Icam1

Functionⁱ

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).By similarity

GO - Molecular functionⁱ

integrin binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23620790
protein-containing complex binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute inflammatory response to antigenic stimulus Source: MGI
adhesion of symbiont to host Source: MGI
cell adhesion
Source: MGI
Inferred from direct assayⁱ
- 10528208
cell adhesion mediated by integrin
Source: MGI
Inferred from direct assayⁱ
- 10601245
cell-cell adhesion Source: MGI
cellular response to glucose stimulus
Source: MGI
Inferred from direct assayⁱ
- 17670746
cellular response to leukemia inhibitory factor
Source: MGI
Inferred from expression patternⁱ
- 20439489
establishment of endothelial barrier Source: MGI
establishment of endothelial intestinal barrier Source: MGI
establishment of Sertoli cell barrier Source: MGI
leukocyte cell-cell adhesion
Source: MGI
Inferred from mutant phenotypeⁱ
- 8562500
membrane to membrane docking Source: Ensembl
negative regulation of calcium ion transport Source: MGI
negative regulation of endothelial cell apoptotic process Source: MGI
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
positive regulation of actin filament polymerization Source: MGI
positive regulation of cellular extravasation Source: MGI
positive regulation of ERK1 and ERK2 cascade Source: MGI
positive regulation of GTPase activity Source: MGI
positive regulation of leukocyte adhesion to vascular endothelial cell Source: MGI
positive regulation of NF-kappaB transcription factor activity Source: MGI
positive regulation of nitric oxide biosynthetic process Source: MGI
positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
positive regulation of vasoconstriction Source: MGI
receptor-mediated virion attachment to host cell Source: MGI
regulation of cell adhesion
Source: MGI
Inferred from direct assayⁱ
- 15249579
regulation of cell shape Source: MGI
regulation of ruffle assembly
Source: MGI
Inferred from direct assayⁱ
- 23372835
sensory perception of sound Source: MGI
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: MGI
T cell antigen processing and presentation
Source: MGI
Inferred from direct assayⁱ
- 2479693
T cell extravasation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17344467

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083 Integrin cell surface interactions

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Intercellular adhesion molecule 1 Short name: ICAM-1 Alternative name(s): MALA-2 MyD10 CD_antigen: CD54
Gene namesⁱ	Name:Icam1 Synonyms:Icam-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:96392 Icam1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	28 – 485	ExtracellularSequence analysisAdd BLAST	458
Transmembraneⁱ	486 – 509	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	510 – 537	CytoplasmicSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Spontaneous onset of obesity in 16-week old mice with higher levels of white and brown fat and a slightly heavier liver. Enhanced susceptibility to high fat diet-induced obesity characterized by a weight increase and higher levels of white and brown fat.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	By similarityAdd BLAST		27
ChainⁱPRO_0000014785	28 – 537	Intercellular adhesion molecule 1Add BLAST		510

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	48 ↔ 91	PROSITE-ProRule annotation
Disulfide bondⁱ	52 ↔ 95	PROSITE-ProRule annotation
Disulfide bondⁱ	134 ↔ 188	PROSITE-ProRule annotation
Glycosylationⁱ	185	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	204	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	239 ↔ 292	PROSITE-ProRule annotation
Glycosylationⁱ	267	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	311	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	334 ↔ 374	PROSITE-ProRule annotation
Glycosylationⁱ	362	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	388	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	406 ↔ 422	By similarity
Glycosylationⁱ	409	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	422 ↔ 461	PROSITE-ProRule annotation
Disulfide bondⁱ	434 ↔ 461	By similarity
Glycosylationⁱ	456	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	469	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	469	Not glycosylated1 Publication		1
Siteⁱ	485	Not glycosylated1 Publication		1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P13597
PeptideAtlas More...PeptideAtlasⁱ	P13597
PRIDEⁱ	P13597

PTM databases

iPTMnetⁱ	P13597
PhosphoSitePlusⁱ	P13597

Expressionⁱ

Tissue specificityⁱ

Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells.

Gene expression databases

Bgeeⁱ	ENSMUSG00000037405 Expressed in 212 organ(s), highest expression level in lung
CleanExⁱ	MM_ICAM1
ExpressionAtlasⁱ	P13597 baseline and differential
Genevisibleⁱ	P13597 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF (By similarity).By similarity

GO - Molecular functionⁱ

integrin binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23620790

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-29096N
IntActⁱ	P13597, 2 interactors
Molecular INTeraction database More...MINTⁱ	P13597
STRINGⁱ	10090.ENSMUSP00000083587

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13597
SMRⁱ	P13597
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	41 – 102	Ig-like C2-type 1Add BLAST	62
Domainⁱ	127 – 195	Ig-like C2-type 2Add BLAST	69
Domainⁱ	232 – 299	Ig-like C2-type 3Add BLAST	68
Domainⁱ	327 – 381	Ig-like C2-type 4Add BLAST	55
Domainⁱ	415 – 468	Ig-like C2-type 5Add BLAST	54

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	151 – 153	Cell attachment site; atypicalSequence analysis		3
Motifⁱ	179 – 181	Cell attachment siteSequence analysis		3

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPHM Eukaryota ENOG410YQ1Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063246
HOGENOMⁱ	HOG000059554
HOVERGENⁱ	HBG052074
InParanoidⁱ	P13597
KEGG Orthology (KO) More...KOⁱ	K06490
OMAⁱ	QTLRCQA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G022Y
PhylomeDBⁱ	P13597
TreeFamⁱ	TF333745

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR003988 ICAM IPR013768 ICAM_N IPR003987 ICAM_VCAM_N IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03921 ICAM_N, 1 hit PF13895 Ig_2, 1 hit
PRINTSⁱ	PR01473 ICAM PR01472 ICAMVCAM1
SMARTⁱ	View protein in SMART SM00409 IG, 4 hits
SUPFAMⁱ	SSF48726 SSF48726, 5 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P13597-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTRAKPTL PLLLALVTVV IPGPGDAQVS IHPREAFLPQ GGSVQVNCSS 
        60         70         80         90        100
SCKEDLSLGL ETQWLKDELE SGPNWKLFEL SEIGEDSSPL CFENCGTVQS 
       110        120        130        140        150
SASATITVYS FPESVELRPL PAWQQVGKDL TLRCHVDGGA PRTQLSAVLL 
       160        170        180        190        200
RGEEILSRQP VGGHPKDPKE ITFTVLASRG DHGANFSCRT ELDLRPQGLA 
       210        220        230        240        250
LFSNVSEARS LRTFDLPATI PKLDTPDLLE VGTQQKLFCS LEGLFPASEA 
       260        270        280        290        300
RIYLELGGQM PTQESTNSSD SVSATALVEV TEEFDRTLPL RCVLELADQI 
       310        320        330        340        350
LETQRTLTVY NFSAPVLTLS QLEVSEGSQV TVKCEAHSGS KVVLLSGVEP 
       360        370        380        390        400
RPPTPQVQFT LNASSEDHKR SFFCSAALEV AGKFLFKNQT LELHVLYGPR 
       410        420        430        440        450
LDETDCLGNW TWQEGSQQTL KCQAWGNPSP KMTCRRKADG ALLPIGVVKS 
       460        470        480        490        500
VKQEMNGTYV CHAFSSHGNV TRNVYLTVLY HSQNNWTIII LVPVLLVIVG 
       510        520        530 
LVMAASYVYN RQRKIRIYKL QKAQEEAIKL KGQAPPP

Length:537

Mass (Da):58,844

Last modified:January 1, 1990 - v1

Checksum:ⁱ6124167753774555

GO

Isoform 2 (identifier: P13597-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: MASTRAKPTLPLLLALVTVVIPGPGDAQVSIHPR → MITHRHPVREKSINSYQFIKEKQFPAEN

« Hide

        10         20         30         40         50
MITHRHPVRE KSINSYQFIK EKQFPAENEA FLPQGGSVQV NCSSSCKEDL 
        60         70         80         90        100
SLGLETQWLK DELESGPNWK LFELSEIGED SSPLCFENCG TVQSSASATI 
       110        120        130        140        150
TVYSFPESVE LRPLPAWQQV GKDLTLRCHV DGGAPRTQLS AVLLRGEEIL 
       160        170        180        190        200
SRQPVGGHPK DPKEITFTVL ASRGDHGANF SCRTELDLRP QGLALFSNVS 
       210        220        230        240        250
EARSLRTFDL PATIPKLDTP DLLEVGTQQK LFCSLEGLFP ASEARIYLEL 
       260        270        280        290        300
GGQMPTQEST NSSDSVSATA LVEVTEEFDR TLPLRCVLEL ADQILETQRT 
       310        320        330        340        350
LTVYNFSAPV LTLSQLEVSE GSQVTVKCEA HSGSKVVLLS GVEPRPPTPQ 
       360        370        380        390        400
VQFTLNASSE DHKRSFFCSA ALEVAGKFLF KNQTLELHVL YGPRLDETDC 
       410        420        430        440        450
LGNWTWQEGS QQTLKCQAWG NPSPKMTCRR KADGALLPIG VVKSVKQEMN 
       460        470        480        490        500
GTYVCHAFSS HGNVTRNVYL TVLYHSQNNW TIIILVPVLL VIVGLVMAAS 
       510        520        530 
YVYNRQRKIR IYKLQKAQEE AIKLKGQAPP P

Show »

Length:531

Mass (Da):58,753

Checksum:ⁱ23B6CCDA9313761F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	243	G → A in AAA37876 (PubMed:2479693).Curated		1
Sequence conflictⁱ	370	R → A in CAA34621 (PubMed:2573511).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002518	1 – 34	MASTR…SIHPR → MITHRHPVREKSINSYQFIK EKQFPAEN in isoform 2. CuratedAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16624 mRNA Translation: CAA34621.1 X16625 mRNA Translation: CAA34622.1 M31585 mRNA Translation: AAA37876.1 X52264 mRNA Translation: CAA36507.1 M90551 M90550 Genomic DNA Translation: AAA37875.1 X54331 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22889.1 [P13597-1]
PIRⁱ	A45815 I49769 S06016
NCBI Reference Sequences More...RefSeqⁱ	NP_034623.1, NM_010493.3 [P13597-1]
UniGeneⁱ	Mm.435508

Genome annotation databases

Ensemblⁱ	ENSMUST00000086399; ENSMUSP00000083587; ENSMUSG00000037405 [P13597-1]
GeneIDⁱ	15894
KEGGⁱ	mmu:15894
UCSC genome browser More...UCSCⁱ	uc009ojx.1 mouse [P13597-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13597	Intercellular adhesion molecule		MOUSE		537	UniRef100_P13597
Uncharacterized protein (Fragment)		MOUSE		235
Uncharacterized protein (Fragment)		MOUSE		466

Protein	Similar proteins		Species	Score	Length	Source
P13597	Intercellular adhesion molecule		MOUSE		537	UniRef90_P13597
UPI000A317451		MUSCR		536
Uncharacterized protein (Fragment)		MOUSE		235
Uncharacterized protein (Fragment)		MOUSE		466
Uncharacterized protein		MOUSE		537
+9

Protein	Similar proteins		Species	Score	Length	Source
P13597	Intercellular adhesion molecule 1		RAT		545	UniRef50_Q00238
Intercellular adhesion molecule 1		MACMU		532
intercellular adhesion molecule 1		LIPVE		536
intercellular adhesion molecule 1		DELLE		536
intercellular adhesion molecule 1		Yangtze finless porpoise		536
+82

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

ICAM-1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16624 mRNA Translation: CAA34621.1 X16625 mRNA Translation: CAA34622.1 M31585 mRNA Translation: AAA37876.1 X52264 mRNA Translation: CAA36507.1 M90551 M90550 Genomic DNA Translation: AAA37875.1 X54331 mRNA No translation available.
CCDSⁱ	CCDS22889.1 [P13597-1]
PIRⁱ	A45815 I49769 S06016
RefSeqⁱ	NP_034623.1, NM_010493.3 [P13597-1]
UniGeneⁱ	Mm.435508

3D structure databases

ProteinModelPortalⁱ	P13597
SMRⁱ	P13597
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-29096N
IntActⁱ	P13597, 2 interactors
MINTⁱ	P13597
STRINGⁱ	10090.ENSMUSP00000083587

PTM databases

iPTMnetⁱ	P13597
PhosphoSitePlusⁱ	P13597

Proteomic databases

PaxDbⁱ	P13597
PeptideAtlasⁱ	P13597
PRIDEⁱ	P13597

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000086399; ENSMUSP00000083587; ENSMUSG00000037405 [P13597-1]
GeneIDⁱ	15894
KEGGⁱ	mmu:15894
UCSCⁱ	uc009ojx.1 mouse [P13597-1]

Organism-specific databases

CTDⁱ	3383
MGIⁱ	MGI:96392 Icam1

Phylogenomic databases

eggNOGⁱ	ENOG410IPHM Eukaryota ENOG410YQ1Q LUCA
GeneTreeⁱ	ENSGT00530000063246
HOGENOMⁱ	HOG000059554
HOVERGENⁱ	HBG052074
InParanoidⁱ	P13597
KOⁱ	K06490
OMAⁱ	QTLRCQA
OrthoDBⁱ	EOG091G022Y
PhylomeDBⁱ	P13597
TreeFamⁱ	TF333745

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083 Integrin cell surface interactions

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions

Miscellaneous databases

ChiTaRSⁱ	Icam1 mouse
Protein Ontology More...PROⁱ	PR:P13597
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037405 Expressed in 212 organ(s), highest expression level in lung
CleanExⁱ	MM_ICAM1
ExpressionAtlasⁱ	P13597 baseline and differential
Genevisibleⁱ	P13597 MM

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR003988 ICAM IPR013768 ICAM_N IPR003987 ICAM_VCAM_N IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub
Pfamⁱ	View protein in Pfam PF03921 ICAM_N, 1 hit PF13895 Ig_2, 1 hit
PRINTSⁱ	PR01473 ICAM PR01472 ICAMVCAM1
SMARTⁱ	View protein in SMART SM00409 IG, 4 hits
SUPFAMⁱ	SSF48726 SSF48726, 5 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ICAM1_MOUSE
Accessionⁱ	P13597Primary (citable) accession number: P13597 Secondary accession number(s): Q61828
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	September 12, 2018
	This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P13597 (ICAM1_MOUSE)

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Intercellular adhesion molecule 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ