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UniProtKB - P13598 (ICAM2_HUMAN)

Entry version 206 (07 Apr 2021)
Sequence version 2 (03 Oct 2006)
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Protein

Intercellular adhesion molecule 2

Gene

ICAM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13598

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083, Integrin cell surface interactions
R-HSA-5621575, CD209 (DC-SIGN) signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P13598

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intercellular adhesion molecule 2
Short name:
ICAM-2
Alternative name(s):
CD_antigen: CD102
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ICAM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5345, ICAM2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		146630, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13598

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108622.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 223ExtracellularSequence analysisAdd BLAST199
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei224 – 248HelicalSequence analysisAdd BLAST25
Topological domaini249 – 275CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3384

Open Targets

More...OpenTargetsi		ENSG00000108622

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29593

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13598, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ICAM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		115502404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001479025 – 275Intercellular adhesion molecule 2Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineCombined sources1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 91Combined sources1 Publication
Disulfide bondi52 ↔ 95Combined sources1 Publication
Glycosylationi82N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi105N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Disulfide bondi134 ↔ 190Combined sources1 Publication
Glycosylationi153N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi176N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi187N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-677

Encyclopedia of Proteome Dynamics

More...EPDi		P13598

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13598

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13598

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13598

PeptideAtlas

More...PeptideAtlasi		P13598

PRoteomics IDEntifications database

More...PRIDEi		P13598

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52937

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		682, 18 N-Linked glycans (6 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13598, 8 sites, 3 N-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13598

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13598

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13598

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108622, Expressed in blood and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13598, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13598, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108622, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RDX, EZR and MSN.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109611, 19 interactors

Protein interaction database and analysis system

More...IntActi		P13598, 14 interactors

Molecular INTeraction database

More...MINTi		P13598

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000415283

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13598, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13598

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P13598

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 98Ig-like C2-type 1Add BLAST58
Domaini127 – 197Ig-like C2-type 2Add BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 275Required for interaction with EZR, MSN and RDX and co-localization to microvilliBy similarityAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RZRA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_088446_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13598

Identification of Orthologs from Complete Genome Data

More...OMAi		QVYEPVQ

Database of Orthologous Groups

More...OrthoDBi		731140at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13598

TreeFam database of animal gene trees

More...TreeFami		TF333745

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003988, ICAM
IPR015653, ICAM2
IPR013768, ICAM_N
IPR003987, ICAM_VCAM_N
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold

The PANTHER Classification System

More...PANTHERi		PTHR13771:SF3, PTHR13771:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03921, ICAM_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01473, ICAM
PR01472, ICAMVCAM1

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P13598-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST 
        60         70         80         90        100
TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE 
       110        120        130        140        150
SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF 
       160        170        180        190        200
RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG 
       210        220        230        240        250
GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ 
       260        270 
HLRQQRMGTY GVRAAWRRLP QAFRP
Length:275
Mass (Da):30,654
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC54FB34D92A6FC38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRT5J3QRT5_HUMAN
Intercellular adhesion molecule 2
ICAM2
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQR8J3QQR8_HUMAN
Intercellular adhesion molecule 2
ICAM2
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQX6J3QQX6_HUMAN
Intercellular adhesion molecule 2
ICAM2
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRQ1J3QRQ1_HUMAN
Intercellular adhesion molecule 2
ICAM2
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKR4J3QKR4_HUMAN
Intercellular adhesion molecule 2
ICAM2
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSR9J3KSR9_HUMAN
Intercellular adhesion molecule 2
ICAM2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65D → N (PubMed:2497351).Curated1
Sequence conflicti65D → N (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01465537A → T. Corresponds to variant dbSNP:rs5503Ensembl.1
Natural variantiVAR_014656199R → H. Corresponds to variant dbSNP:rs5504Ensembl.1
Natural variantiVAR_021920256R → Q. Corresponds to variant dbSNP:rs3764867Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X15606 mRNA Translation: CAA33630.1
M32334 M32333 Genomic DNA Translation: AAA36035.1
BC003097 mRNA Translation: AAH03097.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11657.1

Protein sequence database of the Protein Information Resource

More...PIRi		S03967

NCBI Reference Sequences

More...RefSeqi		NP_000864.2, NM_000873.3
NP_001093256.1, NM_001099786.1
NP_001093257.1, NM_001099787.1
NP_001093258.1, NM_001099788.1
NP_001093259.1, NM_001099789.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000412356; ENSP00000415283; ENSG00000108622
ENST00000418105; ENSP00000388666; ENSG00000108622
ENST00000449662; ENSP00000392634; ENSG00000108622
ENST00000579687; ENSP00000462579; ENSG00000108622
ENST00000579788; ENSP00000464665; ENSG00000108622

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3384

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3384

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

ICAM-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15606 mRNA Translation: CAA33630.1
M32334 M32333 Genomic DNA Translation: AAA36035.1
BC003097 mRNA Translation: AAH03097.1
CCDSiCCDS11657.1
PIRiS03967
RefSeqiNP_000864.2, NM_000873.3
NP_001093256.1, NM_001099786.1
NP_001093257.1, NM_001099787.1
NP_001093258.1, NM_001099788.1
NP_001093259.1, NM_001099789.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZXQX-ray2.20A25-216[»]
SMRiP13598
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109611, 19 interactors
IntActiP13598, 14 interactors
MINTiP13598
STRINGi9606.ENSP00000415283

PTM databases

GlyConnecti682, 18 N-Linked glycans (6 sites)
GlyGeniP13598, 8 sites, 3 N-linked glycans (3 sites)
iPTMnetiP13598
PhosphoSitePlusiP13598
SwissPalmiP13598

Genetic variation databases

BioMutaiICAM2
DMDMi115502404

Proteomic databases

CPTACiCPTAC-677
EPDiP13598
jPOSTiP13598
MassIVEiP13598
PaxDbiP13598
PeptideAtlasiP13598
PRIDEiP13598
ProteomicsDBi52937

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		796, 910 antibodies

The DNASU plasmid repository

More...DNASUi		3384

Genome annotation databases

EnsembliENST00000412356; ENSP00000415283; ENSG00000108622
ENST00000418105; ENSP00000388666; ENSG00000108622
ENST00000449662; ENSP00000392634; ENSG00000108622
ENST00000579687; ENSP00000462579; ENSG00000108622
ENST00000579788; ENSP00000464665; ENSG00000108622
GeneIDi3384
KEGGihsa:3384

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3384
DisGeNETi3384

GeneCards: human genes, protein and diseases

More...GeneCardsi		ICAM2
HGNCiHGNC:5345, ICAM2
HPAiENSG00000108622, Tissue enhanced (blood, lymphoid tissue)
MIMi146630, gene
neXtProtiNX_P13598
OpenTargetsiENSG00000108622
PharmGKBiPA29593
VEuPathDBiHostDB:ENSG00000108622.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RZRA, Eukaryota
GeneTreeiENSGT00940000161654
HOGENOMiCLU_088446_0_0_1
InParanoidiP13598
OMAiQVYEPVQ
OrthoDBi731140at2759
PhylomeDBiP13598
TreeFamiTF333745

Enzyme and pathway databases

PathwayCommonsiP13598
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083, Integrin cell surface interactions
R-HSA-5621575, CD209 (DC-SIGN) signaling
SIGNORiP13598

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3384, 2 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ICAM2, human
EvolutionaryTraceiP13598

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ICAM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3384
PharosiP13598, Tbio

Protein Ontology

More...PROi		PR:P13598
RNActiP13598, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108622, Expressed in blood and 233 other tissues
ExpressionAtlasiP13598, baseline and differential
GenevisibleiP13598, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003988, ICAM
IPR015653, ICAM2
IPR013768, ICAM_N
IPR003987, ICAM_VCAM_N
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
PANTHERiPTHR13771:SF3, PTHR13771:SF3, 1 hit
PfamiView protein in Pfam
PF03921, ICAM_N, 1 hit
PRINTSiPR01473, ICAM
PR01472, ICAMVCAM1
SUPFAMiSSF48726, SSF48726, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICAM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13598
Secondary accession number(s): Q14600
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 3, 2006
Last modified: April 7, 2021
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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