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Protein

Mannosyl-D-glycerate transport/metabolism system repressor MngR

Gene

mngR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Represses mngA and mngB. Regulates its own expression.2 Publications

Caution

Originally proposed to be involved in the regulation of the acid citric cycle in response to fatty acids. This was based on in vitro experiments showing that MngR was released from its DNA-binding sites by high concentration sof fatty acids and acyl-CoAs. These results could be explained by the fact that these high-concentrations of fatty acids could have denatured the MngR protein.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi32 – 51H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to heat Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD01103

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-D-glycerate transport/metabolism system repressor MngR
Alternative name(s):
Fatty acyl-responsive regulator
Protein P30
Gene namesi
Name:mngR
Synonyms:farR, g30, ybgB
Ordered Locus Names:b0730, JW0719
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11109 mngR

Pathology & Biotechi

Disruption phenotypei

In cells lacking this gene the expression of mngA and mngB increases by 9-fold and 23-fold, respectively.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506411 – 240Mannosyl-D-glycerate transport/metabolism system repressor MngRAdd BLAST240

Proteomic databases

PaxDbiP13669
PRIDEiP13669

Expressioni

Inductioni

Induced by mannosyl-D-glycerate.

Interactioni

Protein-protein interaction databases

BioGridi4261225, 5 interactors
DIPiDIP-9565N
IntActiP13669, 4 interactors
STRINGi316385.ECDH10B_0796

Structurei

3D structure databases

ProteinModelPortaliP13669
SMRiP13669
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 72HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG4105FDP Bacteria
COG2188 LUCA
HOGENOMiHOG000228717
InParanoidiP13669
KOiK11922
PhylomeDBiP13669

Family and domain databases

CDDicd07377 WHTH_GntR, 1 hit
Gene3Di1.10.10.10, 1 hit
3.40.1410.10, 1 hit
InterProiView protein in InterPro
IPR028978 Chorismate_lyase_/UTRA_dom_sf
IPR000524 Tscrpt_reg_HTH_GntR
IPR011663 UTRA
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00392 GntR, 1 hit
PF07702 UTRA, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00345 HTH_GNTR, 1 hit
SM00866 UTRA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF64288 SSF64288, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P13669-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHKPLYRQI ADRIREQIAR GELKPGDALP TESALQTEFG VSRVTVRQAL
60 70 80 90 100
RQLVEQQILE SIQGSGTYVK EERVNYDIFQ LTSFDEKLSD RHVDTHSEVL
110 120 130 140 150
IFEVIPADDF LQQQLQITPQ DRVWHVKRVR YRKQKPMALE ETWMPLALFP
160 170 180 190 200
DLTWQVMENS KYHFIEEVKK MVIDRSEQEI IPLMPTEEMS RLLNISQTKP
210 220 230 240
ILEKVSRGYL VDGRVFEYSR NAFNTDDYKF TLIAQRKSSR
Length:240
Mass (Da):28,273
Last modified:January 1, 1990 - v1
Checksum:i69CBB5AFAB2DCDD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15790 Genomic DNA Translation: CAA33791.1
U00096 Genomic DNA Translation: AAC73824.1
AP009048 Genomic DNA Translation: BAA35396.2
D64014 Genomic DNA No translation available.
PIRiS04645
RefSeqiNP_415258.1, NC_000913.3
WP_000509902.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73824; AAC73824; b0730
BAA35396; BAA35396; BAA35396
GeneIDi945371
KEGGiecj:JW0719
eco:b0730
PATRICifig|1411691.4.peg.1543

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15790 Genomic DNA Translation: CAA33791.1
U00096 Genomic DNA Translation: AAC73824.1
AP009048 Genomic DNA Translation: BAA35396.2
D64014 Genomic DNA No translation available.
PIRiS04645
RefSeqiNP_415258.1, NC_000913.3
WP_000509902.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP13669
SMRiP13669
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261225, 5 interactors
DIPiDIP-9565N
IntActiP13669, 4 interactors
STRINGi316385.ECDH10B_0796

Proteomic databases

PaxDbiP13669
PRIDEiP13669

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73824; AAC73824; b0730
BAA35396; BAA35396; BAA35396
GeneIDi945371
KEGGiecj:JW0719
eco:b0730
PATRICifig|1411691.4.peg.1543

Organism-specific databases

EchoBASEiEB1100
EcoGeneiEG11109 mngR

Phylogenomic databases

eggNOGiENOG4105FDP Bacteria
COG2188 LUCA
HOGENOMiHOG000228717
InParanoidiP13669
KOiK11922
PhylomeDBiP13669

Enzyme and pathway databases

BioCyciEcoCyc:PD01103

Miscellaneous databases

PROiPR:P13669

Family and domain databases

CDDicd07377 WHTH_GntR, 1 hit
Gene3Di1.10.10.10, 1 hit
3.40.1410.10, 1 hit
InterProiView protein in InterPro
IPR028978 Chorismate_lyase_/UTRA_dom_sf
IPR000524 Tscrpt_reg_HTH_GntR
IPR011663 UTRA
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00392 GntR, 1 hit
PF07702 UTRA, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00345 HTH_GNTR, 1 hit
SM00866 UTRA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF64288 SSF64288, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMNGR_ECOLI
AccessioniPrimary (citable) accession number: P13669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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