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UniProtKB - P13646 (K1C13_HUMAN)

Protein

Keratin, type I cytoskeletal 13

Gene

KRT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cornification Source: Reactome
  • cytoskeleton organization Source: UniProtKB
  • keratinization Source: Reactome
View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000171401.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:6415 KRT13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		148065 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13646

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

White sponge nevus 2 (WSN2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
See also OMIM:615785
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016035108M → T in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60364670EnsemblClinVar.1
Natural variantiVAR_023924111L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59897026EnsemblClinVar.1
Natural variantiVAR_016036112N → S in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59970018EnsemblClinVar.1
Natural variantiVAR_016037115L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60906702EnsemblClinVar.1
Natural variantiVAR_003836119L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60440396EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		3860

MalaCards human disease database

More...MalaCardsi		KRT13
MIMi615785 phenotype

Open Targets

More...OpenTargetsi		ENSG00000171401

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		171723 White sponge nevus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30202

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRT13

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849755

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636471 – 458Keratin, type I cytoskeletal 13Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27Omega-N-methylarginineCombined sources1
Modified residuei35Omega-N-methylarginineCombined sources1
Modified residuei427PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.1 Publication

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13646

PeptideAtlas

More...PeptideAtlasi		P13646

PRoteomics IDEntifications database

More...PRIDEi		P13646

ProteomicsDB human proteome resource

More...ProteomicsDBi		52951
52952 [P13646-2]
52953 [P13646-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		311

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13646

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13646

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13646

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P13646

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171401 Expressed in 121 organ(s), highest expression level in esophagus mucosa

CleanEx database of gene expression profiles

More...CleanExi		HS_KRT13

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13646 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13646 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB000133
HPA030877
HPA069771

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110058, 59 interactors

Protein interaction database and analysis system

More...IntActi		P13646, 32 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000246635

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P13646

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13646

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 416IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 103HeadAdd BLAST103
Regioni104 – 139Coil 1AAdd BLAST36
Regioni140 – 158Linker 1Add BLAST19
Regioni159 – 250Coil 1BAdd BLAST92
Regioni251 – 273Linker 12Add BLAST23
Regioni274 – 412Coil 2Add BLAST139
Regioni413 – 458TailAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 102Gly-richAdd BLAST90

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFTF Eukaryota
ENOG410Y9IV LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000165872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000230975

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG013015

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13646

KEGG Orthology (KO)

More...KOi		K07604

Identification of Orthologs from Complete Genome Data

More...OMAi		DAKMTGF

Database of Orthologous Groups

More...OrthoDBi		EOG091G087I

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13646

TreeFam database of animal gene trees

More...TreeFami		TF332742

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I

The PANTHER Classification System

More...PANTHERi		PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13646-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS 
        60         70         80         90        100
CGFGGGAGSG FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL 
       110        120        130        140        150
TGNEKITMQN LNDRLASYLE KVRALEEANA DLEVKIRDWH LKQSPASPER 
       160        170        180        190        200
DYSPYYKTIE ELRDKILTAT IENNRVILEI DNARLAADDF RLKYENELAL 
       210        220        230        240        250
RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK KNHEEEMKEF 
       260        270        280        290        300
SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHTKS 
       310        320        330        340        350
AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA 
       360        370        380        390        400
ETECRYALQL QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ 
       410        420        430        440        450
EIATYRSLLE GQDAKMIGFP SSAGSVSPRS TSVTTTSSAS VTTTSNASGR 

RTSDVRRP
Length:458
Mass (Da):49,588
Last modified:November 24, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA51AECFD6195ACB4
GO
Isoform 2 (identifier: P13646-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-73: Missing.
     351-458: ETECRYALQL...GRRTSDVRRP → DPGTHQQHRGPAERAPQ

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):38,581
Checksum:i4961456B245B173B
GO
Isoform 3 (identifier: P13646-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-458: MIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → KRQPP

Show »
Length:420
Mass (Da):45,867
Checksum:i2C1A7FAF2BD62DCD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERE3K7ERE3_HUMAN
Keratin, type I cytoskeletal 13
KRT13
415Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQH6K7EQH6_HUMAN
Keratin, type I cytoskeletal 13
KRT13
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMD9K7EMD9_HUMAN
Keratin, type I cytoskeletal 13
KRT13
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMJ2K7EMJ2_HUMAN
Keratin, type I cytoskeletal 13
KRT13
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46G → R in BAD96771 (Ref. 6) Curated1
Sequence conflicti46G → R in BAD96797 (Ref. 6) Curated1
Sequence conflicti58G → D in CAA32786 (PubMed:2475110).Curated1
Sequence conflicti58G → D (PubMed:2477803).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05937681F → Y. Corresponds to variant dbSNP:rs12150581Ensembl.1
Natural variantiVAR_016035108M → T in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60364670EnsemblClinVar.1
Natural variantiVAR_023924111L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59897026EnsemblClinVar.1
Natural variantiVAR_016036112N → S in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59970018EnsemblClinVar.1
Natural variantiVAR_016037115L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60906702EnsemblClinVar.1
Natural variantiVAR_003836119L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60440396EnsemblClinVar.1
Natural variantiVAR_024488146A → G. Corresponds to variant dbSNP:rs760134EnsemblClinVar.1
Natural variantiVAR_060724187A → VCombined sources7 PublicationsCorresponds to variant dbSNP:rs9891361EnsemblClinVar.1
Natural variantiVAR_059377298T → A7 PublicationsCorresponds to variant dbSNP:rs4796697Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01637662 – 73Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_016377351 – 458ETECR…DVRRP → DPGTHQQHRGPAERAPQ in isoform 2. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_038433416 – 458MIGFP…DVRRP → KRQPP in isoform 3. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X14640 mRNA Translation: CAA32786.1
X52426 mRNA Translation: CAA36673.1
AF049259 Genomic DNA Translation: AAC35754.1
AK092276 mRNA Translation: BAC03847.1
AK223051 mRNA Translation: BAD96771.1
AK223077 mRNA Translation: BAD96797.1
AC019349 Genomic DNA No translation available.
BC002661 mRNA Translation: AAH02661.3
BC077718 mRNA Translation: AAH77718.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11396.1 [P13646-1]
CCDS11397.1 [P13646-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A37343
S06088 KRHU3

NCBI Reference Sequences

More...RefSeqi		NP_002265.2, NM_002274.3
NP_705694.2, NM_153490.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.654550

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246635; ENSP00000246635; ENSG00000171401 [P13646-1]
ENST00000336861; ENSP00000336604; ENSG00000171401 [P13646-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3860

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3860

UCSC genome browser

More...UCSCi		uc002hwu.2 human [P13646-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14640 mRNA Translation: CAA32786.1
X52426 mRNA Translation: CAA36673.1
AF049259 Genomic DNA Translation: AAC35754.1
AK092276 mRNA Translation: BAC03847.1
AK223051 mRNA Translation: BAD96771.1
AK223077 mRNA Translation: BAD96797.1
AC019349 Genomic DNA No translation available.
BC002661 mRNA Translation: AAH02661.3
BC077718 mRNA Translation: AAH77718.2
CCDSiCCDS11396.1 [P13646-1]
CCDS11397.1 [P13646-3]
PIRiA37343
S06088 KRHU3
RefSeqiNP_002265.2, NM_002274.3
NP_705694.2, NM_153490.2
UniGeneiHs.654550

3D structure databases

ProteinModelPortaliP13646
SMRiP13646
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110058, 59 interactors
IntActiP13646, 32 interactors
STRINGi9606.ENSP00000246635

PTM databases

GlyConnecti311
iPTMnetiP13646
PhosphoSitePlusiP13646
SwissPalmiP13646
UniCarbKBiP13646

Polymorphism and mutation databases

BioMutaiKRT13
DMDMi269849755

Proteomic databases

PaxDbiP13646
PeptideAtlasiP13646
PRIDEiP13646
ProteomicsDBi52951
52952 [P13646-2]
52953 [P13646-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3860
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246635; ENSP00000246635; ENSG00000171401 [P13646-1]
ENST00000336861; ENSP00000336604; ENSG00000171401 [P13646-3]
GeneIDi3860
KEGGihsa:3860
UCSCiuc002hwu.2 human [P13646-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3860
DisGeNETi3860
EuPathDBiHostDB:ENSG00000171401.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRT13
HGNCiHGNC:6415 KRT13
HPAiCAB000133
HPA030877
HPA069771
MalaCardsiKRT13
MIMi148065 gene
615785 phenotype
neXtProtiNX_P13646
OpenTargetsiENSG00000171401
Orphaneti171723 White sponge nevus
PharmGKBiPA30202

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00940000165872
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP13646
KOiK07604
OMAiDAKMTGF
OrthoDBiEOG091G087I
PhylomeDBiP13646
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KRT13 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Keratin_13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3860

Protein Ontology

More...PROi		PR:P13646

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171401 Expressed in 121 organ(s), highest expression level in esophagus mucosa
CleanExiHS_KRT13
ExpressionAtlasiP13646 baseline and differential
GenevisibleiP13646 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13646
Secondary accession number(s): Q53G54, Q6AZK5, Q8N240
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 24, 2009
Last modified: December 5, 2018
This is version 194 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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