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Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Was originally thought to be a deoxycytidine kinase.1 Publication

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • chaperone-mediated protein folding Source: UniProtKB
  • protein folding Source: GO_Central
  • protein secretion Source: ProtInc
  • response to endoplasmic reticulum stress Source: GO_Central

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BRENDAi5.3.4.1 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A4 (EC:5.3.4.1)
Alternative name(s):
Endoplasmic reticulum resident protein 70
Short name:
ER protein 70
Short name:
ERp70
Endoplasmic reticulum resident protein 72
Short name:
ER protein 72
Short name:
ERp-72
Short name:
ERp72
Gene namesi
Name:PDIA4
Synonyms:ERP70, ERP72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000155660.10
HGNCiHGNC:30167 PDIA4
neXtProtiNX_P13667

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi9601
OpenTargetsiENSG00000155660
PharmGKBiPA142671190

Polymorphism and mutation databases

BioMutaiPDIA4
DMDMi119530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003422921 – 645Protein disulfide-isomerase A4Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 94Redox-activePROSITE-ProRule annotation
Disulfide bondi206 ↔ 209Redox-activePROSITE-ProRule annotation
Modified residuei366N6-acetyllysineCombined sources1
Disulfide bondi555 ↔ 558Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP13667
MaxQBiP13667
PaxDbiP13667
PeptideAtlasiP13667
PRIDEiP13667
ProteomicsDBi52955

2D gel databases

OGPiP13667
REPRODUCTION-2DPAGEiIPI00009904

PTM databases

iPTMnetiP13667
PhosphoSitePlusiP13667
SwissPalmiP13667

Expressioni

Gene expression databases

BgeeiENSG00000155660 Expressed in 229 organ(s), highest expression level in oviduct epithelium
CleanExiHS_PDIA4
ExpressionAtlasiP13667 baseline and differential
GenevisibleiP13667 HS

Organism-specific databases

HPAiCAB017368
HPA006139
HPA006140

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Binary interactionsi

Protein-protein interaction databases

BioGridi114966, 75 interactors
IntActiP13667, 44 interactors
MINTiP13667
STRINGi9606.ENSP00000286091

Structurei

Secondary structure

1645
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13667
SMRiP13667
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13667

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 169Thioredoxin 1PROSITE-ProRule annotationAdd BLAST149
Domaini158 – 301Thioredoxin 2PROSITE-ProRule annotationAdd BLAST144
Domaini505 – 636Thioredoxin 3PROSITE-ProRule annotationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi642 – 645Prevents secretion from ER4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 55Asp/Glu-rich (acidic)Add BLAST17

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
HOGENOMiHOG000162459
HOVERGENiHBG005920
InParanoidiP13667
KOiK09582
OMAiTQFWRNK
OrthoDBiEOG091G05J9
PhylomeDBiP13667
TreeFamiTF106382

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13667-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPRKAFLLL LLLGLVQLLA VAGAEGPDED SSNRENAIED EEEEEEEDDD
60 70 80 90 100
EEEDDLEVKE ENGVLVLNDA NFDNFVADKD TVLLEFYAPW CGHCKQFAPE
110 120 130 140 150
YEKIANILKD KDPPIPVAKI DATSASVLAS RFDVSGYPTI KILKKGQAVD
160 170 180 190 200
YEGSRTQEEI VAKVREVSQP DWTPPPEVTL VLTKENFDEV VNDADIILVE
210 220 230 240 250
FYAPWCGHCK KLAPEYEKAA KELSKRSPPI PLAKVDATAE TDLAKRFDVS
260 270 280 290 300
GYPTLKIFRK GRPYDYNGPR EKYGIVDYMI EQSGPPSKEI LTLKQVQEFL
310 320 330 340 350
KDGDDVIIIG VFKGESDPAY QQYQDAANNL REDYKFHHTF STEIAKFLKV
360 370 380 390 400
SQGQLVVMQP EKFQSKYEPR SHMMDVQGST QDSAIKDFVL KYALPLVGHR
410 420 430 440 450
KVSNDAKRYT RRPLVVVYYS VDFSFDYRAA TQFWRSKVLE VAKDFPEYTF
460 470 480 490 500
AIADEEDYAG EVKDLGLSES GEDVNAAILD ESGKKFAMEP EEFDSDTLRE
510 520 530 540 550
FVTAFKKGKL KPVIKSQPVP KNNKGPVKVV VGKTFDSIVM DPKKDVLIEF
560 570 580 590 600
YAPWCGHCKQ LEPVYNSLAK KYKGQKGLVI AKMDATANDV PSDRYKVEGF
610 620 630 640
PTIYFAPSGD KKNPVKFEGG DRDLEHLSKF IEEHATKLSR TKEEL
Length:645
Mass (Da):72,932
Last modified:May 1, 1991 - v2
Checksum:i1919C2AE12CD2684
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMN9C9JMN9_HUMAN
Protein disulfide-isomerase A4
PDIA4
163Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102E → G in BAF83660 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052580173T → M. Corresponds to variant dbSNP:rs2290971Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05016 mRNA Translation: AAA58460.1
AK290971 mRNA Translation: BAF83660.1
AC093743 Genomic DNA Translation: AAQ96863.1
CH471146 Genomic DNA Translation: EAW80065.1
CH471146 Genomic DNA Translation: EAW80066.1
BC000425 mRNA Translation: AAH00425.1
BC001928 mRNA Translation: AAH01928.1
BC006344 mRNA Translation: AAH06344.1
BC011754 mRNA Translation: AAH11754.1
CCDSiCCDS5893.1
PIRiA23723
RefSeqiNP_004902.1, NM_004911.4
UniGeneiHs.93659

Genome annotation databases

EnsembliENST00000286091; ENSP00000286091; ENSG00000155660
GeneIDi9601
KEGGihsa:9601
UCSCiuc003wff.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05016 mRNA Translation: AAA58460.1
AK290971 mRNA Translation: BAF83660.1
AC093743 Genomic DNA Translation: AAQ96863.1
CH471146 Genomic DNA Translation: EAW80065.1
CH471146 Genomic DNA Translation: EAW80066.1
BC000425 mRNA Translation: AAH00425.1
BC001928 mRNA Translation: AAH01928.1
BC006344 mRNA Translation: AAH06344.1
BC011754 mRNA Translation: AAH11754.1
CCDSiCCDS5893.1
PIRiA23723
RefSeqiNP_004902.1, NM_004911.4
UniGeneiHs.93659

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IDVX-ray1.95A53-284[»]
ProteinModelPortaliP13667
SMRiP13667
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114966, 75 interactors
IntActiP13667, 44 interactors
MINTiP13667
STRINGi9606.ENSP00000286091

PTM databases

iPTMnetiP13667
PhosphoSitePlusiP13667
SwissPalmiP13667

Polymorphism and mutation databases

BioMutaiPDIA4
DMDMi119530

2D gel databases

OGPiP13667
REPRODUCTION-2DPAGEiIPI00009904

Proteomic databases

EPDiP13667
MaxQBiP13667
PaxDbiP13667
PeptideAtlasiP13667
PRIDEiP13667
ProteomicsDBi52955

Protocols and materials databases

DNASUi9601
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286091; ENSP00000286091; ENSG00000155660
GeneIDi9601
KEGGihsa:9601
UCSCiuc003wff.3 human

Organism-specific databases

CTDi9601
DisGeNETi9601
EuPathDBiHostDB:ENSG00000155660.10
GeneCardsiPDIA4
HGNCiHGNC:30167 PDIA4
HPAiCAB017368
HPA006139
HPA006140
neXtProtiNX_P13667
OpenTargetsiENSG00000155660
PharmGKBiPA142671190
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
HOGENOMiHOG000162459
HOVERGENiHBG005920
InParanoidiP13667
KOiK09582
OMAiTQFWRNK
OrthoDBiEOG091G05J9
PhylomeDBiP13667
TreeFamiTF106382

Enzyme and pathway databases

BRENDAi5.3.4.1 2681

Miscellaneous databases

ChiTaRSiPDIA4 human
EvolutionaryTraceiP13667
GenomeRNAii9601
PROiPR:P13667

Gene expression databases

BgeeiENSG00000155660 Expressed in 229 organ(s), highest expression level in oviduct epithelium
CleanExiHS_PDIA4
ExpressionAtlasiP13667 baseline and differential
GenevisibleiP13667 HS

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPDIA4_HUMAN
AccessioniPrimary (citable) accession number: P13667
Secondary accession number(s): A8K4K6, Q549T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 1991
Last modified: November 7, 2018
This is version 205 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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