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Protein

Neural cell adhesion molecule 1

Gene

Ncam1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

GO - Molecular functioni

  • cytoskeletal protein binding Source: RGD
  • fibroblast growth factor receptor binding Source: RGD
  • heparin binding Source: UniProtKB-KW
  • LRR domain binding Source: RGD
  • phosphatase binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule 1
Short name:
N-CAM-1
Short name:
NCAM-1
Alternative name(s):
CD_antigen: CD56
Gene namesi
Name:Ncam1
Synonyms:Ncam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi67378 Ncam1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 721ExtracellularSequence analysisAdd BLAST702
Transmembranei722 – 739HelicalSequence analysisAdd BLAST18
Topological domaini740 – 858CytoplasmicSequence analysisAdd BLAST119

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001501520 – 858Neural cell adhesion molecule 1Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 96PROSITE-ProRule annotation
Disulfide bondi139 ↔ 189PROSITE-ProRule annotation
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi235 ↔ 288PROSITE-ProRule annotation
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi330 ↔ 396PROSITE-ProRule annotation
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi437 ↔ 490PROSITE-ProRule annotation
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei780PhosphoserineCombined sources1
Modified residuei784PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13596
PRIDEiP13596

PTM databases

iPTMnetiP13596
PhosphoSitePlusiP13596
SwissPalmiP13596
UniCarbKBiP13596

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246729, 4 interactors
CORUMiP13596
IntActiP13596, 3 interactors
MINTiP13596
STRINGi10116.ENSRNOP00000048442

Structurei

Secondary structure

1858
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13596
SMRiP13596
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13596

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 111Ig-like C2-type 1Add BLAST92
Domaini116 – 205Ig-like C2-type 2Add BLAST90
Domaini212 – 302Ig-like C2-type 3Add BLAST91
Domaini309 – 414Ig-like C2-type 4Add BLAST106
Domaini417 – 502Ig-like C2-type 5Add BLAST86
Domaini510 – 609Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST100
Domaini611 – 706Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Heparin-bindingSequence analysis5
Regioni161 – 165Heparin-bindingSequence analysis5

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQJI Eukaryota
ENOG410XTGB LUCA
HOGENOMiHOG000074124
HOVERGENiHBG052579
InParanoidiP13596
KOiK06491
PhylomeDBiP13596

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033019 Ncam1
IPR009138 Neural_cell_adh
PANTHERiPTHR44059:SF2 PTHR44059:SF2, 2 hits
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
PRINTSiPR01838 NCAMFAMILY
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13596-1) [UniParc]FASTAAdd to basket
Also known as: N-CAM 140

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA
110 120 130 140 150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD
260 270 280 290 300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS
310 320 330 340 350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS
360 370 380 390 400
SEEKASWTRP EKQETLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN
410 420 430 440 450
TIGQDSQSMY LEVQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF
460 470 480 490 500
RDGQLLPSSN YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES
510 520 530 540 550
LEFILVQADT PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS
560 570 580 590 600
LGEEAWHSKW YDAKEANMEG IVTIMGLKPE TRYAVRLAAL NGKGLGEISA
610 620 630 640 650
ATEFKTQPVR EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR
660 670 680 690 700
ALASEWKPEI RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF
710 720 730 740 750
RTSAQPTAIP ANGSPTAGLS TGAIVGILIV IFVLLLVVMD ITCYFLNKCG
760 770 780 790 800
LLMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN
810 820 830 840 850
HDGGKHTEPN ETTPLTEPEK GPVETKSEPQ ESEAKPAPTE VKTVPNEATQ

TKENESKA
Length:858
Mass (Da):94,658
Last modified:January 1, 1990 - v1
Checksum:iEA1A06A4EA0550F6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K0M8A0A0G2K0M8_RAT
Neural cell adhesion molecule 1
Ncam1
1,016Annotation score:
F1LNY3F1LNY3_RAT
Neural cell adhesion molecule 1
Ncam1
842Annotation score:
F1LUV9F1LUV9_RAT
Neural cell adhesion molecule 1
Ncam1
833Annotation score:
M0R6C2M0R6C2_RAT
Neural cell adhesion molecule 1
Ncam1
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06564 mRNA Translation: CAA29809.1
M32611 Genomic DNA Translation: AAA41679.1
PIRiS00846 IJRTNC
RefSeqiNP_113709.1, NM_031521.1 [P13596-1]
UniGeneiRn.11283
Rn.214248

Genome annotation databases

GeneIDi24586
KEGGirno:24586
UCSCiRGD:67378 rat [P13596-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06564 mRNA Translation: CAA29809.1
M32611 Genomic DNA Translation: AAA41679.1
PIRiS00846 IJRTNC
RefSeqiNP_113709.1, NM_031521.1 [P13596-1]
UniGeneiRn.11283
Rn.214248

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EPFX-ray1.85A/B/C/D20-208[»]
1LWRNMR-A612-705[»]
1QZ1X-ray2.00A20-308[»]
ProteinModelPortaliP13596
SMRiP13596
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246729, 4 interactors
CORUMiP13596
IntActiP13596, 3 interactors
MINTiP13596
STRINGi10116.ENSRNOP00000048442

PTM databases

iPTMnetiP13596
PhosphoSitePlusiP13596
SwissPalmiP13596
UniCarbKBiP13596

Proteomic databases

PaxDbiP13596
PRIDEiP13596

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24586
KEGGirno:24586
UCSCiRGD:67378 rat [P13596-1]

Organism-specific databases

CTDi4684
RGDi67378 Ncam1

Phylogenomic databases

eggNOGiENOG410IQJI Eukaryota
ENOG410XTGB LUCA
HOGENOMiHOG000074124
HOVERGENiHBG052579
InParanoidiP13596
KOiK06491
PhylomeDBiP13596

Miscellaneous databases

EvolutionaryTraceiP13596
PROiPR:P13596

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033019 Ncam1
IPR009138 Neural_cell_adh
PANTHERiPTHR44059:SF2 PTHR44059:SF2, 2 hits
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
PRINTSiPR01838 NCAMFAMILY
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNCAM1_RAT
AccessioniPrimary (citable) accession number: P13596
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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