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Protein

Carbonic anhydrase 1

Gene

Ca1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Activity regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorPROSITE-ProRule annotation1
Metal bindingi95Zinc 1; catalyticBy similarity1
Metal bindingi95Zinc; catalyticBy similarity1
Metal bindingi97Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc; catalyticBy similarity1
Metal bindingi120Zinc 1; catalyticBy similarity1
Metal bindingi120Zinc; catalyticBy similarity1
Active sitei129By similarity1
Binding sitei200SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-MMU-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 1 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase I
Carbonic anhydrase I
Short name:
CA-I
Gene namesi
Name:Ca1
Synonyms:Car1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88268 Car1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000774132 – 261Carbonic anhydrase 1Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP13634
PeptideAtlasiP13634
PRIDEiP13634

PTM databases

iPTMnetiP13634
PhosphoSitePlusiP13634

Expressioni

Gene expression databases

BgeeiENSMUSG00000027556 Expressed in 57 organ(s), highest expression level in colon
CleanExiMM_CAR1
ExpressionAtlasiP13634 baseline and differential
GenevisibleiP13634 MM

Interactioni

Protein-protein interaction databases

BioGridi198481, 3 interactors
IntActiP13634, 1 interactor
MINTiP13634
STRINGi10090.ENSMUSP00000091925

Structurei

3D structure databases

ProteinModelPortaliP13634
SMRiP13634
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 261Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 201Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP13634
KOiK01672
OMAiDYGSEHT
OrthoDBiEOG091G0XFM
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13634-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASADWGYGS ENGPDQWSKL YPIANGNNQS PIDIKTSEAN HDSSLKPLSI
60 70 80 90 100
SYNPATAKEI VNVGHSFHVI FDDSSNQSVL KGGPLADSYR LTQFHFHWGN
110 120 130 140 150
SNDHGSEHTV DGTRYSGELH LVHWNSAKYS SASEAISKAD GLAILGVLMK
160 170 180 190 200
VGPANPSLQK VLDALNSVKT KGKRAPFTNF DPSSLLPSSL DYWTYFGSLT
210 220 230 240 250
HPPLHESVTW VICKDSISLS PEQLAQLRGL LSSAEGEPAV PVLSNHRPPQ
260
PLKGRTVRAS F
Length:261
Mass (Da):28,331
Last modified:October 3, 2012 - v4
Checksum:iD179AA7BA38EDF0E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YYQ4D3YYQ4_MOUSE
Carbonic anhydrase 1
Car1
92Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238P → S in AAA37354 (PubMed:3104601).Curated1
Sequence conflicti238P → S in AAA50291 (PubMed:3104601).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32452 mRNA Translation: AAA37354.1
L36655
, M28197, L36650, L36651, L36652, L36653, L36654 Genomic DNA Translation: AAA50291.1
AK003066 mRNA Translation: BAB22544.1
AK146372 mRNA Translation: BAE27121.1
AK162331 mRNA Translation: BAE36857.1
AK167969 mRNA Translation: BAE39964.1
AK172076 mRNA Translation: BAE42813.1
AC167976 Genomic DNA No translation available.
CH466577 Genomic DNA Translation: EDL05133.1
BC110681 mRNA Translation: AAI10682.1
BC132432 mRNA Translation: AAI32433.1
BC132434 mRNA Translation: AAI32435.1
BC011223 mRNA Translation: AAH11223.1
CCDSiCCDS17248.1
PIRiA26344
RefSeqiNP_001077426.1, NM_001083957.1
NP_033929.2, NM_009799.4
XP_011246439.1, XM_011248137.1
UniGeneiMm.273195

Genome annotation databases

EnsembliENSMUST00000094365; ENSMUSP00000091925; ENSMUSG00000027556
ENSMUST00000181860; ENSMUSP00000137926; ENSMUSG00000027556
GeneIDi12346
KEGGimmu:12346
UCSCiuc008oqp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32452 mRNA Translation: AAA37354.1
L36655
, M28197, L36650, L36651, L36652, L36653, L36654 Genomic DNA Translation: AAA50291.1
AK003066 mRNA Translation: BAB22544.1
AK146372 mRNA Translation: BAE27121.1
AK162331 mRNA Translation: BAE36857.1
AK167969 mRNA Translation: BAE39964.1
AK172076 mRNA Translation: BAE42813.1
AC167976 Genomic DNA No translation available.
CH466577 Genomic DNA Translation: EDL05133.1
BC110681 mRNA Translation: AAI10682.1
BC132432 mRNA Translation: AAI32433.1
BC132434 mRNA Translation: AAI32435.1
BC011223 mRNA Translation: AAH11223.1
CCDSiCCDS17248.1
PIRiA26344
RefSeqiNP_001077426.1, NM_001083957.1
NP_033929.2, NM_009799.4
XP_011246439.1, XM_011248137.1
UniGeneiMm.273195

3D structure databases

ProteinModelPortaliP13634
SMRiP13634
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198481, 3 interactors
IntActiP13634, 1 interactor
MINTiP13634
STRINGi10090.ENSMUSP00000091925

PTM databases

iPTMnetiP13634
PhosphoSitePlusiP13634

Proteomic databases

PaxDbiP13634
PeptideAtlasiP13634
PRIDEiP13634

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094365; ENSMUSP00000091925; ENSMUSG00000027556
ENSMUST00000181860; ENSMUSP00000137926; ENSMUSG00000027556
GeneIDi12346
KEGGimmu:12346
UCSCiuc008oqp.1 mouse

Organism-specific databases

CTDi12346
MGIiMGI:88268 Car1

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP13634
KOiK01672
OMAiDYGSEHT
OrthoDBiEOG091G0XFM
TreeFamiTF316425

Enzyme and pathway databases

ReactomeiR-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-MMU-1475029 Reversible hydration of carbon dioxide

Miscellaneous databases

PROiPR:P13634
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027556 Expressed in 57 organ(s), highest expression level in colon
CleanExiMM_CAR1
ExpressionAtlasiP13634 baseline and differential
GenevisibleiP13634 MM

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAH1_MOUSE
AccessioniPrimary (citable) accession number: P13634
Secondary accession number(s): Q3TS19, Q9DC84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 156 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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