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Protein

Tartrate-resistant acid phosphatase type 5

Gene

ACP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi33Iron 11
Metal bindingi71Iron 11
Metal bindingi71Iron 21
Metal bindingi74Iron 11
Metal bindingi110Iron 21
Metal bindingi205Iron 21
Metal bindingi240Iron 21
Metal bindingi242Iron 11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acid phosphatase activity Source: GO_Central
  • ferric iron binding Source: UniProtKB
  • ferrous iron binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196843 Vitamin B2 (riboflavin) metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P13686

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P13686

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000102575.10

Human Gene Nomenclature Database

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HGNCi
HGNC:124 ACP5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
171640 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P13686

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spondyloenchondrodysplasia with immune dysregulation (SPENCDI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease.
Disease descriptionA disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone.
See also OMIM:607944
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06592052K → M in SPENCDI. 1 Publication1
Natural variantiVAR_06592189T → I in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906668EnsemblClinVar.1
Natural variantiVAR_065922109G → R in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs781050795EnsemblClinVar.1
Natural variantiVAR_065923201L → P in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906672EnsemblClinVar.1
Natural variantiVAR_065924215G → R in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs781199182EnsemblClinVar.1
Natural variantiVAR_065925241D → N in SPENCDI. 1 Publication1
Natural variantiVAR_065926262N → H in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs1449857485Ensembl.1
Natural variantiVAR_065927264M → K in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs387906670EnsemblClinVar.1
Natural variantiVAR_065928278Missing in SPENCDI. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
54

MalaCards human disease database

More...
MalaCardsi
ACP5
MIMi607944 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000102575

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1855 Spondyloenchondrodysplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24448

Chemistry databases

Drug and drug target database

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DrugBanki
DB02325 Isopropyl Alcohol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56757583

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 214 PublicationsAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002398122 – 325Tartrate-resistant acid phosphatase type 5Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi116N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi161 ↔ 219By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P13686

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13686

PeptideAtlas

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PeptideAtlasi
P13686

PRoteomics IDEntifications database

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PRIDEi
P13686

ProteomicsDB human proteome resource

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ProteomicsDBi
52960

PTM databases

DEPOD human dephosphorylation database

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DEPODi
P13686

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13686

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13686

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P13686

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000102575 Expressed in 159 organ(s), highest expression level in periodontal ligament

CleanEx database of gene expression profiles

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CleanExi
HS_ACP5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P13686 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13686 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB002584
HPA057655
HPA059463

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106570, 25 interactors

Protein interaction database and analysis system

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IntActi
P13686, 9 interactors

Molecular INTeraction database

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MINTi
P13686

STRING: functional protein association networks

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STRINGi
9606.ENSP00000218758

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13686

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13686

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P13686

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2679 Eukaryota
COG1409 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000016735

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000433

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13686

KEGG Orthology (KO)

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KOi
K14379

Identification of Orthologs from Complete Genome Data

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OMAi
WNFPSPY

Database of Orthologous Groups

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OrthoDBi
EOG091G0J5W

Database for complete collections of gene phylogenies

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PhylomeDBi
P13686

TreeFam database of animal gene trees

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TreeFami
TF313175

Family and domain databases

Conserved Domains Database

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CDDi
cd07378 MPP_ACP5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.60.21.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024927 Acid_PPase
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like

Pfam protein domain database

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Pfami
View protein in Pfam
PF00149 Metallophos, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000898 Acid_Ptase_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P13686-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMWTALLIL QALLLPSLAD GATPALRFVA VGDWGGVPNA PFHTAREMAN
60 70 80 90 100
AKEIARTVQI LGADFILSLG DNFYFTGVQD INDKRFQETF EDVFSDRSLR
110 120 130 140 150
KVPWYVLAGN HDHLGNVSAQ IAYSKISKRW NFPSPFYRLH FKIPQTNVSV
160 170 180 190 200
AIFMLDTVTL CGNSDDFLSQ QPERPRDVKL ARTQLSWLKK QLAAAREDYV
210 220 230 240 250
LVAGHYPVWS IAEHGPTHCL VKQLRPLLAT YGVTAYLCGH DHNLQYLQDE
260 270 280 290 300
NGVGYVLSGA GNFMDPSKRH QRKVPNGYLR FHYGTEDSLG GFAYVEISSK
310 320
EMTVTYIEAS GKSLFKTRLP RRARP
Length:325
Mass (Da):36,599
Last modified:December 21, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i079174A71A5BA264
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJD9K7EJD9_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESF2K7ESF2_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIP0K7EIP0_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES19K7ES19_HUMAN
Tartrate-resistant acid phosphatase...
ACP5
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45 – 46AR → GP in AAA76849 (PubMed:2909539).Curated2
Sequence conflicti47E → G AA sequence (PubMed:1477968).Curated1
Sequence conflicti47E → Q AA sequence (PubMed:2775236).Curated1
Sequence conflicti50N → W AA sequence (PubMed:2775236).Curated1
Sequence conflicti177 – 180DVKL → LT in AAA76849 (PubMed:2909539).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06592052K → M in SPENCDI. 1 Publication1
Natural variantiVAR_06592189T → I in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906668EnsemblClinVar.1
Natural variantiVAR_065922109G → R in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs781050795EnsemblClinVar.1
Natural variantiVAR_020602148V → M1 PublicationCorresponds to variant dbSNP:rs2305799EnsemblClinVar.1
Natural variantiVAR_020603200V → M1 PublicationCorresponds to variant dbSNP:rs2229531EnsemblClinVar.1
Natural variantiVAR_065923201L → P in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs387906672EnsemblClinVar.1
Natural variantiVAR_065924215G → R in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs781199182EnsemblClinVar.1
Natural variantiVAR_029288221V → I. Corresponds to variant dbSNP:rs2229532EnsemblClinVar.1
Natural variantiVAR_065925241D → N in SPENCDI. 1 Publication1
Natural variantiVAR_065926262N → H in SPENCDI. 1 PublicationCorresponds to variant dbSNP:rs1449857485Ensembl.1
Natural variantiVAR_065927264M → K in SPENCDI. 2 PublicationsCorresponds to variant dbSNP:rs387906670EnsemblClinVar.1
Natural variantiVAR_065928278Missing in SPENCDI. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04430 mRNA Translation: AAA76849.1
X14618 mRNA Translation: CAA32771.1
CR457078 mRNA Translation: CAG33359.1
AK290717 mRNA Translation: BAF83406.1
BC025414 mRNA Translation: AAH25414.1
BC111014 mRNA Translation: AAI11015.1
X67123 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS12265.1

Protein sequence database of the Protein Information Resource

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PIRi
S15752

NCBI Reference Sequences

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RefSeqi
NP_001104504.1, NM_001111034.2
NP_001104505.1, NM_001111035.2
NP_001104506.1, NM_001111036.2
NP_001308952.1, NM_001322023.1
NP_001602.1, NM_001611.4
XP_005259995.1, XM_005259938.1
XP_011526371.1, XM_011528069.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.1211

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000218758; ENSP00000218758; ENSG00000102575
ENST00000412435; ENSP00000392374; ENSG00000102575
ENST00000433365; ENSP00000413456; ENSG00000102575
ENST00000592828; ENSP00000468767; ENSG00000102575
ENST00000648477; ENSP00000496973; ENSG00000102575

Database of genes from NCBI RefSeq genomes

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GeneIDi
54

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54

UCSC genome browser

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UCSCi
uc002msg.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Tartrate-resistant acid phosphatase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04430 mRNA Translation: AAA76849.1
X14618 mRNA Translation: CAA32771.1
CR457078 mRNA Translation: CAG33359.1
AK290717 mRNA Translation: BAF83406.1
BC025414 mRNA Translation: AAH25414.1
BC111014 mRNA Translation: AAI11015.1
X67123 Genomic DNA No translation available.
CCDSiCCDS12265.1
PIRiS15752
RefSeqiNP_001104504.1, NM_001111034.2
NP_001104505.1, NM_001111035.2
NP_001104506.1, NM_001111036.2
NP_001308952.1, NM_001322023.1
NP_001602.1, NM_001611.4
XP_005259995.1, XM_005259938.1
XP_011526371.1, XM_011528069.2
UniGeneiHs.1211

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WARX-ray2.22A22-325[»]
2BQ8X-ray2.20X22-325[»]
ProteinModelPortaliP13686
SMRiP13686
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106570, 25 interactors
IntActiP13686, 9 interactors
MINTiP13686
STRINGi9606.ENSP00000218758

Chemistry databases

DrugBankiDB02325 Isopropyl Alcohol

PTM databases

DEPODiP13686
iPTMnetiP13686
PhosphoSitePlusiP13686

Polymorphism and mutation databases

BioMutaiACP5
DMDMi56757583

Proteomic databases

EPDiP13686
PaxDbiP13686
PeptideAtlasiP13686
PRIDEiP13686
ProteomicsDBi52960

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218758; ENSP00000218758; ENSG00000102575
ENST00000412435; ENSP00000392374; ENSG00000102575
ENST00000433365; ENSP00000413456; ENSG00000102575
ENST00000592828; ENSP00000468767; ENSG00000102575
ENST00000648477; ENSP00000496973; ENSG00000102575
GeneIDi54
KEGGihsa:54
UCSCiuc002msg.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54
DisGeNETi54
EuPathDBiHostDB:ENSG00000102575.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ACP5
HGNCiHGNC:124 ACP5
HPAiCAB002584
HPA057655
HPA059463
MalaCardsiACP5
MIMi171640 gene
607944 phenotype
neXtProtiNX_P13686
OpenTargetsiENSG00000102575
Orphaneti1855 Spondyloenchondrodysplasia
PharmGKBiPA24448

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2679 Eukaryota
COG1409 LUCA
GeneTreeiENSGT00390000016735
HOVERGENiHBG000433
InParanoidiP13686
KOiK14379
OMAiWNFPSPY
OrthoDBiEOG091G0J5W
PhylomeDBiP13686
TreeFamiTF313175

Enzyme and pathway databases

BRENDAi3.1.3.2 2681
ReactomeiR-HSA-196843 Vitamin B2 (riboflavin) metabolism
SABIO-RKiP13686
SIGNORiP13686

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACP5 human
EvolutionaryTraceiP13686

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Tartrate-resistant_acid_phosphatase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54
PMAP-CutDBiP13686

Protein Ontology

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PROi
PR:P13686

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102575 Expressed in 159 organ(s), highest expression level in periodontal ligament
CleanExiHS_ACP5
ExpressionAtlasiP13686 baseline and differential
GenevisibleiP13686 HS

Family and domain databases

CDDicd07378 MPP_ACP5, 1 hit
Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR024927 Acid_PPase
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF000898 Acid_Ptase_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13686
Secondary accession number(s): A8K3V2
, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 21, 2004
Last modified: December 5, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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