Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sarcalumenin

Gene

SRL

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of calcium transport.

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcalumenin
Gene namesi
Name:SRL
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002241320 – 908SarcalumeninAdd BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi824N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015642

Structurei

3D structure databases

ProteinModelPortaliP13666
SMRiP13666
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini525 – 766Dynamin-type GPROSITE-ProRule annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 457Acidic domain, probably binds calciumAdd BLAST438
Regioni535 – 542G1 motifPROSITE-ProRule annotation8
Regioni563 – 564G2 motifPROSITE-ProRule annotation2
Regioni625 – 628G3 motifPROSITE-ProRule annotation4
Regioni690 – 693G4 motifPROSITE-ProRule annotation4
Regioni713G5 motifPROSITE-ProRule annotation1

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1954 Eukaryota
ENOG410XYGB LUCA
HOGENOMiHOG000290639
HOVERGENiHBG017848
InParanoidiP13666

Family and domain databases

InterProiView protein in InterPro
IPR022812 Dynamin_SF
IPR031692 EHD_N
IPR030381 G_DYNAMIN_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00350 Dynamin_N, 1 hit
PF16880 EHD_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51718 G_DYNAMIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: P13666-1) [UniParc]FASTAAdd to basket
Also known as: 160 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRALLLFCFV ASLLLSGQAE LQVPASGGTE DVGNLLENHF SAGDASLEEK
60 70 80 90 100
ERALYADAAP RDENLLLHYP DGREAESAER TTAGAPPAAP GPGSEPEASL
110 120 130 140 150
PNASATESAP PGDATGPREE QGPAAASALP PGGDEGSLQE ERQELSSGEG
160 170 180 190 200
PGEEAAGLGL PSEGAASGEM QGQAGGGKVP KEAEGVLGDS PVQGAAAETA
210 220 230 240 250
EPEASGIAPS SEDEQIHTLE GEGKGSPGPD HGPTELDGTP DGASAGEEPK
260 270 280 290 300
ADLDTEARER AEDQHQVHTL ETEGKGGPGP HQGPAEVDGG PDTVSVGESL
310 320 330 340 350
EAREGAEDQG KPSPSQEAGP AAAEAGTEPG GTKHSEEEGM EQDRPPEGQV
360 370 380 390 400
PVMRQDEGGE ASSEEEGDEE GGSEEEEGDP SEEDSGEDSG DGASSEEAGA
410 420 430 440 450
ASEEASGTAG LGEEETQPST EGLDSGPAGS QAQDTEAEEP EEGHQGPESP
460 470 480 490 500
ITAPQEETED VSEEVPMRDR SHIQKTLMLN EDKPTDDFSA VLQRLRKIYH
510 520 530 540 550
SSIKPLEQSY KYNELRQHEI TDGEITSKPM VLFLGPWSVG KSTMINYLLG
560 570 580 590 600
LENTRYQLYT GAEPTTSEFT VLMHGPKLKT IEGIVMAADS ARSFSPLEKF
610 620 630 640 650
GQNFLEKLIG IEVPHKLLER VTFVDTPGII ENRKQQERGY PFNDVCQWFI
660 670 680 690 700
DRADLIFVVF DPTKLDVGLE LETLFRQLKG RESQIRIILN KADNLATQML
710 720 730 740 750
MRVYGALFWS LAPLINVTEP PRVYVSSFWP QEYKPDTHRE LFLREEISLL
760 770 780 790 800
EDLNQVIENR LENKIAFIRQ HAIRVRIHAL LVDRYLQTYK DKMTFFSDGE
810 820 830 840 850
LVFKDIVEDP DKFYIFKTIL AKTNVSKFDL PNREAYKDFF GINPISSFKL
860 870 880 890 900
LSQQCSYMGG CFLEKIERAI TQELPSLLGS LGLGKNPGAL NCDKTGCGET

PKNRYKKH
Length:908
Mass (Da):97,921
Last modified:January 1, 1990 - v1
Checksum:iA48CAA221AE1418B
GO
Isoform 2 (identifier: P13666-2) [UniParc]FASTAAdd to basket
Also known as: 58 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     20-455: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):54,450
Checksum:i71E95D3CD8ABB41A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1TFF2G1TFF2_RABIT
Sarcalumenin
SRL
908Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti474Q → E in AAA60730 (PubMed:2521635).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00442920 – 455Missing in isoform 2. 1 PublicationAdd BLAST436

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25750 mRNA Translation: AAA31189.1
J04480 mRNA Translation: AAA60730.1
PIRiA33280
A33312
RefSeqiNP_001075750.1, NM_001082281.1 [P13666-1]
XP_008247813.1, XM_008249591.2
UniGeneiOcu.595

Genome annotation databases

GeneIDi100009112
KEGGiocu:100009112

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25750 mRNA Translation: AAA31189.1
J04480 mRNA Translation: AAA60730.1
PIRiA33280
A33312
RefSeqiNP_001075750.1, NM_001082281.1 [P13666-1]
XP_008247813.1, XM_008249591.2
UniGeneiOcu.595

3D structure databases

ProteinModelPortaliP13666
SMRiP13666
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015642

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009112
KEGGiocu:100009112

Organism-specific databases

CTDi6345

Phylogenomic databases

eggNOGiKOG1954 Eukaryota
ENOG410XYGB LUCA
HOGENOMiHOG000290639
HOVERGENiHBG017848
InParanoidiP13666

Family and domain databases

InterProiView protein in InterPro
IPR022812 Dynamin_SF
IPR031692 EHD_N
IPR030381 G_DYNAMIN_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00350 Dynamin_N, 1 hit
PF16880 EHD_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51718 G_DYNAMIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRCA_RABIT
AccessioniPrimary (citable) accession number: P13666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again