UniProtKB - P13598 (ICAM2_HUMAN)
Protein
Intercellular adhesion molecule 2
Gene
ICAM2
Organism
Homo sapiens (Human)
Status
Functioni
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
GO - Molecular functioni
- integrin binding Source: BHF-UCL
GO - Biological processi
- cell adhesion Source: GO_Central
- cell-cell adhesion Source: InterPro
- extracellular matrix organization Source: Reactome
- regulation of immune response Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P13598 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083, Integrin cell surface interactions R-HSA-5621575, CD209 (DC-SIGN) signaling |
SIGNORi | P13598 |
Names & Taxonomyi
Protein namesi | Recommended name: Intercellular adhesion molecule 2Short name: ICAM-2 Alternative name(s): CD_antigen: CD102 |
Gene namesi | Name:ICAM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5345, ICAM2 |
MIMi | 146630, gene |
neXtProti | NX_P13598 |
VEuPathDBi | HostDB:ENSG00000108622.10 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Single-pass type I membrane protein Sequence analysis
- microvillus By similarity
Note: Co-localizes with RDX, EZR and MSN in microvilli.By similarity
Plasma Membrane
- cleavage furrow Source: HGNC
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- membrane Source: UniProtKB
- microvillus Source: UniProtKB
- uropod Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 223 | ExtracellularSequence analysisAdd BLAST | 199 | |
Transmembranei | 224 – 248 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 249 – 275 | CytoplasmicSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3384 |
OpenTargetsi | ENSG00000108622 |
PharmGKBi | PA29593 |
Miscellaneous databases
Pharosi | P13598, Tbio |
Genetic variation databases
BioMutai | ICAM2 |
DMDMi | 115502404 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000014790 | 25 – 275 | Intercellular adhesion molecule 2Add BLAST | 251 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 47 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 48 ↔ 91 | Combined sources1 Publication | ||
Disulfide bondi | 52 ↔ 95 | Combined sources1 Publication | ||
Glycosylationi | 82 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Glycosylationi | 105 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Disulfide bondi | 134 ↔ 190 | Combined sources1 Publication | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | CPTAC-677 |
EPDi | P13598 |
jPOSTi | P13598 |
MassIVEi | P13598 |
PaxDbi | P13598 |
PeptideAtlasi | P13598 |
PRIDEi | P13598 |
ProteomicsDBi | 52937 |
PTM databases
GlyConnecti | 682, 18 N-Linked glycans (6 sites) |
GlyGeni | P13598, 8 sites, 3 N-linked glycans (3 sites) |
iPTMneti | P13598 |
PhosphoSitePlusi | P13598 |
SwissPalmi | P13598 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108622, Expressed in blood and 233 other tissues |
ExpressionAtlasi | P13598, baseline and differential |
Genevisiblei | P13598, HS |
Organism-specific databases
HPAi | ENSG00000108622, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with RDX, EZR and MSN.
By similarityGO - Molecular functioni
- integrin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109611, 18 interactors |
IntActi | P13598, 14 interactors |
MINTi | P13598 |
STRINGi | 9606.ENSP00000415283 |
Miscellaneous databases
RNActi | P13598, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P13598 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P13598 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 98 | Ig-like C2-type 1Add BLAST | 58 | |
Domaini | 127 – 197 | Ig-like C2-type 2Add BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 251 – 275 | Required for interaction with EZR, MSN and RDX and co-localization to microvilliBy similarityAdd BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZRA, Eukaryota |
GeneTreei | ENSGT00940000161654 |
HOGENOMi | CLU_088446_0_0_1 |
InParanoidi | P13598 |
OMAi | QVYEPVQ |
OrthoDBi | 731140at2759 |
PhylomeDBi | P13598 |
TreeFami | TF333745 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003988, ICAM IPR015653, ICAM2 IPR013768, ICAM_N IPR003987, ICAM_VCAM_N IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
PANTHERi | PTHR13771:SF3, PTHR13771:SF3, 1 hit |
Pfami | View protein in Pfam PF03921, ICAM_N, 1 hit |
PRINTSi | PR01473, ICAM PR01472, ICAMVCAM1 |
SUPFAMi | SSF48726, SSF48726, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P13598-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST
60 70 80 90 100
TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE
110 120 130 140 150
SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF
160 170 180 190 200
RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG
210 220 230 240 250
GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ
260 270
HLRQQRMGTY GVRAAWRRLP QAFRP
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QRT5 | J3QRT5_HUMAN | Intercellular adhesion molecule 2 | ICAM2 | 251 | Annotation score: | ||
J3QQR8 | J3QQR8_HUMAN | Intercellular adhesion molecule 2 | ICAM2 | 166 | Annotation score: | ||
J3QQX6 | J3QQX6_HUMAN | Intercellular adhesion molecule 2 | ICAM2 | 214 | Annotation score: | ||
J3QRQ1 | J3QRQ1_HUMAN | Intercellular adhesion molecule 2 | ICAM2 | 216 | Annotation score: | ||
J3QKR4 | J3QKR4_HUMAN | Intercellular adhesion molecule 2 | ICAM2 | 174 | Annotation score: | ||
J3KSR9 | J3KSR9_HUMAN | Intercellular adhesion molecule 2 | ICAM2 | 53 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | D → N (PubMed:2497351).Curated | 1 | |
Sequence conflicti | 65 | D → N (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014655 | 37 | A → T. Corresponds to variant dbSNP:rs5503Ensembl. | 1 | |
Natural variantiVAR_014656 | 199 | R → H. Corresponds to variant dbSNP:rs5504Ensembl. | 1 | |
Natural variantiVAR_021920 | 256 | R → Q. Corresponds to variant dbSNP:rs3764867Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15606 mRNA Translation: CAA33630.1 M32334 , M32331, M32332, M32333 Genomic DNA Translation: AAA36035.1 BC003097 mRNA Translation: AAH03097.1 |
CCDSi | CCDS11657.1 |
PIRi | S03967 |
RefSeqi | NP_000864.2, NM_000873.3 NP_001093256.1, NM_001099786.1 NP_001093257.1, NM_001099787.1 NP_001093258.1, NM_001099788.1 NP_001093259.1, NM_001099789.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding ICAM-2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15606 mRNA Translation: CAA33630.1 M32334 , M32331, M32332, M32333 Genomic DNA Translation: AAA36035.1 BC003097 mRNA Translation: AAH03097.1 |
CCDSi | CCDS11657.1 |
PIRi | S03967 |
RefSeqi | NP_000864.2, NM_000873.3 NP_001093256.1, NM_001099786.1 NP_001093257.1, NM_001099787.1 NP_001093258.1, NM_001099788.1 NP_001093259.1, NM_001099789.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZXQ | X-ray | 2.20 | A | 25-216 | [»] | |
SMRi | P13598 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109611, 18 interactors |
IntActi | P13598, 14 interactors |
MINTi | P13598 |
STRINGi | 9606.ENSP00000415283 |
PTM databases
GlyConnecti | 682, 18 N-Linked glycans (6 sites) |
GlyGeni | P13598, 8 sites, 3 N-linked glycans (3 sites) |
iPTMneti | P13598 |
PhosphoSitePlusi | P13598 |
SwissPalmi | P13598 |
Genetic variation databases
BioMutai | ICAM2 |
DMDMi | 115502404 |
Proteomic databases
CPTACi | CPTAC-677 |
EPDi | P13598 |
jPOSTi | P13598 |
MassIVEi | P13598 |
PaxDbi | P13598 |
PeptideAtlasi | P13598 |
PRIDEi | P13598 |
ProteomicsDBi | 52937 |
Protocols and materials databases
Antibodypediai | 796, 899 antibodies |
DNASUi | 3384 |
Genome annotation databases
Organism-specific databases
CTDi | 3384 |
DisGeNETi | 3384 |
GeneCardsi | ICAM2 |
HGNCi | HGNC:5345, ICAM2 |
HPAi | ENSG00000108622, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 146630, gene |
neXtProti | NX_P13598 |
OpenTargetsi | ENSG00000108622 |
PharmGKBi | PA29593 |
VEuPathDBi | HostDB:ENSG00000108622.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZRA, Eukaryota |
GeneTreei | ENSGT00940000161654 |
HOGENOMi | CLU_088446_0_0_1 |
InParanoidi | P13598 |
OMAi | QVYEPVQ |
OrthoDBi | 731140at2759 |
PhylomeDBi | P13598 |
TreeFami | TF333745 |
Enzyme and pathway databases
PathwayCommonsi | P13598 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083, Integrin cell surface interactions R-HSA-5621575, CD209 (DC-SIGN) signaling |
SIGNORi | P13598 |
Miscellaneous databases
BioGRID-ORCSi | 3384, 2 hits in 874 CRISPR screens |
ChiTaRSi | ICAM2, human |
EvolutionaryTracei | P13598 |
GeneWikii | ICAM2 |
GenomeRNAii | 3384 |
Pharosi | P13598, Tbio |
PROi | PR:P13598 |
RNActi | P13598, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108622, Expressed in blood and 233 other tissues |
ExpressionAtlasi | P13598, baseline and differential |
Genevisiblei | P13598, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003988, ICAM IPR015653, ICAM2 IPR013768, ICAM_N IPR003987, ICAM_VCAM_N IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
PANTHERi | PTHR13771:SF3, PTHR13771:SF3, 1 hit |
Pfami | View protein in Pfam PF03921, ICAM_N, 1 hit |
PRINTSi | PR01473, ICAM PR01472, ICAMVCAM1 |
SUPFAMi | SSF48726, SSF48726, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ICAM2_HUMAN | |
Accessioni | P13598Primary (citable) accession number: P13598 Secondary accession number(s): Q14600 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 10, 2021 | |
This is version 205 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries