	259 ↔ 299	PROSITE-ProRule annotation
Glycosylationⁱ	274	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	288	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	292	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	302	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	309	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	345	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	348 ↔ 396	PROSITE-ProRule annotationBy similarity
Glycosylationⁱ	351	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	363	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	378	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	405	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Modified residueⁱ	493	Phosphotyrosine; by SRC, LCK, INSR and EGFR2 Publications	1
Modified residueⁱ	508	PhosphoserineBy similarity	1
Modified residueⁱ	520	Phosphotyrosine; by INSR, SRC and LCK2 Publications	1

Post-translational modificationⁱ

Isoform 1:

Phosphorylated on serine and tyrosine (By similarity). Isoform 1 is phosphorylated on tyrosine by Src family kinases like SRC and LCK and by receptor like CSF3R, EGFR and INSR upon stimulation (PubMed:15467833, PubMed:18424730, PubMed:7478590). Phosphorylated at Ser-508; mediates activity. Phosphorylated at Tyr-493; regulates activity (By similarity). Phosphorylated at Tyr-493 by EGFR and INSR upon stimulation; this phosphorylation is Ser-508-phosphorylation-dependent; mediates cellular internalization; increases interaction with downstream proteins like SHC1 and FASN (By similarity). Phosphorylated at Tyr-493 and Tyr-520 by LCK; mediates PTPN6 association and is regulated by homophilic ligation of CEACAM1 in the absence of T cell activation (PubMed:18424730). Phosphorylated at Tyr-520; mediates interaction with PTPN11 (By similarity).By similarity3 Publications

Isoform 8:

Phosphorylated on serine and threonine.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-1179
EPDⁱ	P13688
jPOSTⁱ	P13688
MassIVEⁱ	P13688
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13688
PaxDbⁱ	P13688
PeptideAtlas More...PeptideAtlasⁱ	P13688
PRIDEⁱ	P13688
ProteomicsDBⁱ	52961 [P13688-1] 52962 [P13688-10] 52963 [P13688-11] 52964 [P13688-2] 52965 [P13688-3] 52966 [P13688-4] 52967 [P13688-5] 52968 [P13688-6] 52969 [P13688-7] 52970 [P13688-8] 52971 [P13688-9]
TopDownProteomicsⁱ	P13688-2 [P13688-2]

PTM databases

GlyConnectⁱ	1070, 14 N-Linked glycans (5 sites)
GlyGenⁱ	P13688, 24 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
iPTMnetⁱ	P13688
PhosphoSitePlusⁱ	P13688

Expressionⁱ

Tissue specificityⁱ

Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468).3 Publications

Inductionⁱ

Induced in primary T cells by activation with IL-2.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000079385, Expressed in colonic mucosa and 176 other tissues
ExpressionAtlasⁱ	P13688, baseline and differential
Genevisibleⁱ	P13688, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000079385, Tissue enhanced (intestine)

HPAⁱ

ENSG00000079385, Tissue enhanced (intestine)

Interactionⁱ

Subunit structureⁱ

Monomer. Oligomer. Heterodimer. Homodimer (PubMed:26483485). Cis-dimer/oligomer (via Ig-like C2-type and/or via cytoplasmic domains); induced by trans-homophilic cell adhesion through an allosteric mechanism transmitted by the Ig-like V-type domain, and is regulated by intracellular calcium and calmodulin.

Interacts (via cytoplasmic domain) with calmodulin in a calcium dependent manner; reduces homophilic cell adhesion through dissociation of dimer (By similarity). Isoform 1 interacts (via cytoplasmic domain) with PTPN11 (preferentially) and PTPN6; cis-homodimer form is preferred; this interaction is decreased by formation of Isoform 1 /Isoform 8 cis-heterodimers and is dependent on the monomer/dimer equilibrium; this interaction is phosphorylation-dependent (PubMed:23696226).

Isoform 1 interacts with LYN (By similarity). Isoform 1 interacts (via cytoplasmic domain) with SRC (via SH2 domain); this interaction is regulated by trans-homophilic cell adhesion (PubMed:7478590). Isoform 1 interacts (via cytoplasmic domain) with LCK; mediates phosphorylation at Tyr-493 and Tyr-520 resulting in PTPN6 association.

Isoform 1 interacts with PTPN6; this interaction is phosphorylation-dependent and causes a profound decrease in TCR stimulation-induced CD247 and ZAP70 phosphorylation.

Isoform 1 interacts with TCR/CD3 complex through TCR beta chain and CD3E; colocalizes at the cell surface and upon stimulation of the TCR/CD3 complex recruits PTPN6 in the TCR/CD3 complex, resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Isoform 1 interacts (via cytoplasmic domain) with SHC1 (via SH2 domain); SHC1 mediates interaction with INSR or EGFR in a Ser-508 phosphorylation-dependent manner (By similarity).

Isoform 1 interacts with EGFR; the interaction is indirect (PubMed:15467833).

Isoform 1 interacts with CSF3R; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Isoform 1 (phosphorylated form) interacts with TLR4 and SYK; recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, leading to a reduction of the inflammasome activity (By similarity).

Isoform 1 interacts with FLNA; inhibits cell migration and cell scattering by interfering with the interaction of FLNA with RALA (PubMed:16291724). Isoform 1 interacts (via cytoplasmic domain) with PXN; the interaction is phosphotyrosyl-dependent (PubMed:11035932).

Isoform 1 interacts with KLRK1; recruits PTPN6 that dephosphorylates VAV1 (PubMed:23696226).

Isoform 1 interacts with CEACAM8 (PubMed:11994468).

Isoform 1 interacts with FASN; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity).

Interacts (via Ig-like V-type) with HAVCR2 (via Ig-like V-type); facilitates the maturation and cell surface expression of HAVCR2 thereby regulating T cell tolerance induction (PubMed:25363763). Isoform 8 interacts (via the cytoplasmic domain) with ANXA2; this interaction is regulated by phosphorylation and appears in the AIIt complex (PubMed:14522961).

Interacts (via Lewis X moieties) with CD209 (via C-type lectin domain); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils (PubMed:16246332).

By similarity11 Publications

Binary interactionsⁱ

Hide details

P13688

With	#Exp.	IntAct
CARTPT [Q16568]	3	EBI-4314481,EBI-4314526
itself	3	EBI-4314481,EBI-4314481
CEACAM6 [P40199]	2	EBI-4314481,EBI-4314501
HAVCR2 [Q8TDQ0]	4	EBI-4314481,EBI-11472922
opaD [Q04883] from Neisseria gonorrhoeae.	2	EBI-4314481,EBI-26495131
opaH [Q04884] from Neisseria gonorrhoeae.	3	EBI-4314481,EBI-26495102
uspa1 [Q8GH87] from Moraxella catarrhalis.	12	EBI-4314481,EBI-7936357

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	107103, 12 interactors
Database of interacting proteins More...DIPⁱ	DIP-42683N
IntActⁱ	P13688, 11 interactors
Molecular INTeraction database More...MINTⁱ	P13688
STRINGⁱ	9606.ENSP00000161559

Miscellaneous databases

RNActⁱ	P13688, protein

RNActⁱ

P13688, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	37 – 46	Combined sources	10
Beta strandⁱ	51 – 56	Combined sources	6
Beta strandⁱ	60 – 72	Combined sources	13
Helixⁱ	75 – 77	Combined sources	3
Beta strandⁱ	78 – 83	Combined sources	6
Turnⁱ	84 – 87	Combined sources	4
Beta strandⁱ	88 – 91	Combined sources	4
Beta strandⁱ	97 – 101	Combined sources	5
Beta strandⁱ	107 – 109	Combined sources	3
Helixⁱ	114 – 116	Combined sources	3
Beta strandⁱ	118 – 126	Combined sources	9
Beta strandⁱ	131 – 141	Combined sources	11

Show more details

3D structure databases

AlphaFoldDBⁱ	P13688
SMRⁱ	P13688
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13688

EvolutionaryTraceⁱ

P13688

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	35 – 142	Ig-like V-typeBy similarityAdd BLAST	108
Domainⁱ	145 – 232	Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST	88
Domainⁱ	237 – 317	Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST	81
Domainⁱ	323 – 413	Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST	91

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	39 – 142	Required for homophilic bindingBy similarityAdd BLAST	104
Regionⁱ	450 – 462	Interaction with calmodulinBy similarityAdd BLAST	13
Regionⁱ	452 – 526	Interaction with FLNABy similarityAdd BLAST	75
Regionⁱ	461 – 513	DisorderedSequence analysisAdd BLAST	53
Regionⁱ	489 – 526	Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation levelBy similarityAdd BLAST	38
Regionⁱ	520 – 523	Essential for interaction with PTPN11 and PTPN6By similarity	4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	461 – 476	Basic and acidic residuesSequence analysisAdd BLAST		16
Compositional biasⁱ	477 – 513	Polar residuesSequence analysisAdd BLAST		37

Domainⁱ

Ig-like V-type domain mediates trans-homophilic cell adhesion through homodimerization and this active process is regulated by tyrosine kinase, PTPN11 AND PTPN6. Ig-like C2-type and/or cytoplasmic domains mediate cis-dimer/oligomer.By similarity

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502RXPD, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00960000186634
HOGENOMⁱ	CLU_024555_2_0_1
InParanoidⁱ	P13688
OMAⁱ	WENSENY
Database of Orthologous Groups More...OrthoDBⁱ	998214at2759
PhylomeDBⁱ	P13688
TreeFamⁱ	TF336859

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit PF07686, V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits
SUPFAMⁱ	SSF48726, SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 3 hits

Sequences (11+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P13688-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST 
       360        370        380        390        400
NDTGISIRWF FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN 
       410        420        430        440        450
PISKNQSDPI MLNVNYNALP QENGLSPGAI AGIVIGVVAL VALIAVALAC 
       460        470        480        490        500
FLHFGKTGRA SDQRDLTEHK PSVSNHTQDH SNDPPNKMNE VTYSTLNFEA 
       510        520 
QQPTQPTSAS PSLTATEIIY SEVKKQ

Length:526

Mass (Da):57,560

Last modified:July 1, 1993 - v2

Checksum:ⁱCAD1B2328D069AF8

GO

Isoform 2 (identifier: P13688-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
416-417: YN → CK
418-526: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST 
       360        370        380        390        400
NDTGISIRWF FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN 
       410 
PISKNQSDPI MLNVNCK

Show »

Length:417

Mass (Da):45,950

Checksum:ⁱ5D4B9F86184AA4B4

GO

Isoform 3 (identifier: P13688-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
320-321: EL → GK
322-526: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320 
ANNSVTGCNR TTVKTIIVTG K

Show »

Length:321

Mass (Da):35,302

Checksum:ⁱ81DE2F4E62AD42A7

GO

Isoform 4 (identifier: P13688-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
321-351: LSPVVAKPQIKASKTTVTGDKDSVNLTCSTN → SPVLGEDEAVPGQHHPQHKPCQEGGCWDVLV
352-526: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTE SPVLGEDEAV PGQHHPQHKP CQEGGCWDVL 

V

Show »

Length:351

Mass (Da):38,578

Checksum:ⁱ33CEF445429E8DD4

GO

Isoform 5 (identifier: P13688-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
321-416: LSPVVAKPQI...SDPIMLNVNY → RQNLTMLPRLDSNSWAQAILPSVSQSAEITD

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTE RQNLTMLPRL DSNSWAQAIL PSVSQSAEIT 
       360        370        380        390        400
DNALPQENGL SPGAIAGIVI GVVALVALIA VALACFLHFG KTGRASDQRD 
       410        420        430        440        450
LTEHKPSVSN HTQDHSNDPP NKMNEVTYST LNFEAQQPTQ PTSASPSLTA 
       460 
TEIIYSEVKK Q

Show »

Length:461

Mass (Da):50,349

Checksum:ⁱE7810D2559DF7A8F

GO

Isoform 6 (identifier: P13688-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
320-416: ELSPVVAKPQ...SDPIMLNVNY → D

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTD NALPQENGLS PGAIAGIVIG VVALVALIAV 
       360        370        380        390        400
ALACFLHFGK TGRASDQRDL TEHKPSVSNH TQDHSNDPPN KMNEVTYSTL 
       410        420        430
NFEAQQPTQP TSASPSLTAT EIIYSEVKKQ

Show »

Length:430

Mass (Da):46,910

Checksum:ⁱ195DE9F171D1414F

GO

Isoform 7 (identifier: P13688-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
143-416: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPNALPQENG 
       160        170        180        190        200
LSPGAIAGIV IGVVALVALI AVALACFLHF GKTGRASDQR DLTEHKPSVS 
       210        220        230        240        250
NHTQDHSNDP PNKMNEVTYS TLNFEAQQPT QPTSASPSLT ATEIIYSEVK 

KQ

Show »

Length:252

Mass (Da):27,431

Checksum:ⁱ6C85A702292B6367

GO

Isoform 8 (identifier: P13688-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
459-464: RASDQR → SSGPLQ
465-526: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST 
       360        370        380        390        400
NDTGISIRWF FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN 
       410        420        430        440        450
PISKNQSDPI MLNVNYNALP QENGLSPGAI AGIVIGVVAL VALIAVALAC 
       460 
FLHFGKTGSS GPLQ

Note: Pseudophosphorylated double mutant Thr-457->Asp and Ser-459->Asp. The single mutant Ser-459->Asp mutant highly binds with ANXA2.1 Publication

Show »

Length:464

Mass (Da):50,521

Checksum:ⁱ598E4D71BF05EDA9

GO

Isoform 9 (identifier: P13688-9) [UniParc]FASTA Add to basket

Also known as: BGPz, CEACAM1-3AS

The sequence of this isoform differs from the canonical sequence as follows:
     321-416: LSPVVAKPQI...SDPIMLNVNY → MAFHHVAKAGLKLLSSSNPPASTSQSAKITD
     459-464: RASDQR → SSGPLQ
     465-526: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTE MAFHHVAKAG LKLLSSSNPP ASTSQSAKIT 
       360        370        380        390 
DNALPQENGL SPGAIAGIVI GVVALVALIA VALACFLHFG KTGSSGPLQ

Show »

Length:399

Mass (Da):43,062

Checksum:ⁱ0BC49C50F3525841

GO

Isoform 10 (identifier: P13688-10) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
460-468: ASDQRDLTE → TTPMTHLTR
469-526: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST 
       360        370        380        390        400
NDTGISIRWF FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN 
       410        420        430        440        450
PISKNQSDPI MLNVNYNALP QENGLSPGAI AGIVIGVVAL VALIAVALAC 
       460 
FLHFGKTGRT TPMTHLTR

Show »

Length:468

Mass (Da):51,147

Checksum:ⁱ215C1A33EEFFFD68

GO

Isoform 11 (identifier: P13688-11) [UniParc]FASTA Add to basket

Also known as: BGPd, CEACAM1-3S

The sequence of this isoform differs from the canonical sequence as follows:
     320-416: ELSPVVAKPQ...SDPIMLNVNY → D
     459-464: RASDQR → SSGPLQ
     465-526: Missing.

« Hide

        10         20         30         40         50
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET 
       110        120        130        140        150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 
       160        170        180        190        200
SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR 
       260        270        280        290        300
PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 
       310        320        330        340        350
ANNSVTGCNR TTVKTIIVTD NALPQENGLS PGAIAGIVIG VVALVALIAV 
       360 
ALACFLHFGK TGSSGPLQ

Show »

Length:368

Mass (Da):39,871

Checksum:ⁱ23D7E54B4DC54318

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A7I2V3A7	A0A7I2V3A7_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	54	Annotation score:
M0R109	M0R109_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	99	Annotation score:
M0R2K4	M0R2K4_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	94	Annotation score:

Sequence cautionⁱ

The sequence AAA57141 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	142	P → H in AAA57142 (PubMed:8423792).Curated	1
Sequence conflictⁱ	246	D → Y in BAA02063 (Ref. 5) Curated	1
Isoform 5 (identifier: P13688-5)
Sequence conflictⁱ	323	N → L in AAA57143 (PubMed:8423792).Curated	1
Sequence conflictⁱ	329	R → G in BAA02063 (Ref. 5) Curated	1
Sequence conflictⁱ	337	Q → E in AAA57143 (PubMed:8423792).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049844	35	Q → K1 PublicationCorresponds to variant dbSNP:rs8111171Ensembl.	1
Natural variantⁱVAR_049845	83	A → V1 PublicationCorresponds to variant dbSNP:rs8110904Ensembl.	1
Natural variantⁱVAR_049846	123	Q → H1 PublicationCorresponds to variant dbSNP:rs8111468Ensembl.	1
Natural variantⁱVAR_049847	376	Q → R1 PublicationCorresponds to variant dbSNP:rs41355544Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_012222	143 – 416	Missing in isoform 7. 1 PublicationAdd BLAST	274
Alternative sequenceⁱVSP_010938	320 – 416	ELSPV…LNVNY → D in isoform 6 and isoform 11. 2 PublicationsAdd BLAST	97
Alternative sequenceⁱVSP_002478	320 – 321	EL → GK in isoform 3. 1 Publication	2
Alternative sequenceⁱVSP_009227	321 – 416	LSPVV…LNVNY → RQNLTMLPRLDSNSWAQAIL PSVSQSAEITD in isoform 5. 2 PublicationsAdd BLAST	96
Alternative sequenceⁱVSP_040571	321 – 416	LSPVV…LNVNY → MAFHHVAKAGLKLLSSSNPP ASTSQSAKITD in isoform 9. 1 PublicationAdd BLAST	96
Alternative sequenceⁱVSP_002480	321 – 351	LSPVV…TCSTN → SPVLGEDEAVPGQHHPQHKP CQEGGCWDVLV in isoform 4. 1 PublicationAdd BLAST	31
Alternative sequenceⁱVSP_002479	322 – 526	Missing in isoform 3. 1 PublicationAdd BLAST	205
Alternative sequenceⁱVSP_002481	352 – 526	Missing in isoform 4. 1 PublicationAdd BLAST	175
Alternative sequenceⁱVSP_002482	416 – 417	YN → CK in isoform 2. 1 Publication	2
Alternative sequenceⁱVSP_002483	418 – 526	Missing in isoform 2. 1 PublicationAdd BLAST	109
Alternative sequenceⁱVSP_040572	459 – 464	RASDQR → SSGPLQ in isoform 8, isoform 9 and isoform 11. 4 Publications	6
Alternative sequenceⁱVSP_040573	460 – 468	ASDQRDLTE → TTPMTHLTR in isoform 10. 1 Publication	9
Alternative sequenceⁱVSP_040574	465 – 526	Missing in isoform 8, isoform 9 and isoform 11. 4 PublicationsAdd BLAST	62
Alternative sequenceⁱVSP_040575	469 – 526	Missing in isoform 10. 1 PublicationAdd BLAST	58

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03858 mRNA Translation: AAA51826.1 X14831 mRNA Translation: CAA32940.1 X16354 mRNA Translation: CAA34404.1 X16356 mRNA Translation: CAA34405.1 D90311 mRNA Translation: BAA14341.1 D90312 mRNA Translation: BAA14342.1 D90313 mRNA Translation: BAA14343.1 M69176 mRNA Translation: AAA51825.1 M72238 mRNA Translation: AAA58393.1 M72238 mRNA Translation: AAA58394.1 M76741 Genomic DNA Translation: AAA57141.1 Sequence problems. M76742 mRNA Translation: AAA57142.1 M76743 mRNA Translation: AAA57143.1 M76744 mRNA Translation: AAA57144.1 S71326 mRNA Translation: AAB31183.1 D12502 mRNA Translation: BAA02063.1 AY766113 mRNA Translation: AAV34600.1 DQ989182 Genomic DNA Translation: ABI75349.1 AC004785 Genomic DNA Translation: AAC18433.1 AC004785 Genomic DNA Translation: AAC18434.1 AC004785 Genomic DNA Translation: AAC18435.1 AC004785 Genomic DNA Translation: AAC18436.1 AC004785 Genomic DNA Translation: AAC18437.1 AC004785 Genomic DNA Translation: AAC18438.1 AC004785 Genomic DNA Translation: AAC18439.1 CH471126 Genomic DNA Translation: EAW57137.1 CH471126 Genomic DNA Translation: EAW57140.1 CH471126 Genomic DNA Translation: EAW57141.1 CH471126 Genomic DNA Translation: EAW57143.1 BC014473 mRNA Translation: AAH14473.1 X67277 Genomic DNA Translation: CAA47694.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12609.1 [P13688-1] CCDS46089.1 [P13688-8] CCDS54272.1 [P13688-11] CCDS54273.1 [P13688-6] CCDS54274.1 [P13688-5]
PIRⁱ	A32164 B48078 JH0394 JH0395 JH0396
NCBI Reference Sequences More...RefSeqⁱ	NP_001020083.1, NM_001024912.2 [P13688-8] NP_001171742.1, NM_001184813.1 [P13688-6] NP_001171744.1, NM_001184815.1 [P13688-5] NP_001171745.1, NM_001184816.1 [P13688-11] NP_001192273.1, NM_001205344.1 [P13688-10] NP_001703.2, NM_001712.4 [P13688-1] XP_011525508.1, XM_011527206.1 [P13688-4]

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13688	Carcinoembryonic antigen-related cell adhesion molecule 1 (Fragment)		HUMAN		94	UniRef100_P13688
Carcinoembryonic antigen-related cell adhesion molecule 1 (Fragment)		HUMAN		99
+2

Protein	Similar proteins		Species	Score	Length	Source
P13688	Carcinoembryonic antigen-related cell adhesion molecule 1 (Fragment)		HUMAN		94	UniRef90_P13688
CEA cell adhesion molecule 1		GORGO		525
CEA cell adhesion molecule 1		PANTR		518
Carcinoembryonic antigen-related cell adhesion molecule 1 (Fragment)		HUMAN		99
CEACAM1 isoform 3		PANTR		494
+15
P13688-2	CEACAM1 protein (Fragment)		HUMAN		493	UniRef90_P13688-2
P13688-5	CEA cell adhesion molecule 1		PANPA		460	UniRef90_P13688-5
Isoform 9 of Carcinoembryonic antigen-related cell adhesion molecule 1		HUMAN		399
CEA cell adhesion molecule 1		GORGO		388
+1
P13688-11	CEACAM1 isoform 8		PONAB		399	UniRef90_P13688-11
CEACAM1 isoform 9		PANTR		399
CEA cell adhesion molecule 1		PANTR		399
CEACAM1 isoform 5		PANTR		368
CEACAM1 isoform 4		PONAB		368
+1

Protein	Similar proteins		Species	Score	Length	Source
P13688	Carcinoembryonic antigen-related cell adhesion molecule 1 (Fragment)		HUMAN		94	UniRef50_P13688
CEA cell adhesion molecule 1		GORGO		525
CEA cell adhesion molecule 1		PANTR		518
Carcinoembryonic antigen-related cell adhesion molecule 6		Ugandan red Colobus		542
Uncharacterized protein		RHIRO		527
+63
P13688-2	Isoform 5 of Carcinoembryonic antigen-related cell adhesion molecule 1		HUMAN		461	UniRef50_P13688-5
CEA cell adhesion molecule 1		PANPA		460
CEA cell adhesion molecule 1		GORGO		388
Carcinoembryonic antigen-related cell adhesion molecule 1 (Fragment)		MUSPF		464
Uncharacterized protein		DICBM		457
+315
P13688-3	Isoform 4 of Carcinoembryonic antigen-related cell adhesion molecule 1		HUMAN		351	UniRef50_P13688-4
Uncharacterized protein		MACFA		436
Carcinoembryonic antigen-related cell adhesion molecule 6		Ugandan red Colobus		422
carcinoembryonic antigen-related cell adhesion molecule 8-like isoform X8		SAPAP		349
Uncharacterized protein		CALJA		353
+44
P13688-7	Carcinoembryonic antigen-related cell adhesion molecule 3	)	HUMAN		252	UniRef50_P13688-7
CEACAM3 isoform 1		PONAB		252
IGv domain-containing protein		RHIRO		252
IGv domain-containing protein		RHIBE		252
Carcinoembryonic antigen-related cell adhesion molecule 3		COLAP		252
+21
P13688-11	CEACAM1 isoform 8		PONAB		399	UniRef50_P13688-11
CEACAM1 isoform 9		PANTR		399
Uncharacterized protein		URSAM		496
carcinoembryonic antigen-related cell adhesion molecule 1-like		ODORO		424
Uncharacterized protein		AILME		462
+36

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03858 mRNA Translation: AAA51826.1 X14831 mRNA Translation: CAA32940.1 X16354 mRNA Translation: CAA34404.1 X16356 mRNA Translation: CAA34405.1 D90311 mRNA Translation: BAA14341.1 D90312 mRNA Translation: BAA14342.1 D90313 mRNA Translation: BAA14343.1 M69176 mRNA Translation: AAA51825.1 M72238 mRNA Translation: AAA58393.1 M72238 mRNA Translation: AAA58394.1 M76741 Genomic DNA Translation: AAA57141.1 Sequence problems. M76742 mRNA Translation: AAA57142.1 M76743 mRNA Translation: AAA57143.1 M76744 mRNA Translation: AAA57144.1 S71326 mRNA Translation: AAB31183.1 D12502 mRNA Translation: BAA02063.1 AY766113 mRNA Translation: AAV34600.1 DQ989182 Genomic DNA Translation: ABI75349.1 AC004785 Genomic DNA Translation: AAC18433.1 AC004785 Genomic DNA Translation: AAC18434.1 AC004785 Genomic DNA Translation: AAC18435.1 AC004785 Genomic DNA Translation: AAC18436.1 AC004785 Genomic DNA Translation: AAC18437.1 AC004785 Genomic DNA Translation: AAC18438.1 AC004785 Genomic DNA Translation: AAC18439.1 CH471126 Genomic DNA Translation: EAW57137.1 CH471126 Genomic DNA Translation: EAW57140.1 CH471126 Genomic DNA Translation: EAW57141.1 CH471126 Genomic DNA Translation: EAW57143.1 BC014473 mRNA Translation: AAH14473.1 X67277 Genomic DNA Translation: CAA47694.1
CCDSⁱ	CCDS12609.1 [P13688-1] CCDS46089.1 [P13688-8] CCDS54272.1 [P13688-11] CCDS54273.1 [P13688-6] CCDS54274.1 [P13688-5]
PIRⁱ	A32164 B48078 JH0394 JH0395 JH0396
RefSeqⁱ	NP_001020083.1, NM_001024912.2 [P13688-8] NP_001171742.1, NM_001184813.1 [P13688-6] NP_001171744.1, NM_001184815.1 [P13688-5] NP_001171745.1, NM_001184816.1 [P13688-11] NP_001192273.1, NM_001205344.1 [P13688-10] NP_001703.2, NM_001712.4 [P13688-1] XP_011525508.1, XM_011527206.1 [P13688-4]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2GK2	X-ray	2.20	A/B	34-141	[»]
	4QXW	X-ray	2.04	A/B	35-141	[»]
	4WHD	X-ray	2.50	A/B	34-141	[»]
	5DZL	X-ray	3.40	A/B/C/D	35-141	[»]
	6AW2	X-ray	2.68	A	34-141	[»]
	6GBG	X-ray	2.80	D	35-142	[»]
	6GBH	X-ray	2.59	B/D	35-142	[»]
	6V3P	X-ray	3.25	A/B	34-141	[»]
	6XNO	X-ray	1.90	A/B	35-141	[»]
	6XNT	X-ray	3.10	A/B	35-141	[»]
	6XNW	X-ray	1.90	A/B/C/D	35-141	[»]
	6XO1	X-ray	1.76	A/B	35-141	[»]
AlphaFoldDBⁱ	P13688
SMRⁱ	P13688
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	107103, 12 interactors
DIPⁱ	DIP-42683N
IntActⁱ	P13688, 11 interactors
MINTⁱ	P13688
STRINGⁱ	9606.ENSP00000161559

Chemistry databases

DrugBankⁱ	DB00113, Technetium Tc-99m arcitumomab

DrugBankⁱ

DB00113, Technetium Tc-99m arcitumomab

PTM databases

GlyConnectⁱ	1070, 14 N-Linked glycans (5 sites)
GlyGenⁱ	P13688, 24 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
iPTMnetⁱ	P13688
PhosphoSitePlusⁱ	P13688

Genetic variation databases

BioMutaⁱ	CEACAM1
DMDMⁱ	399116

Proteomic databases

CPTACⁱ	CPTAC-1179
EPDⁱ	P13688
jPOSTⁱ	P13688
MassIVEⁱ	P13688
MaxQBⁱ	P13688
PaxDbⁱ	P13688
PeptideAtlasⁱ	P13688
PRIDEⁱ	P13688
ProteomicsDBⁱ	52961 [P13688-1] 52962 [P13688-10] 52963 [P13688-11] 52964 [P13688-2] 52965 [P13688-3] 52966 [P13688-4] 52967 [P13688-5] 52968 [P13688-6] 52969 [P13688-7] 52970 [P13688-8] 52971 [P13688-9]
TopDownProteomicsⁱ	P13688-2 [P13688-2]

Protocols and materials databases

Antibodypediaⁱ	3684, 997 antibodies from 44 providers
The DNASU plasmid repository More...DNASUⁱ	634

Genome annotation databases

Ensemblⁱ	ENST00000161559.11; ENSP00000161559.6; ENSG00000079385.23 ENST00000352591.9; ENSP00000244291.6; ENSG00000079385.23 [P13688-6] ENST00000358394.7; ENSP00000351165.2; ENSG00000079385.23 [P13688-5] ENST00000403444.7; ENSP00000384709.3; ENSG00000079385.23 [P13688-8] ENST00000403461.5; ENSP00000384083.1; ENSG00000079385.23 [P13688-11] ENST00000599389.1; ENSP00000471918.1; ENSG00000079385.23 [P13688-9]
GeneIDⁱ	634
KEGGⁱ	hsa:634
MANE-Selectⁱ	ENST00000161559.11; ENSP00000161559.6; NM_001712.5; NP_001703.2
UCSCⁱ	uc002otv.3, human [P13688-1]

Organism-specific databases

CTDⁱ	634
DisGeNETⁱ	634
GeneCardsⁱ	CEACAM1
HGNCⁱ	HGNC:1814, CEACAM1
HPAⁱ	ENSG00000079385, Tissue enhanced (intestine)
MIMⁱ	109770, gene
neXtProtⁱ	NX_P13688
OpenTargetsⁱ	ENSG00000079385
PharmGKBⁱ	PA26358
VEuPathDBⁱ	HostDB:ENSG00000079385
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502RXPD, Eukaryota
GeneTreeⁱ	ENSGT00960000186634
HOGENOMⁱ	CLU_024555_2_0_1
InParanoidⁱ	P13688
OMAⁱ	WENSENY
OrthoDBⁱ	998214at2759
PhylomeDBⁱ	P13688
TreeFamⁱ	TF336859

Enzyme and pathway databases

PathwayCommonsⁱ	P13688
Reactomeⁱ	R-HSA-1566977, Fibronectin matrix formation R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-6798695, Neutrophil degranulation
SignaLinkⁱ	P13688
SIGNORⁱ	P13688

Miscellaneous databases

BioGRID-ORCSⁱ	634, 17 hits in 1081 CRISPR screens
EvolutionaryTraceⁱ	P13688
GeneWikiⁱ	CEACAM1
GenomeRNAiⁱ	634
Pharosⁱ	P13688, Tbio
Protein Ontology More...PROⁱ	PR:P13688
RNActⁱ	P13688, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000079385, Expressed in colonic mucosa and 176 other tissues
ExpressionAtlasⁱ	P13688, baseline and differential
Genevisibleⁱ	P13688, HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin
Pfamⁱ	View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit PF07686, V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits
SUPFAMⁱ	SSF48726, SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 3 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEAM1_HUMAN
Accessionⁱ	P13688Primary (citable) accession number: P13688 Secondary accession number(s): A6NE38 Q9UQV9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	July 1, 1993
	Last modified:	May 25, 2022
	This is version 225 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P13688 (CEAM1_HUMAN)

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Carcinoembryonic antigen-related cell adhesion molecule 1

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P13688

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