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Protein

Prolyl 4-hydroxylase subunit alpha-1

Gene

P4HA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi429IronPROSITE-ProRule annotation1
Metal bindingi431IronPROSITE-ProRule annotation1
Metal bindingi500IronPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei5102-oxoglutaratePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • collagen fibril organization Source: Ensembl
  • peptidyl-proline hydroxylation to 4-hydroxy-L-proline Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding, Vitamin C

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS04613-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.11.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814 Collagen biosynthesis and modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolyl 4-hydroxylase subunit alpha-1 (EC:1.14.11.2)
Short name:
4-PH alpha-1
Alternative name(s):
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P4HA1
Synonyms:P4HA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000122884.12

Human Gene Nomenclature Database

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HGNCi
HGNC:8546 P4HA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176710 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13674

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi210Y → A: Strongly reduced affinity for peptide substrate. 1 Publication1
Mutagenesisi213Y → A: Strongly reduced affinity for peptide substrate. 1 Publication1
Mutagenesisi247Y → A: Strongly reduced affinity for peptide substrate. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5033

MalaCards human disease database

More...
MalaCardsi
P4HA1

Open Targets

More...
OpenTargetsi
ENSG00000122884

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2953 Ehlers-Danlos syndrome, musculocontractural type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32874

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1250350

Drug and drug target database

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DrugBanki
DB01275 Hydralazine
DB00172 L-Proline
DB00139 Succinic acid
DB00126 Vitamin C

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
P4HA1

Domain mapping of disease mutations (DMDM)

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DMDMi
2507090

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Combined sourcesAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002272318 – 534Prolyl 4-hydroxylase subunit alpha-1Add BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi113N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi259N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P13674

MaxQB - The MaxQuant DataBase

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MaxQBi
P13674

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13674

PeptideAtlas

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PeptideAtlasi
P13674

PRoteomics IDEntifications database

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PRIDEi
P13674

ProteomicsDB human proteome resource

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ProteomicsDBi
52957
52958 [P13674-2]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1640

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13674

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13674

SwissPalm database of S-palmitoylation events

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SwissPalmi
P13674

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000122884 Expressed in 228 organ(s), highest expression level in cartilage tissue

CleanEx database of gene expression profiles

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CleanExi
HS_P4HA1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P13674 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13674 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA007599
HPA026593

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two alpha-1 chains and two beta chains (the beta chain is the multi-functional PDI).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111072, 48 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P13674

Database of interacting proteins

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DIPi
DIP-38180N

Protein interaction database and analysis system

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IntActi
P13674, 53 interactors

Molecular INTeraction database

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MINTi
P13674

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263556

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P13674

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1534
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13674

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13674

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P13674

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati205 – 238TPRAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini411 – 519Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST109

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P4HA family.Curated

Keywords - Domaini

Signal, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1591 Eukaryota
ENOG410XS5J LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156635

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230465

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006834

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13674

KEGG Orthology (KO)

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KOi
K00472

Identification of Orthologs from Complete Genome Data

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OMAi
DRPYIVR

Database for complete collections of gene phylogenies

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PhylomeDBi
P13674

TreeFam database of animal gene trees

More...
TreeFami
TF313393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR006620 Pro_4_hyd_alph
IPR013547 Pro_4_hyd_alph_N
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13640 2OG-FeII_Oxy_3, 1 hit
PF08336 P4Ha_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00702 P4Hc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51471 FE2OG_OXY, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P13674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIWYILIIGI LLPQSLAHPG FFTSIGQMTD LIHTEKDLVT SLKDYIKAEE
60 70 80 90 100
DKLEQIKKWA EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN
110 120 130 140 150
LVLKDMSDGF ISNLTIQRQY FPNDEDQVGA AKALLRLQDT YNLDTDTISK
160 170 180 190 200
GNLPGVKHKS FLTAEDCFEL GKVAYTEADY YHTELWMEQA LRQLDEGEIS
210 220 230 240 250
TIDKVSVLDY LSYAVYQQGD LDKALLLTKK LLELDPEHQR ANGNLKYFEY
260 270 280 290 300
IMAKEKDVNK SASDDQSDQK TTPKKKGVAV DYLPERQKYE MLCRGEGIKM
310 320 330 340 350
TPRRQKKLFC RYHDGNRNPK FILAPAKQED EWDKPRIIRF HDIISDAEIE
360 370 380 390 400
IVKDLAKPRL RRATISNPIT GDLETVHYRI SKSAWLSGYE NPVVSRINMR
410 420 430 440 450
IQDLTGLDVS TAEELQVANY GVGGQYEPHF DFARKDEPDA FKELGTGNRI
460 470 480 490 500
ATWLFYMSDV SAGGATVFPE VGASVWPKKG TAVFWYNLFA SGEGDYSTRH
510 520 530
AACPVLVGNK WVSNKWLHER GQEFRRPCTL SELE
Length:534
Mass (Da):61,049
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBAFA8CCF09A1DDB
GO
Isoform 2 (identifier: P13674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-380: RRATISNPITGDLETVHYRI → SRATVHDPETGKLTTAQYRV

Show »
Length:534
Mass (Da):60,967
Checksum:i5FE1B10A8AC5E792
GO
Isoform 3 (identifier: P13674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-380: RRATISNPITGDLETVHYRI → SRATVHDPETGKLTTAQYRV
     417-434: Missing.

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):58,958
Checksum:iED30BECCFB48CD7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119 – 122QYFP → PVLS in AAA36534 (PubMed:2543975).Curated4
Sequence conflicti119 – 122QYFP → PVLS in AAA36535 (PubMed:2543975).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004504361 – 380RRATI…VHYRI → SRATVHDPETGKLTTAQYRV in isoform 2 and isoform 3. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_044578417 – 434Missing in isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M24486 mRNA Translation: AAA36534.1
M24487 mRNA Translation: AAA36535.1
U14620
, U14607, U14605, U14608, U14609, U14611, U14610, U14612, U14614, U14615, U14616, U14617, U14618, U14619 Genomic DNA Translation: AAA59068.1
U14620
, U14607, U14605, U14608, U14609, U14611, U14610, U14612, U14613, U14615, U14616, U14617, U14618, U14619 Genomic DNA Translation: AAA59069.1
CD013929 Genomic DNA No translation available.
AL731563 Genomic DNA No translation available.
BC034998 mRNA Translation: AAH34998.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41537.1 [P13674-1]
CCDS44432.1 [P13674-3]
CCDS7320.1 [P13674-2]

Protein sequence database of the Protein Information Resource

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PIRi
A33919 DAHUA1
I37173 DAHUA2

NCBI Reference Sequences

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RefSeqi
NP_000908.2, NM_000917.3 [P13674-2]
NP_001017962.1, NM_001017962.2 [P13674-1]
NP_001136067.1, NM_001142595.1 [P13674-1]
NP_001136068.1, NM_001142596.1 [P13674-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.500047
Hs.593005

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000263556; ENSP00000263556; ENSG00000122884 [P13674-2]
ENST00000307116; ENSP00000307318; ENSG00000122884 [P13674-1]
ENST00000373008; ENSP00000362099; ENSG00000122884 [P13674-2]
ENST00000394890; ENSP00000378353; ENSG00000122884 [P13674-1]
ENST00000440381; ENSP00000414464; ENSG00000122884 [P13674-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5033

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5033

UCSC genome browser

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UCSCi
uc001jtg.4 human [P13674-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24486 mRNA Translation: AAA36534.1
M24487 mRNA Translation: AAA36535.1
U14620
, U14607, U14605, U14608, U14609, U14611, U14610, U14612, U14614, U14615, U14616, U14617, U14618, U14619 Genomic DNA Translation: AAA59068.1
U14620
, U14607, U14605, U14608, U14609, U14611, U14610, U14612, U14613, U14615, U14616, U14617, U14618, U14619 Genomic DNA Translation: AAA59069.1
CD013929 Genomic DNA No translation available.
AL731563 Genomic DNA No translation available.
BC034998 mRNA Translation: AAH34998.1
CCDSiCCDS41537.1 [P13674-1]
CCDS44432.1 [P13674-3]
CCDS7320.1 [P13674-2]
PIRiA33919 DAHUA1
I37173 DAHUA2
RefSeqiNP_000908.2, NM_000917.3 [P13674-2]
NP_001017962.1, NM_001017962.2 [P13674-1]
NP_001136067.1, NM_001142595.1 [P13674-1]
NP_001136068.1, NM_001142596.1 [P13674-3]
UniGeneiHs.500047
Hs.593005

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TJCX-ray2.30A/B161-261[»]
2V5FX-ray2.03A161-263[»]
2YQ8X-ray2.99A/B18-255[»]
4BT8X-ray2.20A/B18-255[»]
4BT9X-ray1.90A/B18-255[»]
4BTAX-ray2.95A/B18-261[»]
4BTBX-ray1.90A18-255[»]
ProteinModelPortaliP13674
SMRiP13674
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111072, 48 interactors
CORUMiP13674
DIPiDIP-38180N
IntActiP13674, 53 interactors
MINTiP13674
STRINGi9606.ENSP00000263556

Chemistry databases

BindingDBiP13674
ChEMBLiCHEMBL1250350
DrugBankiDB01275 Hydralazine
DB00172 L-Proline
DB00139 Succinic acid
DB00126 Vitamin C

PTM databases

GlyConnecti1640
iPTMnetiP13674
PhosphoSitePlusiP13674
SwissPalmiP13674

Polymorphism and mutation databases

BioMutaiP4HA1
DMDMi2507090

Proteomic databases

EPDiP13674
MaxQBiP13674
PaxDbiP13674
PeptideAtlasiP13674
PRIDEiP13674
ProteomicsDBi52957
52958 [P13674-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5033
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263556; ENSP00000263556; ENSG00000122884 [P13674-2]
ENST00000307116; ENSP00000307318; ENSG00000122884 [P13674-1]
ENST00000373008; ENSP00000362099; ENSG00000122884 [P13674-2]
ENST00000394890; ENSP00000378353; ENSG00000122884 [P13674-1]
ENST00000440381; ENSP00000414464; ENSG00000122884 [P13674-3]
GeneIDi5033
KEGGihsa:5033
UCSCiuc001jtg.4 human [P13674-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5033
DisGeNETi5033
EuPathDBiHostDB:ENSG00000122884.12

GeneCards: human genes, protein and diseases

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GeneCardsi
P4HA1
HGNCiHGNC:8546 P4HA1
HPAiHPA007599
HPA026593
MalaCardsiP4HA1
MIMi176710 gene
neXtProtiNX_P13674
OpenTargetsiENSG00000122884
Orphaneti2953 Ehlers-Danlos syndrome, musculocontractural type
PharmGKBiPA32874

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1591 Eukaryota
ENOG410XS5J LUCA
GeneTreeiENSGT00940000156635
HOGENOMiHOG000230465
HOVERGENiHBG006834
InParanoidiP13674
KOiK00472
OMAiDRPYIVR
PhylomeDBiP13674
TreeFamiTF313393

Enzyme and pathway databases

BioCyciMetaCyc:HS04613-MONOMER
BRENDAi1.14.11.2 2681
ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
P4HA1 human
EvolutionaryTraceiP13674

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
P4HA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5033

Protein Ontology

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PROi
PR:P13674

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122884 Expressed in 228 organ(s), highest expression level in cartilage tissue
CleanExiHS_P4HA1
ExpressionAtlasiP13674 baseline and differential
GenevisibleiP13674 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR006620 Pro_4_hyd_alph
IPR013547 Pro_4_hyd_alph_N
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13640 2OG-FeII_Oxy_3, 1 hit
PF08336 P4Ha_N, 1 hit
SMARTiView protein in SMART
SM00702 P4Hc, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS51471 FE2OG_OXY, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP4HA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13674
Secondary accession number(s): C9JL12
, Q15082, Q15083, Q5VSQ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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