Atpalpha

Functionⁱ

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.3 Publications

Miscellaneous

Ouabain-sensitive electrogenic ion pump.

Catalytic activityⁱ

ATP
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See the description of this molecule in ChEBI.
+
H₂O
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+
K⁺
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(out) +
Na⁺
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(in) =
ADP
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+
H⁺
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+
K⁺
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(in) +
Na⁺
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(out) +
phosphate
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EC:
7.2.2.13
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
H₂O
+
K⁺(out)
+
Na⁺(in)
=
ADP
+
H⁺
+
K⁺(in)
+
Na⁺(out)
+
phosphate
zoom

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	394	4-aspartylphosphate intermediateCurated		1
Binding siteⁱ	526	ATPBy similarity		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Biological process	Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
Ligand	ATP-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-DME-936837, Ion transport by P-type ATPases

Reactomeⁱ

R-DME-936837, Ion transport by P-type ATPases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium/potassium-transporting ATPase subunit alpha (EC:7.2.2.13) Short name: Na(+)/K(+) ATPase alpha subunit Alternative name(s): Sodium pump subunit alpha
Gene namesⁱ	Name:Atpalpha Synonyms:Na-p ORF Names:CG5670
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome 3R

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0002921, Atpalpha

FlyBaseⁱ

FBgn0002921, Atpalpha

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	115 – 135	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	147 – 167	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	312 – 332	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	338 – 358	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	808 – 828	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	870 – 890	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	935 – 955	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	970 – 990	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1020	D → N in allele ATP-alpha-dts2; homozygous lethal and temperature dependent bang sensitive paralysis, shortened life span and neurodegeneration when heterozygous. 1 Publication		1
Mutagenesisⁱ	1021	E → K in allele ATP-alpha-dts1; homozygous lethal and temperature dependent bang sensitive paralysis, shortened life span and neurodegeneration when heterozygous. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046309	1 – 1041	Sodium/potassium-transporting ATPase subunit alphaAdd BLAST		1041

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P13607
PRIDEⁱ	P13607

Expressionⁱ

Tissue specificityⁱ

High levels are found in some adult tissues: Malpighian tubules, indirect flight muscles, tubular leg muscles and throughout the nervous system (brain, optic lobes, retina and ventral thoracic neuromere). Lower levels are detected at the posterior end where the reproductive organs and rectum are located.2 Publications

Gene expression databases

Bgeeⁱ	FBgn0002921, Expressed in adult Malpighian tubule (Drosophila) and 37 other tissues
ExpressionAtlasⁱ	P13607, baseline and differential
Genevisibleⁱ	P13607, DM

Interactionⁱ

Subunit structureⁱ

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Curated

Protein-protein interaction databases

BioGRIDⁱ	71866, 59 interactors
Database of interacting proteins More...DIPⁱ	DIP-19649N
IntActⁱ	P13607, 36 interactors
STRINGⁱ	7227.FBpp0088502

Structureⁱ

3D structure databases

SMRⁱ	P13607
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0203, Eukaryota
InParanoidⁱ	P13607
OMAⁱ	CFTDCAA
PhylomeDBⁱ	P13607

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02608, P-type_ATPase_Na-K_like, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit
SFLDⁱ	SFLDF00027, p-type_atpase, 1 hit
SMARTⁱ	View protein in SMART SM00831, Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Exon 6 has 4 mutually exclusive forms (6a, 6b, 6c and 6d). Additional isoforms may exist.

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P13607-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MALRSDYEHG RADSYRVATV IATDDDNRTA DGQYKSRRKM PAKVNKKENL 
        60         70         80         90        100
DDLKQELDID FHKISPEELY QRFQTHPENG LSHAKAKENL ERDGPNALTP 
       110        120        130        140        150
PKQTPEWVKF CKNLFGGFAM LLWIGAILCF VAYSIQASTS EEPADDNLYL 
       160        170        180        190        200
GIVLSAVVIV TGIFSYYQES KSSKIMESFK NMVPQFATVI REGEKLTLRA 
       210        220        230        240        250
EDLVLGDVVE VKFGDRIPAD IRIIEARNFK VDNSSLTGES EPQSRGAEFT 
       260        270        280        290        300
HENPLETKNL AFFSTNAVEG TAKGVVISCG DHTVMGRIAG LASGLDTGET 
       310        320        330        340        350
PIAKEIHHFI HLITGVAVFL GVTFFVIAFI LGYHWLDAVI FLIGIIVANV 
       360        370        380        390        400
PEGLLATVTV CLTLTAKRMA SKNCLVKNLE AVETLGSTST ICSDKTGTLT 
       410        420        430        440        450
QNRMTVAHMW FDNQIIEADT TEDQSGVQYD RTSPGFKALS RIATLCNRAE 
       460        470        480        490        500
FKGGQDGVPI LKKEVSGDAS EAALLKCMEL ALGDVMNIRK RNKKIAEVPF 
       510        520        530        540        550
NSTNKYQVSI HETEDTNDPR YLLVMKGAPE RILERCSTIF INGKEKVLDE 
       560        570        580        590        600
EMKEAFNNAY MELGGLGERV LGFCDFMLPS DKYPNGFKFN TDDINFPIDN 
       610        620        630        640        650
LRFVGLMSMI DPPRAAVPDA VAKCRSAGIK VIMVTGDHPI TAKAIAKSVG 
       660        670        680        690        700
IISEGNETVE DIAQRLNIPV SEVNPREAKA AVVHGAELRD VSSDQLDEIL 
       710        720        730        740        750
RYHTEIVFAR TSPQQKLIIV EGCQRMGAIV AVTGDGVNDS PALKKADIGV 
       760        770        780        790        800
AMGIAGSDVS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS 
       810        820        830        840        850
NIPEISPFLA FILCDIPLPL GTVTILCIDL GTDMVPAISL AYEHAEADIM 
       860        870        880        890        900
KRPPRDPFND KLVNSRLISM AYGQIGMIQA AAGFFVYFVI MAENGFLPKK 
       910        920        930        940        950
LFGIRKMWDS KAVNDLTDSY GQEWTYRDRK TLEYTCHTAF FISIVVVQWA 
       960        970        980        990       1000
DLIICKTRRN SIFQQGMRNW ALNFGLVFET VLAAFLSYCP GMEKGLRMYP 
      1010       1020       1030       1040 
LKLVWWFPAI PFALAIFIYD ETRRFYLRRN PGGWLEQETY Y

Length:1,041

Mass (Da):115,605

Last modified:June 20, 2001 - v3

Checksum:ⁱB2DD36B2E9029F43

GO

Isoform 2 (identifier: P13607-2) [UniParc]FASTA Add to basket

Also known as: B, C, E

The sequence of this isoform differs from the canonical sequence as follows:
1-39: Missing.

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        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMVPAIS 
       810        820        830        840        850
LAYEHAEADI MKRPPRDPFN DKLVNSRLIS MAYGQIGMIQ AAAGFFVYFV 
       860        870        880        890        900
IMAENGFLPK KLFGIRKMWD SKAVNDLTDS YGQEWTYRDR KTLEYTCHTA 
       910        920        930        940        950
FFISIVVVQW ADLIICKTRR NSIFQQGMRN WALNFGLVFE TVLAAFLSYC 
       960        970        980        990       1000
PGMEKGLRMY PLKLVWWFPA IPFALAIFIY DETRRFYLRR NPGGWLEQET 

YY

Show »

Length:1,002

Mass (Da):111,133

Checksum:ⁱCA77B36B10EB23E2

GO

Isoform 3 (identifier: P13607-3) [UniParc]FASTA Add to basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     836-878: PAISLAYEHA...SMAYGQIGMI → SLDLCPKPKL...CSPSQLIVKN
     879-1041: Missing.

« Hide

        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMVSLDL 
       810        820        830 
CPKPKLHRRL KLKLLLSQYH SSKLYSYTSC SPSQLIVKN

Show »

Length:839

Mass (Da):91,981

Checksum:ⁱD8D38F5B5BE2CD37

GO

Isoform 4 (identifier: P13607-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-8: MALRSDYE → MSAQ

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        10         20         30         40         50
MSAQHGRADS YRVATVIATD DDNRTADGQY KSRRKMPAKV NKKENLDDLK 
        60         70         80         90        100
QELDIDFHKI SPEELYQRFQ THPENGLSHA KAKENLERDG PNALTPPKQT 
       110        120        130        140        150
PEWVKFCKNL FGGFAMLLWI GAILCFVAYS IQASTSEEPA DDNLYLGIVL 
       160        170        180        190        200
SAVVIVTGIF SYYQESKSSK IMESFKNMVP QFATVIREGE KLTLRAEDLV 
       210        220        230        240        250
LGDVVEVKFG DRIPADIRII EARNFKVDNS SLTGESEPQS RGAEFTHENP 
       260        270        280        290        300
LETKNLAFFS TNAVEGTAKG VVISCGDHTV MGRIAGLASG LDTGETPIAK 
       310        320        330        340        350
EIHHFIHLIT GVAVFLGVTF FVIAFILGYH WLDAVIFLIG IIVANVPEGL 
       360        370        380        390        400
LATVTVCLTL TAKRMASKNC LVKNLEAVET LGSTSTICSD KTGTLTQNRM 
       410        420        430        440        450
TVAHMWFDNQ IIEADTTEDQ SGVQYDRTSP GFKALSRIAT LCNRAEFKGG 
       460        470        480        490        500
QDGVPILKKE VSGDASEAAL LKCMELALGD VMNIRKRNKK IAEVPFNSTN 
       510        520        530        540        550
KYQVSIHETE DTNDPRYLLV MKGAPERILE RCSTIFINGK EKVLDEEMKE 
       560        570        580        590        600
AFNNAYMELG GLGERVLGFC DFMLPSDKYP NGFKFNTDDI NFPIDNLRFV 
       610        620        630        640        650
GLMSMIDPPR AAVPDAVAKC RSAGIKVIMV TGDHPITAKA IAKSVGIISE 
       660        670        680        690        700
GNETVEDIAQ RLNIPVSEVN PREAKAAVVH GAELRDVSSD QLDEILRYHT 
       710        720        730        740        750
EIVFARTSPQ QKLIIVEGCQ RMGAIVAVTG DGVNDSPALK KADIGVAMGI 
       760        770        780        790        800
AGSDVSKQAA DMILLDDNFA SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE 
       810        820        830        840        850
ISPFLAFILC DIPLPLGTVT ILCIDLGTDM VPAISLAYEH AEADIMKRPP 
       860        870        880        890        900
RDPFNDKLVN SRLISMAYGQ IGMIQAAAGF FVYFVIMAEN GFLPKKLFGI 
       910        920        930        940        950
RKMWDSKAVN DLTDSYGQEW TYRDRKTLEY TCHTAFFISI VVVQWADLII 
       960        970        980        990       1000
CKTRRNSIFQ QGMRNWALNF GLVFETVLAA FLSYCPGMEK GLRMYPLKLV 
      1010       1020       1030 
WWFPAIPFAL AIFIYDETRR FYLRRNPGGW LEQETYY

Show »

Length:1,037

Mass (Da):115,056

Checksum:ⁱ62722EDBA74BBC88

GO

Isoform 5 (identifier: P13607-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
835-865: VPAISLAYEHAEADIMKRPPRDPFNDKLVNS → IPAISLAYEGPEADIMKRRPRNPEIDNLVNE

« Hide

        10         20         30         40         50
MALRSDYEHG RADSYRVATV IATDDDNRTA DGQYKSRRKM PAKVNKKENL 
        60         70         80         90        100
DDLKQELDID FHKISPEELY QRFQTHPENG LSHAKAKENL ERDGPNALTP 
       110        120        130        140        150
PKQTPEWVKF CKNLFGGFAM LLWIGAILCF VAYSIQASTS EEPADDNLYL 
       160        170        180        190        200
GIVLSAVVIV TGIFSYYQES KSSKIMESFK NMVPQFATVI REGEKLTLRA 
       210        220        230        240        250
EDLVLGDVVE VKFGDRIPAD IRIIEARNFK VDNSSLTGES EPQSRGAEFT 
       260        270        280        290        300
HENPLETKNL AFFSTNAVEG TAKGVVISCG DHTVMGRIAG LASGLDTGET 
       310        320        330        340        350
PIAKEIHHFI HLITGVAVFL GVTFFVIAFI LGYHWLDAVI FLIGIIVANV 
       360        370        380        390        400
PEGLLATVTV CLTLTAKRMA SKNCLVKNLE AVETLGSTST ICSDKTGTLT 
       410        420        430        440        450
QNRMTVAHMW FDNQIIEADT TEDQSGVQYD RTSPGFKALS RIATLCNRAE 
       460        470        480        490        500
FKGGQDGVPI LKKEVSGDAS EAALLKCMEL ALGDVMNIRK RNKKIAEVPF 
       510        520        530        540        550
NSTNKYQVSI HETEDTNDPR YLLVMKGAPE RILERCSTIF INGKEKVLDE 
       560        570        580        590        600
EMKEAFNNAY MELGGLGERV LGFCDFMLPS DKYPNGFKFN TDDINFPIDN 
       610        620        630        640        650
LRFVGLMSMI DPPRAAVPDA VAKCRSAGIK VIMVTGDHPI TAKAIAKSVG 
       660        670        680        690        700
IISEGNETVE DIAQRLNIPV SEVNPREAKA AVVHGAELRD VSSDQLDEIL 
       710        720        730        740        750
RYHTEIVFAR TSPQQKLIIV EGCQRMGAIV AVTGDGVNDS PALKKADIGV 
       760        770        780        790        800
AMGIAGSDVS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS 
       810        820        830        840        850
NIPEISPFLA FILCDIPLPL GTVTILCIDL GTDMIPAISL AYEGPEADIM 
       860        870        880        890        900
KRRPRNPEID NLVNERLISM AYGQIGMIQA AAGFFVYFVI MAENGFLPKK 
       910        920        930        940        950
LFGIRKMWDS KAVNDLTDSY GQEWTYRDRK TLEYTCHTAF FISIVVVQWA 
       960        970        980        990       1000
DLIICKTRRN SIFQQGMRNW ALNFGLVFET VLAAFLSYCP GMEKGLRMYP 
      1010       1020       1030       1040 
LKLVWWFPAI PFALAIFIYD ETRRFYLRRN PGGWLEQETY Y

Show »

Length:1,041

Mass (Da):115,632

Checksum:ⁱD6084967A87F4FAD

GO

Isoform 6 (identifier: P13607-6) [UniParc]FASTA Add to basket

Also known as: F, H

The sequence of this isoform differs from the canonical sequence as follows:
1-39: Missing.
844-865: HAEADIMKRPPRDPFNDKLVNS → TAESDIMKRQPRNPFQDKLVNE

« Hide

        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMVPAIS 
       810        820        830        840        850
LAYETAESDI MKRQPRNPFQ DKLVNERLIS MAYGQIGMIQ AAAGFFVYFV 
       860        870        880        890        900
IMAENGFLPK KLFGIRKMWD SKAVNDLTDS YGQEWTYRDR KTLEYTCHTA 
       910        920        930        940        950
FFISIVVVQW ADLIICKTRR NSIFQQGMRN WALNFGLVFE TVLAAFLSYC 
       960        970        980        990       1000
PGMEKGLRMY PLKLVWWFPA IPFALAIFIY DETRRFYLRR NPGGWLEQET 

YY

Show »

Length:1,002

Mass (Da):111,199

Checksum:ⁱ4146F52C60C4114A

GO

Isoform 7 (identifier: P13607-7) [UniParc]FASTA Add to basket

Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
1-39: Missing.
835-865: VPAISLAYEHAEADIMKRPPRDPFNDKLVNS → IPAISLAYEQAESDIMKRQPRDPYRDNLVNR

« Hide

        10         20         30         40         50
MPAKVNKKEN LDDLKQELDI DFHKISPEEL YQRFQTHPEN GLSHAKAKEN 
        60         70         80         90        100
LERDGPNALT PPKQTPEWVK FCKNLFGGFA MLLWIGAILC FVAYSIQAST 
       110        120        130        140        150
SEEPADDNLY LGIVLSAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV 
       160        170        180        190        200
IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARNF KVDNSSLTGE 
       210        220        230        240        250
SEPQSRGAEF THENPLETKN LAFFSTNAVE GTAKGVVISC GDHTVMGRIA 
       260        270        280        290        300
GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFVIAF ILGYHWLDAV 
       310        320        330        340        350
IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS 
       360        370        380        390        400
TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL 
       410        420        430        440        450
SRIATLCNRA EFKGGQDGVP ILKKEVSGDA SEAALLKCME LALGDVMNIR 
       460        470        480        490        500
KRNKKIAEVP FNSTNKYQVS IHETEDTNDP RYLLVMKGAP ERILERCSTI 
       510        520        530        540        550
FINGKEKVLD EEMKEAFNNA YMELGGLGER VLGFCDFMLP SDKYPNGFKF 
       560        570        580        590        600
NTDDINFPID NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP 
       610        620        630        640        650
ITAKAIAKSV GIISEGNETV EDIAQRLNIP VSEVNPREAK AAVVHGAELR 
       660        670        680        690        700
DVSSDQLDEI LRYHTEIVFA RTSPQQKLII VEGCQRMGAI VAVTGDGVND 
       710        720        730        740        750
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 
       760        770        780        790        800
LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMIPAIS 
       810        820        830        840        850
LAYEQAESDI MKRQPRDPYR DNLVNRRLIS MAYGQIGMIQ AAAGFFVYFV 
       860        870        880        890        900
IMAENGFLPK KLFGIRKMWD SKAVNDLTDS YGQEWTYRDR KTLEYTCHTA 
       910        920        930        940        950
FFISIVVVQW ADLIICKTRR NSIFQQGMRN WALNFGLVFE TVLAAFLSYC 
       960        970        980        990       1000
PGMEKGLRMY PLKLVWWFPA IPFALAIFIY DETRRFYLRR NPGGWLEQET 

YY

Show »

Length:1,002

Mass (Da):111,298

Checksum:ⁱ9762610EA4A85D45

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E1JIR4	E1JIR4_DROME	Sodium/potassium-transporting ATPas... Sodium/potassium-transporting ATPase subunit alpha	Atpalpha (Na[+], alpha-ATPase, Atp, Atp a, ATP-alpha	1,002	Annotation score:
A0A0B4KGG8	A0A0B4KGG8_DROME	Sodium/potassium-transporting ATPas... Sodium/potassium-transporting ATPase subunit alpha	Atpalpha (Na[+], alpha-ATPase, Atp, Atp a, ATP-alpha	1,002	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	69	L → M in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	85	K → R in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	97	Missing in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	112 – 113	KN → ED in CAA32638 (PubMed:2540956).Curated	2
Sequence conflictⁱ	117 – 118	GF → V in CAA32638 (PubMed:2540956).Curated	2
Sequence conflictⁱ	163	I → V in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	192	E → G in AAC05260 (PubMed:9648860).Curated	1
Sequence conflictⁱ	196 – 197	LT → PS in CAA32638 (PubMed:2540956).Curated	2
Sequence conflictⁱ	207 – 208	DV → VL in CAA32638 (PubMed:2540956).Curated	2
Sequence conflictⁱ	211 – 212	VK → LE in CAA32638 (PubMed:2540956).Curated	2
Sequence conflictⁱ	216 – 221	RIPADI → LIPLVY in CAA32638 (PubMed:2540956).Curated	6
Sequence conflictⁱ	228	N → D in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	270 – 272	GTA → ALP in CAA32638 (PubMed:2540956).Curated	3
Sequence conflictⁱ	290	G → A in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	299	Missing in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	402	N → T in CAA35504 (PubMed:2557235).Curated	1
Sequence conflictⁱ	488	I → N in CAA35504 (PubMed:2557235).Curated	1
Sequence conflictⁱ	811	F → S in CAA32638 (PubMed:2540956).Curated	1
Sequence conflictⁱ	843	E → D in CAA32638 (PubMed:2540956).Curated	1

RNA editingⁱ

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	429	Y → C in RNA edited version.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000417	1 – 39	Missing in isoform 2, isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST	39
Alternative sequenceⁱVSP_008074	1 – 8	MALRSDYE → MSAQ in isoform 4. Curated	8
Alternative sequenceⁱVSP_008075	835 – 865	VPAIS…KLVNS → IPAISLAYEGPEADIMKRRP RNPEIDNLVNE in isoform 5. CuratedAdd BLAST	31
Alternative sequenceⁱVSP_008076	835 – 865	VPAIS…KLVNS → IPAISLAYEQAESDIMKRQP RDPYRDNLVNR in isoform 7. CuratedAdd BLAST	31
Alternative sequenceⁱVSP_008077	836 – 878	PAISL…QIGMI → SLDLCPKPKLHRRLKLKLLL SQYHSSKLYSYTSCSPSQLI VKN in isoform 3. 1 PublicationAdd BLAST	43
Alternative sequenceⁱVSP_000418	844 – 865	HAEAD…KLVNS → TAESDIMKRQPRNPFQDKLV NE in isoform 6. CuratedAdd BLAST	22
Alternative sequenceⁱVSP_008078	879 – 1041	Missing in isoform 3. 1 PublicationAdd BLAST	163

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14476 mRNA Translation: CAA32638.1 AF044974 mRNA Translation: AAC05260.1 AE014297 Genomic DNA Translation: AAF55825.3 AE014297 Genomic DNA Translation: AAF55826.2 AE014297 Genomic DNA Translation: AAF55828.1 AE014297 Genomic DNA Translation: AAS65183.1 AE014297 Genomic DNA Translation: AAS65184.1 AE014297 Genomic DNA Translation: AAS65185.1 AE014297 Genomic DNA Translation: AAS65186.1 AY069184 mRNA Translation: AAL39329.1 AY174097 Genomic DNA Translation: AAO33930.1 AY174097 Genomic DNA Translation: AAO33931.1 AY174097 Genomic DNA Translation: AAO33932.1 AY174097 Genomic DNA Translation: AAO33933.1 AY174098 Genomic DNA Translation: AAO33929.1 U55767 Genomic DNA Translation: AAB01189.1 X17471 mRNA Translation: CAA35504.1
PIRⁱ	S03632
NCBI Reference Sequences More...RefSeqⁱ	NP_001262790.1, NM_001275861.1 [P13607-2] NP_001262791.1, NM_001275862.2 [P13607-2] NP_732572.1, NM_169936.3 [P13607-1] NP_732573.1, NM_169937.3 [P13607-2] NP_732574.1, NM_169938.3 [P13607-2] NP_732575.1, NM_169939.2 [P13607-3] NP_996247.1, NM_206525.3 [P13607-6] NP_996248.1, NM_206526.3 [P13607-7] NP_996249.1, NM_206527.3 [P13607-6] NP_996250.1, NM_206528.3 [P13607-2]

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0089509; FBpp0088501; FBgn0002921 [P13607-2] FBtr0089510; FBpp0088502; FBgn0002921 [P13607-1] FBtr0089511; FBpp0088503; FBgn0002921 [P13607-2] FBtr0089512; FBpp0088504; FBgn0002921 [P13607-3] FBtr0089513; FBpp0088984; FBgn0002921 [P13607-2] FBtr0089514; FBpp0088983; FBgn0002921 [P13607-6] FBtr0089515; FBpp0088982; FBgn0002921 [P13607-7] FBtr0089516; FBpp0088981; FBgn0002921 [P13607-6] FBtr0333324; FBpp0305516; FBgn0002921 [P13607-2] FBtr0333325; FBpp0305517; FBgn0002921 [P13607-2]
GeneIDⁱ	48971
KEGGⁱ	dme:Dmel_CG5670
UCSC genome browser More...UCSCⁱ	CG5670-RE, d. melanogaster CG5670-RH, d. melanogaster

Keywords - Coding sequence diversityⁱ

Alternative splicing, RNA editing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13607	Sodium/potassium-transporting ATPase subunit alpha		DROME		1041	UniRef100_P13607
Sodium/potassium-transporting ATPase subunit alpha		DROME		1002
Isoform 2 of Sodium/potassium-transporting ATPase subunit alpha		DROME		1002
P13607-3	Sodium/potassium-transporting ATPase subunit alpha		DROME		839	UniRef100_B5RIT8
P13607-5	Sodium/potassium-transporting ATPase subunit alpha		DROME		1002	UniRef100_E1JIR4

Protein	Similar proteins		Species	Score	Length	Source
P13607	Sodium/potassium-transporting ATPase subunit alpha		DROME		1041	UniRef90_P13607
CSON012052 protein		CULSO		1276
Sodium/potassium-transporting ATPase subunit alpha		Anopheles atroparvus		1045
Sodium/potassium-transporting ATPase subunit alpha		DROGR		1042
Sodium/potassium-transporting ATPase subunit alpha		DROBP		1041
+159
P13607-3	Sodium/potassium-transporting ATPase subunit alpha		Glossina brevipalpis		847	UniRef90_A0A1A9WFR7
Sodium/potassium-transporting ATPase subunit alpha		AEDAL		1046
Sodium potassium ATPase (Fragment)		AEDAE		107
Sodium/potassium-transporting ATPase subunit alpha		DROME		839
Sodium/potassium channel (Fragment)		AEDAE		60
+1
P13607-5	Isoform 7 of Sodium/potassium-transporting ATPase subunit alpha		DROME		1002	UniRef90_P13607-7
Sodium/potassium-transporting ATPase subunit alpha		LUCCU		1093
Na+/K+ ATPase alpha subunit (Fragment)		LUCSE		144
Sodium-potassium adenosine triposphatase (Fragment)		Temnostoma vespiforme		146
Sodium/potassium-transporting ATPase subunit alpha (Fragment)		Lucilia bufonivora		717
+165

Protein	Similar proteins		Species	Score	Length	Source
P13607	Sodium/potassium-transporting ATPase subunit alpha		DROME		1041	UniRef50_P13607
CSON012052 protein		CULSO		1276
Sodium/potassium-transporting ATPase subunit alpha		Anopheles atroparvus		1045
Sodium/potassium-transporting ATPase subunit alpha		DROGR		1042
Sodium/potassium-transporting ATPase subunit alpha		DRORH		1041
+455
P13607-3	Sodium/potassium-transporting ATPase subunit alpha		HORSE		1045	UniRef50_A0A3Q2KVK7
Uncharacterized protein		DICBM		1134
Sodium/potassium-transporting ATPase subunit alpha		URSAM		1041
Sodium/potassium-transporting ATPase subunit alpha		CASCN		1020
Sodium/potassium-transporting ATPase subunit alpha		PHACI		928
+127
P13607-5	Isoform 7 of Sodium/potassium-transporting ATPase subunit alpha		DROME		1002	UniRef50_P13607-7
Potassium-transporting ATPase alpha chain 2		CAVPO		1033
Potassium-transporting ATPase alpha chain 2		RABIT		1094
Potassium-transporting ATPase alpha chain 1		MOUSE		1033
Potassium-transporting ATPase alpha chain 1		RAT		1033
+1031

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14476 mRNA Translation: CAA32638.1 AF044974 mRNA Translation: AAC05260.1 AE014297 Genomic DNA Translation: AAF55825.3 AE014297 Genomic DNA Translation: AAF55826.2 AE014297 Genomic DNA Translation: AAF55828.1 AE014297 Genomic DNA Translation: AAS65183.1 AE014297 Genomic DNA Translation: AAS65184.1 AE014297 Genomic DNA Translation: AAS65185.1 AE014297 Genomic DNA Translation: AAS65186.1 AY069184 mRNA Translation: AAL39329.1 AY174097 Genomic DNA Translation: AAO33930.1 AY174097 Genomic DNA Translation: AAO33931.1 AY174097 Genomic DNA Translation: AAO33932.1 AY174097 Genomic DNA Translation: AAO33933.1 AY174098 Genomic DNA Translation: AAO33929.1 U55767 Genomic DNA Translation: AAB01189.1 X17471 mRNA Translation: CAA35504.1
PIRⁱ	S03632
RefSeqⁱ	NP_001262790.1, NM_001275861.1 [P13607-2] NP_001262791.1, NM_001275862.2 [P13607-2] NP_732572.1, NM_169936.3 [P13607-1] NP_732573.1, NM_169937.3 [P13607-2] NP_732574.1, NM_169938.3 [P13607-2] NP_732575.1, NM_169939.2 [P13607-3] NP_996247.1, NM_206525.3 [P13607-6] NP_996248.1, NM_206526.3 [P13607-7] NP_996249.1, NM_206527.3 [P13607-6] NP_996250.1, NM_206528.3 [P13607-2]

3D structure databases

SMRⁱ	P13607
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	71866, 59 interactors
DIPⁱ	DIP-19649N
IntActⁱ	P13607, 36 interactors
STRINGⁱ	7227.FBpp0088502

Proteomic databases

PaxDbⁱ	P13607
PRIDEⁱ	P13607

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0089509; FBpp0088501; FBgn0002921 [P13607-2] FBtr0089510; FBpp0088502; FBgn0002921 [P13607-1] FBtr0089511; FBpp0088503; FBgn0002921 [P13607-2] FBtr0089512; FBpp0088504; FBgn0002921 [P13607-3] FBtr0089513; FBpp0088984; FBgn0002921 [P13607-2] FBtr0089514; FBpp0088983; FBgn0002921 [P13607-6] FBtr0089515; FBpp0088982; FBgn0002921 [P13607-7] FBtr0089516; FBpp0088981; FBgn0002921 [P13607-6] FBtr0333324; FBpp0305516; FBgn0002921 [P13607-2] FBtr0333325; FBpp0305517; FBgn0002921 [P13607-2]
GeneIDⁱ	48971
KEGGⁱ	dme:Dmel_CG5670
UCSCⁱ	CG5670-RE, d. melanogaster CG5670-RH, d. melanogaster

Organism-specific databases

CTDⁱ	48971
FlyBaseⁱ	FBgn0002921, Atpalpha

Phylogenomic databases

eggNOGⁱ	KOG0203, Eukaryota
InParanoidⁱ	P13607
OMAⁱ	CFTDCAA
PhylomeDBⁱ	P13607

Enzyme and pathway databases

Reactomeⁱ	R-DME-936837, Ion transport by P-type ATPases

Reactomeⁱ

R-DME-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID-ORCSⁱ	48971, 1 hit in 3 CRISPR screens
ChiTaRSⁱ	Atpalpha, fly
GenomeRNAiⁱ	48971
Protein Ontology More...PROⁱ	PR:P13607

Gene expression databases

Bgeeⁱ	FBgn0002921, Expressed in adult Malpighian tubule (Drosophila) and 37 other tissues
ExpressionAtlasⁱ	P13607, baseline and differential
Genevisibleⁱ	P13607, DM

Family and domain databases

CDDⁱ	cd02608, P-type_ATPase_Na-K_like, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom
Pfamⁱ	View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit
SFLDⁱ	SFLDF00027, p-type_atpase, 1 hit
SMARTⁱ	View protein in SMART SM00831, Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATNA_DROME
Accessionⁱ	P13607Primary (citable) accession number: P13607 Secondary accession number(s): A4V366 Q9VDG8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	June 20, 2001
	Last modified:	April 7, 2021
	This is version 211 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

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UniProtKB - P13607 (ATNA_DROME)

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Sodium/potassium-transporting ATPase subunit alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ