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Protein

Metallothionein-1G

Gene

MT1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi14Divalent metal cation; cluster B1
Metal bindingi16Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster B1
Metal bindingi22Divalent metal cation; cluster B1
Metal bindingi25Divalent metal cation; cluster B1
Metal bindingi27Divalent metal cation; cluster B1
Metal bindingi30Divalent metal cation; cluster B1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi35Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi38Divalent metal cation; cluster A1
Metal bindingi42Divalent metal cation; cluster A1
Metal bindingi45Divalent metal cation; cluster A1
Metal bindingi49Divalent metal cation; cluster A1
Metal bindingi51Divalent metal cation; cluster A1
Metal bindingi58Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1
Metal bindingi61Divalent metal cation; cluster A1

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals
SIGNORiP13640

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1G
Short name:
MT-1G
Alternative name(s):
Metallothionein-1K
Short name:
MT-1K
Metallothionein-IG
Short name:
MT-IG
Gene namesi
Name:MT1G
Synonyms:MT1K, MT1M
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000125144.13
HGNCiHGNC:7399 MT1G
MIMi156353 gene
neXtProtiNX_P13640

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4495
OpenTargetsiENSG00000125144
PharmGKBiPA31204

Polymorphism and mutation databases

DMDMi90109444

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972381 – 62Metallothionein-1GAdd BLAST62

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei59PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP13640
MaxQBiP13640
PaxDbiP13640
PeptideAtlasiP13640
PRIDEiP13640
ProteomicsDBi52948
52949 [P13640-2]
TopDownProteomicsiP13640-2 [P13640-2]

PTM databases

iPTMnetiP13640
PhosphoSitePlusiP13640

Expressioni

Gene expression databases

BgeeiENSG00000125144 Expressed in 230 organ(s), highest expression level in kidney epithelium
CleanExiHS_MT1G
HS_MT1M
ExpressionAtlasiP13640 baseline and differential
GenevisibleiP13640 HS

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
SPINK7P580623EBI-1182473,EBI-1182445

Protein-protein interaction databases

BioGridi110601, 3 interactors
IntActiP13640, 2 interactors
STRINGi9606.ENSP00000391397

Structurei

3D structure databases

ProteinModelPortaliP13640
SMRiP13640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni31 – 62AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IUWR Eukaryota
ENOG4110PT3 LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
InParanoidiP13640
KOiK14739
OMAiDPNCSCV
PhylomeDBiP13640
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13640-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPNCSCAAA GVSCTCASSC KCKECKCTSC KKSCCSCCPV GCAKCAQGCI
60
CKGASEKCSC CA
Length:62
Mass (Da):6,141
Last modified:February 7, 2006 - v2
Checksum:iA1B390F5899DD040
GO
Isoform 2 (identifier: P13640-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: Missing.

Show »
Length:61
Mass (Da):6,070
Checksum:i7B0A61FF89CA94CC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSF1H3BSF1_HUMAN
Metallothionein
MT1G
39Annotation score:
H3BSS0H3BSS0_HUMAN
Metallothionein
MT1G
68Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01723010Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03910 Genomic DNA Translation: AAA59873.1
BC020757 mRNA Translation: AAH20757.1
S68954 mRNA Translation: AAB30083.1
CCDSiCCDS10766.1 [P13640-2]
CCDS76873.1 [P13640-1]
PIRiA29236 SMHU1G
RefSeqiNP_001288196.1, NM_001301267.1 [P13640-1]
NP_005941.1, NM_005950.2 [P13640-2]
UniGeneiHs.433391

Genome annotation databases

EnsembliENST00000379811; ENSP00000369139; ENSG00000125144 [P13640-1]
ENST00000444837; ENSP00000391397; ENSG00000125144 [P13640-2]
GeneIDi4495
KEGGihsa:4495
UCSCiuc002eju.2 human [P13640-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03910 Genomic DNA Translation: AAA59873.1
BC020757 mRNA Translation: AAH20757.1
S68954 mRNA Translation: AAB30083.1
CCDSiCCDS10766.1 [P13640-2]
CCDS76873.1 [P13640-1]
PIRiA29236 SMHU1G
RefSeqiNP_001288196.1, NM_001301267.1 [P13640-1]
NP_005941.1, NM_005950.2 [P13640-2]
UniGeneiHs.433391

3D structure databases

ProteinModelPortaliP13640
SMRiP13640
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110601, 3 interactors
IntActiP13640, 2 interactors
STRINGi9606.ENSP00000391397

PTM databases

iPTMnetiP13640
PhosphoSitePlusiP13640

Polymorphism and mutation databases

DMDMi90109444

Proteomic databases

EPDiP13640
MaxQBiP13640
PaxDbiP13640
PeptideAtlasiP13640
PRIDEiP13640
ProteomicsDBi52948
52949 [P13640-2]
TopDownProteomicsiP13640-2 [P13640-2]

Protocols and materials databases

DNASUi4495
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379811; ENSP00000369139; ENSG00000125144 [P13640-1]
ENST00000444837; ENSP00000391397; ENSG00000125144 [P13640-2]
GeneIDi4495
KEGGihsa:4495
UCSCiuc002eju.2 human [P13640-1]

Organism-specific databases

CTDi4495
DisGeNETi4495
EuPathDBiHostDB:ENSG00000125144.13
GeneCardsiMT1G
H-InvDBiHIX0021664
HGNCiHGNC:7399 MT1G
MIMi156353 gene
neXtProtiNX_P13640
OpenTargetsiENSG00000125144
PharmGKBiPA31204
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUWR Eukaryota
ENOG4110PT3 LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
InParanoidiP13640
KOiK14739
OMAiDPNCSCV
PhylomeDBiP13640
TreeFamiTF336054

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals
SIGNORiP13640

Miscellaneous databases

ChiTaRSiMT1G human
GeneWikiiMetallothionein_1G
GenomeRNAii4495
PROiPR:P13640
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125144 Expressed in 230 organ(s), highest expression level in kidney epithelium
CleanExiHS_MT1G
HS_MT1M
ExpressionAtlasiP13640 baseline and differential
GenevisibleiP13640 HS

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT1G_HUMAN
AccessioniPrimary (citable) accession number: P13640
Secondary accession number(s): P80296
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 7, 2006
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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