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Protein

Keratin, type II cytoskeletal 5

Gene

KRT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei419Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • scaffold protein binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-446107 Type I hemidesmosome assembly
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

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SIGNORi
P13647

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
58 kDa cytokeratin
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186081.11

Human Gene Nomenclature Database

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HGNCi
HGNC:6442 KRT5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
148040 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P13647

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epidermolysis bullosa simplex, autosomal recessive 1 (EBSB1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering and cleavage within basal keratinocytes, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma.
See also OMIM:601001
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026537170E → K in EBSB1. 1 PublicationCorresponds to variant dbSNP:rs59115483EnsemblClinVar.1
Natural variantiVAR_026544418E → K in EBSB1. 1 PublicationCorresponds to variant dbSNP:rs121912476EnsemblClinVar.1
Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
See also OMIM:131760
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071630165R → S in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs267607456EnsemblClinVar.1
Natural variantiVAR_027722168E → K in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs58619430EnsemblClinVar.1
Natural variantiVAR_027723169R → P in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs60720877EnsemblClinVar.1
Natural variantiVAR_010456175L → F in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs57890479EnsemblClinVar.1
Natural variantiVAR_010457176N → S in DM-EBS. 3 PublicationsCorresponds to variant dbSNP:rs59092197EnsemblClinVar.1
Natural variantiVAR_010458179F → S in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs57781042EnsemblClinVar.1
Natural variantiVAR_010459181S → P in DM-EBS; with laryngeal involvement. 1 PublicationCorresponds to variant dbSNP:rs60715293EnsemblClinVar.1
Natural variantiVAR_003873193N → K in DM-EBS and WC-EBS. 3 PublicationsCorresponds to variant dbSNP:rs60586163EnsemblClinVar.1
Natural variantiVAR_010466467I → T in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs60271599EnsemblClinVar.1
Natural variantiVAR_027726469T → P in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs60596287EnsemblClinVar.1
Natural variantiVAR_003877475E → G in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs61348633EnsemblClinVar.1
Natural variantiVAR_023728475E → K in DM-EBS. 2 PublicationsCorresponds to variant dbSNP:rs57155193EnsemblClinVar.1
Natural variantiVAR_010467477E → K in DM-EBS. 4 PublicationsCorresponds to variant dbSNP:rs59190510EnsemblClinVar.1
Epidermolysis bullosa simplex, with migratory circinate erythema (EBSMCE)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands, feet, and legs but spare nails, ocular epithelia and mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS, with no evidence of tonofilament clumping.
See also OMIM:609352
Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS)15 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
See also OMIM:131800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010454152P → L in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs60617604EnsemblClinVar.1
Natural variantiVAR_031641158D → V in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs61222761EnsemblClinVar.1
Natural variantiVAR_003872161I → S in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs58058996EnsemblClinVar.1
Natural variantiVAR_026536167E → K in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs57378129EnsemblClinVar.1
Natural variantiVAR_026538177N → S in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs61495052EnsemblClinVar.1
Natural variantiVAR_071631186V → E in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs267607457EnsemblClinVar.1
Natural variantiVAR_027724190E → K in WC-EBS; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs58976397EnsemblClinVar.1
Natural variantiVAR_003873193N → K in DM-EBS and WC-EBS. 3 PublicationsCorresponds to variant dbSNP:rs60586163EnsemblClinVar.1
Natural variantiVAR_026539199K → T in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs58766676EnsemblClinVar.1
Natural variantiVAR_026540311L → P in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59864957Ensembl.1
Natural variantiVAR_071632321T → P in WC-EBS. 1 Publication1
Natural variantiVAR_026541324V → D in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59335325EnsemblClinVar.1
Natural variantiVAR_010462327M → K in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs58072617EnsemblClinVar.1
Natural variantiVAR_003874327M → T in WC-EBS. 2 PublicationsCorresponds to variant dbSNP:rs58072617EnsemblClinVar.1
Natural variantiVAR_026542328D → E in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59464425EnsemblClinVar.1
Natural variantiVAR_026543328D → G in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs57142010EnsemblClinVar.1
Natural variantiVAR_010463328D → H in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs56790237EnsemblClinVar.1
Natural variantiVAR_010464328D → V in WC-EBS. 2 PublicationsCorresponds to variant dbSNP:rs57142010EnsemblClinVar.1
Natural variantiVAR_010465329N → K in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59730172EnsemblClinVar.1
Natural variantiVAR_003875331R → C in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs61297109EnsemblClinVar.1
Natural variantiVAR_027725331R → H in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs56729325EnsemblClinVar.1
Natural variantiVAR_031644352R → S in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59112594EnsemblClinVar.1
Natural variantiVAR_023726404K → E in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs60809982EnsemblClinVar.1
Natural variantiVAR_071633428A → T in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs267607458EnsemblClinVar.1
Natural variantiVAR_023727438A → D in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs57845028EnsemblClinVar.1
Epidermolysis bullosa simplex, Koebner type (K-EBS)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.
See also OMIM:131900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031640143V → D in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs59851104EnsemblClinVar.1
Natural variantiVAR_010455173K → N in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs58163069EnsemblClinVar.1
Natural variantiVAR_013829186V → L in K-EBS. 2 PublicationsCorresponds to variant dbSNP:rs121912475EnsemblClinVar.1
Natural variantiVAR_031642186V → M in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs121912475EnsemblClinVar.1
Natural variantiVAR_031643191Q → P in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs57751134EnsemblClinVar.1
Natural variantiVAR_010460323V → A in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs59840738EnsemblClinVar.1
Natural variantiVAR_010461325L → P in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs58107458EnsemblClinVar.1
Natural variantiVAR_003876463L → P in K-EBS. 2 PublicationsCorresponds to variant dbSNP:rs57599352EnsemblClinVar.1
Natural variantiVAR_031645517G → D in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs58608695EnsemblClinVar.1
Epidermolysis bullosa simplex, with mottled pigmentation (MP-EBS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of intraepidermal epidermolysis bullosa characterized by blistering at acral sites and 'mottled' pigmentation of the trunk and proximal extremities with hyper- and hypopigmentation macules.
See also OMIM:131960
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01045325P → L in MP-EBS. 4 PublicationsCorresponds to variant dbSNP:rs57499817EnsemblClinVar.1
Dowling-Degos disease 1 (DDD1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.
See also OMIM:179850

Keywords - Diseasei

Disease mutation, Epidermolysis bullosa

Organism-specific databases

DisGeNET

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DisGeNETi
3852

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
KRT5

MalaCards human disease database

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MalaCardsi
KRT5
MIMi131760 phenotype
131800 phenotype
131900 phenotype
131960 phenotype
179850 phenotype
601001 phenotype
609352 phenotype

Open Targets

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OpenTargetsi
ENSG00000186081

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
79145 Dowling-Degos disease
158681 Epidermolysis bullosa simplex with circinate migratory erythema
79397 Epidermolysis bullosa simplex with mottled pigmentation
79399 Epidermolysis bullosa simplex, generalized intermediate
79396 Epidermolysis bullosa simplex, generalized severe
79400 Localized epidermolysis bullosa simplex

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30230

Protein family/group databases

Allergome; a platform for allergen knowledge

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Allergomei
415 Hom s 5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KRT5

Domain mapping of disease mutations (DMDM)

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DMDMi
143811411

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000637271 – 590Keratin, type II cytoskeletal 5Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei26PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei82PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P13647

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13647

PeptideAtlas

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PeptideAtlasi
P13647

PRoteomics IDEntifications database

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PRIDEi
P13647

ProteomicsDB human proteome resource

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ProteomicsDBi
52954

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13647

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13647

SwissPalm database of S-palmitoylation events

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SwissPalmi
P13647

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000186081 Expressed in 135 organ(s), highest expression level in ectocervix

CleanEx database of gene expression profiles

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CleanExi
HS_KRT5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P13647 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13647 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB000027
CAB000129
HPA059479

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network (PubMed:28899683). Heterodimer with KRT14 (PubMed:22705788). Interacts with TCHP (PubMed:15731013). Interacts with EPPK1 (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110050, 66 interactors

Database of interacting proteins

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DIPi
DIP-39N

Protein interaction database and analysis system

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IntActi
P13647, 36 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000252242

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1590
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TNUX-ray3.00B350-477[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13647

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13647

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 481IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 167HeadAdd BLAST167
Regioni168 – 203Coil 1AAdd BLAST36
Regioni204 – 222Linker 1Add BLAST19
Regioni223 – 315Coil 1BAdd BLAST93
Regioni316 – 338Linker 12Add BLAST23
Regioni339 – 477Coil 2Add BLAST139
Regioni478 – 590TailAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 139Gly-richAdd BLAST101
Compositional biasi528 – 590Ser-richAdd BLAST63

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG4R Eukaryota
ENOG410YY6B LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160458

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230976

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG013015

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13647

KEGG Orthology (KO)

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KOi
K07605

Identification of Orthologs from Complete Genome Data

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OMAi
RDYERHV

Database of Orthologous Groups

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OrthoDBi
1273622at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P13647

TreeFam database of animal gene trees

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TreeFami
TF317854

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II

The PANTHER Classification System

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PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01276 TYPE2KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P13647-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQSSVSFR SGGSRSFSTA SAITPSVSRT SFTSVSRSGG GGGGGFGRVS
60 70 80 90 100
LAGACGVGGY GSRSLYNLGG SKRISISTSG GSFRNRFGAG AGGGYGFGGG
110 120 130 140 150
AGSGFGFGGG AGGGFGLGGG AGFGGGFGGP GFPVCPPGGI QEVTVNQSLL
160 170 180 190 200
TPLNLQIDPS IQRVRTEERE QIKTLNNKFA SFIDKVRFLE QQNKVLDTKW
210 220 230 240 250
TLLQEQGTKT VRQNLEPLFE QYINNLRRQL DSIVGERGRL DSELRNMQDL
260 270 280 290 300
VEDFKNKYED EINKRTTAEN EFVMLKKDVD AAYMNKVELE AKVDALMDEI
310 320 330 340 350
NFMKMFFDAE LSQMQTHVSD TSVVLSMDNN RNLDLDSIIA EVKAQYEEIA
360 370 380 390 400
NRSRTEAESW YQTKYEELQQ TAGRHGDDLR NTKHEISEMN RMIQRLRAEI
410 420 430 440 450
DNVKKQCANL QNAIADAEQR GELALKDARN KLAELEEALQ KAKQDMARLL
460 470 480 490 500
REYQELMNTK LALDVEIATY RKLLEGEECR LSGEGVGPVN ISVVTSSVSS
510 520 530 540 550
GYGSGSGYGG GLGGGLGGGL GGGLAGGSSG SYYSSSSGGV GLGGGLSVGG
560 570 580 590
SGFSASSGRG LGVGFGSGGG SSSSVKFVST TSSSRKSFKS
Length:590
Mass (Da):62,378
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9D5318E01F55145
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YI76H0YI76_HUMAN
Keratin, type II cytoskeletal 5
KRT5
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIN9H0YIN9_HUMAN
Keratin, type II cytoskeletal 5
KRT5
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0C6F8W0C6_HUMAN
Keratin, type II cytoskeletal 5
KRT5
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VV57F8VV57_HUMAN
Keratin, type II cytoskeletal 5
KRT5
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU69F8VU69_HUMAN
Keratin, type II cytoskeletal 5
KRT5
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9 – 11FRS → SGA (PubMed:2476664).Curated3
Sequence conflicti261E → Q in AAA36145 (PubMed:2447486).Curated1
Sequence conflicti271E → H in AAA36145 (PubMed:2447486).Curated1
Sequence conflicti375H → E (PubMed:2455002).Curated1
Sequence conflicti558G → S (PubMed:2476664).Curated1
Sequence conflicti558G → S in AAA36145 (PubMed:2447486).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01045325P → L in MP-EBS. 4 PublicationsCorresponds to variant dbSNP:rs57499817EnsemblClinVar.1
Natural variantiVAR_02876379S → R2 PublicationsCorresponds to variant dbSNP:rs1065115EnsemblClinVar.1
Natural variantiVAR_003871138G → E1 PublicationCorresponds to variant dbSNP:rs11170164EnsemblClinVar.1
Natural variantiVAR_031640143V → D in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs59851104EnsemblClinVar.1
Natural variantiVAR_010454152P → L in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs60617604EnsemblClinVar.1
Natural variantiVAR_031641158D → V in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs61222761EnsemblClinVar.1
Natural variantiVAR_003872161I → S in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs58058996EnsemblClinVar.1
Natural variantiVAR_071630165R → S in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs267607456EnsemblClinVar.1
Natural variantiVAR_026536167E → K in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs57378129EnsemblClinVar.1
Natural variantiVAR_027722168E → K in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs58619430EnsemblClinVar.1
Natural variantiVAR_027723169R → P in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs60720877EnsemblClinVar.1
Natural variantiVAR_026537170E → K in EBSB1. 1 PublicationCorresponds to variant dbSNP:rs59115483EnsemblClinVar.1
Natural variantiVAR_010455173K → N in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs58163069EnsemblClinVar.1
Natural variantiVAR_010456175L → F in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs57890479EnsemblClinVar.1
Natural variantiVAR_010457176N → S in DM-EBS. 3 PublicationsCorresponds to variant dbSNP:rs59092197EnsemblClinVar.1
Natural variantiVAR_026538177N → S in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs61495052EnsemblClinVar.1
Natural variantiVAR_010458179F → S in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs57781042EnsemblClinVar.1
Natural variantiVAR_010459181S → P in DM-EBS; with laryngeal involvement. 1 PublicationCorresponds to variant dbSNP:rs60715293EnsemblClinVar.1
Natural variantiVAR_071631186V → E in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs267607457EnsemblClinVar.1
Natural variantiVAR_013829186V → L in K-EBS. 2 PublicationsCorresponds to variant dbSNP:rs121912475EnsemblClinVar.1
Natural variantiVAR_031642186V → M in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs121912475EnsemblClinVar.1
Natural variantiVAR_027724190E → K in WC-EBS; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs58976397EnsemblClinVar.1
Natural variantiVAR_031643191Q → P in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs57751134EnsemblClinVar.1
Natural variantiVAR_003873193N → K in DM-EBS and WC-EBS. 3 PublicationsCorresponds to variant dbSNP:rs60586163EnsemblClinVar.1
Natural variantiVAR_028764197D → E2 PublicationsCorresponds to variant dbSNP:rs641615EnsemblClinVar.1
Natural variantiVAR_026539199K → T in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs58766676EnsemblClinVar.1
Natural variantiVAR_028765232S → N. Corresponds to variant dbSNP:rs200333163Ensembl.1
Natural variantiVAR_026540311L → P in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59864957Ensembl.1
Natural variantiVAR_071632321T → P in WC-EBS. 1 Publication1
Natural variantiVAR_010460323V → A in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs59840738EnsemblClinVar.1
Natural variantiVAR_026541324V → D in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59335325EnsemblClinVar.1
Natural variantiVAR_010461325L → P in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs58107458EnsemblClinVar.1
Natural variantiVAR_010462327M → K in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs58072617EnsemblClinVar.1
Natural variantiVAR_003874327M → T in WC-EBS. 2 PublicationsCorresponds to variant dbSNP:rs58072617EnsemblClinVar.1
Natural variantiVAR_026542328D → E in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59464425EnsemblClinVar.1
Natural variantiVAR_026543328D → G in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs57142010EnsemblClinVar.1
Natural variantiVAR_010463328D → H in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs56790237EnsemblClinVar.1
Natural variantiVAR_010464328D → V in WC-EBS. 2 PublicationsCorresponds to variant dbSNP:rs57142010EnsemblClinVar.1
Natural variantiVAR_010465329N → K in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59730172EnsemblClinVar.1
Natural variantiVAR_003875331R → C in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs61297109EnsemblClinVar.1
Natural variantiVAR_027725331R → H in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs56729325EnsemblClinVar.1
Natural variantiVAR_031644352R → S in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs59112594EnsemblClinVar.1
Natural variantiVAR_028766387S → T2 PublicationsCorresponds to variant dbSNP:rs2669875EnsemblClinVar.1
Natural variantiVAR_023726404K → E in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs60809982EnsemblClinVar.1
Natural variantiVAR_026544418E → K in EBSB1. 1 PublicationCorresponds to variant dbSNP:rs121912476EnsemblClinVar.1
Natural variantiVAR_071633428A → T in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs267607458EnsemblClinVar.1
Natural variantiVAR_023727438A → D in WC-EBS. 1 PublicationCorresponds to variant dbSNP:rs57845028EnsemblClinVar.1
Natural variantiVAR_003876463L → P in K-EBS. 2 PublicationsCorresponds to variant dbSNP:rs57599352EnsemblClinVar.1
Natural variantiVAR_010466467I → T in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs60271599EnsemblClinVar.1
Natural variantiVAR_027726469T → P in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs60596287EnsemblClinVar.1
Natural variantiVAR_003877475E → G in DM-EBS. 1 PublicationCorresponds to variant dbSNP:rs61348633EnsemblClinVar.1
Natural variantiVAR_023728475E → K in DM-EBS. 2 PublicationsCorresponds to variant dbSNP:rs57155193EnsemblClinVar.1
Natural variantiVAR_010467477E → K in DM-EBS. 4 PublicationsCorresponds to variant dbSNP:rs59190510EnsemblClinVar.1
Natural variantiVAR_031645517G → D in K-EBS. 1 PublicationCorresponds to variant dbSNP:rs58608695EnsemblClinVar.1
Natural variantiVAR_028767528S → G1 PublicationCorresponds to variant dbSNP:rs11549950EnsemblClinVar.1
Natural variantiVAR_028768543G → S2 PublicationsCorresponds to variant dbSNP:rs11549949EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M21389 mRNA Translation: AAA36143.1
M28496 Genomic DNA No translation available.
AF274874 Genomic DNA Translation: AAF97931.1
BC024292 mRNA Translation: AAH24292.1
BC042132 mRNA Translation: AAH42132.1
BC071906 mRNA Translation: AAH71906.1
M19723 mRNA Translation: AAA36145.1
AY373434 mRNA Translation: AAQ81588.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8830.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A29904

NCBI Reference Sequences

More...
RefSeqi
NP_000415.2, NM_000424.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.433845

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252242; ENSP00000252242; ENSG00000186081

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3852

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3852

UCSC genome browser

More...
UCSCi
uc001san.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21389 mRNA Translation: AAA36143.1
M28496 Genomic DNA No translation available.
AF274874 Genomic DNA Translation: AAF97931.1
BC024292 mRNA Translation: AAH24292.1
BC042132 mRNA Translation: AAH42132.1
BC071906 mRNA Translation: AAH71906.1
M19723 mRNA Translation: AAA36145.1
AY373434 mRNA Translation: AAQ81588.1
CCDSiCCDS8830.1
PIRiA29904
RefSeqiNP_000415.2, NM_000424.3
UniGeneiHs.433845

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TNUX-ray3.00B350-477[»]
ProteinModelPortaliP13647
SMRiP13647
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110050, 66 interactors
DIPiDIP-39N
IntActiP13647, 36 interactors
STRINGi9606.ENSP00000252242

Protein family/group databases

Allergomei415 Hom s 5

PTM databases

iPTMnetiP13647
PhosphoSitePlusiP13647
SwissPalmiP13647

Polymorphism and mutation databases

BioMutaiKRT5
DMDMi143811411

Proteomic databases

jPOSTiP13647
PaxDbiP13647
PeptideAtlasiP13647
PRIDEiP13647
ProteomicsDBi52954

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3852
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252242; ENSP00000252242; ENSG00000186081
GeneIDi3852
KEGGihsa:3852
UCSCiuc001san.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3852
DisGeNETi3852
EuPathDBiHostDB:ENSG00000186081.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT5
GeneReviewsiKRT5

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010655
HGNCiHGNC:6442 KRT5
HPAiCAB000027
CAB000129
HPA059479
MalaCardsiKRT5
MIMi131760 phenotype
131800 phenotype
131900 phenotype
131960 phenotype
148040 gene
179850 phenotype
601001 phenotype
609352 phenotype
neXtProtiNX_P13647
OpenTargetsiENSG00000186081
Orphaneti79145 Dowling-Degos disease
158681 Epidermolysis bullosa simplex with circinate migratory erythema
79397 Epidermolysis bullosa simplex with mottled pigmentation
79399 Epidermolysis bullosa simplex, generalized intermediate
79396 Epidermolysis bullosa simplex, generalized severe
79400 Localized epidermolysis bullosa simplex
PharmGKBiPA30230

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00940000160458
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiP13647
KOiK07605
OMAiRDYERHV
OrthoDBi1273622at2759
PhylomeDBiP13647
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-446107 Type I hemidesmosome assembly
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP13647

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRT5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Keratin_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3852

Protein Ontology

More...
PROi
PR:P13647

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186081 Expressed in 135 organ(s), highest expression level in ectocervix
CleanExiHS_KRT5
ExpressionAtlasiP13647 baseline and differential
GenevisibleiP13647 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK2C5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13647
Secondary accession number(s): Q6PI71, Q6UBJ0, Q8TA91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 3, 2007
Last modified: January 16, 2019
This is version 217 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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