UniProtKB - P13611 (CSPG2_HUMAN)
Versican core protein
VCAN
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- carbohydrate binding Source: UniProtKB-KW
- extracellular matrix structural constituent conferring compression resistance Source: BHF-UCL
- glycosaminoglycan binding Source: ProtInc
- hyaluronic acid binding Source: ProtInc
GO - Biological processi
- cell adhesion Source: ProtInc
- cell recognition Source: ProtInc
- cellular protein metabolic process Source: Reactome
- central nervous system development Source: GO_Central
- chondroitin sulfate biosynthetic process Source: Reactome
- chondroitin sulfate catabolic process Source: Reactome
- dermatan sulfate biosynthetic process Source: Reactome
- extracellular matrix organization Source: Reactome
- glial cell migration Source: BHF-UCL
- multicellular organism development Source: ProtInc
- osteoblast differentiation Source: UniProtKB
- post-translational protein modification Source: Reactome
- skeletal system development Source: GO_Central
Keywordsi
Ligand | Calcium, Hyaluronic acid, Lectin |
Enzyme and pathway databases
PathwayCommonsi | P13611 |
Reactomei | R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022870, Chondroitin sulfate biosynthesis R-HSA-2022923, Dermatan sulfate biosynthesis R-HSA-2024101, CS/DS degradation R-HSA-3000178, ECM proteoglycans R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801, Defective B3GAT3 causes JDSSDHD R-HSA-3595172, Defective CHST3 causes SEDCJD R-HSA-3595174, Defective CHST14 causes EDS, musculocontractural type R-HSA-3595177, Defective CHSY1 causes TPBS R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | P13611 |
Names & Taxonomyi
Protein namesi | Recommended name: Versican core proteinAlternative name(s): Chondroitin sulfate proteoglycan core protein 2 Short name: Chondroitin sulfate proteoglycan 2 Glial hyaluronate-binding protein Short name: GHAP Large fibroblast proteoglycan PG-M |
Gene namesi | Name:VCAN Synonyms:CSPG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2464, VCAN |
MIMi | 118661, gene |
neXtProti | NX_P13611 |
VEuPathDBi | HostDB:ENSG00000038427.15 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix 1 Publication
- interphotoreceptor matrix 1 Publication
Other locations
- photoreceptor outer segment 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi lumen Source: Reactome
Lysosome
- lysosomal lumen Source: Reactome
Other locations
- collagen-containing extracellular matrix Source: UniProtKB
- extracellular matrix Source: GO_Central
- interphotoreceptor matrix Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- photoreceptor outer segment Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Wagner vitreoretinopathy (WGVRP)2 Publications
Keywords - Diseasei
CataractOrganism-specific databases
DisGeNETi | 1462 |
GeneReviewsi | VCAN |
MalaCardsi | VCAN |
MIMi | 143200, phenotype |
OpenTargetsi | ENSG00000038427 |
Orphaneti | 898, Wagner disease |
PharmGKBi | PA162408788 |
Miscellaneous databases
Pharosi | P13611, Tbio |
Chemistry databases
DrugBanki | DB08818, Hyaluronic acid |
Genetic variation databases
BioMutai | VCAN |
DMDMi | 2506816 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000017522 | 21 – 3396 | Versican core proteinAdd BLAST | 3376 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 130 | By similarity | ||
Glycosylationi | 57 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 172 ↔ 243 | By similarity | ||
Disulfide bondi | 196 ↔ 217 | By similarity | ||
Disulfide bondi | 270 ↔ 345 | By similarity | ||
Disulfide bondi | 294 ↔ 315 | By similarity | ||
Glycosylationi | 330 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 615 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 782 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 809 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1332 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1398 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1442 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1468 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1663 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1898 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 2116 | Phosphoserine; by FAM20CCombined sources1 Publication | 1 | |
Glycosylationi | 2179 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2272 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2360 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2385 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2392 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2496 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 2608 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2617 | PhosphothreonineCombined sources | 1 | |
Glycosylationi | 2628 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2934 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 3067 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 3093 ↔ 3104 | By similarity | ||
Disulfide bondi | 3098 ↔ 3113 | By similarity | ||
Disulfide bondi | 3115 ↔ 3124 | By similarity | ||
Disulfide bondi | 3131 ↔ 3142 | By similarity | ||
Disulfide bondi | 3136 ↔ 3151 | By similarity | ||
Disulfide bondi | 3153 ↔ 3162 | By similarity | ||
Disulfide bondi | 3169 ↔ 3180 | By similarity | ||
Disulfide bondi | 3197 ↔ 3289 | By similarity | ||
Disulfide bondi | 3265 ↔ 3281 | By similarity | ||
Disulfide bondi | 3296 ↔ 3339 | By similarity | ||
Disulfide bondi | 3325 ↔ 3352 | By similarity | ||
Glycosylationi | 3369 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 3379 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1428 – 1429 | Cleavage; by ADAMTS15By similarity | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, ProteoglycanProteomic databases
EPDi | P13611 |
jPOSTi | P13611 |
MassIVEi | P13611 |
MaxQBi | P13611 |
PaxDbi | P13611 |
PeptideAtlasi | P13611 |
PRIDEi | P13611 |
ProteomicsDBi | 52938 [P13611-1] 52939 [P13611-2] 52940 [P13611-3] 52941 [P13611-4] 52942 [P13611-5] |
PTM databases
CarbonylDBi | P13611 |
GlyConnecti | 1890, 14 N-Linked glycans (9 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P13611, 192 sites, 8 O-linked glycans (165 sites) |
iPTMneti | P13611 |
PhosphoSitePlusi | P13611 |
SwissPalmi | P13611 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000038427, Expressed in endometrium and 251 other tissues |
ExpressionAtlasi | P13611, baseline and differential |
Genevisiblei | P13611, HS |
Organism-specific databases
HPAi | ENSG00000038427, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with FBLN1.
By similarityBinary interactionsi
P13611
With | #Exp. | IntAct |
---|---|---|
MMP9 [P14780] | 3 | EBI-8515977,EBI-1382326 |
Protein-protein interaction databases
BioGRIDi | 107844, 23 interactors |
IntActi | P13611, 11 interactors |
MINTi | P13611 |
STRINGi | 9606.ENSP00000265077 |
Miscellaneous databases
RNActi | P13611, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 146 | Ig-like V-typeAdd BLAST | 126 | |
Domaini | 150 – 245 | Link 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 251 – 347 | Link 2PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 3089 – 3125 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 3127 – 3163 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 3176 – 3290 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 3294 – 3354 | SushiPROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 348 – 1335 | GAG-alpha (glucosaminoglycan attachment domain)Add BLAST | 988 | |
Regioni | 1336 – 3089 | GAG-betaAdd BLAST | 1754 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Immunoglobulin domain, Repeat, Signal, SushiPhylogenomic databases
eggNOGi | ENOG502QRBE, Eukaryota |
GeneTreei | ENSGT00940000156102 |
HOGENOMi | CLU_000303_1_1_1 |
InParanoidi | P13611 |
OMAi | FPFEPTG |
PhylomeDBi | P13611 |
TreeFami | TF332134 |
Family and domain databases
CDDi | cd00033, CCP, 1 hit cd03588, CLECT_CSPGs, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 3 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033987, CSPG_CTLD IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00008, EGF, 2 hits PF00059, Lectin_C, 1 hit PF00084, Sushi, 1 hit PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00034, CLECT, 1 hit SM00181, EGF, 2 hits SM00179, EGF_CA, 2 hits SM00409, IG, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 3 hits SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 2 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits PS50923, SUSHI, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP
60 70 80 90 100
TLPPSYNTSE FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR
110 120 130 140 150
VSVPTHPEAV GDASLTVVKL LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV
160 170 180 190 200
VFHYRAATSR YTLNFEAAQK ACLDVGAVIA TPEQLFAAYE DGFEQCDAGW
210 220 230 240 250
LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD VYCYVDHLDG
260 270 280 290 300
DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS
310 320 330 340 350
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE
360 370 380 390 400
ATTIDLSILA ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN
410 420 430 440 450
IVSFEQKATV QPQAITDSLA TKLPTPTGST KKPWDMDDYS PSASGPLGKL
460 470 480 490 500
DISEIKEEVL QSTTGVSHYA TDSWDGVVED KQTQESVTQI EQIEVGPLVT
510 520 530 540 550
SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS ELVTTGHYGF
560 570 580 590 600
TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV
610 620 630 640 650
SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR
660 670 680 690 700
TEIELFPYSG DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT
710 720 730 740 750
DEIQEEITKS PFMGKTEEEV FSGMKLSTSL SEPIHVTESS VEMTKSFDFP
760 770 780 790 800
TLITKLSAEP TEVRDMEEDF TATPGTTKYD ENITTVLLAH GTLSVEAATV
810 820 830 840 850
SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD KDIPSFTEDG
860 870 880 890 900
ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS
910 920 930 940 950
TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE
960 970 980 990 1000
GLAFVSYSST QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP
1010 1020 1030 1040 1050
SQDILVIDQT RLEATISPET MRTTKITEGT TQEEFPWKEQ TAEKPVPALS
1060 1070 1080 1090 1100
STAWTPKEAV TPLDEQEGDG SAYTVSEDEL LTGSERVPVL ETTPVGKIDH
1110 1120 1130 1140 1150
SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY ETEGSSTTGF
1160 1170 1180 1190 1200
TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK
1210 1220 1230 1240 1250
VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI
1260 1270 1280 1290 1300
IGESTSHVPP TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE
1310 1320 1330 1340 1350
AFGPQALSTP QPPASTKFHP DINVYIIEVR ENKTGRMSDL SVIGHPIDSE
1360 1370 1380 1390 1400
SKEDEPCSEE TDPVHDLMAE ILPEFPDIIE IDLYHSEENE EEEEECANAT
1410 1420 1430 1440 1450
DVTTTPSVQY INGKHLVTTV PKDPEAAEAR RGQFESVAPS QNFSDSSESD
1460 1470 1480 1490 1500
THPFVIAKTE LSTAVQPNES TETTESLEVT WKPETYPETS EHFSGGEPDV
1510 1520 1530 1540 1550
FPTVPFHEEF ESGTAKKGAE SVTERDTEVG HQAHEHTEPV SLFPEESSGE
1560 1570 1580 1590 1600
IAIDQESQKI AFARATEVTF GEEVEKSTSV TYTPTIVPSS ASAYVSEEEA
1610 1620 1630 1640 1650
VTLIGNPWPD DLLSTKESWV EATPRQVVEL SGSSSIPITE GSGEAEEDED
1660 1670 1680 1690 1700
TMFTMVTDLS QRNTTDTLIT LDTSRIITES FFEVPATTIY PVSEQPSAKV
1710 1720 1730 1740 1750
VPTKFVSETD TSEWISSTTV EEKKRKEEEG TTGTASTFEV YSSTQRSDQL
1760 1770 1780 1790 1800
ILPFELESPN VATSSDSGTR KSFMSLTTPT QSEREMTDST PVFTETNTLE
1810 1820 1830 1840 1850
NLGAQTTEHS SIHQPGVQEG LTTLPRSPAS VFMEQGSGEA AADPETTTVS
1860 1870 1880 1890 1900
SFSLNVEYAI QAEKEVAGTL SPHVETTFST EPTGLVLSTV MDRVVAENIT
1910 1920 1930 1940 1950
QTSREIVISE RLGEPNYGAE IRGFSTGFPL EEDFSGDFRE YSTVSHPIAK
1960 1970 1980 1990 2000
EETVMMEGSG DAAFRDTQTS PSTVPTSVHI SHISDSEGPS STMVSTSAFP
2010 2020 2030 2040 2050
WEEFTSSAEG SGEQLVTVSS SVVPVLPSAV QKFSGTASSI IDEGLGEVGT
2060 2070 2080 2090 2100
VNEIDRRSTI LPTAEVEGTK APVEKEEVKV SGTVSTNFPQ TIEPAKLWSR
2110 2120 2130 2140 2150
QEVNPVRQEI ESETTSEEQI QEEKSFESPQ NSPATEQTIF DSQTFTETEL
2160 2170 2180 2190 2200
KTTDYSVLTT KKTYSDDKEM KEEDTSLVNM STPDPDANGL ESYTTLPEAT
2210 2220 2230 2240 2250
EKSHFFLATA LVTESIPAEH VVTDSPIKKE ESTKHFPKGM RPTIQESDTE
2260 2270 2280 2290 2300
LLFSGLGSGE EVLPTLPTES VNFTEVEQIN NTLYPHTSQV ESTSSDKIED
2310 2320 2330 2340 2350
FNRMENVAKE VGPLVSQTDI FEGSGSVTST TLIEILSDTG AEGPTVAPLP
2360 2370 2380 2390 2400
FSTDIGHPQN QTVRWAEEIQ TSRPQTITEQ DSNKNSSTAE INETTTSSTD
2410 2420 2430 2440 2450
FLARAYGFEM AKEFVTSAPK PSDLYYEPSG EGSGEVDIVD SFHTSATTQA
2460 2470 2480 2490 2500
TRQESSTTFV SDGSLEKHPE VPSAKAVTAD GFPTVSVMLP LHSEQNKSSP
2510 2520 2530 2540 2550
DPTSTLSNTV SYERSTDGSF QDRFREFEDS TLKPNRKKPT ENIIIDLDKE
2560 2570 2580 2590 2600
DKDLILTITE STILEILPEL TSDKNTIIDI DHTKPVYEDI LGMQTDIDTE
2610 2620 2630 2640 2650
VPSEPHDSND ESNDDSTQVQ EIYEAAVNLS LTEETFEGSA DVLASYTQAT
2660 2670 2680 2690 2700
HDESMTYEDR SQLDHMGFHF TTGIPAPSTE TELDVLLPTA TSLPIPRKSA
2710 2720 2730 2740 2750
TVIPEIEGIK AEAKALDDMF ESSTLSDGQA IADQSEIIPT LGQFERTQEE
2760 2770 2780 2790 2800
YEDKKHAGPS FQPEFSSGAE EALVDHTPYL SIATTHLMDQ SVTEVPDVME
2810 2820 2830 2840 2850
GSNPPYYTDT TLAVSTFAKL SSQTPSSPLT IYSGSEASGH TEIPQPSALP
2860 2870 2880 2890 2900
GIDVGSSVMS PQDSFKEIHV NIEATFKPSS EEYLHITEPP SLSPDTKLEP
2910 2920 2930 2940 2950
SEDDGKPELL EEMEASPTEL IAVEGTEILQ DFQNKTDGQV SGEAIKMFPT
2960 2970 2980 2990 3000
IKTPEAGTVI TTADEIELEG ATQWPHSTSA SATYGVEAGV VPWLSPQTSE
3010 3020 3030 3040 3050
RPTLSSSPEI NPETQAALIR GQDSTIAASE QQVAARILDS NDQATVNPVE
3060 3070 3080 3090 3100
FNTEVATPPF SLLETSNETD FLIGINEESV EGTAIYLPGP DRCKMNPCLN
3110 3120 3130 3140 3150
GGTCYPTETS YVCTCVPGYS GDQCELDFDE CHSNPCRNGA TCVDGFNTFR
3160 3170 3180 3190 3200
CLCLPSYVGA LCEQDTETCD YGWHKFQGQC YKYFAHRRTW DAAERECRLQ
3210 3220 3230 3240 3250
GAHLTSILSH EEQMFVNRVG HDYQWIGLND KMFEHDFRWT DGSTLQYENW
3260 3270 3280 3290 3300
RPNQPDSFFS AGEDCVVIIW HENGQWNDVP CNYHLTYTCK KGTVACGQPP
3310 3320 3330 3340 3350
VVENAKTFGK MKPRYEINSL IRYHCKDGFI QRHLPTIRCL GNGRWAIPKI
3360 3370 3380 3390
TCMNPSAYQR TYSMKYFKNS SSAKDNSINT SKHDHRWSRR WQESRR
The sequence of this isoform differs from the canonical sequence as follows:
348-348: P → R
349-1335: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1336-3089: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
348-348: P → R
349-3089: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
3355-3396: PSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR → RKWSFRKNGLPCYNNY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PF17 | E9PF17_HUMAN | Versican core protein | VCAN | 1,594 | Annotation score: | ||
D6RGZ6 | D6RGZ6_HUMAN | Versican core protein | VCAN | 1,240 | Annotation score: | ||
Q86W61 | Q86W61_HUMAN | VCAN protein | VCAN | 354 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 88 | N → D AA sequence (PubMed:2466833).Curated | 1 | |
Sequence conflicti | 260 | K → I AA sequence (PubMed:2466833).Curated | 1 | |
Sequence conflicti | 274 | D → A in BAA06801 (PubMed:7876137).Curated | 1 | |
Sequence conflicti | 284 | Q → G AA sequence (PubMed:2466833).Curated | 1 | |
Sequence conflicti | 2709 – 2713 | IKAEA → EFREV in AAA36437 (PubMed:2820964).Curated | 5 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021958 | 300 | S → L. Corresponds to variant dbSNP:rs2652098EnsemblClinVar. | 1 | |
Natural variantiVAR_020214 | 428 | G → D. Corresponds to variant dbSNP:rs2287926EnsemblClinVar. | 1 | |
Natural variantiVAR_021959 | 1516 | K → R. Corresponds to variant dbSNP:rs309559EnsemblClinVar. | 1 | |
Natural variantiVAR_031632 | 1826 | R → H. Corresponds to variant dbSNP:rs188703EnsemblClinVar. | 1 | |
Natural variantiVAR_020215 | 2301 | F → Y. Corresponds to variant dbSNP:rs160278EnsemblClinVar. | 1 | |
Natural variantiVAR_020216 | 2315 | V → L. Corresponds to variant dbSNP:rs3734094EnsemblClinVar. | 1 | |
Natural variantiVAR_021960 | 2937 | D → Y. Corresponds to variant dbSNP:rs160277EnsemblClinVar. | 1 | |
Natural variantiVAR_031633 | 3011 | N → K. Corresponds to variant dbSNP:rs16900532EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003082 | 348 | P → R in isoform V1 and isoform V3. 3 Publications | 1 | |
Alternative sequenceiVSP_003085 | 349 – 3089 | Missing in isoform V3. 1 PublicationAdd BLAST | 2741 | |
Alternative sequenceiVSP_003083 | 349 – 1335 | Missing in isoform V1. 2 PublicationsAdd BLAST | 987 | |
Alternative sequenceiVSP_003084 | 1336 – 3089 | Missing in isoform V2. 1 PublicationAdd BLAST | 1754 | |
Alternative sequenceiVSP_003086 | 3355 – 3396 | PSAYQ…QESRR → RKWSFRKNGLPCYNNY in isoform Vint. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15998 mRNA Translation: CAA34128.1 U16306 mRNA Translation: AAA65018.1 U26555 mRNA Translation: AAA67565.1 D32039 mRNA Translation: BAA06801.1 S52488 Genomic DNA Translation: AAB24878.1 J02814 mRNA Translation: AAA36437.1 AF084545 mRNA Translation: AAD48545.1 |
CCDSi | CCDS4060.1 [P13611-1] CCDS47242.1 [P13611-4] CCDS54875.1 [P13611-3] CCDS54876.1 [P13611-2] |
PIRi | S06014, A60979 |
RefSeqi | NP_001119808.1, NM_001126336.2 [P13611-4] NP_001157569.1, NM_001164097.1 [P13611-2] NP_001157570.1, NM_001164098.1 [P13611-3] NP_004376.2, NM_004385.4 [P13611-1] |
Genome annotation databases
Ensembli | ENST00000265077; ENSP00000265077; ENSG00000038427 [P13611-1] ENST00000342785; ENSP00000342768; ENSG00000038427 [P13611-3] ENST00000343200; ENSP00000340062; ENSG00000038427 [P13611-2] ENST00000502527; ENSP00000421362; ENSG00000038427 [P13611-4] |
GeneIDi | 1462 |
KEGGi | hsa:1462 |
UCSCi | uc003kii.4, human [P13611-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Versican |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15998 mRNA Translation: CAA34128.1 U16306 mRNA Translation: AAA65018.1 U26555 mRNA Translation: AAA67565.1 D32039 mRNA Translation: BAA06801.1 S52488 Genomic DNA Translation: AAB24878.1 J02814 mRNA Translation: AAA36437.1 AF084545 mRNA Translation: AAD48545.1 |
CCDSi | CCDS4060.1 [P13611-1] CCDS47242.1 [P13611-4] CCDS54875.1 [P13611-3] CCDS54876.1 [P13611-2] |
PIRi | S06014, A60979 |
RefSeqi | NP_001119808.1, NM_001126336.2 [P13611-4] NP_001157569.1, NM_001164097.1 [P13611-2] NP_001157570.1, NM_001164098.1 [P13611-3] NP_004376.2, NM_004385.4 [P13611-1] |
3D structure databases
SMRi | P13611 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107844, 23 interactors |
IntActi | P13611, 11 interactors |
MINTi | P13611 |
STRINGi | 9606.ENSP00000265077 |
Chemistry databases
DrugBanki | DB08818, Hyaluronic acid |
PTM databases
CarbonylDBi | P13611 |
GlyConnecti | 1890, 14 N-Linked glycans (9 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P13611, 192 sites, 8 O-linked glycans (165 sites) |
iPTMneti | P13611 |
PhosphoSitePlusi | P13611 |
SwissPalmi | P13611 |
Genetic variation databases
BioMutai | VCAN |
DMDMi | 2506816 |
Proteomic databases
EPDi | P13611 |
jPOSTi | P13611 |
MassIVEi | P13611 |
MaxQBi | P13611 |
PaxDbi | P13611 |
PeptideAtlasi | P13611 |
PRIDEi | P13611 |
ProteomicsDBi | 52938 [P13611-1] 52939 [P13611-2] 52940 [P13611-3] 52941 [P13611-4] 52942 [P13611-5] |
Protocols and materials databases
Antibodypediai | 1346, 320 antibodies |
DNASUi | 1462 |
Genome annotation databases
Ensembli | ENST00000265077; ENSP00000265077; ENSG00000038427 [P13611-1] ENST00000342785; ENSP00000342768; ENSG00000038427 [P13611-3] ENST00000343200; ENSP00000340062; ENSG00000038427 [P13611-2] ENST00000502527; ENSP00000421362; ENSG00000038427 [P13611-4] |
GeneIDi | 1462 |
KEGGi | hsa:1462 |
UCSCi | uc003kii.4, human [P13611-1] |
Organism-specific databases
CTDi | 1462 |
DisGeNETi | 1462 |
GeneCardsi | VCAN |
GeneReviewsi | VCAN |
HGNCi | HGNC:2464, VCAN |
HPAi | ENSG00000038427, Low tissue specificity |
MalaCardsi | VCAN |
MIMi | 118661, gene 143200, phenotype |
neXtProti | NX_P13611 |
OpenTargetsi | ENSG00000038427 |
Orphaneti | 898, Wagner disease |
PharmGKBi | PA162408788 |
VEuPathDBi | HostDB:ENSG00000038427.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRBE, Eukaryota |
GeneTreei | ENSGT00940000156102 |
HOGENOMi | CLU_000303_1_1_1 |
InParanoidi | P13611 |
OMAi | FPFEPTG |
PhylomeDBi | P13611 |
TreeFami | TF332134 |
Enzyme and pathway databases
PathwayCommonsi | P13611 |
Reactomei | R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022870, Chondroitin sulfate biosynthesis R-HSA-2022923, Dermatan sulfate biosynthesis R-HSA-2024101, CS/DS degradation R-HSA-3000178, ECM proteoglycans R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801, Defective B3GAT3 causes JDSSDHD R-HSA-3595172, Defective CHST3 causes SEDCJD R-HSA-3595174, Defective CHST14 causes EDS, musculocontractural type R-HSA-3595177, Defective CHSY1 causes TPBS R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | P13611 |
Miscellaneous databases
BioGRID-ORCSi | 1462, 4 hits in 983 CRISPR screens |
ChiTaRSi | VCAN, human |
GeneWikii | Versican |
GenomeRNAii | 1462 |
Pharosi | P13611, Tbio |
PROi | PR:P13611 |
RNActi | P13611, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000038427, Expressed in endometrium and 251 other tissues |
ExpressionAtlasi | P13611, baseline and differential |
Genevisiblei | P13611, HS |
Family and domain databases
CDDi | cd00033, CCP, 1 hit cd03588, CLECT_CSPGs, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 3 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033987, CSPG_CTLD IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00008, EGF, 2 hits PF00059, Lectin_C, 1 hit PF00084, Sushi, 1 hit PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00034, CLECT, 1 hit SM00181, EGF, 2 hits SM00179, EGF_CA, 2 hits SM00409, IG, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 3 hits SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 2 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits PS50923, SUSHI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSPG2_HUMAN | |
Accessioni | P13611Primary (citable) accession number: P13611 Secondary accession number(s): P20754 Q9UNW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 237 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families