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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Trifolium repens (Creeping white clover)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi50Zinc 1By similarity1
Binding sitei50NADBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi178Zinc 1; catalyticBy similarity1
Binding sitei227NADBy similarity1
Binding sitei232NADBy similarity1
Binding sitei273NAD; via carbonyl oxygenBy similarity1
Binding sitei296NAD; via carbonyl oxygenBy similarity1
Binding sitei373NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 208NADBy similarity6
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH1
OrganismiTrifolium repens (Creeping white clover)
Taxonomic identifieri3899 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeHologaleginaIRL cladeTrifolieaeTrifolium

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607151 – 380Alcohol dehydrogenase 1Add BLAST380

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP13603
SMRiP13603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P13603-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNTAGQVIK CRAAVAWEAG KPLVIEEVEV APPQAGEVRL KILFTSLCHT
60 70 80 90 100
DVYFWEAKGQ TPLFPRIFGH EAGGIVESVG EGVTHLKPGD HALPVFTGEC
110 120 130 140 150
GECPHCKSEE SNMCNLLRIN TDRGVMINDN KSRFSIKGQP VHHFVGTSTF
160 170 180 190 200
SEYTVVHAGC VAKINPDAPL DKVCILSCGI CTGLGATVNV AKPKPGSSVA
210 220 230 240 250
IFGLGAVGLA AAEGARMSGA SRIIGVDLVS SRFELAKKFG VNEFVNPKDH
260 270 280 290 300
DKPVQQVIAE MTDGGVDRAV ECTGSIQAMI SAFECVHDGW GVAVLVGVPK
310 320 330 340 350
KDDAFKTHPM NFLNERTLKG TFYGNYKPRT DLPNVVEQYM KGELELEKFI
360 370 380
THSIPFSEIN KAFDYMLKGE SIRCIIRMEE
Length:380
Mass (Da):41,172
Last modified:January 1, 1990 - v1
Checksum:i6C6E805FC3ABA663
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14826 mRNA Translation: CAA32934.1
PIRiS14680 DEJYAW

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14826 mRNA Translation: CAA32934.1
PIRiS14680 DEJYAW

3D structure databases

ProteinModelPortaliP13603
SMRiP13603
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_TRIRP
AccessioniPrimary (citable) accession number: P13603
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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