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UniProtKB - P13611 (CSPG2_HUMAN)

Protein

Versican core protein

Gene

VCAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP13611

Names & Taxonomyi

Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Glial hyaluronate-binding protein
Short name:
GHAP
Large fibroblast proteoglycan
PG-M
Gene namesi
Name:VCAN
Synonyms:CSPG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000038427.15
HGNCiHGNC:2464 VCAN
MIMi118661 gene
neXtProtiNX_P13611

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Wagner vitreoretinopathy (WGVRP)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitave imbalance of the normally occurring splice variants (PubMed:22739342).1 Publication
Disease descriptionA rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia.
See also OMIM:143200

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNETi1462
GeneReviewsiVCAN
MalaCardsiVCAN
MIMi143200 phenotype
OpenTargetsiENSG00000038427
Orphaneti898 Wagner disease
PharmGKBiPA162408788

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaiVCAN
DMDMi2506816

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001752221 – 3396Versican core proteinAdd BLAST3376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 130By similarity
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 243By similarity
Disulfide bondi196 ↔ 217By similarity
Disulfide bondi270 ↔ 345By similarity
Disulfide bondi294 ↔ 315By similarity
Glycosylationi330N-linked (GlcNAc...) asparagine1
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi809N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1663N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1898N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2116Phosphoserine; by FAM20CCombined sources1 Publication1
Glycosylationi2179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2385N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2496N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2608PhosphoserineBy similarity1
Modified residuei2617PhosphothreonineCombined sources1
Glycosylationi2628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2934N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3067N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3093 ↔ 3104By similarity
Disulfide bondi3098 ↔ 3113By similarity
Disulfide bondi3115 ↔ 3124By similarity
Disulfide bondi3131 ↔ 3142By similarity
Disulfide bondi3136 ↔ 3151By similarity
Disulfide bondi3153 ↔ 3162By similarity
Disulfide bondi3169 ↔ 3180By similarity
Disulfide bondi3197 ↔ 3289By similarity
Disulfide bondi3265 ↔ 3281By similarity
Disulfide bondi3296 ↔ 3339By similarity
Disulfide bondi3325 ↔ 3352By similarity
Glycosylationi3369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3379N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

EPDiP13611
MaxQBiP13611
PaxDbiP13611
PeptideAtlasiP13611
PRIDEiP13611
ProteomicsDBi52938
52939 [P13611-2]
52940 [P13611-3]
52941 [P13611-4]
52942 [P13611-5]

PTM databases

CarbonylDBiP13611
iPTMnetiP13611
PhosphoSitePlusiP13611
SwissPalmiP13611

Miscellaneous databases

PMAP-CutDBiP13611

Expressioni

Tissue specificityi

Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

Developmental stagei

Disappears after the cartilage development.

Gene expression databases

BgeeiENSG00000038427 Expressed in 242 organ(s), highest expression level in endometrium
CleanExiHS_VCAN
ExpressionAtlasiP13611 baseline and differential
GenevisibleiP13611 HS

Organism-specific databases

HPAiCAB008979
HPA004726

Interactioni

Subunit structurei

Interacts with FBLN1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MMP9P147803EBI-8515977,EBI-1382326

Protein-protein interaction databases

BioGridi107844, 19 interactors
IntActiP13611, 6 interactors
MINTiP13611
STRINGi9606.ENSP00000265077

Structurei

3D structure databases

ProteinModelPortaliP13611
SMRiP13611
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 146Ig-like V-typeAdd BLAST126
Domaini150 – 245Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini251 – 347Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini3089 – 3125EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini3127 – 3163EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3176 – 3290C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini3294 – 3354SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 1335GAG-alpha (glucosaminoglycan attachment domain)Add BLAST988
Regioni1336 – 3089GAG-betaAdd BLAST1754

Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IFXS Eukaryota
ENOG410ZPDG LUCA
GeneTreeiENSGT00760000119025
HOVERGENiHBG051140
InParanoidiP13611
KOiK06793
OMAiREYFTTS
OrthoDBiEOG091G0CY8
PhylomeDBiP13611
TreeFamiTF332134

Family and domain databases

CDDicd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 2 hits
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00409 IG, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform V0 (identifier: P13611-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP 
        60         70         80         90        100
TLPPSYNTSE FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR 
       110        120        130        140        150
VSVPTHPEAV GDASLTVVKL LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV 
       160        170        180        190        200
VFHYRAATSR YTLNFEAAQK ACLDVGAVIA TPEQLFAAYE DGFEQCDAGW 
       210        220        230        240        250
LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD VYCYVDHLDG 
       260        270        280        290        300
DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 
       310        320        330        340        350
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE 
       360        370        380        390        400
ATTIDLSILA ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN 
       410        420        430        440        450
IVSFEQKATV QPQAITDSLA TKLPTPTGST KKPWDMDDYS PSASGPLGKL 
       460        470        480        490        500
DISEIKEEVL QSTTGVSHYA TDSWDGVVED KQTQESVTQI EQIEVGPLVT 
       510        520        530        540        550
SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS ELVTTGHYGF 
       560        570        580        590        600
TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV 
       610        620        630        640        650
SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR 
       660        670        680        690        700
TEIELFPYSG DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT 
       710        720        730        740        750
DEIQEEITKS PFMGKTEEEV FSGMKLSTSL SEPIHVTESS VEMTKSFDFP 
       760        770        780        790        800
TLITKLSAEP TEVRDMEEDF TATPGTTKYD ENITTVLLAH GTLSVEAATV 
       810        820        830        840        850
SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD KDIPSFTEDG 
       860        870        880        890        900
ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS 
       910        920        930        940        950
TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE 
       960        970        980        990       1000
GLAFVSYSST QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP 
      1010       1020       1030       1040       1050
SQDILVIDQT RLEATISPET MRTTKITEGT TQEEFPWKEQ TAEKPVPALS 
      1060       1070       1080       1090       1100
STAWTPKEAV TPLDEQEGDG SAYTVSEDEL LTGSERVPVL ETTPVGKIDH 
      1110       1120       1130       1140       1150
SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY ETEGSSTTGF 
      1160       1170       1180       1190       1200
TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK 
      1210       1220       1230       1240       1250
VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI 
      1260       1270       1280       1290       1300
IGESTSHVPP TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE 
      1310       1320       1330       1340       1350
AFGPQALSTP QPPASTKFHP DINVYIIEVR ENKTGRMSDL SVIGHPIDSE 
      1360       1370       1380       1390       1400
SKEDEPCSEE TDPVHDLMAE ILPEFPDIIE IDLYHSEENE EEEEECANAT 
      1410       1420       1430       1440       1450
DVTTTPSVQY INGKHLVTTV PKDPEAAEAR RGQFESVAPS QNFSDSSESD 
      1460       1470       1480       1490       1500
THPFVIAKTE LSTAVQPNES TETTESLEVT WKPETYPETS EHFSGGEPDV 
      1510       1520       1530       1540       1550
FPTVPFHEEF ESGTAKKGAE SVTERDTEVG HQAHEHTEPV SLFPEESSGE 
      1560       1570       1580       1590       1600
IAIDQESQKI AFARATEVTF GEEVEKSTSV TYTPTIVPSS ASAYVSEEEA 
      1610       1620       1630       1640       1650
VTLIGNPWPD DLLSTKESWV EATPRQVVEL SGSSSIPITE GSGEAEEDED 
      1660       1670       1680       1690       1700
TMFTMVTDLS QRNTTDTLIT LDTSRIITES FFEVPATTIY PVSEQPSAKV 
      1710       1720       1730       1740       1750
VPTKFVSETD TSEWISSTTV EEKKRKEEEG TTGTASTFEV YSSTQRSDQL 
      1760       1770       1780       1790       1800
ILPFELESPN VATSSDSGTR KSFMSLTTPT QSEREMTDST PVFTETNTLE 
      1810       1820       1830       1840       1850
NLGAQTTEHS SIHQPGVQEG LTTLPRSPAS VFMEQGSGEA AADPETTTVS 
      1860       1870       1880       1890       1900
SFSLNVEYAI QAEKEVAGTL SPHVETTFST EPTGLVLSTV MDRVVAENIT 
      1910       1920       1930       1940       1950
QTSREIVISE RLGEPNYGAE IRGFSTGFPL EEDFSGDFRE YSTVSHPIAK 
      1960       1970       1980       1990       2000
EETVMMEGSG DAAFRDTQTS PSTVPTSVHI SHISDSEGPS STMVSTSAFP 
      2010       2020       2030       2040       2050
WEEFTSSAEG SGEQLVTVSS SVVPVLPSAV QKFSGTASSI IDEGLGEVGT 
      2060       2070       2080       2090       2100
VNEIDRRSTI LPTAEVEGTK APVEKEEVKV SGTVSTNFPQ TIEPAKLWSR 
      2110       2120       2130       2140       2150
QEVNPVRQEI ESETTSEEQI QEEKSFESPQ NSPATEQTIF DSQTFTETEL 
      2160       2170       2180       2190       2200
KTTDYSVLTT KKTYSDDKEM KEEDTSLVNM STPDPDANGL ESYTTLPEAT 
      2210       2220       2230       2240       2250
EKSHFFLATA LVTESIPAEH VVTDSPIKKE ESTKHFPKGM RPTIQESDTE 
      2260       2270       2280       2290       2300
LLFSGLGSGE EVLPTLPTES VNFTEVEQIN NTLYPHTSQV ESTSSDKIED 
      2310       2320       2330       2340       2350
FNRMENVAKE VGPLVSQTDI FEGSGSVTST TLIEILSDTG AEGPTVAPLP 
      2360       2370       2380       2390       2400
FSTDIGHPQN QTVRWAEEIQ TSRPQTITEQ DSNKNSSTAE INETTTSSTD 
      2410       2420       2430       2440       2450
FLARAYGFEM AKEFVTSAPK PSDLYYEPSG EGSGEVDIVD SFHTSATTQA 
      2460       2470       2480       2490       2500
TRQESSTTFV SDGSLEKHPE VPSAKAVTAD GFPTVSVMLP LHSEQNKSSP 
      2510       2520       2530       2540       2550
DPTSTLSNTV SYERSTDGSF QDRFREFEDS TLKPNRKKPT ENIIIDLDKE 
      2560       2570       2580       2590       2600
DKDLILTITE STILEILPEL TSDKNTIIDI DHTKPVYEDI LGMQTDIDTE 
      2610       2620       2630       2640       2650
VPSEPHDSND ESNDDSTQVQ EIYEAAVNLS LTEETFEGSA DVLASYTQAT 
      2660       2670       2680       2690       2700
HDESMTYEDR SQLDHMGFHF TTGIPAPSTE TELDVLLPTA TSLPIPRKSA 
      2710       2720       2730       2740       2750
TVIPEIEGIK AEAKALDDMF ESSTLSDGQA IADQSEIIPT LGQFERTQEE 
      2760       2770       2780       2790       2800
YEDKKHAGPS FQPEFSSGAE EALVDHTPYL SIATTHLMDQ SVTEVPDVME 
      2810       2820       2830       2840       2850
GSNPPYYTDT TLAVSTFAKL SSQTPSSPLT IYSGSEASGH TEIPQPSALP 
      2860       2870       2880       2890       2900
GIDVGSSVMS PQDSFKEIHV NIEATFKPSS EEYLHITEPP SLSPDTKLEP 
      2910       2920       2930       2940       2950
SEDDGKPELL EEMEASPTEL IAVEGTEILQ DFQNKTDGQV SGEAIKMFPT 
      2960       2970       2980       2990       3000
IKTPEAGTVI TTADEIELEG ATQWPHSTSA SATYGVEAGV VPWLSPQTSE 
      3010       3020       3030       3040       3050
RPTLSSSPEI NPETQAALIR GQDSTIAASE QQVAARILDS NDQATVNPVE 
      3060       3070       3080       3090       3100
FNTEVATPPF SLLETSNETD FLIGINEESV EGTAIYLPGP DRCKMNPCLN 
      3110       3120       3130       3140       3150
GGTCYPTETS YVCTCVPGYS GDQCELDFDE CHSNPCRNGA TCVDGFNTFR 
      3160       3170       3180       3190       3200
CLCLPSYVGA LCEQDTETCD YGWHKFQGQC YKYFAHRRTW DAAERECRLQ 
      3210       3220       3230       3240       3250
GAHLTSILSH EEQMFVNRVG HDYQWIGLND KMFEHDFRWT DGSTLQYENW 
      3260       3270       3280       3290       3300
RPNQPDSFFS AGEDCVVIIW HENGQWNDVP CNYHLTYTCK KGTVACGQPP 
      3310       3320       3330       3340       3350
VVENAKTFGK MKPRYEINSL IRYHCKDGFI QRHLPTIRCL GNGRWAIPKI 
      3360       3370       3380       3390 
TCMNPSAYQR TYSMKYFKNS SSAKDNSINT SKHDHRWSRR WQESRR
Length:3,396
Mass (Da):372,820
Last modified:November 1, 1997 - v3
Checksum:iD174A1BBB8304FEC
GO
Isoform V1 (identifier: P13611-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-1335: Missing.

Show »
Length:2,409
Mass (Da):265,050
Checksum:i4D290F9BF5A3F704
GO
Isoform V2 (identifier: P13611-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1336-3089: Missing.

Show »
Length:1,642
Mass (Da):182,062
Checksum:i25C238F0C5E94DBE
GO
Isoform V3 (identifier: P13611-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-3089: Missing.

Show »
Length:655
Mass (Da):74,293
Checksum:i4933DFA2E0D7A0AD
GO
Isoform Vint (identifier: P13611-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3355-3396: PSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR → RKWSFRKNGLPCYNNY

Show »
Length:3,370
Mass (Da):369,688
Checksum:iE76563A26BDA34C6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86W61Q86W61_HUMAN
VCAN protein
VCAN
354Annotation score:
D6RGZ6D6RGZ6_HUMAN
Versican core protein
VCAN
1,240Annotation score:
E9PF17E9PF17_HUMAN
Versican core protein
VCAN
1,594Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88N → D AA sequence (PubMed:2466833).Curated1
Sequence conflicti260K → I AA sequence (PubMed:2466833).Curated1
Sequence conflicti274D → A in BAA06801 (PubMed:7876137).Curated1
Sequence conflicti284Q → G AA sequence (PubMed:2466833).Curated1
Sequence conflicti2709 – 2713IKAEA → EFREV in AAA36437 (PubMed:2820964).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021958300S → L. Corresponds to variant dbSNP:rs2652098EnsemblClinVar.1
Natural variantiVAR_020214428G → D. Corresponds to variant dbSNP:rs2287926EnsemblClinVar.1
Natural variantiVAR_0219591516K → R. Corresponds to variant dbSNP:rs309559EnsemblClinVar.1
Natural variantiVAR_0316321826R → H. Corresponds to variant dbSNP:rs188703EnsemblClinVar.1
Natural variantiVAR_0202152301F → Y. Corresponds to variant dbSNP:rs160278EnsemblClinVar.1
Natural variantiVAR_0202162315V → L. Corresponds to variant dbSNP:rs3734094EnsemblClinVar.1
Natural variantiVAR_0219602937D → Y. Corresponds to variant dbSNP:rs160277EnsemblClinVar.1
Natural variantiVAR_0316333011N → K. Corresponds to variant dbSNP:rs16900532EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003082348P → R in isoform V1 and isoform V3. 3 Publications1
Alternative sequenceiVSP_003085349 – 3089Missing in isoform V3. 1 PublicationAdd BLAST2741
Alternative sequenceiVSP_003083349 – 1335Missing in isoform V1. 2 PublicationsAdd BLAST987
Alternative sequenceiVSP_0030841336 – 3089Missing in isoform V2. 1 PublicationAdd BLAST1754
Alternative sequenceiVSP_0030863355 – 3396PSAYQ…QESRR → RKWSFRKNGLPCYNNY in isoform Vint. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15998 mRNA Translation: CAA34128.1
U16306 mRNA Translation: AAA65018.1
U26555 mRNA Translation: AAA67565.1
D32039 mRNA Translation: BAA06801.1
S52488 Genomic DNA Translation: AAB24878.1
J02814 mRNA Translation: AAA36437.1
AF084545 mRNA Translation: AAD48545.1
CCDSiCCDS4060.1 [P13611-1]
CCDS47242.1 [P13611-4]
CCDS54875.1 [P13611-3]
CCDS54876.1 [P13611-2]
PIRiS06014 A60979
RefSeqiNP_001119808.1, NM_001126336.2 [P13611-4]
NP_001157569.1, NM_001164097.1 [P13611-2]
NP_001157570.1, NM_001164098.1 [P13611-3]
NP_004376.2, NM_004385.4 [P13611-1]
UniGeneiHs.643801

Genome annotation databases

EnsembliENST00000265077; ENSP00000265077; ENSG00000038427 [P13611-1]
ENST00000342785; ENSP00000342768; ENSG00000038427 [P13611-3]
ENST00000343200; ENSP00000340062; ENSG00000038427 [P13611-2]
ENST00000502527; ENSP00000421362; ENSG00000038427 [P13611-4]
GeneIDi1462
KEGGihsa:1462
UCSCiuc003kii.4 human [P13611-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Versican

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15998 mRNA Translation: CAA34128.1
U16306 mRNA Translation: AAA65018.1
U26555 mRNA Translation: AAA67565.1
D32039 mRNA Translation: BAA06801.1
S52488 Genomic DNA Translation: AAB24878.1
J02814 mRNA Translation: AAA36437.1
AF084545 mRNA Translation: AAD48545.1
CCDSiCCDS4060.1 [P13611-1]
CCDS47242.1 [P13611-4]
CCDS54875.1 [P13611-3]
CCDS54876.1 [P13611-2]
PIRiS06014 A60979
RefSeqiNP_001119808.1, NM_001126336.2 [P13611-4]
NP_001157569.1, NM_001164097.1 [P13611-2]
NP_001157570.1, NM_001164098.1 [P13611-3]
NP_004376.2, NM_004385.4 [P13611-1]
UniGeneiHs.643801

3D structure databases

ProteinModelPortaliP13611
SMRiP13611
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107844, 19 interactors
IntActiP13611, 6 interactors
MINTiP13611
STRINGi9606.ENSP00000265077

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

PTM databases

CarbonylDBiP13611
iPTMnetiP13611
PhosphoSitePlusiP13611
SwissPalmiP13611

Polymorphism and mutation databases

BioMutaiVCAN
DMDMi2506816

Proteomic databases

EPDiP13611
MaxQBiP13611
PaxDbiP13611
PeptideAtlasiP13611
PRIDEiP13611
ProteomicsDBi52938
52939 [P13611-2]
52940 [P13611-3]
52941 [P13611-4]
52942 [P13611-5]

Protocols and materials databases

DNASUi1462
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265077; ENSP00000265077; ENSG00000038427 [P13611-1]
ENST00000342785; ENSP00000342768; ENSG00000038427 [P13611-3]
ENST00000343200; ENSP00000340062; ENSG00000038427 [P13611-2]
ENST00000502527; ENSP00000421362; ENSG00000038427 [P13611-4]
GeneIDi1462
KEGGihsa:1462
UCSCiuc003kii.4 human [P13611-1]

Organism-specific databases

CTDi1462
DisGeNETi1462
EuPathDBiHostDB:ENSG00000038427.15
GeneCardsiVCAN
GeneReviewsiVCAN
HGNCiHGNC:2464 VCAN
HPAiCAB008979
HPA004726
MalaCardsiVCAN
MIMi118661 gene
143200 phenotype
neXtProtiNX_P13611
OpenTargetsiENSG00000038427
Orphaneti898 Wagner disease
PharmGKBiPA162408788
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXS Eukaryota
ENOG410ZPDG LUCA
GeneTreeiENSGT00760000119025
HOVERGENiHBG051140
InParanoidiP13611
KOiK06793
OMAiREYFTTS
OrthoDBiEOG091G0CY8
PhylomeDBiP13611
TreeFamiTF332134

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP13611

Miscellaneous databases

ChiTaRSiVCAN human
GeneWikiiVersican
GenomeRNAii1462
PMAP-CutDBiP13611
PROiPR:P13611
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000038427 Expressed in 242 organ(s), highest expression level in endometrium
CleanExiHS_VCAN
ExpressionAtlasiP13611 baseline and differential
GenevisibleiP13611 HS

Family and domain databases

CDDicd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 2 hits
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00409 IG, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSPG2_HUMAN
AccessioniPrimary (citable) accession number: P13611
Secondary accession number(s): P20754
, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 217 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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