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Protein

Keratin, type I cytoskeletal 10

Gene

KRT10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the establishment of the epidermal barrier on plantar skin.By similarity
(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • structural constituent of epidermis Source: CAFA

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

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SIGNORi
P13645

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
Cytokeratin-10
Short name:
CK-10
Keratin-10
Short name:
K10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT10
Synonyms:KPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186395.6

Human Gene Nomenclature Database

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HGNCi
HGNC:6413 KRT10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
148080 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13645

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epidermolytic hyperkeratosis (EHK)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
See also OMIM:113800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_010506150M → R in EHK. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_010507150M → T in EHK; also found in a patient with hyperkeratotic epidermal nevi due to genetic mosaicism. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_003826154N → H in EHK. 1 PublicationCorresponds to variant dbSNP:rs57784225EnsemblClinVar.1
Natural variantiVAR_003828156R → C in EHK. 4 PublicationsCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003827156R → H in EHK. 5 PublicationsCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003829156R → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003830156R → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003831160Y → D in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58414354EnsemblClinVar.1
Natural variantiVAR_010508160Y → N in EHK; severe phenotype. 1 Publication1
Natural variantiVAR_010509160Y → S in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58735429EnsemblClinVar.1
Natural variantiVAR_003832161L → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs60118264EnsemblClinVar.1
Natural variantiVAR_010510439K → E in EHK; mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs61434181EnsemblClinVar.1
Natural variantiVAR_003833442L → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs58026994EnsemblClinVar.1
Natural variantiVAR_071985449Y → C in EHK. 1 PublicationCorresponds to variant dbSNP:rs267607383EnsemblClinVar.1
Ichthyosis annular epidermolytic (AEI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
See also OMIM:607602
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033145422R → E in AEI; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs59075499EnsemblClinVar.1
Natural variantiVAR_010511446I → T in AEI. 1 PublicationCorresponds to variant dbSNP:rs62651994EnsemblClinVar.1
Erythroderma, ichthyosiform, congenital reticular (CRIE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis.
See also OMIM:609165

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
3858

MalaCards human disease database

More...
MalaCardsi
KRT10
MIMi113800 phenotype
607602 phenotype
609165 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000186395

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
281139 Annular epidermolytic ichthyosis
312 Autosomal dominant epidermolytic ichthyosis
512103 Autosomal recessive epidermolytic ichthyosis
281190 Congenital reticular ichthyosiform erythroderma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30200

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849769

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636421 – 584Keratin, type I cytoskeletal 10Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi401InterchainCombined sources1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P13645

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13645

PeptideAtlas

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PeptideAtlasi
P13645

PRoteomics IDEntifications database

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PRIDEi
P13645

ProteomicsDB human proteome resource

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ProteomicsDBi
12643
52950

Consortium for Top Down Proteomics

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TopDownProteomicsi
P13645

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
P13645

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P13645

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13645

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13645

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Seen in all suprabasal cell layers including stratum corneum.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000186395 Expressed in 244 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

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CleanExi
HS_KRT10

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P13645 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13645 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000132
HPA012014

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins. Heterodimer with KRT1 (PubMed:27595935). Two heterodimers of KRT1 and KRT10 form a heterotetramer (PubMed:27595935). The KRT10 subunit in the heterotetramer is probably disulfide-linked (Probable).1 Publication1 Publication
(Microbial infection) Interacts (via C-terminal tail domain) with the S.aureus clumping factor, clfB; this interaction probably mediates S.aureus attachment to the keratinized squamous epithelial cells from the nasal cavity.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110056, 63 interactors

Protein interaction database and analysis system

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IntActi
P13645, 23 interactors

Molecular INTeraction database

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MINTi
P13645

STRING: functional protein association networks

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STRINGi
9606.ENSP00000269576

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13645

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13645

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 460IF rodPROSITE-ProRule annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 145HeadAdd BLAST145
Regioni146 – 181Coil 1AAdd BLAST36
Regioni182 – 202Linker 1Add BLAST21
Regioni203 – 294Coil 1BAdd BLAST92
Regioni295 – 317Linker 12Add BLAST23
Regioni318 – 456Coil 2Add BLAST139
Regioni457 – 584TailAdd BLAST128

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 575Gly-richAdd BLAST559
Compositional biasi477 – 579Ser-richAdd BLAST103

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGJX Eukaryota
ENOG410YDXS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160849

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230975

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG013015

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13645

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
HQGEPRD

Database of Orthologous Groups

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OrthoDBi
EOG091G087I

Database for complete collections of gene phylogenies

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PhylomeDBi
P13645

TreeFam database of animal gene trees

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TreeFami
TF332742

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG
60 70 80 90 100
GFSGGSFSRG SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG
110 120 130 140 150
IFGGGSFGGG SFGGGSFGGG GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM
160 170 180 190 200
QNLNDRLASY LDKVRALEES NYELEGKIKE WYEKHGNSHQ GEPRDYSKYY
210 220 230 240 250
KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA
260 270 280 290 300
DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG
310 320 330 340 350
DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE
360 370 380 390 400
IDNNIEQISS YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY
410 420 430 440 450
CVQLSQIQAQ ISALEEQLQQ IRAETECQNT EYQQLLDIKI RLENEIQTYR
460 470 480 490 500
SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG GSSGGGHGGG HGGSSGGGYG
510 520 530 540 550
GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG GYGGGSSGGG
560 570 580
SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY
Length:584
Mass (Da):58,827
Last modified:November 24, 2009 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4941ECD2AE46D417
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GVI3A0A1B0GVI3_HUMAN
Keratin, type I cytoskeletal 10
KRT10
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA59468 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9 – 11KHY → SKQF in AAA60544 (PubMed:2459124).Curated3
Sequence conflicti24 – 31Missing in AAA60544 (PubMed:2459124).Curated8
Sequence conflicti86R → H in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti106S → N in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti181 – 184WYEK → RYDQ in AAA60544 (PubMed:2459124).Curated4
Sequence conflicti189H → R in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti197S → G in AAA59199 (PubMed:1378806).Curated1
Sequence conflicti266K → Q in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti279 – 280EL → YV in AAA59468 (PubMed:2448602).Curated2
Sequence conflicti287H → R in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti293D → H in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti312V → I in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti323S → N in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti340F → V in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti374A → R in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti408Q → H in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti420Q → E in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti436L → T in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti451S → G in AAA59199 (PubMed:1378806).Curated1
Sequence conflicti460 – 461GG → RS in AAA59468 (PubMed:2448602).Curated2
Sequence conflicti477S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti482S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti487 – 490Missing in AAA59199 (PubMed:1378806).Curated4
Sequence conflicti491 – 516Missing in AAA60544 (PubMed:2459124).CuratedAdd BLAST26
Sequence conflicti503S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti508S → T in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti513 – 519YGGGSSS → LRGELH in AAA59468 (PubMed:2448602).Curated7
Sequence conflicti523 – 527GGSSS → AHST in AAA59468 (PubMed:2448602).Curated5
Sequence conflicti524G → GGSSSGGHGG in CAA32649 (PubMed:2464696).Curated1
Sequence conflicti534S → N in AAA59468 (PubMed:2448602).Curated1
Sequence conflicti535S → F in AAA60544 (PubMed:2459124).Curated1
Sequence conflicti542 – 546YGGGS → LRGRH in AAA59468 (PubMed:2448602).Curated5
Sequence conflicti565G → GGYGGGSSSGG in AAA60544 (PubMed:2459124).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058202101I → S2 PublicationsCorresponds to variant dbSNP:rs4261597Ensembl.1
Natural variantiVAR_010505126G → S2 PublicationsCorresponds to variant dbSNP:rs77919366EnsemblClinVar.1
Natural variantiVAR_010506150M → R in EHK. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_010507150M → T in EHK; also found in a patient with hyperkeratotic epidermal nevi due to genetic mosaicism. 2 PublicationsCorresponds to variant dbSNP:rs58901407EnsemblClinVar.1
Natural variantiVAR_003826154N → H in EHK. 1 PublicationCorresponds to variant dbSNP:rs57784225EnsemblClinVar.1
Natural variantiVAR_003828156R → C in EHK. 4 PublicationsCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003827156R → H in EHK. 5 PublicationsCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003829156R → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs58075662EnsemblClinVar.1
Natural variantiVAR_003830156R → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs58852768EnsemblClinVar.1
Natural variantiVAR_003831160Y → D in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58414354EnsemblClinVar.1
Natural variantiVAR_010508160Y → N in EHK; severe phenotype. 1 Publication1
Natural variantiVAR_010509160Y → S in EHK; severe phenotype. 1 PublicationCorresponds to variant dbSNP:rs58735429EnsemblClinVar.1
Natural variantiVAR_003832161L → S in EHK. 1 PublicationCorresponds to variant dbSNP:rs60118264EnsemblClinVar.1
Natural variantiVAR_033145422R → E in AEI; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs59075499EnsemblClinVar.1
Natural variantiVAR_010510439K → E in EHK; mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs61434181EnsemblClinVar.1
Natural variantiVAR_003833442L → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs58026994EnsemblClinVar.1
Natural variantiVAR_010511446I → T in AEI. 1 PublicationCorresponds to variant dbSNP:rs62651994EnsemblClinVar.1
Natural variantiVAR_071985449Y → C in EHK. 1 PublicationCorresponds to variant dbSNP:rs267607383EnsemblClinVar.1
Natural variantiVAR_060723487H → Y4 PublicationsCorresponds to variant dbSNP:rs17855579Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04029 mRNA Translation: AAA60544.1
X14487 Genomic DNA Translation: CAA32649.1
AC090283 mRNA No translation available.
BC034697 mRNA Translation: AAH34697.1
M19156 mRNA Translation: AAA59468.1 Different initiation.
L20218 Genomic DNA Translation: AAB59438.1
L20219 Genomic DNA Translation: AAB59439.1
M77663 mRNA Translation: AAA59199.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11377.1

Protein sequence database of the Protein Information Resource

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PIRi
A31994
S02158 KRHU0

NCBI Reference Sequences

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RefSeqi
NP_000412.3, NM_000421.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.99936

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269576; ENSP00000269576; ENSG00000186395

Database of genes from NCBI RefSeq genomes

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GeneIDi
3858

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3858

UCSC genome browser

More...
UCSCi
uc002hvi.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-10 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04029 mRNA Translation: AAA60544.1
X14487 Genomic DNA Translation: CAA32649.1
AC090283 mRNA No translation available.
BC034697 mRNA Translation: AAH34697.1
M19156 mRNA Translation: AAA59468.1 Different initiation.
L20218 Genomic DNA Translation: AAB59438.1
L20219 Genomic DNA Translation: AAB59439.1
M77663 mRNA Translation: AAA59199.1
CCDSiCCDS11377.1
PIRiA31994
S02158 KRHU0
RefSeqiNP_000412.3, NM_000421.3
UniGeneiHs.99936

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ASWX-ray2.60B473-487[»]
4F1ZX-ray2.30Q499-512[»]
4ZRYX-ray3.30A337-456[»]
ProteinModelPortaliP13645
SMRiP13645
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110056, 63 interactors
IntActiP13645, 23 interactors
MINTiP13645
STRINGi9606.ENSP00000269576

PTM databases

iPTMnetiP13645
PhosphoSitePlusiP13645
SwissPalmiP13645

Polymorphism and mutation databases

BioMutaiKRT10
DMDMi269849769

2D gel databases

REPRODUCTION-2DPAGEiP13645
SWISS-2DPAGEiP13645

Proteomic databases

EPDiP13645
PaxDbiP13645
PeptideAtlasiP13645
PRIDEiP13645
ProteomicsDBi12643
52950
TopDownProteomicsiP13645

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3858
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269576; ENSP00000269576; ENSG00000186395
GeneIDi3858
KEGGihsa:3858
UCSCiuc002hvi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3858
DisGeNETi3858
EuPathDBiHostDB:ENSG00000186395.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT10
HGNCiHGNC:6413 KRT10
HPAiCAB000132
HPA012014
MalaCardsiKRT10
MIMi113800 phenotype
148080 gene
607602 phenotype
609165 phenotype
neXtProtiNX_P13645
OpenTargetsiENSG00000186395
Orphaneti281139 Annular epidermolytic ichthyosis
312 Autosomal dominant epidermolytic ichthyosis
512103 Autosomal recessive epidermolytic ichthyosis
281190 Congenital reticular ichthyosiform erythroderma
PharmGKBiPA30200

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGJX Eukaryota
ENOG410YDXS LUCA
GeneTreeiENSGT00940000160849
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP13645
KOiK07604
OMAiHQGEPRD
OrthoDBiEOG091G087I
PhylomeDBiP13645
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP13645

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRT10 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Keratin_10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3858

Protein Ontology

More...
PROi
PR:P13645

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186395 Expressed in 244 organ(s), highest expression level in skin of abdomen
CleanExiHS_KRT10
ExpressionAtlasiP13645 baseline and differential
GenevisibleiP13645 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13645
Secondary accession number(s): Q14664, Q8N175
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 24, 2009
Last modified: December 5, 2018
This is version 197 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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