ICAM2

Functionⁱ

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

GO - Molecular functionⁱ

integrin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1448173

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: GO_Central
cell-cell adhesion Source: InterPro
extracellular matrix organization Source: Reactome
regulation of immune response Source: Reactome
stimulatory C-type lectin receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083 Integrin cell surface interactions R-HSA-5621575 CD209 (DC-SIGN) signaling
SIGNORⁱ	P13598

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Intercellular adhesion molecule 2 Short name: ICAM-2 Alternative name(s): CD_antigen: CD102
Gene namesⁱ	Name:ICAM2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108622.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5345 ICAM2
MIMⁱ	146630 gene
neXtProtⁱ	NX_P13598

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 223	ExtracellularSequence analysisAdd BLAST	199
Transmembraneⁱ	224 – 248	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	249 – 275	CytoplasmicSequence analysisAdd BLAST	27

Keywords - Cellular componentⁱ

Cell projection, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3384
Open Targets More...OpenTargetsⁱ	ENSG00000108622
PharmGKBⁱ	PA29593

Polymorphism and mutation databases

BioMutaⁱ	ICAM2
DMDMⁱ	115502404

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	1 PublicationAdd BLAST		24
ChainⁱPRO_0000014790	25 – 275	Intercellular adhesion molecule 2Add BLAST		251

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	48 ↔ 91	Combined sources1 Publication
Disulfide bondⁱ	52 ↔ 95	Combined sources1 Publication
Glycosylationⁱ	82	N-linked (GlcNAc...) asparagineCombined sources2 Publications	1
Glycosylationⁱ	105	N-linked (GlcNAc...) asparagineCombined sources3 Publications	1
Disulfide bondⁱ	134 ↔ 190	Combined sources1 Publication
Glycosylationⁱ	153	N-linked (GlcNAc...) asparagineCombined sources2 Publications	1
Glycosylationⁱ	176	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	187	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P13598
PaxDbⁱ	P13598
PeptideAtlas More...PeptideAtlasⁱ	P13598
PRIDEⁱ	P13598
ProteomicsDBⁱ	52937

PTM databases

GlyConnectⁱ	682
iPTMnetⁱ	P13598
PhosphoSitePlusⁱ	P13598
SwissPalmⁱ	P13598
UniCarbKBⁱ	P13598

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108622
CleanExⁱ	HS_ICAM2
ExpressionAtlasⁱ	P13598 baseline and differential
Genevisibleⁱ	P13598 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071155

HPAⁱ

HPA071155

Interactionⁱ

Subunit structureⁱ

Interacts with RDX, EZR and MSN.By similarity

GO - Molecular functionⁱ

integrin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1448173

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109611, 18 interactors
IntActⁱ	P13598, 6 interactors
STRINGⁱ	9606.ENSP00000388666

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 38	Combined sources	10
Beta strandⁱ	42 – 51	Combined sources	10
Beta strandⁱ	56 – 61	Combined sources	6
Beta strandⁱ	63 – 72	Combined sources	10
Beta strandⁱ	75 – 83	Combined sources	9
Beta strandⁱ	87 – 95	Combined sources	9
Beta strandⁱ	98 – 108	Combined sources	11
Beta strandⁱ	116 – 125	Combined sources	10
Beta strandⁱ	128 – 136	Combined sources	9
Helixⁱ	142 – 144	Combined sources	3
Beta strandⁱ	145 – 151	Combined sources	7
Beta strandⁱ	154 – 160	Combined sources	7
Beta strandⁱ	171 – 178	Combined sources	8
Helixⁱ	181 – 185	Combined sources	5
Beta strandⁱ	188 – 195	Combined sources	8
Helixⁱ	197 – 199	Combined sources	3
Beta strandⁱ	203 – 207	Combined sources	5
Beta strandⁱ	214 – 216	Combined sources	3

3D structure databases

ProteinModelPortalⁱ	P13598
SMRⁱ	P13598
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13598

EvolutionaryTraceⁱ

P13598

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	41 – 98	Ig-like C2-type 1Add BLAST		58
Domainⁱ	127 – 197	Ig-like C2-type 2Add BLAST		71

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	251 – 275	Required for interaction with EZR, MSN and RDX and co-localization to microvilliBy similarityAdd BLAST		25

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IH57 Eukaryota ENOG410Z9H1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063246
HOVERGENⁱ	HBG052075
InParanoidⁱ	P13598
KEGG Orthology (KO) More...KOⁱ	K06523
OMAⁱ	NFSCLAV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G022Y
PhylomeDBⁱ	P13598
TreeFamⁱ	TF333745

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR003988 ICAM IPR015653 ICAM2 IPR013768 ICAM_N IPR003987 ICAM_VCAM_N IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold
PANTHERⁱ	PTHR13771:SF3 PTHR13771:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03921 ICAM_N, 1 hit
PRINTSⁱ	PR01473 ICAM PR01472 ICAMVCAM1
SUPFAMⁱ	SSF48726 SSF48726, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P13598-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST 
        60         70         80         90        100
TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE 
       110        120        130        140        150
SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF 
       160        170        180        190        200
RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG 
       210        220        230        240        250
GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ 
       260        270 
HLRQQRMGTY GVRAAWRRLP QAFRP

Length:275

Mass (Da):30,654

Last modified:October 3, 2006 - v2

Checksum:ⁱC54FB34D92A6FC38

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	65	D → N (PubMed:2497351).Curated		1
Sequence conflictⁱ	65	D → N (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014655	37	A → T. Corresponds to variant dbSNP:rs5503Ensembl.	1
Natural variantⁱVAR_014656	199	R → H. Corresponds to variant dbSNP:rs5504Ensembl.	1
Natural variantⁱVAR_021920	256	R → Q. Corresponds to variant dbSNP:rs3764867Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15606 mRNA Translation: CAA33630.1 M32334 , M32331, M32332, M32333 Genomic DNA Translation: AAA36035.1 BC003097 mRNA Translation: AAH03097.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11657.1
PIRⁱ	S03967
NCBI Reference Sequences More...RefSeqⁱ	NP_000864.2, NM_000873.3 NP_001093256.1, NM_001099786.1 NP_001093257.1, NM_001099787.1 NP_001093258.1, NM_001099788.1 NP_001093259.1, NM_001099789.1
UniGeneⁱ	Hs.431460

Genome annotation databases

Ensemblⁱ	ENST00000412356; ENSP00000415283; ENSG00000108622 ENST00000418105; ENSP00000388666; ENSG00000108622 ENST00000449662; ENSP00000392634; ENSG00000108622 ENST00000579687; ENSP00000462579; ENSG00000108622 ENST00000579788; ENSP00000464665; ENSG00000108622
GeneIDⁱ	3384
KEGGⁱ	hsa:3384

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P13598	ICAM2 protein		HUMAN		275
Intercellular adhesion molecule 2 variant (Fragment)		HUMAN		344
Intercellular adhesion molecule 2 (Fragment)		HUMAN		214
Intercellular adhesion molecule 2 (Fragment)		HUMAN		20
Intercellular adhesion molecule 2		HUMAN		174
+2

Protein	Similar proteins		Species	Score	Length
P13598	ICAM2 protein		HUMAN		275
Intercellular adhesion molecule 2 variant (Fragment)		HUMAN		344
Intercellular adhesion molecule 2 (Fragment)		HUMAN		214
Intercellular adhesion molecule 2 (Fragment)		HUMAN		20
Intercellular adhesion molecule 2		HUMAN		174
+2

Protein	Similar proteins		Species	Score	Length
P13598	ICAM2 protein		HUMAN		275
Intercellular adhesion molecule 2		NOMLE		275
UPI000C2B2E82		Ugandan red Colobus		289
Intercellular adhesion molecule 2		CALJA		280
Intercellular adhesion molecule 2		SAIBB		321
+42

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

ICAM-2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15606 mRNA Translation: CAA33630.1 M32334 , M32331, M32332, M32333 Genomic DNA Translation: AAA36035.1 BC003097 mRNA Translation: AAH03097.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11657.1
PIRⁱ	S03967
NCBI Reference Sequences More...RefSeqⁱ	NP_000864.2, NM_000873.3 NP_001093256.1, NM_001099786.1 NP_001093257.1, NM_001099787.1 NP_001093258.1, NM_001099788.1 NP_001093259.1, NM_001099789.1
UniGeneⁱ	Hs.431460

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ZXQ	X-ray	2.20	A	25-216	[»]
ProteinModelPortalⁱ	P13598
SMRⁱ	P13598
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109611, 18 interactors
IntActⁱ	P13598, 6 interactors
STRINGⁱ	9606.ENSP00000388666

PTM databases

GlyConnectⁱ	682
iPTMnetⁱ	P13598
PhosphoSitePlusⁱ	P13598
SwissPalmⁱ	P13598
UniCarbKBⁱ	P13598

Polymorphism and mutation databases

BioMutaⁱ	ICAM2
DMDMⁱ	115502404

Proteomic databases

EPDⁱ	P13598
PaxDbⁱ	P13598
PeptideAtlas More...PeptideAtlasⁱ	P13598
PRIDEⁱ	P13598
ProteomicsDBⁱ	52937

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3384
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000412356; ENSP00000415283; ENSG00000108622 ENST00000418105; ENSP00000388666; ENSG00000108622 ENST00000449662; ENSP00000392634; ENSG00000108622 ENST00000579687; ENSP00000462579; ENSG00000108622 ENST00000579788; ENSP00000464665; ENSG00000108622
GeneIDⁱ	3384
KEGGⁱ	hsa:3384

Organism-specific databases

CTDⁱ	3384
DisGeNET More...DisGeNETⁱ	3384
EuPathDBⁱ	HostDB:ENSG00000108622.10
GeneCardsⁱ	ICAM2
H-InvDBⁱ	HIX0014082
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5345 ICAM2
Human Protein Atlas More...HPAⁱ	HPA071155
MIMⁱ	146630 gene
neXtProtⁱ	NX_P13598
Open Targets More...OpenTargetsⁱ	ENSG00000108622
PharmGKBⁱ	PA29593
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH57 Eukaryota ENOG410Z9H1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063246
HOVERGENⁱ	HBG052075
InParanoidⁱ	P13598
KEGG Orthology (KO) More...KOⁱ	K06523
OMAⁱ	NFSCLAV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G022Y
PhylomeDBⁱ	P13598
TreeFamⁱ	TF333745

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083 Integrin cell surface interactions R-HSA-5621575 CD209 (DC-SIGN) signaling
SIGNORⁱ	P13598

Miscellaneous databases

ChiTaRSⁱ	ICAM2 human
EvolutionaryTraceⁱ	P13598
GeneWikiⁱ	ICAM2
GenomeRNAiⁱ	3384
Protein Ontology More...PROⁱ	PR:P13598
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108622
CleanExⁱ	HS_ICAM2
ExpressionAtlasⁱ	P13598 baseline and differential
Genevisibleⁱ	P13598 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR003988 ICAM IPR015653 ICAM2 IPR013768 ICAM_N IPR003987 ICAM_VCAM_N IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold
PANTHERⁱ	PTHR13771:SF3 PTHR13771:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03921 ICAM_N, 1 hit
PRINTSⁱ	PR01473 ICAM PR01472 ICAMVCAM1
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ICAM2_HUMAN
Accessionⁱ	P13598Primary (citable) accession number: P13598 Secondary accession number(s): Q14600
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	October 3, 2006
	Last modified:	June 20, 2018
	This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniRef

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Annotation systems

Supporting data

UniProtKB - P13598 (ICAM2_HUMAN)

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Intercellular adhesion molecule 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ