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UniProtKB - P13611 (CSPG2_HUMAN)

Entry version 239 (29 Sep 2021)
Sequence version 3 (01 Nov 1997)
Previous versions | rss
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Protein

Versican core protein

Gene

VCAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13611

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870, Chondroitin sulfate biosynthesis
R-HSA-2022923, Dermatan sulfate biosynthesis
R-HSA-2024101, CS/DS degradation
R-HSA-3000178, ECM proteoglycans
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3595172, Defective CHST3 causes SEDCJD
R-HSA-3595174, Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177, Defective CHSY1 causes TPBS
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-8957275, Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P13611

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Glial hyaluronate-binding protein
Short name:
GHAP
Large fibroblast proteoglycan
PG-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCAN
Synonyms:CSPG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2464, VCAN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118661, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13611

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000038427

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Wagner vitreoretinopathy (WGVRP)2 Publications
The disease is caused by variants affecting the gene represented in this entry. The pathological mechanism involves a quantitative imbalance of the normally occurring splice variants (PubMed:22739342).1 Publication
Disease descriptionA rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia.
Related information in OMIM

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNET

More...DisGeNETi		1462

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		VCAN

MalaCards human disease database

More...MalaCardsi		VCAN
MIMi143200, phenotype

Open Targets

More...OpenTargetsi		ENSG00000038427

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		898, Wagner disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162408788

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13611, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB08818, Hyaluronic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VCAN

Domain mapping of disease mutations (DMDM)

More...DMDMi		2506816

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001752221 – 3396Versican core proteinAdd BLAST3376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 130By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 243By similarity
Disulfide bondi196 ↔ 217By similarity
Disulfide bondi270 ↔ 345By similarity
Disulfide bondi294 ↔ 315By similarity
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi809N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1663N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1898N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2116Phosphoserine; by FAM20CCombined sources1 Publication1
Glycosylationi2179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2385N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2496N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2608PhosphoserineBy similarity1
Modified residuei2617PhosphothreonineCombined sources1
Glycosylationi2628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2934N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3067N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3093 ↔ 3104By similarity
Disulfide bondi3098 ↔ 3113By similarity
Disulfide bondi3115 ↔ 3124By similarity
Disulfide bondi3131 ↔ 3142By similarity
Disulfide bondi3136 ↔ 3151By similarity
Disulfide bondi3153 ↔ 3162By similarity
Disulfide bondi3169 ↔ 3180By similarity
Disulfide bondi3197 ↔ 3289By similarity
Disulfide bondi3265 ↔ 3281By similarity
Disulfide bondi3296 ↔ 3339By similarity
Disulfide bondi3325 ↔ 3352By similarity
Glycosylationi3369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3379N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.1 Publication
Proteolytically cleaved by ADAMTS5 and ADAMTS15 in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1428 – 1429Cleavage; by ADAMTS15By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P13611

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13611

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13611

MaxQB - The MaxQuant DataBase

More...MaxQBi		P13611

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13611

PeptideAtlas

More...PeptideAtlasi		P13611

PRoteomics IDEntifications database

More...PRIDEi		P13611

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52938 [P13611-1]
52939 [P13611-2]
52940 [P13611-3]
52941 [P13611-4]
52942 [P13611-5]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P13611

GlyConnect protein glycosylation platform

More...GlyConnecti		1890, 14 N-Linked glycans (9 sites), 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13611, 193 sites, 13 N-linked glycans (9 sites), 12 O-linked glycans (167 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13611

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13611

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13611

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina (at protein level) (PubMed:29777959). Cerebral white matter and plasma (PubMed:2469524). Isoform V0: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V1: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V2: Restricted to normal brain and gliomas (PubMed:8627343). Isoform V3: Found in all these tissues except medulloblastomas (PubMed:8627343).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in developing photoreceptors and the interphotoreceptor matrix between 12 and 17 weeks post conception (at protein level) (PubMed:29777959). Disappears in aorta after the cartilage development (PubMed:7921538).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000038427, Expressed in endometrium and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13611, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13611, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000038427, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107844, 24 interactors

Protein interaction database and analysis system

More...IntActi		P13611, 11 interactors

Molecular INTeraction database

More...MINTi		P13611

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265077

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13611, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13611

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 146Ig-like V-typeAdd BLAST126
Domaini150 – 245Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini251 – 347Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini3089 – 3125EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini3127 – 3163EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3176 – 3290C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini3294 – 3354SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 1335GAG-alpha (glucosaminoglycan attachment domain)Add BLAST988
Regioni420 – 439DisorderedSequence analysisAdd BLAST20
Regioni603 – 622DisorderedSequence analysisAdd BLAST20
Regioni807 – 829DisorderedSequence analysisAdd BLAST23
Regioni1126 – 1154DisorderedSequence analysisAdd BLAST29
Regioni1277 – 1316DisorderedSequence analysisAdd BLAST40
Regioni1336 – 3089GAG-betaAdd BLAST1754
Regioni1420 – 1497DisorderedSequence analysisAdd BLAST78
Regioni1510 – 1539DisorderedSequence analysisAdd BLAST30
Regioni1717 – 1737DisorderedSequence analysisAdd BLAST21
Regioni1759 – 1789DisorderedSequence analysisAdd BLAST31
Regioni1962 – 1994DisorderedSequence analysisAdd BLAST33
Regioni2107 – 2134DisorderedSequence analysisAdd BLAST28
Regioni2168 – 2188DisorderedSequence analysisAdd BLAST21
Regioni2371 – 2396DisorderedSequence analysisAdd BLAST26
Regioni2445 – 2473DisorderedSequence analysisAdd BLAST29
Regioni2493 – 2518DisorderedSequence analysisAdd BLAST26
Regioni2598 – 2617DisorderedSequence analysisAdd BLAST20
Regioni2834 – 2856DisorderedSequence analysisAdd BLAST23
Regioni2881 – 2905DisorderedSequence analysisAdd BLAST25
Regioni3371 – 3396DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1138 – 1154Polar residuesSequence analysisAdd BLAST17
Compositional biasi1435 – 1453Polar residuesSequence analysisAdd BLAST19
Compositional biasi1461 – 1480Polar residuesSequence analysisAdd BLAST20
Compositional biasi1717 – 1732Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1963 – 1994Polar residuesSequence analysisAdd BLAST32
Compositional biasi2445 – 2463Polar residuesSequence analysisAdd BLAST19
Compositional biasi2493 – 2517Polar residuesSequence analysisAdd BLAST25
Compositional biasi3378 – 3396Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRBE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156102

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000303_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13611

Identification of Orthologs from Complete Genome Data

More...OMAi		FPFEPTG

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13611

TreeFam database of animal gene trees

More...TreeFami		TF332134

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00445, LINK, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform V0 (identifier: P13611-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP 
        60         70         80         90        100
TLPPSYNTSE FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR 
       110        120        130        140        150
VSVPTHPEAV GDASLTVVKL LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV 
       160        170        180        190        200
VFHYRAATSR YTLNFEAAQK ACLDVGAVIA TPEQLFAAYE DGFEQCDAGW 
       210        220        230        240        250
LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD VYCYVDHLDG 
       260        270        280        290        300
DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 
       310        320        330        340        350
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE 
       360        370        380        390        400
ATTIDLSILA ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN 
       410        420        430        440        450
IVSFEQKATV QPQAITDSLA TKLPTPTGST KKPWDMDDYS PSASGPLGKL 
       460        470        480        490        500
DISEIKEEVL QSTTGVSHYA TDSWDGVVED KQTQESVTQI EQIEVGPLVT 
       510        520        530        540        550
SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS ELVTTGHYGF 
       560        570        580        590        600
TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV 
       610        620        630        640        650
SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR 
       660        670        680        690        700
TEIELFPYSG DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT 
       710        720        730        740        750
DEIQEEITKS PFMGKTEEEV FSGMKLSTSL SEPIHVTESS VEMTKSFDFP 
       760        770        780        790        800
TLITKLSAEP TEVRDMEEDF TATPGTTKYD ENITTVLLAH GTLSVEAATV 
       810        820        830        840        850
SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD KDIPSFTEDG 
       860        870        880        890        900
ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS 
       910        920        930        940        950
TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE 
       960        970        980        990       1000
GLAFVSYSST QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP 
      1010       1020       1030       1040       1050
SQDILVIDQT RLEATISPET MRTTKITEGT TQEEFPWKEQ TAEKPVPALS 
      1060       1070       1080       1090       1100
STAWTPKEAV TPLDEQEGDG SAYTVSEDEL LTGSERVPVL ETTPVGKIDH 
      1110       1120       1130       1140       1150
SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY ETEGSSTTGF 
      1160       1170       1180       1190       1200
TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK 
      1210       1220       1230       1240       1250
VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI 
      1260       1270       1280       1290       1300
IGESTSHVPP TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE 
      1310       1320       1330       1340       1350
AFGPQALSTP QPPASTKFHP DINVYIIEVR ENKTGRMSDL SVIGHPIDSE 
      1360       1370       1380       1390       1400
SKEDEPCSEE TDPVHDLMAE ILPEFPDIIE IDLYHSEENE EEEEECANAT 
      1410       1420       1430       1440       1450
DVTTTPSVQY INGKHLVTTV PKDPEAAEAR RGQFESVAPS QNFSDSSESD 
      1460       1470       1480       1490       1500
THPFVIAKTE LSTAVQPNES TETTESLEVT WKPETYPETS EHFSGGEPDV 
      1510       1520       1530       1540       1550
FPTVPFHEEF ESGTAKKGAE SVTERDTEVG HQAHEHTEPV SLFPEESSGE 
      1560       1570       1580       1590       1600
IAIDQESQKI AFARATEVTF GEEVEKSTSV TYTPTIVPSS ASAYVSEEEA 
      1610       1620       1630       1640       1650
VTLIGNPWPD DLLSTKESWV EATPRQVVEL SGSSSIPITE GSGEAEEDED 
      1660       1670       1680       1690       1700
TMFTMVTDLS QRNTTDTLIT LDTSRIITES FFEVPATTIY PVSEQPSAKV 
      1710       1720       1730       1740       1750
VPTKFVSETD TSEWISSTTV EEKKRKEEEG TTGTASTFEV YSSTQRSDQL 
      1760       1770       1780       1790       1800
ILPFELESPN VATSSDSGTR KSFMSLTTPT QSEREMTDST PVFTETNTLE 
      1810       1820       1830       1840       1850
NLGAQTTEHS SIHQPGVQEG LTTLPRSPAS VFMEQGSGEA AADPETTTVS 
      1860       1870       1880       1890       1900
SFSLNVEYAI QAEKEVAGTL SPHVETTFST EPTGLVLSTV MDRVVAENIT 
      1910       1920       1930       1940       1950
QTSREIVISE RLGEPNYGAE IRGFSTGFPL EEDFSGDFRE YSTVSHPIAK 
      1960       1970       1980       1990       2000
EETVMMEGSG DAAFRDTQTS PSTVPTSVHI SHISDSEGPS STMVSTSAFP 
      2010       2020       2030       2040       2050
WEEFTSSAEG SGEQLVTVSS SVVPVLPSAV QKFSGTASSI IDEGLGEVGT 
      2060       2070       2080       2090       2100
VNEIDRRSTI LPTAEVEGTK APVEKEEVKV SGTVSTNFPQ TIEPAKLWSR 
      2110       2120       2130       2140       2150
QEVNPVRQEI ESETTSEEQI QEEKSFESPQ NSPATEQTIF DSQTFTETEL 
      2160       2170       2180       2190       2200
KTTDYSVLTT KKTYSDDKEM KEEDTSLVNM STPDPDANGL ESYTTLPEAT 
      2210       2220       2230       2240       2250
EKSHFFLATA LVTESIPAEH VVTDSPIKKE ESTKHFPKGM RPTIQESDTE 
      2260       2270       2280       2290       2300
LLFSGLGSGE EVLPTLPTES VNFTEVEQIN NTLYPHTSQV ESTSSDKIED 
      2310       2320       2330       2340       2350
FNRMENVAKE VGPLVSQTDI FEGSGSVTST TLIEILSDTG AEGPTVAPLP 
      2360       2370       2380       2390       2400
FSTDIGHPQN QTVRWAEEIQ TSRPQTITEQ DSNKNSSTAE INETTTSSTD 
      2410       2420       2430       2440       2450
FLARAYGFEM AKEFVTSAPK PSDLYYEPSG EGSGEVDIVD SFHTSATTQA 
      2460       2470       2480       2490       2500
TRQESSTTFV SDGSLEKHPE VPSAKAVTAD GFPTVSVMLP LHSEQNKSSP 
      2510       2520       2530       2540       2550
DPTSTLSNTV SYERSTDGSF QDRFREFEDS TLKPNRKKPT ENIIIDLDKE 
      2560       2570       2580       2590       2600
DKDLILTITE STILEILPEL TSDKNTIIDI DHTKPVYEDI LGMQTDIDTE 
      2610       2620       2630       2640       2650
VPSEPHDSND ESNDDSTQVQ EIYEAAVNLS LTEETFEGSA DVLASYTQAT 
      2660       2670       2680       2690       2700
HDESMTYEDR SQLDHMGFHF TTGIPAPSTE TELDVLLPTA TSLPIPRKSA 
      2710       2720       2730       2740       2750
TVIPEIEGIK AEAKALDDMF ESSTLSDGQA IADQSEIIPT LGQFERTQEE 
      2760       2770       2780       2790       2800
YEDKKHAGPS FQPEFSSGAE EALVDHTPYL SIATTHLMDQ SVTEVPDVME 
      2810       2820       2830       2840       2850
GSNPPYYTDT TLAVSTFAKL SSQTPSSPLT IYSGSEASGH TEIPQPSALP 
      2860       2870       2880       2890       2900
GIDVGSSVMS PQDSFKEIHV NIEATFKPSS EEYLHITEPP SLSPDTKLEP 
      2910       2920       2930       2940       2950
SEDDGKPELL EEMEASPTEL IAVEGTEILQ DFQNKTDGQV SGEAIKMFPT 
      2960       2970       2980       2990       3000
IKTPEAGTVI TTADEIELEG ATQWPHSTSA SATYGVEAGV VPWLSPQTSE 
      3010       3020       3030       3040       3050
RPTLSSSPEI NPETQAALIR GQDSTIAASE QQVAARILDS NDQATVNPVE 
      3060       3070       3080       3090       3100
FNTEVATPPF SLLETSNETD FLIGINEESV EGTAIYLPGP DRCKMNPCLN 
      3110       3120       3130       3140       3150
GGTCYPTETS YVCTCVPGYS GDQCELDFDE CHSNPCRNGA TCVDGFNTFR 
      3160       3170       3180       3190       3200
CLCLPSYVGA LCEQDTETCD YGWHKFQGQC YKYFAHRRTW DAAERECRLQ 
      3210       3220       3230       3240       3250
GAHLTSILSH EEQMFVNRVG HDYQWIGLND KMFEHDFRWT DGSTLQYENW 
      3260       3270       3280       3290       3300
RPNQPDSFFS AGEDCVVIIW HENGQWNDVP CNYHLTYTCK KGTVACGQPP 
      3310       3320       3330       3340       3350
VVENAKTFGK MKPRYEINSL IRYHCKDGFI QRHLPTIRCL GNGRWAIPKI 
      3360       3370       3380       3390 
TCMNPSAYQR TYSMKYFKNS SSAKDNSINT SKHDHRWSRR WQESRR
Length:3,396
Mass (Da):372,820
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD174A1BBB8304FEC
GO
Isoform V1 (identifier: P13611-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-1335: Missing.

Show »
Length:2,409
Mass (Da):265,050
Checksum:i4D290F9BF5A3F704
GO
Isoform V2 (identifier: P13611-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1336-3089: Missing.

Show »
Length:1,642
Mass (Da):182,062
Checksum:i25C238F0C5E94DBE
GO
Isoform V3 (identifier: P13611-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-3089: Missing.

Show »
Length:655
Mass (Da):74,293
Checksum:i4933DFA2E0D7A0AD
GO
Isoform Vint (identifier: P13611-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3355-3396: PSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR → RKWSFRKNGLPCYNNY

Show »
Length:3,370
Mass (Da):369,688
Checksum:iE76563A26BDA34C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PF17E9PF17_HUMAN
Versican core protein
VCAN
1,594Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGZ6D6RGZ6_HUMAN
Versican core protein
VCAN
1,240Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86W61Q86W61_HUMAN
VCAN protein
VCAN
354Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti88N → D AA sequence (PubMed:2466833).Curated1
Sequence conflicti260K → I AA sequence (PubMed:2466833).Curated1
Sequence conflicti274D → A in BAA06801 (PubMed:7876137).Curated1
Sequence conflicti284Q → G AA sequence (PubMed:2466833).Curated1
Sequence conflicti2709 – 2713IKAEA → EFREV in AAA36437 (PubMed:2820964).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021958300S → L. Corresponds to variant dbSNP:rs2652098EnsemblClinVar.1
Natural variantiVAR_020214428G → D. Corresponds to variant dbSNP:rs2287926EnsemblClinVar.1
Natural variantiVAR_0219591516K → R. Corresponds to variant dbSNP:rs309559EnsemblClinVar.1
Natural variantiVAR_0316321826R → H. Corresponds to variant dbSNP:rs188703EnsemblClinVar.1
Natural variantiVAR_0202152301F → Y. Corresponds to variant dbSNP:rs160278EnsemblClinVar.1
Natural variantiVAR_0202162315V → L. Corresponds to variant dbSNP:rs3734094EnsemblClinVar.1
Natural variantiVAR_0219602937D → Y. Corresponds to variant dbSNP:rs160277EnsemblClinVar.1
Natural variantiVAR_0316333011N → K. Corresponds to variant dbSNP:rs16900532EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003082348P → R in isoform V1 and isoform V3. 3 Publications1
Alternative sequenceiVSP_003085349 – 3089Missing in isoform V3. 1 PublicationAdd BLAST2741
Alternative sequenceiVSP_003083349 – 1335Missing in isoform V1. 2 PublicationsAdd BLAST987
Alternative sequenceiVSP_0030841336 – 3089Missing in isoform V2. 1 PublicationAdd BLAST1754
Alternative sequenceiVSP_0030863355 – 3396PSAYQ…QESRR → RKWSFRKNGLPCYNNY in isoform Vint. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X15998 mRNA Translation: CAA34128.1
U16306 mRNA Translation: AAA65018.1
U26555 mRNA Translation: AAA67565.1
D32039 mRNA Translation: BAA06801.1
S52488 Genomic DNA Translation: AAB24878.1
J02814 mRNA Translation: AAA36437.1
AF084545 mRNA Translation: AAD48545.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4060.1 [P13611-1]
CCDS47242.1 [P13611-4]
CCDS54875.1 [P13611-3]
CCDS54876.1 [P13611-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S06014, A60979

NCBI Reference Sequences

More...RefSeqi		NP_001119808.1, NM_001126336.2 [P13611-4]
NP_001157569.1, NM_001164097.1 [P13611-2]
NP_001157570.1, NM_001164098.1 [P13611-3]
NP_004376.2, NM_004385.4 [P13611-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265077; ENSP00000265077; ENSG00000038427 [P13611-1]
ENST00000342785; ENSP00000342768; ENSG00000038427 [P13611-3]
ENST00000343200; ENSP00000340062; ENSG00000038427 [P13611-2]
ENST00000502527; ENSP00000421362; ENSG00000038427 [P13611-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1462

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1462

UCSC genome browser

More...UCSCi		uc003kii.4, human [P13611-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Versican

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15998 mRNA Translation: CAA34128.1
U16306 mRNA Translation: AAA65018.1
U26555 mRNA Translation: AAA67565.1
D32039 mRNA Translation: BAA06801.1
S52488 Genomic DNA Translation: AAB24878.1
J02814 mRNA Translation: AAA36437.1
AF084545 mRNA Translation: AAD48545.1
CCDSiCCDS4060.1 [P13611-1]
CCDS47242.1 [P13611-4]
CCDS54875.1 [P13611-3]
CCDS54876.1 [P13611-2]
PIRiS06014, A60979
RefSeqiNP_001119808.1, NM_001126336.2 [P13611-4]
NP_001157569.1, NM_001164097.1 [P13611-2]
NP_001157570.1, NM_001164098.1 [P13611-3]
NP_004376.2, NM_004385.4 [P13611-1]

3D structure databases

SMRiP13611
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107844, 24 interactors
IntActiP13611, 11 interactors
MINTiP13611
STRINGi9606.ENSP00000265077

Chemistry databases

DrugBankiDB08818, Hyaluronic acid

PTM databases

CarbonylDBiP13611
GlyConnecti1890, 14 N-Linked glycans (9 sites), 1 O-Linked glycan (1 site)
GlyGeniP13611, 193 sites, 13 N-linked glycans (9 sites), 12 O-linked glycans (167 sites)
iPTMnetiP13611
PhosphoSitePlusiP13611
SwissPalmiP13611

Genetic variation databases

BioMutaiVCAN
DMDMi2506816

Proteomic databases

EPDiP13611
jPOSTiP13611
MassIVEiP13611
MaxQBiP13611
PaxDbiP13611
PeptideAtlasiP13611
PRIDEiP13611
ProteomicsDBi52938 [P13611-1]
52939 [P13611-2]
52940 [P13611-3]
52941 [P13611-4]
52942 [P13611-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1346, 322 antibodies

The DNASU plasmid repository

More...DNASUi		1462

Genome annotation databases

EnsembliENST00000265077; ENSP00000265077; ENSG00000038427 [P13611-1]
ENST00000342785; ENSP00000342768; ENSG00000038427 [P13611-3]
ENST00000343200; ENSP00000340062; ENSG00000038427 [P13611-2]
ENST00000502527; ENSP00000421362; ENSG00000038427 [P13611-4]
GeneIDi1462
KEGGihsa:1462
UCSCiuc003kii.4, human [P13611-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1462
DisGeNETi1462

GeneCards: human genes, protein and diseases

More...GeneCardsi		VCAN
GeneReviewsiVCAN
HGNCiHGNC:2464, VCAN
HPAiENSG00000038427, Low tissue specificity
MalaCardsiVCAN
MIMi118661, gene
143200, phenotype
neXtProtiNX_P13611
OpenTargetsiENSG00000038427
Orphaneti898, Wagner disease
PharmGKBiPA162408788
VEuPathDBiHostDB:ENSG00000038427

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRBE, Eukaryota
GeneTreeiENSGT00940000156102
HOGENOMiCLU_000303_1_1_1
InParanoidiP13611
OMAiFPFEPTG
PhylomeDBiP13611
TreeFamiTF332134

Enzyme and pathway databases

PathwayCommonsiP13611
ReactomeiR-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870, Chondroitin sulfate biosynthesis
R-HSA-2022923, Dermatan sulfate biosynthesis
R-HSA-2024101, CS/DS degradation
R-HSA-3000178, ECM proteoglycans
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3595172, Defective CHST3 causes SEDCJD
R-HSA-3595174, Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177, Defective CHSY1 causes TPBS
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-8957275, Post-translational protein phosphorylation
SIGNORiP13611

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1462, 4 hits in 1006 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VCAN, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Versican

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1462
PharosiP13611, Tbio

Protein Ontology

More...PROi		PR:P13611
RNActiP13611, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000038427, Expressed in endometrium and 252 other tissues
ExpressionAtlasiP13611, baseline and differential
GenevisibleiP13611, HS

Family and domain databases

CDDicd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00445, LINK, 2 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13611
Secondary accession number(s): P20754
, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: September 29, 2021
This is version 239 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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