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Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Was originally thought to be a deoxycytidine kinase.1 Publication

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BRENDAi5.3.4.1 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A4 (EC:5.3.4.1)
Alternative name(s):
Endoplasmic reticulum resident protein 70
Short name:
ER protein 70
Short name:
ERp70
Endoplasmic reticulum resident protein 72
Short name:
ER protein 72
Short name:
ERp-72
Short name:
ERp72
Gene namesi
Name:PDIA4
Synonyms:ERP70, ERP72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000155660.10
HGNCiHGNC:30167 PDIA4
neXtProtiNX_P13667

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi9601
OpenTargetsiENSG00000155660
PharmGKBiPA142671190

Polymorphism and mutation databases

BioMutaiPDIA4
DMDMi119530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003422921 – 645Protein disulfide-isomerase A4Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 94Redox-activePROSITE-ProRule annotation
Disulfide bondi206 ↔ 209Redox-activePROSITE-ProRule annotation
Modified residuei366N6-acetyllysineCombined sources1
Disulfide bondi555 ↔ 558Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP13667
MaxQBiP13667
PaxDbiP13667
PeptideAtlasiP13667
PRIDEiP13667
ProteomicsDBi52955

2D gel databases

OGPiP13667
REPRODUCTION-2DPAGEiIPI00009904

PTM databases

iPTMnetiP13667
PhosphoSitePlusiP13667
SwissPalmiP13667

Expressioni

Gene expression databases

BgeeiENSG00000155660
CleanExiHS_PDIA4
ExpressionAtlasiP13667 baseline and differential
GenevisibleiP13667 HS

Organism-specific databases

HPAiCAB017368
HPA006139
HPA006140

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114966, 74 interactors
IntActiP13667, 47 interactors
MINTiP13667
STRINGi9606.ENSP00000286091

Structurei

Secondary structure

1645
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi59 – 61Combined sources3
Beta strandi64 – 66Combined sources3
Turni69 – 71Combined sources3
Helixi72 – 76Combined sources5
Beta strandi80 – 87Combined sources8
Helixi92 – 109Combined sources18
Beta strandi111 – 113Combined sources3
Beta strandi117 – 121Combined sources5
Turni122 – 124Combined sources3
Helixi126 – 131Combined sources6
Beta strandi136 – 144Combined sources9
Beta strandi147 – 150Combined sources4
Helixi157 – 168Combined sources12
Beta strandi178 – 181Combined sources4
Turni184 – 186Combined sources3
Helixi187 – 193Combined sources7
Beta strandi195 – 202Combined sources8
Helixi208 – 211Combined sources4
Helixi213 – 224Combined sources12
Beta strandi226 – 228Combined sources3
Beta strandi232 – 236Combined sources5
Turni237 – 239Combined sources3
Helixi241 – 246Combined sources6
Beta strandi251 – 259Combined sources9
Beta strandi262 – 265Combined sources4
Helixi272 – 282Combined sources11

3D structure databases

ProteinModelPortaliP13667
SMRiP13667
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13667

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 169Thioredoxin 1PROSITE-ProRule annotationAdd BLAST149
Domaini158 – 301Thioredoxin 2PROSITE-ProRule annotationAdd BLAST144
Domaini505 – 636Thioredoxin 3PROSITE-ProRule annotationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi642 – 645Prevents secretion from ER4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 55Asp/Glu-rich (acidic)Add BLAST17

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000162459
HOVERGENiHBG005920
InParanoidiP13667
KOiK09582
OMAiYRAATQF
OrthoDBiEOG091G05J9
PhylomeDBiP13667
TreeFamiTF106382

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRKAFLLL LLLGLVQLLA VAGAEGPDED SSNRENAIED EEEEEEEDDD
60 70 80 90 100
EEEDDLEVKE ENGVLVLNDA NFDNFVADKD TVLLEFYAPW CGHCKQFAPE
110 120 130 140 150
YEKIANILKD KDPPIPVAKI DATSASVLAS RFDVSGYPTI KILKKGQAVD
160 170 180 190 200
YEGSRTQEEI VAKVREVSQP DWTPPPEVTL VLTKENFDEV VNDADIILVE
210 220 230 240 250
FYAPWCGHCK KLAPEYEKAA KELSKRSPPI PLAKVDATAE TDLAKRFDVS
260 270 280 290 300
GYPTLKIFRK GRPYDYNGPR EKYGIVDYMI EQSGPPSKEI LTLKQVQEFL
310 320 330 340 350
KDGDDVIIIG VFKGESDPAY QQYQDAANNL REDYKFHHTF STEIAKFLKV
360 370 380 390 400
SQGQLVVMQP EKFQSKYEPR SHMMDVQGST QDSAIKDFVL KYALPLVGHR
410 420 430 440 450
KVSNDAKRYT RRPLVVVYYS VDFSFDYRAA TQFWRSKVLE VAKDFPEYTF
460 470 480 490 500
AIADEEDYAG EVKDLGLSES GEDVNAAILD ESGKKFAMEP EEFDSDTLRE
510 520 530 540 550
FVTAFKKGKL KPVIKSQPVP KNNKGPVKVV VGKTFDSIVM DPKKDVLIEF
560 570 580 590 600
YAPWCGHCKQ LEPVYNSLAK KYKGQKGLVI AKMDATANDV PSDRYKVEGF
610 620 630 640
PTIYFAPSGD KKNPVKFEGG DRDLEHLSKF IEEHATKLSR TKEEL
Length:645
Mass (Da):72,932
Last modified:May 1, 1991 - v2
Checksum:i1919C2AE12CD2684
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102E → G in BAF83660 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052580173T → M. Corresponds to variant dbSNP:rs2290971Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05016 mRNA Translation: AAA58460.1
AK290971 mRNA Translation: BAF83660.1
AC093743 Genomic DNA Translation: AAQ96863.1
CH471146 Genomic DNA Translation: EAW80065.1
CH471146 Genomic DNA Translation: EAW80066.1
BC000425 mRNA Translation: AAH00425.1
BC001928 mRNA Translation: AAH01928.1
BC006344 mRNA Translation: AAH06344.1
BC011754 mRNA Translation: AAH11754.1
CCDSiCCDS5893.1
PIRiA23723
RefSeqiNP_004902.1, NM_004911.4
UniGeneiHs.93659

Genome annotation databases

EnsembliENST00000286091; ENSP00000286091; ENSG00000155660
GeneIDi9601
KEGGihsa:9601
UCSCiuc003wff.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPDIA4_HUMAN
AccessioniPrimary (citable) accession number: P13667
Secondary accession number(s): A8K4K6, Q549T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 1991
Last modified: July 18, 2018
This is version 202 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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