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Protein

Tartrate-resistant acid phosphatase type 5

Gene

ACP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33Iron 11
Metal bindingi71Iron 11
Metal bindingi71Iron 21
Metal bindingi74Iron 11
Metal bindingi110Iron 21
Metal bindingi205Iron 21
Metal bindingi240Iron 21
Metal bindingi242Iron 11

GO - Molecular functioni

  • acid phosphatase activity Source: Reactome
  • ferric iron binding Source: UniProtKB
  • ferrous iron binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.2 2681
ReactomeiR-HSA-196843 Vitamin B2 (riboflavin) metabolism
SABIO-RKiP13686
SIGNORiP13686

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Gene namesi
Name:ACP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000102575.10
HGNCiHGNC:124 ACP5
MIMi171640 gene
neXtProtiNX_P13686

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Involvement in diseasei

Spondyloenchondrodysplasia with immune dysregulation (SPENCDI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease.
Disease descriptionA disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone.
See also OMIM:607944
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06592052K → M in SPENCDI. 1 Publication1
Natural variantiVAR_06592189T → I in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906668EnsemblClinVar.1
Natural variantiVAR_065922109G → R in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs781050795EnsemblClinVar.1
Natural variantiVAR_065923201L → P in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906672EnsemblClinVar.1
Natural variantiVAR_065924215G → R in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs781199182EnsemblClinVar.1
Natural variantiVAR_065925241D → N in SPENCDI. 1 Publication1
Natural variantiVAR_065926262N → H in SPENCDI. 1 Publication1
Natural variantiVAR_065927264M → K in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs387906670EnsemblClinVar.1
Natural variantiVAR_065928278Missing in SPENCDI. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi54
MalaCardsiACP5
MIMi607944 phenotype
OpenTargetsiENSG00000102575
Orphaneti1855 Spondyloenchondrodysplasia
PharmGKBiPA24448

Chemistry databases

DrugBankiDB02325 Isopropyl Alcohol

Polymorphism and mutation databases

BioMutaiACP5
DMDMi56757583

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 214 PublicationsAdd BLAST21
ChainiPRO_000002398122 – 325Tartrate-resistant acid phosphatase type 5Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi116N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 219By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP13686
PaxDbiP13686
PeptideAtlasiP13686
PRIDEiP13686
ProteomicsDBi52960

PTM databases

DEPODiP13686
iPTMnetiP13686
PhosphoSitePlusiP13686

Miscellaneous databases

PMAP-CutDBiP13686

Expressioni

Gene expression databases

BgeeiENSG00000102575 Expressed in 159 organ(s), highest expression level in periodontal ligament
CleanExiHS_ACP5
ExpressionAtlasiP13686 baseline and differential
GenevisibleiP13686 HS

Organism-specific databases

HPAiCAB002584
HPA057655
HPA059463

Interactioni

Subunit structurei

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).3 Publications

Protein-protein interaction databases

BioGridi106570, 25 interactors
IntActiP13686, 9 interactors
MINTiP13686
STRINGi9606.ENSP00000218758

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13686
SMRiP13686
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13686

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2679 Eukaryota
COG1409 LUCA
GeneTreeiENSGT00390000016735
HOVERGENiHBG000433
InParanoidiP13686
KOiK14379
OMAiWNFPSPY
OrthoDBiEOG091G0J5W
PhylomeDBiP13686
TreeFamiTF313175

Family and domain databases

CDDicd07378 MPP_ACP5, 1 hit
Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR024927 Acid_Pase_5
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF000898 Acid_Ptase_5, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

P13686-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMWTALLIL QALLLPSLAD GATPALRFVA VGDWGGVPNA PFHTAREMAN
60 70 80 90 100
AKEIARTVQI LGADFILSLG DNFYFTGVQD INDKRFQETF EDVFSDRSLR
110 120 130 140 150
KVPWYVLAGN HDHLGNVSAQ IAYSKISKRW NFPSPFYRLH FKIPQTNVSV
160 170 180 190 200
AIFMLDTVTL CGNSDDFLSQ QPERPRDVKL ARTQLSWLKK QLAAAREDYV
210 220 230 240 250
LVAGHYPVWS IAEHGPTHCL VKQLRPLLAT YGVTAYLCGH DHNLQYLQDE
260 270 280 290 300
NGVGYVLSGA GNFMDPSKRH QRKVPNGYLR FHYGTEDSLG GFAYVEISSK
310 320
EMTVTYIEAS GKSLFKTRLP RRARP
Length:325
Mass (Da):36,599
Last modified:December 21, 2004 - v3
Checksum:i079174A71A5BA264
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJD9K7EJD9_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
124Annotation score:
K7ESF2K7ESF2_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
74Annotation score:
K7EIP0K7EIP0_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
52Annotation score:
K7ES19K7ES19_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45 – 46AR → GP in AAA76849 (PubMed:2909539).Curated2
Sequence conflicti47E → G AA sequence (PubMed:1477968).Curated1
Sequence conflicti47E → Q AA sequence (PubMed:2775236).Curated1
Sequence conflicti50N → W AA sequence (PubMed:2775236).Curated1
Sequence conflicti177 – 180DVKL → LT in AAA76849 (PubMed:2909539).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06592052K → M in SPENCDI. 1 Publication1
Natural variantiVAR_06592189T → I in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906668EnsemblClinVar.1
Natural variantiVAR_065922109G → R in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs781050795EnsemblClinVar.1
Natural variantiVAR_020602148V → M1 PublicationCorresponds to variant dbSNP:rs2305799EnsemblClinVar.1
Natural variantiVAR_020603200V → M1 PublicationCorresponds to variant dbSNP:rs2229531EnsemblClinVar.1
Natural variantiVAR_065923201L → P in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906672EnsemblClinVar.1
Natural variantiVAR_065924215G → R in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs781199182EnsemblClinVar.1
Natural variantiVAR_029288221V → I. Corresponds to variant dbSNP:rs2229532EnsemblClinVar.1
Natural variantiVAR_065925241D → N in SPENCDI. 1 Publication1
Natural variantiVAR_065926262N → H in SPENCDI. 1 Publication1
Natural variantiVAR_065927264M → K in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs387906670EnsemblClinVar.1
Natural variantiVAR_065928278Missing in SPENCDI. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04430 mRNA Translation: AAA76849.1
X14618 mRNA Translation: CAA32771.1
CR457078 mRNA Translation: CAG33359.1
AK290717 mRNA Translation: BAF83406.1
BC025414 mRNA Translation: AAH25414.1
BC111014 mRNA Translation: AAI11015.1
X67123 Genomic DNA No translation available.
CCDSiCCDS12265.1
PIRiS15752
RefSeqiNP_001104504.1, NM_001111034.2
NP_001104505.1, NM_001111035.2
NP_001104506.1, NM_001111036.2
NP_001308952.1, NM_001322023.1
NP_001602.1, NM_001611.4
XP_005259995.1, XM_005259938.1
XP_011526371.1, XM_011528069.2
UniGeneiHs.1211

Genome annotation databases

EnsembliENST00000218758; ENSP00000218758; ENSG00000102575
ENST00000412435; ENSP00000392374; ENSG00000102575
ENST00000433365; ENSP00000413456; ENSG00000102575
ENST00000592828; ENSP00000468767; ENSG00000102575
GeneIDi54
KEGGihsa:54
UCSCiuc002msg.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Tartrate-resistant acid phosphatase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04430 mRNA Translation: AAA76849.1
X14618 mRNA Translation: CAA32771.1
CR457078 mRNA Translation: CAG33359.1
AK290717 mRNA Translation: BAF83406.1
BC025414 mRNA Translation: AAH25414.1
BC111014 mRNA Translation: AAI11015.1
X67123 Genomic DNA No translation available.
CCDSiCCDS12265.1
PIRiS15752
RefSeqiNP_001104504.1, NM_001111034.2
NP_001104505.1, NM_001111035.2
NP_001104506.1, NM_001111036.2
NP_001308952.1, NM_001322023.1
NP_001602.1, NM_001611.4
XP_005259995.1, XM_005259938.1
XP_011526371.1, XM_011528069.2
UniGeneiHs.1211

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WARX-ray2.22A22-325[»]
2BQ8X-ray2.20X22-325[»]
ProteinModelPortaliP13686
SMRiP13686
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106570, 25 interactors
IntActiP13686, 9 interactors
MINTiP13686
STRINGi9606.ENSP00000218758

Chemistry databases

DrugBankiDB02325 Isopropyl Alcohol

PTM databases

DEPODiP13686
iPTMnetiP13686
PhosphoSitePlusiP13686

Polymorphism and mutation databases

BioMutaiACP5
DMDMi56757583

Proteomic databases

EPDiP13686
PaxDbiP13686
PeptideAtlasiP13686
PRIDEiP13686
ProteomicsDBi52960

Protocols and materials databases

DNASUi54
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218758; ENSP00000218758; ENSG00000102575
ENST00000412435; ENSP00000392374; ENSG00000102575
ENST00000433365; ENSP00000413456; ENSG00000102575
ENST00000592828; ENSP00000468767; ENSG00000102575
GeneIDi54
KEGGihsa:54
UCSCiuc002msg.5 human

Organism-specific databases

CTDi54
DisGeNETi54
EuPathDBiHostDB:ENSG00000102575.10
GeneCardsiACP5
HGNCiHGNC:124 ACP5
HPAiCAB002584
HPA057655
HPA059463
MalaCardsiACP5
MIMi171640 gene
607944 phenotype
neXtProtiNX_P13686
OpenTargetsiENSG00000102575
Orphaneti1855 Spondyloenchondrodysplasia
PharmGKBiPA24448
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2679 Eukaryota
COG1409 LUCA
GeneTreeiENSGT00390000016735
HOVERGENiHBG000433
InParanoidiP13686
KOiK14379
OMAiWNFPSPY
OrthoDBiEOG091G0J5W
PhylomeDBiP13686
TreeFamiTF313175

Enzyme and pathway databases

BRENDAi3.1.3.2 2681
ReactomeiR-HSA-196843 Vitamin B2 (riboflavin) metabolism
SABIO-RKiP13686
SIGNORiP13686

Miscellaneous databases

ChiTaRSiACP5 human
EvolutionaryTraceiP13686
GeneWikiiTartrate-resistant_acid_phosphatase
GenomeRNAii54
PMAP-CutDBiP13686
PROiPR:P13686
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102575 Expressed in 159 organ(s), highest expression level in periodontal ligament
CleanExiHS_ACP5
ExpressionAtlasiP13686 baseline and differential
GenevisibleiP13686 HS

Family and domain databases

CDDicd07378 MPP_ACP5, 1 hit
Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR024927 Acid_Pase_5
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF000898 Acid_Ptase_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPA5_HUMAN
AccessioniPrimary (citable) accession number: P13686
Secondary accession number(s): A8K3V2
, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health

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