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UniProtKB - P13595 (NCAM1_MOUSE)

Entry version 201 (07 Oct 2020)
Sequence version 3 (22 Jul 2008)
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Protein

Neural cell adhesion molecule 1

Gene

Ncam1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-419037, NCAM1 interactions
R-MMU-445144, Signal transduction by L1
R-MMU-5673001, RAF/MAP kinase cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neural cell adhesion molecule 1
Short name:
N-CAM-1
Short name:
NCAM-1
Alternative name(s):
CD_antigen: CD56
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncam1
Synonyms:Ncam
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:97281, Ncam1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 711ExtracellularSequence analysisAdd BLAST692
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei712 – 729HelicalSequence analysisAdd BLAST18
Topological domaini730 – 1115CytoplasmicSequence analysisAdd BLAST386

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001501220 – 1115Neural cell adhesion molecule 1Add BLAST1096

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 96Combined sources1 Publication
Disulfide bondi139 ↔ 189Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi222N-linked (GlcNAc...) asparagine; partial1 Publication1
Disulfide bondi235 ↔ 288Curated
Glycosylationi316N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi330 ↔ 386Curated
Glycosylationi348N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi424N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi427 ↔ 480Curated
Glycosylationi450N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi479N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei770PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1
Modified residuei929PhosphothreonineCombined sources1
Modified residuei946PhosphoserineCombined sources1
Modified residuei958PhosphoserineCombined sources1
Modified residuei1001PhosphothreonineCombined sources1
Modified residuei1005PhosphoserineCombined sources1
Modified residuei1030PhosphothreonineCombined sources1
Isoform 3 (identifier: P13595-3)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi706GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3846

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13595

MaxQB - The MaxQuant DataBase

More...MaxQBi		P13595

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13595

PeptideAtlas

More...PeptideAtlasi		P13595

PRoteomics IDEntifications database

More...PRIDEi		P13595

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2535, 6 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13595, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13595

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13595

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13595

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MDK.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201699, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P13595

Protein interaction database and analysis system

More...IntActi		P13595, 9 interactors

Molecular INTeraction database

More...MINTi		P13595

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000130668

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13595, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P13595

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13595

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P13595

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 111Ig-like C2-type 1Add BLAST92
Domaini116 – 205Ig-like C2-type 2Add BLAST90
Domaini212 – 302Ig-like C2-type 3Add BLAST91
Domaini309 – 402Ig-like C2-type 4Add BLAST94
Domaini407 – 492Ig-like C2-type 5Add BLAST86
Domaini500 – 599Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST100
Domaini601 – 696Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 156Heparin-bindingSequence analysis5
Regioni161 – 165Heparin-bindingSequence analysis5

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3510, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13595

KEGG Orthology (KO)

More...KOi		K06491

Database of Orthologous Groups

More...OrthoDBi		129648at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13595

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR033019, Ncam1
IPR009138, Neural_cell_adh

The PANTHER Classification System

More...PANTHERi		PTHR12231:SF239, PTHR12231:SF239, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01838, NCAMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 5 hits
SM00408, IGc2, 5 hits
SM00406, IGv, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 2 hits
PS50835, IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13595-1) [UniParc]FASTAAdd to basket
Also known as: N-CAM 180

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK 
        60         70         80         90        100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA 
       110        120        130        140        150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII 
       160        170        180        190        200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 
       210        220        230        240        250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD 
       260        270        280        290        300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS 
       310        320        330        340        350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS 
       360        370        380        390        400
SEEKTLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY 
       410        420        430        440        450
LEFQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN 
       460        470        480        490        500
YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES LEFILVQADT 
       510        520        530        540        550
PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS LGEESWHFKW 
       560        570        580        590        600
YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR 
       610        620        630        640        650
EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR ALASEWKPEI 
       660        670        680        690        700
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP 
       710        720        730        740        750
ANGSPTAGLS TGAIVGILIV IFVLLLVVMD ITCYFLNKCG LLMCIAVNLC 
       760        770        780        790        800
GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN HDGGKHTEPN 
       810        820        830        840        850
ETTPLTEPEL PADTTATVED MLPSVTTVTT NSDTITETFA TAQNSPTSET 
       860        870        880        890        900
TTLTSSIAPP ATTVPDSNSV PAGQATPSKG VTASSSSPAS APKVAPLVDL 
       910        920        930        940        950
SDTPTSAPSA SNLSSTVLAN QGAVLSPSTP ASAGETSKAP PASKASPAPT 
       960        970        980        990       1000
PTPAGAASPL AAVAAPATDA PQAKQEAPST KGPDPEPTQP GTVKNPPEAA 
      1010       1020       1030       1040       1050
TAPASPKSKA ATTNPSQGED LKMDEGNFKT PDIDLAKDVF AALGSPRPAT 
      1060       1070       1080       1090       1100
GASGQASELA PSPADSAVPP APAKTEKGPV ETKSEPPESE AKPAPTEVKT 
      1110 
VPNDATQTKE NESKA
Length:1,115
Mass (Da):119,427
Last modified:July 22, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78AF831BABD23918
GO
Isoform 2 (identifier: P13595-2) [UniParc]FASTAAdd to basket
Also known as: N-CAM 140

The sequence of this isoform differs from the canonical sequence as follows:
     810-1076: Missing.

Show »
Length:848
Mass (Da):93,540
Checksum:i4D77D553F474AD8E
GO
Isoform 3 (identifier: P13595-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: N-CAM 120

The sequence of this isoform differs from the canonical sequence as follows:
     702-725: NGSPTAGLSTGAIVGILIVIFVLL → TLGGSSTSYTLVSLLFSAVTLLLL
     726-1115: Missing.

Show »
Length:725
Mass (Da):80,406
Checksum:i97867C2A61594CC4
GO
Isoform 4 (identifier: P13595-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     601-605: EPSAP → KSSLF
     606-1115: Missing.

Show »
Length:605
Mass (Da):67,353
Checksum:iD497D834C34EAEC0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QB01E9QB01_MOUSE
Neural cell adhesion molecule 1
Ncam1
849Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YY47A0A0A6YY47_MOUSE
Neural cell adhesion molecule 1
Ncam1
848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q589E9Q589_MOUSE
Neural cell adhesion molecule 1
Ncam1
725Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YY91A0A0A6YY91_MOUSE
Neural cell adhesion molecule 1
Ncam1
1,089Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWU2A0A0A6YWU2_MOUSE
Neural cell adhesion molecule 1
Ncam1
605Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWW5A0A0A6YWW5_MOUSE
Neural cell adhesion molecule 1
Ncam1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20L → M in CAA33148 (PubMed:2721486).Curated1
Sequence conflicti158V → F in AAH11310 (PubMed:15489334).Curated1
Sequence conflicti261 – 268DEKHIFSD → ERSRSSVS in CAA68263 (PubMed:3595563).Curated8
Sequence conflicti273L → V in CAA68263 (PubMed:3595563).Curated1
Sequence conflicti354 – 355KT → QD in CAA68263 (PubMed:3595563).Curated2
Sequence conflicti379T → R in CAA68263 (PubMed:3595563).Curated1
Sequence conflicti379T → R in CAA33148 (PubMed:2721486).Curated1
Sequence conflicti385I → M in CAA68263 (PubMed:3595563).Curated1
Sequence conflicti385I → M in CAA33148 (PubMed:2721486).Curated1
Sequence conflicti399 – 400MY → ID in CAA68263 (PubMed:3595563).Curated2
Sequence conflicti399 – 400MY → ID in CAA33148 (PubMed:2721486).Curated2
Sequence conflicti403F → V in AAH11310 (PubMed:15489334).Curated1
Sequence conflicti403F → V in BAC34554 (PubMed:16141072).Curated1
Sequence conflicti403F → V in BAC38551 (PubMed:16141072).Curated1
Sequence conflicti549K → T in CAA68263 (PubMed:3595563).Curated1
Sequence conflicti572R → T in CAA68263 (PubMed:3595563).Curated1
Sequence conflicti575V → D in CAA68263 (PubMed:3595563).Curated1
Sequence conflicti589 – 594SAATEF → MQPSES in CAA68263 (PubMed:3595563).Curated6
Sequence conflicti600 – 602REP → PEL in CAA68263 (PubMed:3595563).Curated3
Sequence conflicti657D → H in CAA68263 (PubMed:3595563).Curated1
Sequence conflicti733C → W in BAC34554 (PubMed:16141072).Curated1
Sequence conflicti1082T → A in BAC34554 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034826601 – 605EPSAP → KSSLF in isoform 4. 1 Publication5
Alternative sequenceiVSP_034827606 – 1115Missing in isoform 4. 1 PublicationAdd BLAST510
Alternative sequenceiVSP_034828702 – 725NGSPT…IFVLL → TLGGSSTSYTLVSLLFSAVT LLLL in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_034829726 – 1115Missing in isoform 3. 1 PublicationAdd BLAST390
Alternative sequenceiVSP_002588810 – 1076Missing in isoform 2. 3 PublicationsAdd BLAST267

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00051 mRNA Translation: CAA68263.1
BC011310 mRNA Translation: AAH11310.1
AK051197 mRNA Translation: BAC34554.2
AK082621 mRNA Translation: BAC38551.2
X15049 mRNA Translation: CAA33148.1
X15051 mRNA Translation: CAA33150.1
X15052 mRNA Translation: CAA33151.1
X06328 mRNA Translation: CAA29641.1
X07195 Genomic DNA Translation: CAA30173.1
X07197 Genomic DNA Translation: CAA30175.1
X07198 Genomic DNA Translation: CAB40820.1
X07200 Genomic DNA Translation: CAA30177.1
X07244 mRNA Translation: CAA30230.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS40617.1 [P13595-2]
CCDS40618.1 [P13595-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A29673, IJMSNL

NCBI Reference Sequences

More...RefSeqi		NP_001074914.1, NM_001081445.1
NP_001106675.1, NM_001113204.1
NP_001297994.1, NM_001311065.1
NP_035005.2, NM_010875.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		17967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:17967

UCSC genome browser

More...UCSCi		uc009pje.2, mouse [P13595-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00051 mRNA Translation: CAA68263.1
BC011310 mRNA Translation: AAH11310.1
AK051197 mRNA Translation: BAC34554.2
AK082621 mRNA Translation: BAC38551.2
X15049 mRNA Translation: CAA33148.1
X15051 mRNA Translation: CAA33150.1
X15052 mRNA Translation: CAA33151.1
X06328 mRNA Translation: CAA29641.1
X07195 Genomic DNA Translation: CAA30173.1
X07197 Genomic DNA Translation: CAA30175.1
X07198 Genomic DNA Translation: CAB40820.1
X07200 Genomic DNA Translation: CAA30177.1
X07244 mRNA Translation: CAA30230.1
CCDSiCCDS40617.1 [P13595-2]
CCDS40618.1 [P13595-3]
PIRiA29673, IJMSNL
RefSeqiNP_001074914.1, NM_001081445.1
NP_001106675.1, NM_001113204.1
NP_001297994.1, NM_001311065.1
NP_035005.2, NM_010875.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NCMNMR-A20-116[»]
3NCMNMR-A119-208[»]
BMRBiP13595
SMRiP13595
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi201699, 17 interactors
CORUMiP13595
IntActiP13595, 9 interactors
MINTiP13595
STRINGi10090.ENSMUSP00000130668

PTM databases

GlyConnecti2535, 6 N-Linked glycans (3 sites)
GlyGeniP13595, 6 sites
iPTMnetiP13595
PhosphoSitePlusiP13595
SwissPalmiP13595

Proteomic databases

CPTACinon-CPTAC-3846
jPOSTiP13595
MaxQBiP13595
PaxDbiP13595
PeptideAtlasiP13595
PRIDEiP13595

Genome annotation databases

GeneIDi17967
KEGGimmu:17967
UCSCiuc009pje.2, mouse [P13595-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4684
MGIiMGI:97281, Ncam1

Phylogenomic databases

eggNOGiKOG3510, Eukaryota
InParanoidiP13595
KOiK06491
OrthoDBi129648at2759
PhylomeDBiP13595

Enzyme and pathway databases

ReactomeiR-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-419037, NCAM1 interactions
R-MMU-445144, Signal transduction by L1
R-MMU-5673001, RAF/MAP kinase cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		17967, 1 hit in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ncam1, mouse
EvolutionaryTraceiP13595

Protein Ontology

More...PROi		PR:P13595
RNActiP13595, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR033019, Ncam1
IPR009138, Neural_cell_adh
PANTHERiPTHR12231:SF239, PTHR12231:SF239, 1 hit
PfamiView protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 3 hits
PRINTSiPR01838, NCAMFAMILY
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 5 hits
SM00408, IGc2, 5 hits
SM00406, IGv, 2 hits
SUPFAMiSSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS50835, IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCAM1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13595
Secondary accession number(s): P13594
, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 22, 2008
Last modified: October 7, 2020
This is version 201 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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