Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 216 (16 Oct 2019)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

ATP1A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3664-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi707MagnesiumBy similarity1
Metal bindingi711MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.1.1 the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:7.2.2.13)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP1A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:801 ATP1A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182350 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13637

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 121ExtracellularSequence analysisAdd BLAST23
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 278CytoplasmicSequence analysisAdd BLAST136
Transmembranei279 – 298HelicalSequence analysisAdd BLAST20
Topological domaini299 – 310ExtracellularSequence analysisAdd BLAST12
Transmembranei311 – 328HelicalSequence analysisAdd BLAST18
Topological domaini329 – 762CytoplasmicSequence analysisAdd BLAST434
Transmembranei763 – 782HelicalSequence analysisAdd BLAST20
Topological domaini783 – 792ExtracellularSequence analysis10
Transmembranei793 – 813HelicalSequence analysisAdd BLAST21
Topological domaini814 – 833CytoplasmicSequence analysisAdd BLAST20
Transmembranei834 – 856HelicalSequence analysisAdd BLAST23
Topological domaini857 – 908ExtracellularSequence analysisAdd BLAST52
Transmembranei909 – 928HelicalSequence analysisAdd BLAST20
Topological domaini929 – 941CytoplasmicSequence analysisAdd BLAST13
Transmembranei942 – 960HelicalSequence analysisAdd BLAST19
Topological domaini961 – 975ExtracellularSequence analysisAdd BLAST15
Transmembranei976 – 996HelicalSequence analysisAdd BLAST21
Topological domaini997 – 1013CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystonia 12 (DYT12)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026735274I → T in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356532EnsemblClinVar.1
Natural variantiVAR_026736277E → K in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356533EnsemblClinVar.1
Natural variantiVAR_026737613T → M in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356534EnsemblClinVar.1
Natural variantiVAR_026738758I → S in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356535EnsemblClinVar.1
Natural variantiVAR_026739780F → L in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356536EnsemblClinVar.1
Natural variantiVAR_026740801D → Y in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356537EnsemblClinVar.1
Natural variantiVAR_068949923D → N in DYT12. 1 PublicationCorresponds to variant dbSNP:rs267606670EnsemblClinVar.1
Natural variantiVAR_0689531013Y → YY in DYT12; there is a drastic 40-to 50-fold reduction in Na(+) affinity in the mutant protein. 1 Publication1
Alternating hemiplegia of childhood 2 (AHC2)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068935137S → F in AHC2. 1 PublicationCorresponds to variant dbSNP:rs542652468EnsemblClinVar.1
Natural variantiVAR_068936137S → Y in AHC2; strong decrease in ATPase activity. 2 PublicationsCorresponds to variant dbSNP:rs542652468EnsemblClinVar.1
Natural variantiVAR_068937140Q → L in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231427EnsemblClinVar.1
Natural variantiVAR_068938220D → N in AHC2; no effect on ATPase activity. 2 PublicationsCorresponds to variant dbSNP:rs1396898460Ensembl.1
Natural variantiVAR_068939274I → N in AHC2; strong decrease in ATPase activity. 3 PublicationsCorresponds to variant dbSNP:rs80356532EnsemblClinVar.1
Natural variantiVAR_070767322V → D in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231428EnsemblClinVar.1
Natural variantiVAR_068940333C → F in AHC2; decreased ATPase activity. 1 PublicationCorresponds to variant dbSNP:rs606231430EnsemblClinVar.1
Natural variantiVAR_070768371L → P in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231433EnsemblClinVar.1
Natural variantiVAR_070769755G → C in AHC2. 2 PublicationsCorresponds to variant dbSNP:rs557052809EnsemblClinVar.1
Natural variantiVAR_068941755G → S in AHC2. 1 PublicationCorresponds to variant dbSNP:rs557052809EnsemblClinVar.1
Natural variantiVAR_070770772S → R in AHC2. 1 PublicationCorresponds to variant dbSNP:rs534926223EnsemblClinVar.1
Natural variantiVAR_070771773N → I in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231437EnsemblClinVar.1
Natural variantiVAR_068942773N → S in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231437EnsemblClinVar.1
Natural variantiVAR_068943801D → N in AHC2; strong decrease in ATPase activity. 4 PublicationsCorresponds to variant dbSNP:rs80356537EnsemblClinVar.1
Natural variantiVAR_068944806M → R in AHC2. 1 PublicationCorresponds to variant dbSNP:rs549006436EnsemblClinVar.1
Natural variantiVAR_068945810I → S in AHC2. 1 PublicationCorresponds to variant dbSNP:rs536681257EnsemblClinVar.1
Natural variantiVAR_068946811S → P in AHC2; decreased ATPase activity. 1 PublicationCorresponds to variant dbSNP:rs387907282EnsemblClinVar.1
Natural variantiVAR_068947815E → K in AHC2; strong decrease in ATPase activity. 4 PublicationsCorresponds to variant dbSNP:rs387907281EnsemblClinVar.1
Natural variantiVAR_068948919Missing in AHC2. 1 Publication1
Natural variantiVAR_070773923D → Y in AHC2. 1 PublicationCorresponds to variant dbSNP:rs267606670EnsemblClinVar.1
Natural variantiVAR_070774927C → Y in AHC2. Corresponds to variant dbSNP:rs606231444EnsemblClinVar.1
Natural variantiVAR_068950947G → R in AHC2; strong decrease in ATPase activity. 3 PublicationsCorresponds to variant dbSNP:rs398122887EnsemblClinVar.1
Natural variantiVAR_068951955A → D in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231446EnsemblClinVar.1
Natural variantiVAR_068952992D → Y in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231447EnsemblClinVar.1
Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurologic disorder characterized by relapsing and partially remitting, early-onset cerebellar ataxia following a febrile illness. Other features include progressive optic atrophy and sensorineural hearing loss, generalized hypotonia, areflexia and pes cavus without evidence of a peripheral neuropathy on neurophysiological studies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070772818E → K in CAPOS. 1 PublicationCorresponds to variant dbSNP:rs587777771EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Dystonia, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
478

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ATP1A3

MalaCards human disease database

More...
MalaCardsi
ATP1A3
MIMi128235 phenotype
601338 phenotype
614820 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000105409

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2131 Alternating hemiplegia of childhood
1171 Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome
71517 Rapid-onset dystonia-parkinsonism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA64

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P13637

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2095186

Drug and drug target database

More...
DrugBanki
DB01092 Ouabain
DB09479 Rubidium Rb-82

DrugCentral

More...
DrugCentrali
P13637

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP1A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241260

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000462981 – 1013Sodium/potassium-transporting ATPase subunit alpha-3Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei218PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1
Modified residuei548PhosphotyrosineBy similarity1
Modified residuei933Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13637

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P13637

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P13637

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P13637

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13637

PeptideAtlas

More...
PeptideAtlasi
P13637

PRoteomics IDEntifications database

More...
PRIDEi
P13637

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
27209
52946 [P13637-1]
6459

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13637

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13637

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13637

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105409 Expressed in 121 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13637 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13637 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033630
HPA045367
HPA056446

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Interacts with regulatory subunit FXYD1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106968, 53 interactors

Protein interaction database and analysis system

More...
IntActi
P13637, 12 interactors

Molecular INTeraction database

More...
MINTi
P13637

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000444688

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P13637

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 74Interaction with phosphoinositide-3 kinaseBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0203 Eukaryota
COG0474 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160476

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000265622

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P13637

KEGG Orthology (KO)

More...
KOi
K01539

Database of Orthologous Groups

More...
OrthoDBi
789556at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13637

TreeFam database of animal gene trees

More...
TreeFami
TF312838

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02608 P-type_ATPase_Na-K_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831 Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDKKDDKDS PKKNKGKERR DLDDLKKEVA MTEHKMSVEE VCRKYNTDCV
60 70 80 90 100
QGLTHSKAQE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SILLWIGAIL
110 120 130 140 150
CFLAYGIQAG TEDDPSGDNL YLGIVLAAVV IITGCFSYYQ EAKSSKIMES
160 170 180 190 200
FKNMVPQQAL VIREGEKMQV NAEEVVVGDL VEIKGGDRVP ADLRIISAHG
210 220 230 240 250
CKVDNSSLTG ESEPQTRSPD CTHDNPLETR NITFFSTNCV EGTARGVVVA
260 270 280 290 300
TGDRTVMGRI ATLASGLEVG KTPIAIEIEH FIQLITGVAV FLGVSFFILS
310 320 330 340 350
LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
360 370 380 390 400
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTEDQSGTS
410 420 430 440 450
FDKSSHTWVA LSHIAGLCNR AVFKGGQDNI PVLKRDVAGD ASESALLKCI
460 470 480 490 500
ELSSGSVKLM RERNKKVAEI PFNSTNKYQL SIHETEDPND NRYLLVMKGA
510 520 530 540 550
PERILDRCST ILLQGKEQPL DEEMKEAFQN AYLELGGLGE RVLGFCHYYL
560 570 580 590 600
PEEQFPKGFA FDCDDVNFTT DNLCFVGLMS MIDPPRAAVP DAVGKCRSAG
610 620 630 640 650
IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA
660 670 680 690 700
KACVIHGTDL KDFTSEQIDE ILQNHTEIVF ARTSPQQKLI IVEGCQRQGA
710 720 730 740 750
IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT
760 770 780 790 800
GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LLFIMANIPL PLGTITILCI
810 820 830 840 850
DLGTDMVPAI SLAYEAAESD IMKRQPRNPR TDKLVNERLI SMAYGQIGMI
860 870 880 890 900
QALGGFFSYF VILAENGFLP GNLVGIRLNW DDRTVNDLED SYGQQWTYEQ
910 920 930 940 950
RKVVEFTCHT AFFVSIVVVQ WADLIICKTR RNSVFQQGMK NKILIFGLFE
960 970 980 990 1000
ETALAAFLSY CPGMDVALRM YPLKPSWWFC AFPYSFLIFV YDEIRKLILR
1010
RNPGGWVEKE TYY
Length:1,013
Mass (Da):111,749
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF28CD9F1E11AF48
GO
Isoform 2 (identifier: P13637-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MG → MGGWEEERNRRAT

Show »
Length:1,024
Mass (Da):113,134
Checksum:iD6F4310E7B68C1D1
GO
Isoform 3 (identifier: P13637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MG → MGSGGSDSYRIATSQ

Show »
Length:1,026
Mass (Da):113,059
Checksum:i50F72BDBADD90225
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R116M0R116_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A3
983Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MT26A0A0A0MT26_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A3
1,226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXF2M0QXF2_HUMAN
Sodium/potassium-transporting ATPas...
ATP1A3
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 2MG → MEIH in CAA31390 (PubMed:2834163).Curated2
Sequence conflicti144S → R in BAH12387 (PubMed:14702039).Curated1
Sequence conflicti336L → V in AAA51798 (PubMed:2838329).Curated1
Sequence conflicti336L → V in CAA31390 (PubMed:2834163).Curated1
Sequence conflicti336L → V in AAA52285 (PubMed:3030810).Curated1
Sequence conflicti336L → V in AAA58380 (PubMed:3036582).Curated1
Sequence conflicti380H → T in AAA52285 (PubMed:3030810).Curated1
Sequence conflicti421A → P in AAA58380 (PubMed:3036582).Curated1
Sequence conflicti430I → M in CAA31390 (PubMed:2834163).Curated1
Sequence conflicti555 – 557FPK → YPQ in AAA51798 (PubMed:2838329).Curated3
Sequence conflicti555 – 557FPK → YPQ in CAA31390 (PubMed:2834163).Curated3
Sequence conflicti555 – 557FPK → YPQ in AAA52286 (PubMed:3030810).Curated3
Sequence conflicti577G → P in AAA51798 (PubMed:2838329).Curated1
Sequence conflicti583D → G in AAA51798 (PubMed:2838329).Curated1
Sequence conflicti583D → G in CAA31390 (PubMed:2834163).Curated1
Sequence conflicti583D → G in AAA52286 (PubMed:3030810).Curated1
Sequence conflicti919V → A in AAA52286 (PubMed:3030810).Curated1
Sequence conflicti944L → M in AAA52286 (PubMed:3030810).Curated1
Sequence conflicti982F → S in CAA31390 (PubMed:2834163).Curated1
Sequence conflicti1006W → S in AAA51798 (PubMed:2838329).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068935137S → F in AHC2. 1 PublicationCorresponds to variant dbSNP:rs542652468EnsemblClinVar.1
Natural variantiVAR_068936137S → Y in AHC2; strong decrease in ATPase activity. 2 PublicationsCorresponds to variant dbSNP:rs542652468EnsemblClinVar.1
Natural variantiVAR_068937140Q → L in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231427EnsemblClinVar.1
Natural variantiVAR_068938220D → N in AHC2; no effect on ATPase activity. 2 PublicationsCorresponds to variant dbSNP:rs1396898460Ensembl.1
Natural variantiVAR_068939274I → N in AHC2; strong decrease in ATPase activity. 3 PublicationsCorresponds to variant dbSNP:rs80356532EnsemblClinVar.1
Natural variantiVAR_026735274I → T in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356532EnsemblClinVar.1
Natural variantiVAR_026736277E → K in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356533EnsemblClinVar.1
Natural variantiVAR_078699320A → T Probable disease-associated mutation found in a patient with tonic-clonic seizures associated with profound developmental delay and paroxysmal movement disorder. 1 PublicationCorresponds to variant dbSNP:rs879255368EnsemblClinVar.1
Natural variantiVAR_070767322V → D in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231428EnsemblClinVar.1
Natural variantiVAR_068940333C → F in AHC2; decreased ATPase activity. 1 PublicationCorresponds to variant dbSNP:rs606231430EnsemblClinVar.1
Natural variantiVAR_070768371L → P in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231433EnsemblClinVar.1
Natural variantiVAR_026737613T → M in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356534EnsemblClinVar.1
Natural variantiVAR_070769755G → C in AHC2. 2 PublicationsCorresponds to variant dbSNP:rs557052809EnsemblClinVar.1
Natural variantiVAR_068941755G → S in AHC2. 1 PublicationCorresponds to variant dbSNP:rs557052809EnsemblClinVar.1
Natural variantiVAR_026738758I → S in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356535EnsemblClinVar.1
Natural variantiVAR_070770772S → R in AHC2. 1 PublicationCorresponds to variant dbSNP:rs534926223EnsemblClinVar.1
Natural variantiVAR_070771773N → I in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231437EnsemblClinVar.1
Natural variantiVAR_068942773N → S in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231437EnsemblClinVar.1
Natural variantiVAR_026739780F → L in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356536EnsemblClinVar.1
Natural variantiVAR_068943801D → N in AHC2; strong decrease in ATPase activity. 4 PublicationsCorresponds to variant dbSNP:rs80356537EnsemblClinVar.1
Natural variantiVAR_026740801D → Y in DYT12. 1 PublicationCorresponds to variant dbSNP:rs80356537EnsemblClinVar.1
Natural variantiVAR_068944806M → R in AHC2. 1 PublicationCorresponds to variant dbSNP:rs549006436EnsemblClinVar.1
Natural variantiVAR_068945810I → S in AHC2. 1 PublicationCorresponds to variant dbSNP:rs536681257EnsemblClinVar.1
Natural variantiVAR_068946811S → P in AHC2; decreased ATPase activity. 1 PublicationCorresponds to variant dbSNP:rs387907282EnsemblClinVar.1
Natural variantiVAR_068947815E → K in AHC2; strong decrease in ATPase activity. 4 PublicationsCorresponds to variant dbSNP:rs387907281EnsemblClinVar.1
Natural variantiVAR_070772818E → K in CAPOS. 1 PublicationCorresponds to variant dbSNP:rs587777771EnsemblClinVar.1
Natural variantiVAR_068948919Missing in AHC2. 1 Publication1
Natural variantiVAR_068949923D → N in DYT12. 1 PublicationCorresponds to variant dbSNP:rs267606670EnsemblClinVar.1
Natural variantiVAR_070773923D → Y in AHC2. 1 PublicationCorresponds to variant dbSNP:rs267606670EnsemblClinVar.1
Natural variantiVAR_070774927C → Y in AHC2. Corresponds to variant dbSNP:rs606231444EnsemblClinVar.1
Natural variantiVAR_068950947G → R in AHC2; strong decrease in ATPase activity. 3 PublicationsCorresponds to variant dbSNP:rs398122887EnsemblClinVar.1
Natural variantiVAR_068951955A → D in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231446EnsemblClinVar.1
Natural variantiVAR_068952992D → Y in AHC2. 1 PublicationCorresponds to variant dbSNP:rs606231447EnsemblClinVar.1
Natural variantiVAR_0689531013Y → YY in DYT12; there is a drastic 40-to 50-fold reduction in Na(+) affinity in the mutant protein. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469561 – 2MG → MGGWEEERNRRAT in isoform 2. 1 Publication2
Alternative sequenceiVSP_0469571 – 2MG → MGSGGSDSYRIATSQ in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37457
, M37436, M37437, M37438, M37462, M37439, M37440, M37441, M37442, M37443, M37444, M37445, M37447, M37448, M37449, M37450, M37451, M37452, M37453, M37454, M37455, M37456 Genomic DNA Translation: AAA51798.1
X12910
, X12911, X12912, X12913, X12914, X12915, X12916, X12917, X12919, X12920, X12921, X12922, X12923 Genomic DNA Translation: CAA31390.1
AK295078 mRNA Translation: BAH11966.1
AK296557 mRNA Translation: BAH12387.1
AC010616 Genomic DNA No translation available.
BC009282 mRNA Translation: AAH09282.1
BC009394 mRNA Translation: AAH09394.1
BC015566 mRNA Translation: AAH15566.1
M28286, M28284, M28285 Genomic DNA Translation: AAA52285.1
M28293
, M28287, M35821, M35822, M28289, M28290, M28291, M28292 Genomic DNA Translation: AAA52286.1
M27577, M27570, M27573 Genomic DNA Translation: AAA58380.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12594.1 [P13637-1]
CCDS58663.1 [P13637-2]
CCDS58664.1 [P13637-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S00801

NCBI Reference Sequences

More...
RefSeqi
NP_001243142.1, NM_001256213.1 [P13637-2]
NP_001243143.1, NM_001256214.1 [P13637-3]
NP_689509.1, NM_152296.4 [P13637-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000543770; ENSP00000437577; ENSG00000105409 [P13637-2]
ENST00000545399; ENSP00000444688; ENSG00000105409 [P13637-3]
ENST00000648268; ENSP00000498113; ENSG00000105409 [P13637-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:478

UCSC genome browser

More...
UCSCi
uc002osg.4 human [P13637-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37457
, M37436, M37437, M37438, M37462, M37439, M37440, M37441, M37442, M37443, M37444, M37445, M37447, M37448, M37449, M37450, M37451, M37452, M37453, M37454, M37455, M37456 Genomic DNA Translation: AAA51798.1
X12910
, X12911, X12912, X12913, X12914, X12915, X12916, X12917, X12919, X12920, X12921, X12922, X12923 Genomic DNA Translation: CAA31390.1
AK295078 mRNA Translation: BAH11966.1
AK296557 mRNA Translation: BAH12387.1
AC010616 Genomic DNA No translation available.
BC009282 mRNA Translation: AAH09282.1
BC009394 mRNA Translation: AAH09394.1
BC015566 mRNA Translation: AAH15566.1
M28286, M28284, M28285 Genomic DNA Translation: AAA52285.1
M28293
, M28287, M35821, M35822, M28289, M28290, M28291, M28292 Genomic DNA Translation: AAA52286.1
M27577, M27570, M27573 Genomic DNA Translation: AAA58380.1
CCDSiCCDS12594.1 [P13637-1]
CCDS58663.1 [P13637-2]
CCDS58664.1 [P13637-3]
PIRiS00801
RefSeqiNP_001243142.1, NM_001256213.1 [P13637-2]
NP_001243143.1, NM_001256214.1 [P13637-3]
NP_689509.1, NM_152296.4 [P13637-1]

3D structure databases

SMRiP13637
ModBaseiSearch...

Protein-protein interaction databases

BioGridi106968, 53 interactors
IntActiP13637, 12 interactors
MINTiP13637
STRINGi9606.ENSP00000444688

Chemistry databases

ChEMBLiCHEMBL2095186
DrugBankiDB01092 Ouabain
DB09479 Rubidium Rb-82
DrugCentraliP13637

Protein family/group databases

TCDBi3.A.3.1.1 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiP13637
PhosphoSitePlusiP13637
SwissPalmiP13637

Polymorphism and mutation databases

BioMutaiATP1A3
DMDMi116241260

Proteomic databases

EPDiP13637
jPOSTiP13637
MassIVEiP13637
MaxQBiP13637
PaxDbiP13637
PeptideAtlasiP13637
PRIDEiP13637
ProteomicsDBi27209
52946 [P13637-1]
6459

Genome annotation databases

EnsembliENST00000543770; ENSP00000437577; ENSG00000105409 [P13637-2]
ENST00000545399; ENSP00000444688; ENSG00000105409 [P13637-3]
ENST00000648268; ENSP00000498113; ENSG00000105409 [P13637-1]
GeneIDi478
KEGGihsa:478
UCSCiuc002osg.4 human [P13637-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
478
DisGeNETi478

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP1A3
GeneReviewsiATP1A3
HGNCiHGNC:801 ATP1A3
HPAiCAB033630
HPA045367
HPA056446
MalaCardsiATP1A3
MIMi128235 phenotype
182350 gene
601338 phenotype
614820 phenotype
neXtProtiNX_P13637
OpenTargetsiENSG00000105409
Orphaneti2131 Alternating hemiplegia of childhood
1171 Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome
71517 Rapid-onset dystonia-parkinsonism
PharmGKBiPA64

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00940000160476
HOGENOMiHOG000265622
InParanoidiP13637
KOiK01539
OrthoDBi789556at2759
PhylomeDBiP13637
TreeFamiTF312838

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATP1A3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATP1A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
478
PharosiP13637

Protein Ontology

More...
PROi
PR:P13637

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105409 Expressed in 121 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP13637 baseline and differential
GenevisibleiP13637 HS

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT1A3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13637
Secondary accession number(s): B7Z2T0
, B7Z401, F5H6J6, Q16732, Q16735, Q969K5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 216 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again