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UniProtKB - P13671 (CO6_HUMAN)

Entry version 211 (25 May 2022)
Sequence version 3 (01 May 2007)
Previous versions | rss
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Protein

Complement component C6

Gene

C6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement pathway, Cytolysis, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13671

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P13671

SIGNOR Signaling Network Open Resource

More...SIGNORi		P13671

Protein family/group databases

Transport Classification Database

More...TCDBi		1.C.39.3.3, the membrane attack complex/perforin (macpf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement component C6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1339, C6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		217050, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13671

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000039537

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane attack complex, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Complement component 6 deficiency (C6D)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		729

MalaCards human disease database

More...MalaCardsi		C6
MIMi612446, phenotype

Open Targets

More...OpenTargetsi		ENSG00000039537

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169150, Immunodeficiency due to a late component of complement deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25921

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13671, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C6

Domain mapping of disease mutations (DMDM)

More...DMDMi		146345396

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002357922 – 934Complement component C6Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi22 ↔ 61
Disulfide bondi24 ↔ 65
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29C-linked (Man) tryptophan1 Publication1
Glycosylationi32C-linked (Man) tryptophan; partial1 Publication1
Disulfide bondi35 ↔ 73
Glycosylationi38O-linked (Fuc...) threonine1 Publication1
Disulfide bondi39 ↔ 78
Disulfide bondi82 ↔ 117
Glycosylationi90C-linked (Man) tryptophan; partial1 Publication1
Disulfide bondi93 ↔ 127
Disulfide bondi96 ↔ 133
Disulfide bondi140 ↔ 151
Disulfide bondi146 ↔ 164
Disulfide bondi158 ↔ 173
Disulfide bondi180 ↔ 218
Glycosylationi324N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi392O-linked (Fuc...) threonine1 Publication1
Disulfide bondi399 ↔ 420
Disulfide bondi499 ↔ 623
Disulfide bondi521 ↔ 570
Disulfide bondi523 ↔ 539
Disulfide bondi526 ↔ 541
Disulfide bondi543 ↔ 552
Glycosylationi568C-linked (Man) tryptophan; partial1 Publication1
Glycosylationi571C-linked (Man) tryptophan; partial1 Publication1
Glycosylationi574C-linked (Man) tryptophan; partial1 Publication1
Disulfide bondi577 ↔ 611
Disulfide bondi589 ↔ 601
Disulfide bondi644 ↔ 686
Disulfide bondi672 ↔ 699
Disulfide bondi704 ↔ 746
Disulfide bondi732 ↔ 761
Disulfide bondi773 ↔ 823
Disulfide bondi784 ↔ 801
Disulfide bondi786 ↔ 837
Disulfide bondi793 ↔ 816
Glycosylationi855N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi862 ↔ 873
Disulfide bondi867 ↔ 919
Disulfide bondi880 ↔ 897
Disulfide bondi882 ↔ 932
Disulfide bondi888 ↔ 912

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P13671

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13671

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13671

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13671

PeptideAtlas

More...PeptideAtlasi		P13671

PRoteomics IDEntifications database

More...PRIDEi		P13671

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52956

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P13671

GlyConnect protein glycosylation platform

More...GlyConnecti		791, 7 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13671, 12 sites, 7 N-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13671

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13671

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000039537, Expressed in liver and 136 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13671, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13671, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000039537, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107190, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6159, Membrane attack complex
CPX-677, C5b6 complement complex

Protein interaction database and analysis system

More...IntActi		P13671, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263413

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13671, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1934
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P13671

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13671

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 79TSP type-1 1PROSITE-ProRule annotationAdd BLAST58
Domaini81 – 134TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini138 – 175LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini176 – 522MACPFPROSITE-ProRule annotationAdd BLAST347
Domaini523 – 553EGF-likeAdd BLAST31
Domaini565 – 612TSP type-1 3PROSITE-ProRule annotationAdd BLAST48
Domaini642 – 701Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini702 – 763Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini780 – 839Kazal-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini876 – 934Kazal-like 2PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni611 – 688CCP 1Add BLAST78
Regioni642 – 934C5b-binding domainAdd BLAST293
Regioni689 – 765CCP 2Add BLAST77
Regioni766 – 840Factor I module (FIM) 1Add BLAST75
Regioni858 – 934Factor I module (FIM) 2Add BLAST77

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPIM, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156814

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014082_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13671

Identification of Orthologs from Complete Genome Data

More...OMAi		FRPCIPS

Database of Orthologous Groups

More...OrthoDBi		100680at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13671

TreeFam database of animal gene trees

More...TreeFami		TF330498

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 2 hits
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 3 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003884, FacI_MAC
IPR002350, Kazal_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00084, Sushi, 2 hits
PF00090, TSP_1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00764, COMPLEMENTC9

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 2 hits
SM00057, FIMAC, 2 hits
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57424, SSF57424, 1 hit
SSF57535, SSF57535, 2 hits
SSF82895, SSF82895, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS51465, KAZAL_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50923, SUSHI, 2 hits
PS50092, TSP1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P13671-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRSVLYFI LLNALINKGQ ACFCDHYAWT QWTSCSKTCN SGTQSRHRQI 
        60         70         80         90        100
VVDKYYQENF CEQICSKQET RECNWQRCPI NCLLGDFGPW SDCDPCIEKQ 
       110        120        130        140        150
SKVRSVLRPS QFGGQPCTAP LVAFQPCIPS KLCKIEEADC KNKFRCDSGR 
       160        170        180        190        200
CIARKLECNG ENDCGDNSDE RDCGRTKAVC TRKYNPIPSV QLMGNGFHFL 
       210        220        230        240        250
AGEPRGEVLD NSFTGGICKT VKSSRTSNPY RVPANLENVG FEVQTAEDDL 
       260        270        280        290        300
KTDFYKDLTS LGHNENQQGS FSSQGGSSFS VPIFYSSKRS ENINHNSAFK 
       310        320        330        340        350
QAIQASHKKD SSFIRIHKVM KVLNFTTKAK DLHLSDVFLK ALNHLPLEYN 
       360        370        380        390        400
SALYSRIFDD FGTHYFTSGS LGGVYDLLYQ FSSEELKNSG LTEEEAKHCV 
       410        420        430        440        450
RIETKKRVLF AKKTKVEHRC TTNKLSEKHE GSFIQGAEKS ISLIRGGRSE 
       460        470        480        490        500
YGAALAWEKG SSGLEEKTFS EWLESVKENP AVIDFELAPI VDLVRNIPCA 
       510        520        530        540        550
VTKRNNLRKA LQEYAAKFDP CQCAPCPNNG RPTLSGTECL CVCQSGTYGE 
       560        570        580        590        600
NCEKQSPDYK SNAVDGQWGC WSSWSTCDAT YKRSRTRECN NPAPQRGGKR 
       610        620        630        640        650
CEGEKRQEED CTFSIMENNG QPCINDDEEM KEVDLPEIEA DSGCPQPVPP 
       660        670        680        690        700
ENGFIRNEKQ LYLVGEDVEI SCLTGFETVG YQYFRCLPDG TWRQGDVECQ 
       710        720        730        740        750
RTECIKPVVQ EVLTITPFQR LYRIGESIEL TCPKGFVVAG PSRYTCQGNS 
       760        770        780        790        800
WTPPISNSLT CEKDTLTKLK GHCQLGQKQS GSECICMSPE EDCSHHSEDL 
       810        820        830        840        850
CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG RQLEWGLERT 
       860        870        880        890        900
RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM 
       910        920        930 
GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA
Length:934
Mass (Da):104,786
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA88F4BED7CC349D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JC72C9JC72_HUMAN
Complement component C6
C6
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JX36C9JX36_HUMAN
Complement component C6
C6
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti567Q → H in BAD02321 (Ref. 4) Curated1
Sequence conflicti616M → I in BAD02321 (Ref. 4) Curated1
Sequence conflicti934A → T in BAD02321 (Ref. 4) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The sequence shown is that of allotype C6 B.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_006056119A → E in allotype C6 A. 5 PublicationsCorresponds to variant dbSNP:rs1801033EnsemblClinVar.1
Natural variantiVAR_027647397K → E. Corresponds to variant dbSNP:rs6896011EnsemblClinVar.1
Natural variantiVAR_027648470S → F. Corresponds to variant dbSNP:rs10462014Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J05064 mRNA Translation: AAA51860.1
J05024 mRNA Translation: AAA59668.1
X72177 Genomic DNA Translation: CAA50994.1
AB126592 mRNA Translation: BAD02321.1
AC008863 Genomic DNA No translation available.
AC091871 Genomic DNA No translation available.
BC035723 mRNA Translation: AAH35723.1
J04506 mRNA Translation: AAB59433.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3936.1

Protein sequence database of the Protein Information Resource

More...PIRi		A34372

NCBI Reference Sequences

More...RefSeqi		NP_000056.2, NM_000065.3
NP_001108603.2, NM_001115131.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263413.7; ENSP00000263413.3; ENSG00000039537.14
ENST00000337836.10; ENSP00000338861.5; ENSG00000039537.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		729

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:729

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000337836.10; ENSP00000338861.5; NM_000065.5; NP_000056.2

UCSC genome browser

More...UCSCi		uc003jmk.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

C6base

C6 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05064 mRNA Translation: AAA51860.1
J05024 mRNA Translation: AAA59668.1
X72177 Genomic DNA Translation: CAA50994.1
AB126592 mRNA Translation: BAD02321.1
AC008863 Genomic DNA No translation available.
AC091871 Genomic DNA No translation available.
BC035723 mRNA Translation: AAH35723.1
J04506 mRNA Translation: AAB59433.1
CCDSiCCDS3936.1
PIRiA34372
RefSeqiNP_000056.2, NM_000065.3
NP_001108603.2, NM_001115131.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T5OX-ray2.87A22-934[»]
4A5WX-ray3.50B22-934[»]
4E0SX-ray4.21B22-934[»]
6H03electron microscopy5.60B22-934[»]
6H04electron microscopy5.60B22-934[»]
7NYCelectron microscopy3.50B22-934[»]
7NYDelectron microscopy3.30B22-934[»]
AlphaFoldDBiP13671
SMRiP13671
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107190, 11 interactors
ComplexPortaliCPX-6159, Membrane attack complex
CPX-677, C5b6 complement complex
IntActiP13671, 10 interactors
STRINGi9606.ENSP00000263413

Protein family/group databases

TCDBi1.C.39.3.3, the membrane attack complex/perforin (macpf) family

PTM databases

CarbonylDBiP13671
GlyConnecti791, 7 N-Linked glycans (4 sites)
GlyGeniP13671, 12 sites, 7 N-linked glycans (4 sites)
iPTMnetiP13671
PhosphoSitePlusiP13671

Genetic variation databases

BioMutaiC6
DMDMi146345396

Proteomic databases

EPDiP13671
jPOSTiP13671
MassIVEiP13671
PaxDbiP13671
PeptideAtlasiP13671
PRIDEiP13671
ProteomicsDBi52956

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P13671, 9 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10692, 304 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		729

Genome annotation databases

EnsembliENST00000263413.7; ENSP00000263413.3; ENSG00000039537.14
ENST00000337836.10; ENSP00000338861.5; ENSG00000039537.14
GeneIDi729
KEGGihsa:729
MANE-SelectiENST00000337836.10; ENSP00000338861.5; NM_000065.5; NP_000056.2
UCSCiuc003jmk.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		729
DisGeNETi729

GeneCards: human genes, protein and diseases

More...GeneCardsi		C6
HGNCiHGNC:1339, C6
HPAiENSG00000039537, Tissue enriched (liver)
MalaCardsiC6
MIMi217050, gene
612446, phenotype
neXtProtiNX_P13671
OpenTargetsiENSG00000039537
Orphaneti169150, Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25921
VEuPathDBiHostDB:ENSG00000039537

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPIM, Eukaryota
GeneTreeiENSGT00940000156814
HOGENOMiCLU_014082_0_0_1
InParanoidiP13671
OMAiFRPCIPS
OrthoDBi100680at2759
PhylomeDBiP13671
TreeFamiTF330498

Enzyme and pathway databases

PathwayCommonsiP13671
ReactomeiR-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade
SignaLinkiP13671
SIGNORiP13671

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		729, 9 hits in 1068 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Complement_component_6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		729
PharosiP13671, Tbio

Protein Ontology

More...PROi		PR:P13671
RNActiP13671, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000039537, Expressed in liver and 136 other tissues
ExpressionAtlasiP13671, baseline and differential
GenevisibleiP13671, HS

Family and domain databases

CDDicd00033, CCP, 2 hits
cd00112, LDLa, 1 hit
Gene3Di2.20.100.10, 3 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR003884, FacI_MAC
IPR002350, Kazal_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00084, Sushi, 2 hits
PF00090, TSP_1, 3 hits
PRINTSiPR00764, COMPLEMENTC9
SMARTiView protein in SMART
SM00032, CCP, 2 hits
SM00057, FIMAC, 2 hits
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 3 hits
SUPFAMiSSF57424, SSF57424, 1 hit
SSF57535, SSF57535, 2 hits
SSF82895, SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS51465, KAZAL_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50923, SUSHI, 2 hits
PS50092, TSP1, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13671
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 2007
Last modified: May 25, 2022
This is version 211 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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