UniProtKB - P13646 (K1C13_HUMAN)
Protein
Keratin, type I cytoskeletal 13
Gene
KRT13
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- cornification Source: Reactome
- cytoskeleton organization Source: UniProtKB
- keratinization Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | P13646 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type I cytoskeletal 13Alternative name(s): Cytokeratin-13 Short name: CK-13 Keratin-13 Short name: K13 |
Gene namesi | Name:KRT13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171401.14 |
HGNCi | HGNC:6415, KRT13 |
MIMi | 148065, gene |
neXtProti | NX_P13646 |
Subcellular locationi
Cytoskeleton
- intermediate filament cytoskeleton Source: UniProtKB
- keratin filament Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
Intermediate filament, KeratinPathology & Biotechi
Involvement in diseasei
White sponge nevus 2 (WSN2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016035 | 108 | M → T in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60364670EnsemblClinVar. | 1 | |
Natural variantiVAR_023924 | 111 | L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59897026EnsemblClinVar. | 1 | |
Natural variantiVAR_016036 | 112 | N → S in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59970018EnsemblClinVar. | 1 | |
Natural variantiVAR_016037 | 115 | L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60906702EnsemblClinVar. | 1 | |
Natural variantiVAR_003836 | 119 | L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60440396EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 3860 |
MalaCardsi | KRT13 |
MIMi | 615785, phenotype |
OpenTargetsi | ENSG00000171401 |
Orphaneti | 171723, White sponge nevus |
PharmGKBi | PA30202 |
Miscellaneous databases
Pharosi | P13646, Tbio |
Polymorphism and mutation databases
BioMutai | KRT13 |
DMDMi | 269849755 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063647 | 1 – 458 | Keratin, type I cytoskeletal 13Add BLAST | 458 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 35 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 427 | PhosphoserineCombined sources1 Publication | 1 |
Post-translational modificationi
O-glycosylated; glycans consist of single N-acetylglucosamine residues.1 Publication
Keywords - PTMi
Glycoprotein, Methylation, PhosphoproteinProteomic databases
jPOSTi | P13646 |
MassIVEi | P13646 |
PaxDbi | P13646 |
PeptideAtlasi | P13646 |
PRIDEi | P13646 |
ProteomicsDBi | 52951 [P13646-1] 52952 [P13646-2] 52953 [P13646-3] |
PTM databases
GlyConnecti | 311, 1 O-Linked glycan |
iPTMneti | P13646 |
PhosphoSitePlusi | P13646 |
SwissPalmi | P13646 |
UniCarbKBi | P13646 |
Expressioni
Tissue specificityi
Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000171401, Expressed in esophagus mucosa and 133 other tissues |
ExpressionAtlasi | P13646, baseline and differential |
Genevisiblei | P13646, HS |
Organism-specific databases
HPAi | ENSG00000171401, Tissue enhanced (esophagus, lymphoid tissue, tongue) |
Interactioni
Subunit structurei
Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.
Binary interactionsi
Hide detailsP13646
Protein-protein interaction databases
BioGRIDi | 110058, 86 interactors |
IntActi | P13646, 48 interactors |
STRINGi | 9606.ENSP00000246635 |
Miscellaneous databases
RNActi | P13646, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 104 – 416 | IF rodPROSITE-ProRule annotationAdd BLAST | 313 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 103 | HeadAdd BLAST | 103 | |
Regioni | 104 – 139 | Coil 1AAdd BLAST | 36 | |
Regioni | 140 – 158 | Linker 1Add BLAST | 19 | |
Regioni | 159 – 250 | Coil 1BAdd BLAST | 92 | |
Regioni | 251 – 273 | Linker 12Add BLAST | 23 | |
Regioni | 274 – 412 | Coil 2Add BLAST | 139 | |
Regioni | 413 – 458 | TailAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 102 | Gly-richAdd BLAST | 90 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTM6, Eukaryota |
GeneTreei | ENSGT00950000183311 |
HOGENOMi | CLU_012560_8_1_1 |
InParanoidi | P13646 |
OMAi | DAKMTGF |
OrthoDBi | 856254at2759 |
PhylomeDBi | P13646 |
TreeFami | TF332742 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P13646-1) [UniParc]FASTAAdd to basket
Also known as: A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS
60 70 80 90 100
CGFGGGAGSG FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL
110 120 130 140 150
TGNEKITMQN LNDRLASYLE KVRALEEANA DLEVKIRDWH LKQSPASPER
160 170 180 190 200
DYSPYYKTIE ELRDKILTAT IENNRVILEI DNARLAADDF RLKYENELAL
210 220 230 240 250
RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK KNHEEEMKEF
260 270 280 290 300
SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHTKS
310 320 330 340 350
AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA
360 370 380 390 400
ETECRYALQL QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ
410 420 430 440 450
EIATYRSLLE GQDAKMIGFP SSAGSVSPRS TSVTTTSSAS VTTTSNASGR
RTSDVRRP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ERE3 | K7ERE3_HUMAN | Keratin, type I cytoskeletal 13 | KRT13 | 415 | Annotation score: | ||
K7EQH6 | K7EQH6_HUMAN | Keratin, type I cytoskeletal 13 | KRT13 | 162 | Annotation score: | ||
K7EMD9 | K7EMD9_HUMAN | Keratin, type I cytoskeletal 13 | KRT13 | 165 | Annotation score: | ||
K7EMJ2 | K7EMJ2_HUMAN | Keratin, type I cytoskeletal 13 | KRT13 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | G → R in BAD96771 (Ref. 6) Curated | 1 | |
Sequence conflicti | 46 | G → R in BAD96797 (Ref. 6) Curated | 1 | |
Sequence conflicti | 58 | G → D in CAA32786 (PubMed:2475110).Curated | 1 | |
Sequence conflicti | 58 | G → D (PubMed:2477803).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059376 | 81 | F → Y. Corresponds to variant dbSNP:rs12150581Ensembl. | 1 | |
Natural variantiVAR_016035 | 108 | M → T in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60364670EnsemblClinVar. | 1 | |
Natural variantiVAR_023924 | 111 | L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59897026EnsemblClinVar. | 1 | |
Natural variantiVAR_016036 | 112 | N → S in WSN2. 1 PublicationCorresponds to variant dbSNP:rs59970018EnsemblClinVar. | 1 | |
Natural variantiVAR_016037 | 115 | L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60906702EnsemblClinVar. | 1 | |
Natural variantiVAR_003836 | 119 | L → P in WSN2. 1 PublicationCorresponds to variant dbSNP:rs60440396EnsemblClinVar. | 1 | |
Natural variantiVAR_024488 | 146 | A → G. Corresponds to variant dbSNP:rs760134EnsemblClinVar. | 1 | |
Natural variantiVAR_060724 | 187 | A → VCombined sources7 PublicationsCorresponds to variant dbSNP:rs9891361EnsemblClinVar. | 1 | |
Natural variantiVAR_059377 | 298 | T → A7 PublicationsCorresponds to variant dbSNP:rs4796697Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016376 | 62 – 73 | Missing in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_016377 | 351 – 458 | ETECR…DVRRP → DPGTHQQHRGPAERAPQ in isoform 2. 1 PublicationAdd BLAST | 108 | |
Alternative sequenceiVSP_038433 | 416 – 458 | MIGFP…DVRRP → KRQPP in isoform 3. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14640 mRNA Translation: CAA32786.1 X52426 mRNA Translation: CAA36673.1 AF049259 Genomic DNA Translation: AAC35754.1 AK092276 mRNA Translation: BAC03847.1 AK223051 mRNA Translation: BAD96771.1 AK223077 mRNA Translation: BAD96797.1 AC019349 Genomic DNA No translation available. BC002661 mRNA Translation: AAH02661.3 BC077718 mRNA Translation: AAH77718.2 |
CCDSi | CCDS11396.1 [P13646-1] CCDS11397.1 [P13646-3] |
PIRi | A37343 S06088, KRHU3 |
RefSeqi | NP_002265.2, NM_002274.3 [P13646-3] NP_705694.2, NM_153490.2 [P13646-1] |
Genome annotation databases
Ensembli | ENST00000246635; ENSP00000246635; ENSG00000171401 [P13646-1] ENST00000336861; ENSP00000336604; ENSG00000171401 [P13646-3] |
GeneIDi | 3860 |
KEGGi | hsa:3860 |
UCSCi | uc002hwu.2, human [P13646-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Intermediate Filament Mutation Database |
Wikipedia Keratin-13 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14640 mRNA Translation: CAA32786.1 X52426 mRNA Translation: CAA36673.1 AF049259 Genomic DNA Translation: AAC35754.1 AK092276 mRNA Translation: BAC03847.1 AK223051 mRNA Translation: BAD96771.1 AK223077 mRNA Translation: BAD96797.1 AC019349 Genomic DNA No translation available. BC002661 mRNA Translation: AAH02661.3 BC077718 mRNA Translation: AAH77718.2 |
CCDSi | CCDS11396.1 [P13646-1] CCDS11397.1 [P13646-3] |
PIRi | A37343 S06088, KRHU3 |
RefSeqi | NP_002265.2, NM_002274.3 [P13646-3] NP_705694.2, NM_153490.2 [P13646-1] |
3D structure databases
SMRi | P13646 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110058, 86 interactors |
IntActi | P13646, 48 interactors |
STRINGi | 9606.ENSP00000246635 |
PTM databases
GlyConnecti | 311, 1 O-Linked glycan |
iPTMneti | P13646 |
PhosphoSitePlusi | P13646 |
SwissPalmi | P13646 |
UniCarbKBi | P13646 |
Polymorphism and mutation databases
BioMutai | KRT13 |
DMDMi | 269849755 |
Proteomic databases
jPOSTi | P13646 |
MassIVEi | P13646 |
PaxDbi | P13646 |
PeptideAtlasi | P13646 |
PRIDEi | P13646 |
ProteomicsDBi | 52951 [P13646-1] 52952 [P13646-2] 52953 [P13646-3] |
Protocols and materials databases
Antibodypediai | 3599, 561 antibodies |
DNASUi | 3860 |
Genome annotation databases
Ensembli | ENST00000246635; ENSP00000246635; ENSG00000171401 [P13646-1] ENST00000336861; ENSP00000336604; ENSG00000171401 [P13646-3] |
GeneIDi | 3860 |
KEGGi | hsa:3860 |
UCSCi | uc002hwu.2, human [P13646-1] |
Organism-specific databases
CTDi | 3860 |
DisGeNETi | 3860 |
EuPathDBi | HostDB:ENSG00000171401.14 |
GeneCardsi | KRT13 |
HGNCi | HGNC:6415, KRT13 |
HPAi | ENSG00000171401, Tissue enhanced (esophagus, lymphoid tissue, tongue) |
MalaCardsi | KRT13 |
MIMi | 148065, gene 615785, phenotype |
neXtProti | NX_P13646 |
OpenTargetsi | ENSG00000171401 |
Orphaneti | 171723, White sponge nevus |
PharmGKBi | PA30202 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTM6, Eukaryota |
GeneTreei | ENSGT00950000183311 |
HOGENOMi | CLU_012560_8_1_1 |
InParanoidi | P13646 |
OMAi | DAKMTGF |
OrthoDBi | 856254at2759 |
PhylomeDBi | P13646 |
TreeFami | TF332742 |
Enzyme and pathway databases
PathwayCommonsi | P13646 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 3860, 5 hits in 842 CRISPR screens |
ChiTaRSi | KRT13, human |
GeneWikii | Keratin_13 |
GenomeRNAii | 3860 |
Pharosi | P13646, Tbio |
PROi | PR:P13646 |
RNActi | P13646, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171401, Expressed in esophagus mucosa and 133 other tissues |
ExpressionAtlasi | P13646, baseline and differential |
Genevisiblei | P13646, HS |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K1C13_HUMAN | |
Accessioni | P13646Primary (citable) accession number: P13646 Secondary accession number(s): Q53G54, Q6AZK5, Q8N240 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | November 24, 2009 | |
Last modified: | December 2, 2020 | |
This is version 209 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations