Ncam1

Functionⁱ

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

GO - Molecular functionⁱ

heparin binding Source: UniProtKB-KW
LRR domain binding Source: MGI
phosphatase binding Source: MGI

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: MGI
axonal fasciculation Source: MGI
cell surface receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- "Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons."
  Kadmon G., von Bohlen und Halbach F., Horstkorte R., Eckert M., Altevogt P., Schachner M.
  Eur J Neurosci 7:993-1004(1995) [PubMed] [Europe PMC] [Abstract]
commissural neuron axon guidance
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- "gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance."
  Charoy C., Nawabi H., Reynaud F., Derrington E., Bozon M., Wright K., Falk J., Helmbacher F., Kindbeiter K., Castellani V.
  Neuron 75:1051-1066(2012) [PubMed] [Europe PMC] [Abstract]
homotypic cell-cell adhesion
Source: MGI
Inferred from mutant phenotypeⁱ
- "Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons."
  Kadmon G., von Bohlen und Halbach F., Horstkorte R., Eckert M., Altevogt P., Schachner M.
  Eur J Neurosci 7:993-1004(1995) [PubMed] [Europe PMC] [Abstract]
learning or memory Source: MGI
modulation of chemical synaptic transmission Source: MGI
multicellular organismal response to stress Source: MGI
negative regulation of cell death Source: MGI
neuron development Source: MGI
neuron projection development
Source: MGI
Inferred from genetic interactionⁱ
- "The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones."
  Chernyshova Y., Leshchyns'ka I., Hsu S.C., Schachner M., Sytnyk V.
  J Neurosci 31:3522-3535(2011) [PubMed] [Europe PMC] [Abstract]
positive regulation of calcium-mediated signaling
Source: MGI
Inferred from direct assayⁱ
- "Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons."
  Kadmon G., von Bohlen und Halbach F., Horstkorte R., Eckert M., Altevogt P., Schachner M.
  Eur J Neurosci 7:993-1004(1995) [PubMed] [Europe PMC] [Abstract]
positive regulation of cardiac muscle cell proliferation Source: MGI
regulation of exocyst assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- "The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones."
  Chernyshova Y., Leshchyns'ka I., Hsu S.C., Schachner M., Sytnyk V.
  J Neurosci 31:3522-3535(2011) [PubMed] [Europe PMC] [Abstract]
regulation of semaphorin-plexin signaling pathway
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- "gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance."
  Charoy C., Nawabi H., Reynaud F., Derrington E., Bozon M., Wright K., Falk J., Helmbacher F., Kindbeiter K., Castellani V.
  Neuron 75:1051-1066(2012) [PubMed] [Europe PMC] [Abstract]
regulation of sensory perception of pain Source: MGI
response to cocaine Source: MGI
response to drug Source: MGI
response to lead ion Source: MGI
thalamus development Source: MGI

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding
Biological process	Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375165, NCAM signaling for neurite out-growth R-MMU-419037, NCAM1 interactions R-MMU-445144, Signal transduction by L1 R-MMU-5673001, RAF/MAP kinase cascade

Reactomeⁱ

R-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-419037, NCAM1 interactions
R-MMU-445144, Signal transduction by L1
R-MMU-5673001, RAF/MAP kinase cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neural cell adhesion molecule 1 Short name: N-CAM-1 Short name: NCAM-1 Alternative name(s): CD_antigen: CD56
Gene namesⁱ	Name:Ncam1 Synonyms:Ncam
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:97281, Ncam1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 711	ExtracellularSequence analysisAdd BLAST	692
Transmembraneⁱ	712 – 729	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	730 – 1115	CytoplasmicSequence analysisAdd BLAST	386

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST		19
ChainⁱPRO_0000015012	20 – 1115	Neural cell adhesion molecule 1Add BLAST		1096

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	41 ↔ 96	Combined sources1 Publication
Disulfide bondⁱ	139 ↔ 189	Combined sources1 Publication
Glycosylationⁱ	222	N-linked (GlcNAc...) asparagine; partial1 Publication	1
Disulfide bondⁱ	235 ↔ 288	Curated
Glycosylationⁱ	316	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	330 ↔ 386	Curated
Glycosylationⁱ	348	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	424	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	427 ↔ 480	Curated
Glycosylationⁱ	450	N-linked (GlcNAc...) asparagine3 Publications	1
Glycosylationⁱ	479	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	770	PhosphoserineCombined sources	1
Modified residueⁱ	774	PhosphoserineCombined sources	1
Modified residueⁱ	887	PhosphoserineCombined sources	1
Modified residueⁱ	890	PhosphoserineCombined sources	1
Modified residueⁱ	926	PhosphoserineCombined sources	1
Modified residueⁱ	929	PhosphothreonineCombined sources	1
Modified residueⁱ	946	PhosphoserineCombined sources	1
Modified residueⁱ	958	PhosphoserineCombined sources	1
Modified residueⁱ	1001	PhosphothreonineCombined sources	1
Modified residueⁱ	1005	PhosphoserineCombined sources	1
Modified residueⁱ	1030	PhosphothreonineCombined sources	1
Isoform 3 (identifier: P13595-3)
Lipidationⁱ	706	GPI-anchor amidated serineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	non-CPTAC-3846
jPOSTⁱ	P13595
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13595
PaxDbⁱ	P13595
PeptideAtlas More...PeptideAtlasⁱ	P13595
PRIDEⁱ	P13595
ProteomicsDBⁱ	287445 [P13595-1] 287446 [P13595-2] 287447 [P13595-3] 287448 [P13595-4]

PTM databases

GlyConnectⁱ	2535, 6 N-Linked glycans (3 sites)
GlyGenⁱ	P13595, 6 sites, 6 N-linked glycans (3 sites)
iPTMnetⁱ	P13595
PhosphoSitePlusⁱ	P13595
SwissPalmⁱ	P13595

Interactionⁱ

Subunit structureⁱ

Interacts with MDK.

1 Publication

GO - Molecular functionⁱ

LRR domain binding Source: MGI
phosphatase binding Source: MGI

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	201699, 17 interactors
CORUMⁱ	P13595
IntActⁱ	P13595, 8 interactors
Molecular INTeraction database More...MINTⁱ	P13595
STRINGⁱ	10090.ENSMUSP00000130668

Miscellaneous databases

RNActⁱ	P13595, protein

RNActⁱ

P13595, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	21 – 32	Combined sources	12
Beta strandⁱ	37 – 44	Combined sources	8
Beta strandⁱ	47 – 49	Combined sources	3
Beta strandⁱ	51 – 56	Combined sources	6
Turnⁱ	57 – 59	Combined sources	3
Beta strandⁱ	64 – 73	Combined sources	10
Beta strandⁱ	75 – 77	Combined sources	3
Beta strandⁱ	79 – 85	Combined sources	7
Turnⁱ	88 – 90	Combined sources	3
Beta strandⁱ	92 – 99	Combined sources	8
Beta strandⁱ	101 – 103	Combined sources	3
Beta strandⁱ	105 – 115	Combined sources	11
Beta strandⁱ	119 – 122	Combined sources	4
Beta strandⁱ	125 – 128	Combined sources	4
Beta strandⁱ	133 – 137	Combined sources	5
Beta strandⁱ	140 – 143	Combined sources	4
Beta strandⁱ	145 – 157	Combined sources	13
Helixⁱ	158 – 161	Combined sources	4
Beta strandⁱ	166 – 168	Combined sources	3
Beta strandⁱ	174 – 178	Combined sources	5
Beta strandⁱ	185 – 193	Combined sources	9
Turnⁱ	194 – 197	Combined sources	4
Beta strandⁱ	198 – 207	Combined sources	10

Show more details

3D structure databases

BMRBⁱ	P13595
SMRⁱ	P13595
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13595

EvolutionaryTraceⁱ

P13595

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	20 – 111	Ig-like C2-type 1Add BLAST	92
Domainⁱ	116 – 205	Ig-like C2-type 2Add BLAST	90
Domainⁱ	212 – 302	Ig-like C2-type 3Add BLAST	91
Domainⁱ	309 – 402	Ig-like C2-type 4Add BLAST	94
Domainⁱ	407 – 492	Ig-like C2-type 5Add BLAST	86
Domainⁱ	500 – 599	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	100
Domainⁱ	601 – 696	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	96

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	152 – 156	Heparin-bindingSequence analysis	5
Regionⁱ	161 – 165	Heparin-bindingSequence analysis	5
Regionⁱ	756 – 809	DisorderedSequence analysisAdd BLAST	54
Regionⁱ	839 – 912	DisorderedSequence analysisAdd BLAST	74
Regionⁱ	924 – 1115	DisorderedSequence analysisAdd BLAST	192

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	757 – 798	Basic and acidic residuesSequence analysisAdd BLAST	42
Compositional biasⁱ	839 – 891	Polar residuesSequence analysisAdd BLAST	53
Compositional biasⁱ	1006 – 1020	Polar residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	1078 – 1092	Basic and acidic residuesSequence analysisAdd BLAST	15

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3510, Eukaryota
InParanoidⁱ	P13595
Database of Orthologous Groups More...OrthoDBⁱ	129648at2759
PhylomeDBⁱ	P13595

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063, FN3, 2 hits
Gene3Dⁱ	2.60.40.10, 7 hits
InterProⁱ	View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR033019, Ncam1 IPR009138, Neural_cell_adh
PANTHERⁱ	PTHR12231:SF239, PTHR12231:SF239, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 3 hits
PRINTSⁱ	PR01838, NCAMFAMILY
SMARTⁱ	View protein in SMART SM00060, FN3, 2 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 2 hits
SUPFAMⁱ	SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853, FN3, 2 hits PS50835, IG_LIKE, 5 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P13595-1) [UniParc]FASTA Add to basket

Also known as: N-CAM 180

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK 
        60         70         80         90        100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA 
       110        120        130        140        150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII 
       160        170        180        190        200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 
       210        220        230        240        250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD 
       260        270        280        290        300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS 
       310        320        330        340        350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS 
       360        370        380        390        400
SEEKTLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY 
       410        420        430        440        450
LEFQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN 
       460        470        480        490        500
YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES LEFILVQADT 
       510        520        530        540        550
PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS LGEESWHFKW 
       560        570        580        590        600
YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR 
       610        620        630        640        650
EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR ALASEWKPEI 
       660        670        680        690        700
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP 
       710        720        730        740        750
ANGSPTAGLS TGAIVGILIV IFVLLLVVMD ITCYFLNKCG LLMCIAVNLC 
       760        770        780        790        800
GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN HDGGKHTEPN 
       810        820        830        840        850
ETTPLTEPEL PADTTATVED MLPSVTTVTT NSDTITETFA TAQNSPTSET 
       860        870        880        890        900
TTLTSSIAPP ATTVPDSNSV PAGQATPSKG VTASSSSPAS APKVAPLVDL 
       910        920        930        940        950
SDTPTSAPSA SNLSSTVLAN QGAVLSPSTP ASAGETSKAP PASKASPAPT 
       960        970        980        990       1000
PTPAGAASPL AAVAAPATDA PQAKQEAPST KGPDPEPTQP GTVKNPPEAA 
      1010       1020       1030       1040       1050
TAPASPKSKA ATTNPSQGED LKMDEGNFKT PDIDLAKDVF AALGSPRPAT 
      1060       1070       1080       1090       1100
GASGQASELA PSPADSAVPP APAKTEKGPV ETKSEPPESE AKPAPTEVKT 
      1110 
VPNDATQTKE NESKA

Length:1,115

Mass (Da):119,427

Last modified:July 22, 2008 - v3

Checksum:ⁱ78AF831BABD23918

GO

Isoform 2 (identifier: P13595-2) [UniParc]FASTA Add to basket

Also known as: N-CAM 140

The sequence of this isoform differs from the canonical sequence as follows:
810-1076: Missing.

« Hide

        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK 
        60         70         80         90        100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA 
       110        120        130        140        150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII 
       160        170        180        190        200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 
       210        220        230        240        250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD 
       260        270        280        290        300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS 
       310        320        330        340        350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS 
       360        370        380        390        400
SEEKTLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY 
       410        420        430        440        450
LEFQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN 
       460        470        480        490        500
YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES LEFILVQADT 
       510        520        530        540        550
PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS LGEESWHFKW 
       560        570        580        590        600
YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR 
       610        620        630        640        650
EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR ALASEWKPEI 
       660        670        680        690        700
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP 
       710        720        730        740        750
ANGSPTAGLS TGAIVGILIV IFVLLLVVMD ITCYFLNKCG LLMCIAVNLC 
       760        770        780        790        800
GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN HDGGKHTEPN 
       810        820        830        840 
ETTPLTEPEK GPVETKSEPP ESEAKPAPTE VKTVPNDATQ TKENESKA

Show »

Length:848

Mass (Da):93,540

Checksum:ⁱ4D77D553F474AD8E

GO

Isoform 3 (identifier: P13595-3) [UniParc] [UniParc]FASTA Add to basket

Also known as: N-CAM 120

The sequence of this isoform differs from the canonical sequence as follows:
702-725: NGSPTAGLSTGAIVGILIVIFVLL → TLGGSSTSYTLVSLLFSAVTLLLL
726-1115: Missing.

« Hide

        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK 
        60         70         80         90        100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA 
       110        120        130        140        150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII 
       160        170        180        190        200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 
       210        220        230        240        250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD 
       260        270        280        290        300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS 
       310        320        330        340        350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS 
       360        370        380        390        400
SEEKTLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY 
       410        420        430        440        450
LEFQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN 
       460        470        480        490        500
YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES LEFILVQADT 
       510        520        530        540        550
PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS LGEESWHFKW 
       560        570        580        590        600
YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR 
       610        620        630        640        650
EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR ALASEWKPEI 
       660        670        680        690        700
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP 
       710        720 
ATLGGSSTSY TLVSLLFSAV TLLLL

Show »

Length:725

Mass (Da):80,406

Checksum:ⁱ97867C2A61594CC4

GO

Isoform 4 (identifier: P13595-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
601-605: EPSAP → KSSLF
606-1115: Missing.

« Hide

        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK 
        60         70         80         90        100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA 
       110        120        130        140        150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII 
       160        170        180        190        200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 
       210        220        230        240        250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD 
       260        270        280        290        300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS 
       310        320        330        340        350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS 
       360        370        380        390        400
SEEKTLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY 
       410        420        430        440        450
LEFQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN 
       460        470        480        490        500
YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES LEFILVQADT 
       510        520        530        540        550
PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS LGEESWHFKW 
       560        570        580        590        600
YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR 

KSSLF

Show »

Length:605

Mass (Da):67,353

Checksum:ⁱD497D834C34EAEC0

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9QB01	E9QB01_MOUSE	Neural cell adhesion molecule 1 Neural cell adhesion molecule 1	Ncam1	849	Annotation score:
A0A0A6YY47	A0A0A6YY47_MOUSE	Neural cell adhesion molecule 1 Neural cell adhesion molecule 1	Ncam1	848	Annotation score:
A0A0A6YY91	A0A0A6YY91_MOUSE	Neural cell adhesion molecule 1 Neural cell adhesion molecule 1	Ncam1	1,089	Annotation score:
E9Q589	E9Q589_MOUSE	Neural cell adhesion molecule 1 Neural cell adhesion molecule 1	Ncam1	725	Annotation score:
A0A0A6YWU2	A0A0A6YWU2_MOUSE	Neural cell adhesion molecule 1 Neural cell adhesion molecule 1	Ncam1	605	Annotation score:
A0A0A6YWW5	A0A0A6YWW5_MOUSE	Neural cell adhesion molecule 1 Neural cell adhesion molecule 1	Ncam1	49	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	20	L → M in CAA33148 (PubMed:2721486).Curated	1
Sequence conflictⁱ	158	V → F in AAH11310 (PubMed:15489334).Curated	1
Sequence conflictⁱ	261 – 268	DEKHIFSD → ERSRSSVS in CAA68263 (PubMed:3595563).Curated	8
Sequence conflictⁱ	273	L → V in CAA68263 (PubMed:3595563).Curated	1
Sequence conflictⁱ	354 – 355	KT → QD in CAA68263 (PubMed:3595563).Curated	2
Sequence conflictⁱ	379	T → R in CAA68263 (PubMed:3595563).Curated	1
Sequence conflictⁱ	379	T → R in CAA33148 (PubMed:2721486).Curated	1
Sequence conflictⁱ	385	I → M in CAA68263 (PubMed:3595563).Curated	1
Sequence conflictⁱ	385	I → M in CAA33148 (PubMed:2721486).Curated	1
Sequence conflictⁱ	399 – 400	MY → ID in CAA68263 (PubMed:3595563).Curated	2
Sequence conflictⁱ	399 – 400	MY → ID in CAA33148 (PubMed:2721486).Curated	2
Sequence conflictⁱ	403	F → V in AAH11310 (PubMed:15489334).Curated	1
Sequence conflictⁱ	403	F → V in BAC34554 (PubMed:16141072).Curated	1
Sequence conflictⁱ	403	F → V in BAC38551 (PubMed:16141072).Curated	1
Sequence conflictⁱ	549	K → T in CAA68263 (PubMed:3595563).Curated	1
Sequence conflictⁱ	572	R → T in CAA68263 (PubMed:3595563).Curated	1
Sequence conflictⁱ	575	V → D in CAA68263 (PubMed:3595563).Curated	1
Sequence conflictⁱ	589 – 594	SAATEF → MQPSES in CAA68263 (PubMed:3595563).Curated	6
Sequence conflictⁱ	600 – 602	REP → PEL in CAA68263 (PubMed:3595563).Curated	3
Sequence conflictⁱ	657	D → H in CAA68263 (PubMed:3595563).Curated	1
Sequence conflictⁱ	733	C → W in BAC34554 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1082	T → A in BAC34554 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_034826	601 – 605	EPSAP → KSSLF in isoform 4. 1 Publication	5
Alternative sequenceⁱVSP_034827	606 – 1115	Missing in isoform 4. 1 PublicationAdd BLAST	510
Alternative sequenceⁱVSP_034828	702 – 725	NGSPT…IFVLL → TLGGSSTSYTLVSLLFSAVT LLLL in isoform 3. 1 PublicationAdd BLAST	24
Alternative sequenceⁱVSP_034829	726 – 1115	Missing in isoform 3. 1 PublicationAdd BLAST	390
Alternative sequenceⁱVSP_002588	810 – 1076	Missing in isoform 2. 3 PublicationsAdd BLAST	267

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00051 mRNA Translation: CAA68263.1 BC011310 mRNA Translation: AAH11310.1 AK051197 mRNA Translation: BAC34554.2 AK082621 mRNA Translation: BAC38551.2 X15049 mRNA Translation: CAA33148.1 X15051 mRNA Translation: CAA33150.1 X15052 mRNA Translation: CAA33151.1 X06328 mRNA Translation: CAA29641.1 X07195 Genomic DNA Translation: CAA30173.1 X07197 Genomic DNA Translation: CAA30175.1 X07198 Genomic DNA Translation: CAB40820.1 X07200 Genomic DNA Translation: CAA30177.1 X07244 mRNA Translation: CAA30230.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40617.1 [P13595-2] CCDS40618.1 [P13595-3]
PIRⁱ	A29673, IJMSNL
NCBI Reference Sequences More...RefSeqⁱ	NP_001074914.1, NM_001081445.1 NP_001106675.1, NM_001113204.1 NP_001297994.1, NM_001311065.1 NP_035005.2, NM_010875.3

Genome annotation databases

GeneIDⁱ	17967
KEGGⁱ	mmu:17967
UCSC genome browser More...UCSCⁱ	uc009pje.2, mouse [P13595-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13595	neural cell adhesion molecule 1 isoform X5		MUSCR		1122	UniRef90_P13595
Neural cell adhesion molecule (Fragment)		MOUSE		96
Neural cell adhesion molecule 1 (Fragment)		BUBBU		46
neural cell adhesion molecule 1 isoform X6		MUSCR		1116
neural cell adhesion molecule 1 isoform X7		MUSCR		1115
+16
P13595-4	Uncharacterized protein		RHIRO		756	UniRef90_P13595-4
Uncharacterized protein		RHIBE		756
Neural cell adhesion molecule 1		MOUSE		605

Protein	Similar proteins		Species	Score	Length	Source
P13595	Neural cell adhesion molecule 1	)	CHICK		1091	UniRef50_P13595
Neural cell adhesion molecule 1-A		XENLA		1088
neural cell adhesion molecule 1 isoform X5		MUSCR		1122
Neural cell adhesion molecule (Fragment)		MOUSE		96
Neural cell adhesion molecule 1 (Fragment)		BUBBU		46
+1405
P13595-2	Neural cell adhesion molecule 1	)	RAT		858	UniRef50_P13596
Neural cell adhesion molecule 1	)	HUMAN		858
Uncharacterized protein		RHIRO		843
Uncharacterized protein		RHIBE		843
Neural cell adhesion molecule 1		PANTR		877
+601
P13595-3	Neural cell adhesion molecule 1-like		NEOBR		735	UniRef50_P13595-3
Uncharacterized protein		PIG		616
Neural cell adhesion molecule 1-like		Sinocyclocheilus rhinocerous		718
Neural cell adhesion molecule 1		RABIT		761
neural cell adhesion molecule 1 isoform X13		SALSA		721
+823

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00051 mRNA Translation: CAA68263.1 BC011310 mRNA Translation: AAH11310.1 AK051197 mRNA Translation: BAC34554.2 AK082621 mRNA Translation: BAC38551.2 X15049 mRNA Translation: CAA33148.1 X15051 mRNA Translation: CAA33150.1 X15052 mRNA Translation: CAA33151.1 X06328 mRNA Translation: CAA29641.1 X07195 Genomic DNA Translation: CAA30173.1 X07197 Genomic DNA Translation: CAA30175.1 X07198 Genomic DNA Translation: CAB40820.1 X07200 Genomic DNA Translation: CAA30177.1 X07244 mRNA Translation: CAA30230.1
CCDSⁱ	CCDS40617.1 [P13595-2] CCDS40618.1 [P13595-3]
PIRⁱ	A29673, IJMSNL
RefSeqⁱ	NP_001074914.1, NM_001081445.1 NP_001106675.1, NM_001113204.1 NP_001297994.1, NM_001311065.1 NP_035005.2, NM_010875.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2NCM	NMR	-	A	20-116	[»]
	3NCM	NMR	-	A	119-208	[»]
BMRBⁱ	P13595
SMRⁱ	P13595
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	201699, 17 interactors
CORUMⁱ	P13595
IntActⁱ	P13595, 8 interactors
MINTⁱ	P13595
STRINGⁱ	10090.ENSMUSP00000130668

PTM databases

GlyConnectⁱ	2535, 6 N-Linked glycans (3 sites)
GlyGenⁱ	P13595, 6 sites, 6 N-linked glycans (3 sites)
iPTMnetⁱ	P13595
PhosphoSitePlusⁱ	P13595
SwissPalmⁱ	P13595

Proteomic databases

CPTACⁱ	non-CPTAC-3846
jPOSTⁱ	P13595
MaxQBⁱ	P13595
PaxDbⁱ	P13595
PeptideAtlasⁱ	P13595
PRIDEⁱ	P13595
ProteomicsDBⁱ	287445 [P13595-1] 287446 [P13595-2] 287447 [P13595-3] 287448 [P13595-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	17967

DNASUⁱ

17967

Genome annotation databases

GeneIDⁱ	17967
KEGGⁱ	mmu:17967
UCSCⁱ	uc009pje.2, mouse [P13595-1]

Organism-specific databases

CTDⁱ	4684
MGIⁱ	MGI:97281, Ncam1

Phylogenomic databases

eggNOGⁱ	KOG3510, Eukaryota
InParanoidⁱ	P13595
OrthoDBⁱ	129648at2759
PhylomeDBⁱ	P13595

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375165, NCAM signaling for neurite out-growth R-MMU-419037, NCAM1 interactions R-MMU-445144, Signal transduction by L1 R-MMU-5673001, RAF/MAP kinase cascade

Reactomeⁱ

R-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-419037, NCAM1 interactions
R-MMU-445144, Signal transduction by L1
R-MMU-5673001, RAF/MAP kinase cascade

Miscellaneous databases

BioGRID-ORCSⁱ	17967, 1 hit in 64 CRISPR screens
ChiTaRSⁱ	Ncam1, mouse
EvolutionaryTraceⁱ	P13595
Protein Ontology More...PROⁱ	PR:P13595
RNActⁱ	P13595, protein
SOURCEⁱ	Search...

Family and domain databases

CDDⁱ	cd00063, FN3, 2 hits
Gene3Dⁱ	2.60.40.10, 7 hits
InterProⁱ	View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR033019, Ncam1 IPR009138, Neural_cell_adh
PANTHERⁱ	PTHR12231:SF239, PTHR12231:SF239, 1 hit
Pfamⁱ	View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 3 hits
PRINTSⁱ	PR01838, NCAMFAMILY
SMARTⁱ	View protein in SMART SM00060, FN3, 2 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 2 hits
SUPFAMⁱ	SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853, FN3, 2 hits PS50835, IG_LIKE, 5 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NCAM1_MOUSE
Accessionⁱ	P13595Primary (citable) accession number: P13595 Secondary accession number(s): P13594 Q9R2A7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	July 22, 2008
	Last modified:	September 29, 2021
	This is version 206 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P13595 (NCAM1_MOUSE)

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Neural cell adhesion molecule 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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Keywords - Domaini

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Keywords - Technical termⁱ