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UniProtKB - P13646 (K1C13_HUMAN)

Protein

Keratin, type I cytoskeletal 13

Gene

KRT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
Gene namesi
Name:KRT13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171401.14
HGNCiHGNC:6415 KRT13
MIMi148065 gene
neXtProtiNX_P13646

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

White sponge nevus 2 (WSN2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
See also OMIM:615785
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016035108M → T in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60364670EnsemblClinVar.1
Natural variantiVAR_023924111L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59897026EnsemblClinVar.1
Natural variantiVAR_016036112N → S in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59970018EnsemblClinVar.1
Natural variantiVAR_016037115L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60906702EnsemblClinVar.1
Natural variantiVAR_003836119L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60440396EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3860
MalaCardsiKRT13
MIMi615785 phenotype
OpenTargetsiENSG00000171401
Orphaneti171723 White sponge nevus
PharmGKBiPA30202

Polymorphism and mutation databases

BioMutaiKRT13
DMDMi269849755

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636471 – 458Keratin, type I cytoskeletal 13Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Omega-N-methylarginineCombined sources1
Modified residuei35Omega-N-methylarginineCombined sources1
Modified residuei427PhosphoserineCombined sources1 Publication1

Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.1 Publication

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP13646
PeptideAtlasiP13646
PRIDEiP13646
ProteomicsDBi52951
52952 [P13646-2]
52953 [P13646-3]

PTM databases

GlyConnecti311
iPTMnetiP13646
PhosphoSitePlusiP13646
SwissPalmiP13646
UniCarbKBiP13646

Expressioni

Tissue specificityi

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.1 Publication

Gene expression databases

BgeeiENSG00000171401 Expressed in 121 organ(s), highest expression level in esophagus mucosa
CleanExiHS_KRT13
ExpressionAtlasiP13646 baseline and differential
GenevisibleiP13646 HS

Organism-specific databases

HPAiCAB000133
HPA030877
HPA069771

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.

Binary interactionsi

Protein-protein interaction databases

BioGridi110058, 59 interactors
IntActiP13646, 32 interactors
STRINGi9606.ENSP00000246635

Structurei

3D structure databases

ProteinModelPortaliP13646
SMRiP13646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 416IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 103HeadAdd BLAST103
Regioni104 – 139Coil 1AAdd BLAST36
Regioni140 – 158Linker 1Add BLAST19
Regioni159 – 250Coil 1BAdd BLAST92
Regioni251 – 273Linker 12Add BLAST23
Regioni274 – 412Coil 2Add BLAST139
Regioni413 – 458TailAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 102Gly-richAdd BLAST90

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP13646
KOiK07604
OMAiKIRDWHL
OrthoDBiEOG091G087I
PhylomeDBiP13646
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P13646-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS 
        60         70         80         90        100
CGFGGGAGSG FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL 
       110        120        130        140        150
TGNEKITMQN LNDRLASYLE KVRALEEANA DLEVKIRDWH LKQSPASPER 
       160        170        180        190        200
DYSPYYKTIE ELRDKILTAT IENNRVILEI DNARLAADDF RLKYENELAL 
       210        220        230        240        250
RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK KNHEEEMKEF 
       260        270        280        290        300
SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHTKS 
       310        320        330        340        350
AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA 
       360        370        380        390        400
ETECRYALQL QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ 
       410        420        430        440        450
EIATYRSLLE GQDAKMIGFP SSAGSVSPRS TSVTTTSSAS VTTTSNASGR 

RTSDVRRP
Length:458
Mass (Da):49,588
Last modified:November 24, 2009 - v4
Checksum:iA51AECFD6195ACB4
GO
Isoform 2 (identifier: P13646-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-73: Missing.
     351-458: ETECRYALQL...GRRTSDVRRP → DPGTHQQHRGPAERAPQ

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):38,581
Checksum:i4961456B245B173B
GO
Isoform 3 (identifier: P13646-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-458: MIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → KRQPP

Show »
Length:420
Mass (Da):45,867
Checksum:i2C1A7FAF2BD62DCD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERE3K7ERE3_HUMAN
Keratin, type I cytoskeletal 13
KRT13
415Annotation score:
K7EQH6K7EQH6_HUMAN
Keratin, type I cytoskeletal 13
KRT13
162Annotation score:
K7EMD9K7EMD9_HUMAN
Keratin, type I cytoskeletal 13
KRT13
165Annotation score:
K7EMJ2K7EMJ2_HUMAN
Keratin, type I cytoskeletal 13
KRT13
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46G → R in BAD96771 (Ref. 6) Curated1
Sequence conflicti46G → R in BAD96797 (Ref. 6) Curated1
Sequence conflicti58G → D in CAA32786 (PubMed:2475110).Curated1
Sequence conflicti58G → D (PubMed:2477803).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05937681F → Y. Corresponds to variant dbSNP:rs12150581Ensembl.1
Natural variantiVAR_016035108M → T in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60364670EnsemblClinVar.1
Natural variantiVAR_023924111L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59897026EnsemblClinVar.1
Natural variantiVAR_016036112N → S in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59970018EnsemblClinVar.1
Natural variantiVAR_016037115L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60906702EnsemblClinVar.1
Natural variantiVAR_003836119L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60440396EnsemblClinVar.1
Natural variantiVAR_024488146A → G. Corresponds to variant dbSNP:rs760134EnsemblClinVar.1
Natural variantiVAR_060724187A → VCombined sources7 PublicationsCorresponds to variant dbSNP:rs9891361EnsemblClinVar.1
Natural variantiVAR_059377298T → A7 PublicationsCorresponds to variant dbSNP:rs4796697Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01637662 – 73Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_016377351 – 458ETECR…DVRRP → DPGTHQQHRGPAERAPQ in isoform 2. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_038433416 – 458MIGFP…DVRRP → KRQPP in isoform 3. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14640 mRNA Translation: CAA32786.1
X52426 mRNA Translation: CAA36673.1
AF049259 Genomic DNA Translation: AAC35754.1
AK092276 mRNA Translation: BAC03847.1
AK223051 mRNA Translation: BAD96771.1
AK223077 mRNA Translation: BAD96797.1
AC019349 Genomic DNA No translation available.
BC002661 mRNA Translation: AAH02661.3
BC077718 mRNA Translation: AAH77718.2
CCDSiCCDS11396.1 [P13646-1]
CCDS11397.1 [P13646-3]
PIRiA37343
S06088 KRHU3
RefSeqiNP_002265.2, NM_002274.3
NP_705694.2, NM_153490.2
UniGeneiHs.654550

Genome annotation databases

EnsembliENST00000246635; ENSP00000246635; ENSG00000171401 [P13646-1]
ENST00000336861; ENSP00000336604; ENSG00000171401 [P13646-3]
GeneIDi3860
KEGGihsa:3860
UCSCiuc002hwu.2 human [P13646-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14640 mRNA Translation: CAA32786.1
X52426 mRNA Translation: CAA36673.1
AF049259 Genomic DNA Translation: AAC35754.1
AK092276 mRNA Translation: BAC03847.1
AK223051 mRNA Translation: BAD96771.1
AK223077 mRNA Translation: BAD96797.1
AC019349 Genomic DNA No translation available.
BC002661 mRNA Translation: AAH02661.3
BC077718 mRNA Translation: AAH77718.2
CCDSiCCDS11396.1 [P13646-1]
CCDS11397.1 [P13646-3]
PIRiA37343
S06088 KRHU3
RefSeqiNP_002265.2, NM_002274.3
NP_705694.2, NM_153490.2
UniGeneiHs.654550

3D structure databases

ProteinModelPortaliP13646
SMRiP13646
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110058, 59 interactors
IntActiP13646, 32 interactors
STRINGi9606.ENSP00000246635

PTM databases

GlyConnecti311
iPTMnetiP13646
PhosphoSitePlusiP13646
SwissPalmiP13646
UniCarbKBiP13646

Polymorphism and mutation databases

BioMutaiKRT13
DMDMi269849755

Proteomic databases

PaxDbiP13646
PeptideAtlasiP13646
PRIDEiP13646
ProteomicsDBi52951
52952 [P13646-2]
52953 [P13646-3]

Protocols and materials databases

DNASUi3860
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246635; ENSP00000246635; ENSG00000171401 [P13646-1]
ENST00000336861; ENSP00000336604; ENSG00000171401 [P13646-3]
GeneIDi3860
KEGGihsa:3860
UCSCiuc002hwu.2 human [P13646-1]

Organism-specific databases

CTDi3860
DisGeNETi3860
EuPathDBiHostDB:ENSG00000171401.14
GeneCardsiKRT13
HGNCiHGNC:6415 KRT13
HPAiCAB000133
HPA030877
HPA069771
MalaCardsiKRT13
MIMi148065 gene
615785 phenotype
neXtProtiNX_P13646
OpenTargetsiENSG00000171401
Orphaneti171723 White sponge nevus
PharmGKBiPA30202
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP13646
KOiK07604
OMAiKIRDWHL
OrthoDBiEOG091G087I
PhylomeDBiP13646
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiKRT13 human
GeneWikiiKeratin_13
GenomeRNAii3860
PROiPR:P13646
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171401 Expressed in 121 organ(s), highest expression level in esophagus mucosa
CleanExiHS_KRT13
ExpressionAtlasiP13646 baseline and differential
GenevisibleiP13646 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK1C13_HUMAN
AccessioniPrimary (citable) accession number: P13646
Secondary accession number(s): Q53G54, Q6AZK5, Q8N240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 192 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health

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