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Protein

Retinoic acid receptor gamma

Gene

RARG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi90 – 155Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri90 – 110NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri126 – 150NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SignaLinkiP13631
SIGNORiP13631

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor gamma
Short name:
RAR-gamma
Alternative name(s):
Nuclear receptor subfamily 1 group B member 3
Gene namesi
Name:RARG
Synonyms:NR1B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000172819.16
HGNCiHGNC:9866 RARG
MIMi180190 gene
neXtProtiNX_P13631

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5916
OpenTargetsiENSG00000172819
PharmGKBiPA34227

Chemistry databases

ChEMBLiCHEMBL2003
DrugBankiDB00459 Acitretin
DB00210 Adapalene
DB00523 Alitretinoin
DB03466 BMS184394
DB02741 CD564
DB03279 Dodecyl-Alpha-D-Maltoside
DB00926 Etretinate
DB05785 LGD-1550
DB05467 R667
DB02258 SR11254
DB00799 Tazarotene
DB00755 Tretinoin
GuidetoPHARMACOLOGYi592

Polymorphism and mutation databases

BioMutaiRARG
DMDMi133498

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534721 – 454Retinoic acid receptor gammaAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Omega-N-methylarginineBy similarity1
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiP13631
MaxQBiP13631
PaxDbiP13631
PeptideAtlasiP13631
PRIDEiP13631
ProteomicsDBi52944
52945 [P13631-2]

PTM databases

iPTMnetiP13631
PhosphoSitePlusiP13631

Expressioni

Gene expression databases

BgeeiENSG00000172819 Expressed in 155 organ(s), highest expression level in esophagus mucosa
CleanExiHS_RARG
ExpressionAtlasiP13631 baseline and differential
GenevisibleiP13631 HS

Organism-specific databases

HPAiHPA053883

Interactioni

Subunit structurei

Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111851, 37 interactors
IntActiP13631, 21 interactors
MINTiP13631
STRINGi9606.ENSP00000377947

Chemistry databases

BindingDBiP13631

Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13631
SMRiP13631
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13631

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 419NR LBDPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 89ModulatingAdd BLAST89
Regioni156 – 184HingeAdd BLAST29

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri90 – 110NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri126 – 150NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOVERGENiHBG005606
InParanoidiP13631
KOiK08529
OMAiNKERLFV
OrthoDBiEOG091G0XCQ
PhylomeDBiP13631
TreeFamiTF328382

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms differ only in their N-terminal regions.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG
60 70 80 90 100
QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY
110 120 130 140 150
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC
160 170 180 190 200
FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY ELSPQLEELI TKVSKAHQET
210 220 230 240 250
FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG
260 270 280 290 300
FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH
310 320 330 340 350
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV
360 370 380 390 400
DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL
410 420 430 440 450
KMEIPGPMPP LIREMLENPE MFEDDSSQPG PHPNASSEDE VPGGQGKGGL

KSPA
Length:454
Mass (Da):50,342
Last modified:January 1, 1990 - v1
Checksum:i1EE27B22772D4AFD
GO
Isoform 2 (identifier: P13631-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MATNKERLFA...PDLPKEMASL → MYDCMETFAP...FAWPQPASLQ

Show »
Length:443
Mass (Da):49,308
Checksum:i4D709194F5111E86
GO
Isoform 3 (identifier: P13631-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):42,926
Checksum:i37AF909319A4B140
GO
Isoform 4 (identifier: P13631-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: MATNKERLFA...YGVSSCEGCK → MLALPLPPCW...LPGRNPPACN

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):47,931
Checksum:iAA332A06D720ADB8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMK1H3BMK1_HUMAN
Retinoic acid receptor gamma
RARG
57Annotation score:
H3BMY6H3BMY6_HUMAN
Retinoic acid receptor gamma
RARG
32Annotation score:
H3BMH6H3BMH6_HUMAN
Retinoic acid receptor gamma
RARG
15Annotation score:

Sequence cautioni

The sequence CAA40548 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118I → T in CAB60726 (Ref. 10) Curated1
Sequence conflicti172K → R in AAG41594 (Ref. 11) Curated1
Sequence conflicti252T → A in CAB60726 (Ref. 10) Curated1
Sequence conflicti342M → V in BAH12478 (PubMed:14702039).Curated1
Sequence conflicti421M → L in CAB60726 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038554427S → L. Corresponds to variant dbSNP:rs2229774Ensembl.1
Natural variantiVAR_036061430G → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0447761 – 111MATNK…CEGCK → MLALPLPPCWSGAPPGEEGE SAAGPWCFQHPVSLQAGSRC TTVWKRLPRVRDGCTGRPGP GPACCAEPPAAPVSPDLNLL PGRNPPACN in isoform 4. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0447771 – 72Missing in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0310801 – 61MATNK…EMASL → MYDCMETFAPGPRRLYGAAG PGAGLLRRATGGSCFAGLES FAWPQPASLQ in isoform 2. 2 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24857 mRNA Translation: AAA52692.1
M57707 mRNA Translation: AAA63254.1
M38258 mRNA Translation: AAA60254.1
AK297023 mRNA Translation: BAH12478.1
AK297277 mRNA Translation: BAH12537.1
AK316259 mRNA Translation: BAH14630.1
AC021072 Genomic DNA No translation available.
AC073573 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96676.1
BC093727 mRNA Translation: AAH93727.1
BC093729 mRNA Translation: AAH93729.1
M32074 mRNA Translation: AAA60253.1
X57280 Genomic DNA Translation: CAA40548.1 Sequence problems.
AJ250835 Genomic DNA Translation: CAB60726.1
AY013703 Genomic DNA Translation: AAG41594.2
AY013704 Genomic DNA Translation: AAG41595.1
CCDSiCCDS41790.1 [P13631-2]
CCDS58236.1 [P13631-3]
CCDS58237.1 [P13631-4]
CCDS8850.1 [P13631-1]
PIRiA33903
C35991
RefSeqiNP_000957.1, NM_000966.5 [P13631-1]
NP_001036193.1, NM_001042728.2 [P13631-2]
NP_001230659.1, NM_001243730.1 [P13631-3]
NP_001230661.1, NM_001243732.1 [P13631-4]
UniGeneiHs.1497
Hs.733399

Genome annotation databases

EnsembliENST00000338561; ENSP00000343698; ENSG00000172819 [P13631-2]
ENST00000394426; ENSP00000377947; ENSG00000172819 [P13631-3]
ENST00000425354; ENSP00000388510; ENSG00000172819 [P13631-1]
ENST00000543726; ENSP00000444335; ENSG00000172819 [P13631-4]
GeneIDi5916
KEGGihsa:5916
UCSCiuc001scd.4 human [P13631-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Retinoic acid receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24857 mRNA Translation: AAA52692.1
M57707 mRNA Translation: AAA63254.1
M38258 mRNA Translation: AAA60254.1
AK297023 mRNA Translation: BAH12478.1
AK297277 mRNA Translation: BAH12537.1
AK316259 mRNA Translation: BAH14630.1
AC021072 Genomic DNA No translation available.
AC073573 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96676.1
BC093727 mRNA Translation: AAH93727.1
BC093729 mRNA Translation: AAH93729.1
M32074 mRNA Translation: AAA60253.1
X57280 Genomic DNA Translation: CAA40548.1 Sequence problems.
AJ250835 Genomic DNA Translation: CAB60726.1
AY013703 Genomic DNA Translation: AAG41594.2
AY013704 Genomic DNA Translation: AAG41595.1
CCDSiCCDS41790.1 [P13631-2]
CCDS58236.1 [P13631-3]
CCDS58237.1 [P13631-4]
CCDS8850.1 [P13631-1]
PIRiA33903
C35991
RefSeqiNP_000957.1, NM_000966.5 [P13631-1]
NP_001036193.1, NM_001042728.2 [P13631-2]
NP_001230659.1, NM_001243730.1 [P13631-3]
NP_001230661.1, NM_001243732.1 [P13631-4]
UniGeneiHs.1497
Hs.733399

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EXAX-ray1.59A178-423[»]
1EXXX-ray1.67A178-423[»]
1FCXX-ray1.47A183-417[»]
1FCYX-ray1.30A183-417[»]
1FCZX-ray1.38A183-417[»]
1FD0X-ray1.38A183-417[»]
2LBDX-ray2.06A178-423[»]
3LBDX-ray2.40A178-423[»]
4LBDX-ray2.50A178-423[»]
5M24X-ray1.69A178-423[»]
6FX0X-ray1.90A1-454[»]
ProteinModelPortaliP13631
SMRiP13631
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111851, 37 interactors
IntActiP13631, 21 interactors
MINTiP13631
STRINGi9606.ENSP00000377947

Chemistry databases

BindingDBiP13631
ChEMBLiCHEMBL2003
DrugBankiDB00459 Acitretin
DB00210 Adapalene
DB00523 Alitretinoin
DB03466 BMS184394
DB02741 CD564
DB03279 Dodecyl-Alpha-D-Maltoside
DB00926 Etretinate
DB05785 LGD-1550
DB05467 R667
DB02258 SR11254
DB00799 Tazarotene
DB00755 Tretinoin
GuidetoPHARMACOLOGYi592

PTM databases

iPTMnetiP13631
PhosphoSitePlusiP13631

Polymorphism and mutation databases

BioMutaiRARG
DMDMi133498

Proteomic databases

EPDiP13631
MaxQBiP13631
PaxDbiP13631
PeptideAtlasiP13631
PRIDEiP13631
ProteomicsDBi52944
52945 [P13631-2]

Protocols and materials databases

DNASUi5916
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338561; ENSP00000343698; ENSG00000172819 [P13631-2]
ENST00000394426; ENSP00000377947; ENSG00000172819 [P13631-3]
ENST00000425354; ENSP00000388510; ENSG00000172819 [P13631-1]
ENST00000543726; ENSP00000444335; ENSG00000172819 [P13631-4]
GeneIDi5916
KEGGihsa:5916
UCSCiuc001scd.4 human [P13631-1]

Organism-specific databases

CTDi5916
DisGeNETi5916
EuPathDBiHostDB:ENSG00000172819.16
GeneCardsiRARG
H-InvDBiHIX0129677
HGNCiHGNC:9866 RARG
HPAiHPA053883
MIMi180190 gene
neXtProtiNX_P13631
OpenTargetsiENSG00000172819
PharmGKBiPA34227
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOVERGENiHBG005606
InParanoidiP13631
KOiK08529
OMAiNKERLFV
OrthoDBiEOG091G0XCQ
PhylomeDBiP13631
TreeFamiTF328382

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SignaLinkiP13631
SIGNORiP13631

Miscellaneous databases

ChiTaRSiRARG human
EvolutionaryTraceiP13631
GeneWikiiRetinoic_acid_receptor_gamma
GenomeRNAii5916
PROiPR:P13631
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172819 Expressed in 155 organ(s), highest expression level in esophagus mucosa
CleanExiHS_RARG
ExpressionAtlasiP13631 baseline and differential
GenevisibleiP13631 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRARG_HUMAN
AccessioniPrimary (citable) accession number: P13631
Secondary accession number(s): B7Z492
, B7Z4F1, B7ZAE4, J3KNP6, P22932, Q15281, Q52LZ8, Q9BYX8, Q9H1I3, Q9UJ38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 10, 2018
This is version 218 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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