Sodium/potassium-transporting ATPase subunit alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• sodium:potassium-exchanging ATPase activity Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 8110464
  • 9680312

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• adult locomotory behavior Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12598616
  • 19455355
• cation transport Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 9648860
  • 9680312
• chemical synaptic transmission Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15281071
• determination of adult lifespan Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12598616
  • 19455355
  • 16272407
• embryonic development via the syncytial blastoderm Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 8978055
• jump response Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 19455355
• locomotory behavior Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 11691629
• neuromuscular process Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12598616
• regulation of cell shape Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12466193
• regulation of tube architecture, open tracheal system Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 14570584
• regulation of tube diameter, open tracheal system Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12466193
  • 12930776
• regulation of tube length, open tracheal system Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12466193
  • 12930776
• response to mechanical stimulus Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 8110464
  • 12598616
  • 11691629
• response to temperature stimulus Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 9680312
  • 12598616
• sensory perception of sound Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23248276
• septate junction assembly Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12930776
• synaptic growth at neuromuscular junction Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 15281071
• tissue homeostasis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12598616
• trachea morphogenesis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 19455355

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MALRSDYEHG RADSYRVATV IATDDDNRTA DGQYKSRRKM PAKVNKKENL 
        60         70         80         90        100
DDLKQELDID FHKISPEELY QRFQTHPENG LSHAKAKENL ERDGPNALTP 
       110        120        130        140        150
PKQTPEWVKF CKNLFGGFAM LLWIGAILCF VAYSIQASTS EEPADDNLYL 
       160        170        180        190        200
GIVLSAVVIV TGIFSYYQES KSSKIMESFK NMVPQFATVI REGEKLTLRA 
       210        220        230        240        250
EDLVLGDVVE VKFGDRIPAD IRIIEARNFK VDNSSLTGES EPQSRGAEFT 
       260        270        280        290        300
HENPLETKNL AFFSTNAVEG TAKGVVISCG DHTVMGRIAG LASGLDTGET 
       310        320        330        340        350
PIAKEIHHFI HLITGVAVFL GVTFFVIAFI LGYHWLDAVI FLIGIIVANV 
       360        370        380        390        400
PEGLLATVTV CLTLTAKRMA SKNCLVKNLE AVETLGSTST ICSDKTGTLT 
       410        420        430        440        450
QNRMTVAHMW FDNQIIEADT TEDQSGVQYD RTSPGFKALS RIATLCNRAE 
       460        470        480        490        500
FKGGQDGVPI LKKEVSGDAS EAALLKCMEL ALGDVMNIRK RNKKIAEVPF 
       510        520        530        540        550
NSTNKYQVSI HETEDTNDPR YLLVMKGAPE RILERCSTIF INGKEKVLDE 
       560        570        580        590        600
EMKEAFNNAY MELGGLGERV LGFCDFMLPS DKYPNGFKFN TDDINFPIDN 
       610        620        630        640        650
LRFVGLMSMI DPPRAAVPDA VAKCRSAGIK VIMVTGDHPI TAKAIAKSVG 
       660        670        680        690        700
IISEGNETVE DIAQRLNIPV SEVNPREAKA AVVHGAELRD VSSDQLDEIL 
       710        720        730        740        750
RYHTEIVFAR TSPQQKLIIV EGCQRMGAIV AVTGDGVNDS PALKKADIGV 
       760        770        780        790        800
AMGIAGSDVS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS 
       810        820        830        840        850
NIPEISPFLA FILCDIPLPL GTVTILCIDL GTDMVPAISL AYEHAEADIM 
       860        870        880        890        900
KRPPRDPFND KLVNSRLISM AYGQIGMIQA AAGFFVYFVI MAENGFLPKK 
       910        920        930        940        950
LFGIRKMWDS KAVNDLTDSY GQEWTYRDRK TLEYTCHTAF FISIVVVQWA 
       960        970        980        990       1000
DLIICKTRRN SIFQQGMRNW ALNFGLVFET VLAAFLSYCP GMEKGLRMYP 
      1010       1020       1030       1040 
LKLVWWFPAI PFALAIFIYD ETRRFYLRRN PGGWLEQETY Y          

        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMVPAIS 
       810        820        830        840        850
LAYEHAEADI MKRPPRDPFN DKLVNSRLIS MAYGQIGMIQ AAAGFFVYFV 
       860        870        880        890        900
IMAENGFLPK KLFGIRKMWD SKAVNDLTDS YGQEWTYRDR KTLEYTCHTA 
       910        920        930        940        950
FFISIVVVQW ADLIICKTRR NSIFQQGMRN WALNFGLVFE TVLAAFLSYC 
       960        970        980        990       1000
PGMEKGLRMY PLKLVWWFPA IPFALAIFIY DETRRFYLRR NPGGWLEQET 

YY                                                     

        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMVSLDL 
       810        820        830 
CPKPKLHRRL KLKLLLSQYH SSKLYSYTSC SPSQLIVKN             

        10         20         30         40         50
MSAQHGRADS YRVATVIATD DDNRTADGQY KSRRKMPAKV NKKENLDDLK 
        60         70         80         90        100
QELDIDFHKI SPEELYQRFQ THPENGLSHA KAKENLERDG PNALTPPKQT 
       110        120        130        140        150
PEWVKFCKNL FGGFAMLLWI GAILCFVAYS IQASTSEEPA DDNLYLGIVL 
       160        170        180        190        200
SAVVIVTGIF SYYQESKSSK IMESFKNMVP QFATVIREGE KLTLRAEDLV 
       210        220        230        240        250
LGDVVEVKFG DRIPADIRII EARNFKVDNS SLTGESEPQS RGAEFTHENP 
       260        270        280        290        300
LETKNLAFFS TNAVEGTAKG VVISCGDHTV MGRIAGLASG LDTGETPIAK 
       310        320        330        340        350
EIHHFIHLIT GVAVFLGVTF FVIAFILGYH WLDAVIFLIG IIVANVPEGL 
       360        370        380        390        400
LATVTVCLTL TAKRMASKNC LVKNLEAVET LGSTSTICSD KTGTLTQNRM 
       410        420        430        440        450
TVAHMWFDNQ IIEADTTEDQ SGVQYDRTSP GFKALSRIAT LCNRAEFKGG 
       460        470        480        490        500
QDGVPILKKE VSGDASEAAL LKCMELALGD VMNIRKRNKK IAEVPFNSTN 
       510        520        530        540        550
KYQVSIHETE DTNDPRYLLV MKGAPERILE RCSTIFINGK EKVLDEEMKE 
       560        570        580        590        600
AFNNAYMELG GLGERVLGFC DFMLPSDKYP NGFKFNTDDI NFPIDNLRFV 
       610        620        630        640        650
GLMSMIDPPR AAVPDAVAKC RSAGIKVIMV TGDHPITAKA IAKSVGIISE 
       660        670        680        690        700
GNETVEDIAQ RLNIPVSEVN PREAKAAVVH GAELRDVSSD QLDEILRYHT 
       710        720        730        740        750
EIVFARTSPQ QKLIIVEGCQ RMGAIVAVTG DGVNDSPALK KADIGVAMGI 
       760        770        780        790        800
AGSDVSKQAA DMILLDDNFA SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE 
       810        820        830        840        850
ISPFLAFILC DIPLPLGTVT ILCIDLGTDM VPAISLAYEH AEADIMKRPP 
       860        870        880        890        900
RDPFNDKLVN SRLISMAYGQ IGMIQAAAGF FVYFVIMAEN GFLPKKLFGI 
       910        920        930        940        950
RKMWDSKAVN DLTDSYGQEW TYRDRKTLEY TCHTAFFISI VVVQWADLII 
       960        970        980        990       1000
CKTRRNSIFQ QGMRNWALNF GLVFETVLAA FLSYCPGMEK GLRMYPLKLV 
      1010       1020       1030 
WWFPAIPFAL AIFIYDETRR FYLRRNPGGW LEQETYY               

        10         20         30         40         50
MALRSDYEHG RADSYRVATV IATDDDNRTA DGQYKSRRKM PAKVNKKENL 
        60         70         80         90        100
DDLKQELDID FHKISPEELY QRFQTHPENG LSHAKAKENL ERDGPNALTP 
       110        120        130        140        150
PKQTPEWVKF CKNLFGGFAM LLWIGAILCF VAYSIQASTS EEPADDNLYL 
       160        170        180        190        200
GIVLSAVVIV TGIFSYYQES KSSKIMESFK NMVPQFATVI REGEKLTLRA 
       210        220        230        240        250
EDLVLGDVVE VKFGDRIPAD IRIIEARNFK VDNSSLTGES EPQSRGAEFT 
       260        270        280        290        300
HENPLETKNL AFFSTNAVEG TAKGVVISCG DHTVMGRIAG LASGLDTGET 
       310        320        330        340        350
PIAKEIHHFI HLITGVAVFL GVTFFVIAFI LGYHWLDAVI FLIGIIVANV 
       360        370        380        390        400
PEGLLATVTV CLTLTAKRMA SKNCLVKNLE AVETLGSTST ICSDKTGTLT 
       410        420        430        440        450
QNRMTVAHMW FDNQIIEADT TEDQSGVQYD RTSPGFKALS RIATLCNRAE 
       460        470        480        490        500
FKGGQDGVPI LKKEVSGDAS EAALLKCMEL ALGDVMNIRK RNKKIAEVPF 
       510        520        530        540        550
NSTNKYQVSI HETEDTNDPR YLLVMKGAPE RILERCSTIF INGKEKVLDE 
       560        570        580        590        600
EMKEAFNNAY MELGGLGERV LGFCDFMLPS DKYPNGFKFN TDDINFPIDN 
       610        620        630        640        650
LRFVGLMSMI DPPRAAVPDA VAKCRSAGIK VIMVTGDHPI TAKAIAKSVG 
       660        670        680        690        700
IISEGNETVE DIAQRLNIPV SEVNPREAKA AVVHGAELRD VSSDQLDEIL 
       710        720        730        740        750
RYHTEIVFAR TSPQQKLIIV EGCQRMGAIV AVTGDGVNDS PALKKADIGV 
       760        770        780        790        800
AMGIAGSDVS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS 
       810        820        830        840        850
NIPEISPFLA FILCDIPLPL GTVTILCIDL GTDMIPAISL AYEGPEADIM 
       860        870        880        890        900
KRRPRNPEID NLVNERLISM AYGQIGMIQA AAGFFVYFVI MAENGFLPKK 
       910        920        930        940        950
LFGIRKMWDS KAVNDLTDSY GQEWTYRDRK TLEYTCHTAF FISIVVVQWA 
       960        970        980        990       1000
DLIICKTRRN SIFQQGMRNW ALNFGLVFET VLAAFLSYCP GMEKGLRMYP 
      1010       1020       1030       1040 
LKLVWWFPAI PFALAIFIYD ETRRFYLRRN PGGWLEQETY Y          

        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMVPAIS 
       810        820        830        840        850
LAYETAESDI MKRQPRNPFQ DKLVNERLIS MAYGQIGMIQ AAAGFFVYFV 
       860        870        880        890        900
IMAENGFLPK KLFGIRKMWD SKAVNDLTDS YGQEWTYRDR KTLEYTCHTA 
       910        920        930        940        950
FFISIVVVQW ADLIICKTRR NSIFQQGMRN WALNFGLVFE TVLAAFLSYC 
       960        970        980        990       1000
PGMEKGLRMY PLKLVWWFPA IPFALAIFIY DETRRFYLRR NPGGWLEQET 

YY                                                     

        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMIPAIS 
       810        820        830        840        850
LAYEQAESDI MKRQPRDPYR DNLVNRRLIS MAYGQIGMIQ AAAGFFVYFV 
       860        870        880        890        900
IMAENGFLPK KLFGIRKMWD SKAVNDLTDS YGQEWTYRDR KTLEYTCHTA 
       910        920        930        940        950
FFISIVVVQW ADLIICKTRR NSIFQQGMRN WALNFGLVFE TVLAAFLSYC 
       960        970        980        990       1000
PGMEKGLRMY PLKLVWWFPA IPFALAIFIY DETRRFYLRR NPGGWLEQET 

YY                                                     

Experimental Info

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families