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Protein

Neural cell adhesion molecule 1

Gene

NCAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
(Microbial infection) Acts as a receptor for rabies virus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processCell adhesion, Host-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000178 ECM proteoglycans
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-419037 NCAM1 interactions
R-HSA-445144 Signal transduction by L1
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P13591

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neural cell adhesion molecule 1
Short name:
N-CAM-1
Short name:
NCAM-1
Alternative name(s):
CD_antigen: CD56
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCAM1
Synonyms:NCAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149294.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7656 NCAM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
116930 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13591

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 718ExtracellularSequence analysisAdd BLAST699
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei719 – 739HelicalSequence analysisAdd BLAST21
Topological domaini740 – 858CytoplasmicSequence analysisAdd BLAST119

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4684

Open Targets

More...
OpenTargetsi
ENSG00000149294

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31459

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712938

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCAM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205830665

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001500920 – 858Neural cell adhesion molecule 1Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 96By similarity
Disulfide bondi139 ↔ 189By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi235 ↔ 287By similarity
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 395Curated
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi436 ↔ 489Curated
Glycosylationi459N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei780PhosphoserineBy similarity1
Modified residuei784PhosphoserineBy similarity1
Isoform 4 (identifier: P13591-4)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi706GPI-anchor amidated asparagineSequence analysis1
Isoform 3 (identifier: P13591-3)
Lipidationi741GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13591

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P13591

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13591

PeptideAtlas

More...
PeptideAtlasi
P13591

PRoteomics IDEntifications database

More...
PRIDEi
P13591

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52931
52932 [P13591-1]
52933 [P13591-3]
52934 [P13591-4]
52935 [P13591-5]
52936 [P13591-6]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1545

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13591

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13591

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13591

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149294 Expressed in 220 organ(s), highest expression level in neocortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13591 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13591 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000142
CAB018071
HPA039835

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

(Microbial infection) Interacts with rabies virus glycoprotein.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110764, 32 interactors

Database of interacting proteins

More...
DIPi
DIP-59530N

Protein interaction database and analysis system

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IntActi
P13591, 10 interactors

Molecular INTeraction database

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MINTi
P13591

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000318472

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1858
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E3VX-ray1.95A/B/C510-619[»]
2HAZX-ray1.70A508-608[»]
2VKWX-ray2.30A/B506-702[»]
2VKXX-ray2.70A/B/C/D/E/F506-702[»]
3MTRX-ray1.80A/B414-611[»]
5AEAX-ray1.90A/B20-116[»]
5LKNNMR-A611-702[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P13591

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13591

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P13591

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 111Ig-like C2-type 1Add BLAST92
Domaini116 – 205Ig-like C2-type 2Add BLAST90
Domaini212 – 301Ig-like C2-type 3Add BLAST90
Domaini308 – 413Ig-like C2-type 4Add BLAST106
Domaini416 – 501Ig-like C2-type 5Add BLAST86
Domaini509 – 608Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST100
Domaini611 – 706Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQJI Eukaryota
ENOG410XTGB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155743

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052579

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P13591

KEGG Orthology (KO)

More...
KOi
K06491

Database of Orthologous Groups

More...
OrthoDBi
129648at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13591

TreeFam database of animal gene trees

More...
TreeFami
TF326195

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033019 Ncam1
IPR009138 Neural_cell_adh

The PANTHER Classification System

More...
PANTHERi
PTHR44059:SF2 PTHR44059:SF2, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01838 NCAMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13591-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG
110 120 130 140 150
EDGSESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF PEPTMSWTKD
260 270 280 290 300
GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI
310 320 330 340 350
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS
360 370 380 390 400
EEKASWTRPE KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT
410 420 430 440 450
IGQDSQSMYL EVQYAPKLQG PVAVYTWEGN QVNITCEVFA YPSATISWFR
460 470 480 490 500
DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS ENDFGNYNCT AVNRIGQESL
510 520 530 540 550
EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI LKYKAEWRAV
560 570 580 590 600
GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA
610 620 630 640 650
SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR
660 670 680 690 700
ALSSEWKPEI RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF
710 720 730 740 750
RTSAQPTAIP ANGSPTSGLS TGAIVGILIV IFVLLLVVVD ITCYFLNKCG
760 770 780 790 800
LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN
810 820 830 840 850
HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE VKTVPNDATQ

TKENESKA
Length:858
Mass (Da):94,574
Last modified:July 22, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD3B9DE80D802554
GO
Isoform 2 (identifier: P13591-1) [UniParc]FASTAAdd to basket
Also known as: N-CAM 140

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.

Show »
Length:848
Mass (Da):93,361
Checksum:i68D2F0C0E6C1C2AD
GO
Isoform 3 (identifier: P13591-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: N-CAM 120

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.
     609-609: Q → HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAK
     712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
     737-858: Missing.

Show »
Length:761
Mass (Da):83,770
Checksum:iF0CAD3292D7AB67E
GO
Isoform 4 (identifier: P13591-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.
     712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
     737-858: Missing.

Show »
Length:726
Mass (Da):80,312
Checksum:i1B6D55D0BF65200F
GO
Isoform 5 (identifier: P13591-5) [UniParc] [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     609-665: QGEPSAPKLE...WKPEIRLPSG → HSPPPPASAS...QAGLHNALMK
     666-858: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:665
Mass (Da):73,473
Checksum:iE496F232C162C614
GO
Isoform 6 (identifier: P13591-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-364: T → V
     365-858: Missing.

Show »
Length:364
Mass (Da):40,760
Checksum:iAC697008755FE6FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWD4A0A087WWD4_HUMAN
Neural cell adhesion molecule 1
NCAM1
884Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV75A0A087WV75_HUMAN
Neural cell adhesion molecule 1
NCAM1
884Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTF6A0A087WTF6_HUMAN
Neural cell adhesion molecule 1
NCAM1
848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX77A0A087WX77_HUMAN
Neural cell adhesion molecule 1
NCAM1
858Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYX6H7BYX6_HUMAN
Neural cell adhesion molecule 1
NCAM1
725Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTE4A0A087WTE4_HUMAN
Neural cell adhesion molecule 1
NCAM1
761Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1V2A0A087X1V2_HUMAN
Neural cell adhesion molecule 1
NCAM1
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVU1A0A087WVU1_HUMAN
Neural cell adhesion molecule 1
NCAM1
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWJ5A0A087WWJ5_HUMAN
Neural cell adhesion molecule 1
NCAM1
372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SF98A0A0D9SF98_HUMAN
Neural cell adhesion molecule 1
NCAM1
357Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92680 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti215Q → R in AAB04558 (PubMed:1710251).Curated1
Sequence conflicti239G → R in AAB04558 (PubMed:1710251).Curated1
Sequence conflicti500L → F in AAB04558 (PubMed:1710251).Curated1
Sequence conflicti560Y → H in BAF85142 (PubMed:14702039).Curated1
Sequence conflicti609 – 610QG → R in AAA59913 (PubMed:2887295).Curated2
Sequence conflicti730 – 731Missing in AAA59913 (PubMed:2887295).Curated2
Sequence conflicti821G → A in AAA59913 (PubMed:2887295).Curated1
Sequence conflicti856S → N in AAH47244 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0613317L → F. Corresponds to variant dbSNP:rs7105734Ensembl.1
Natural variantiVAR_049960260D → N. Corresponds to variant dbSNP:rs17115160Ensembl.1
Natural variantiVAR_049961679E → D1 PublicationCorresponds to variant dbSNP:rs17115280Ensembl.1
Natural variantiVAR_049962834T → M. Corresponds to variant dbSNP:rs17174409Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034818354 – 363Missing in isoform 2, isoform 3 and isoform 4. 5 Publications10
Alternative sequenceiVSP_034819364T → V in isoform 6. 1 Publication1
Alternative sequenceiVSP_034820365 – 858Missing in isoform 6. 1 PublicationAdd BLAST494
Alternative sequenceiVSP_034821609 – 665QGEPS…RLPSG → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAKNIAQ NHCCNMFQAGLHNALMK in isoform 5. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_034822609Q → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAK in isoform 3. 2 Publications1
Alternative sequenceiVSP_034823666 – 858Missing in isoform 5. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_034824712 – 736NGSPT…FVLLL → TLGGNSASYTFVSLLFSAVT LLLLC in isoform 3 and isoform 4. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_034825737 – 858Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16841 mRNA Translation: CAA34739.1
U63041 mRNA Translation: AAB04558.1
S71824 mRNA Translation: AAB31836.1
AK292453 mRNA Translation: BAF85142.1
AB209443 mRNA Translation: BAD92680.1 Different initiation.
BC014205 mRNA Translation: AAH14205.2
BC029119 mRNA Translation: AAH29119.1
BC047244 mRNA Translation: AAH47244.1
S73101 mRNA Translation: AAB20698.1
M17410 mRNA Translation: AAA59913.1
M17409 mRNA Translation: AAA59912.1
M22094 mRNA Translation: AAA59910.1
M22092, M22091 Genomic DNA Translation: AAA59911.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73385.1 [P13591-2]
CCDS73386.1 [P13591-3]
CCDS73387.1 [P13591-4]
CCDS73388.1 [P13591-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A31635
I54773
S07784 IJHUNG

NCBI Reference Sequences

More...
RefSeqi
NP_000606.3, NM_000615.6 [P13591-1]
NP_001070150.1, NM_001076682.3 [P13591-3]
NP_001229537.1, NM_001242608.1 [P13591-4]
NP_851996.2, NM_181351.4 [P13591-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.503878
Hs.711235
Hs.733031

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316851; ENSP00000318472; ENSG00000149294 [P13591-2]
ENST00000529356; ENSP00000482205; ENSG00000149294 [P13591-6]
ENST00000531044; ENSP00000484943; ENSG00000149294 [P13591-1]
ENST00000621128; ENSP00000481083; ENSG00000149294 [P13591-4]
ENST00000621850; ENSP00000480774; ENSG00000149294 [P13591-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4684

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4684

UCSC genome browser

More...
UCSCi
uc031yfh.2 human [P13591-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

NCAM entry

Functional Glycomics Gateway - Glycan Binding

N-CAM 140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16841 mRNA Translation: CAA34739.1
U63041 mRNA Translation: AAB04558.1
S71824 mRNA Translation: AAB31836.1
AK292453 mRNA Translation: BAF85142.1
AB209443 mRNA Translation: BAD92680.1 Different initiation.
BC014205 mRNA Translation: AAH14205.2
BC029119 mRNA Translation: AAH29119.1
BC047244 mRNA Translation: AAH47244.1
S73101 mRNA Translation: AAB20698.1
M17410 mRNA Translation: AAA59913.1
M17409 mRNA Translation: AAA59912.1
M22094 mRNA Translation: AAA59910.1
M22092, M22091 Genomic DNA Translation: AAA59911.1
CCDSiCCDS73385.1 [P13591-2]
CCDS73386.1 [P13591-3]
CCDS73387.1 [P13591-4]
CCDS73388.1 [P13591-1]
PIRiA31635
I54773
S07784 IJHUNG
RefSeqiNP_000606.3, NM_000615.6 [P13591-1]
NP_001070150.1, NM_001076682.3 [P13591-3]
NP_001229537.1, NM_001242608.1 [P13591-4]
NP_851996.2, NM_181351.4 [P13591-2]
UniGeneiHs.503878
Hs.711235
Hs.733031

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E3VX-ray1.95A/B/C510-619[»]
2HAZX-ray1.70A508-608[»]
2VKWX-ray2.30A/B506-702[»]
2VKXX-ray2.70A/B/C/D/E/F506-702[»]
3MTRX-ray1.80A/B414-611[»]
5AEAX-ray1.90A/B20-116[»]
5LKNNMR-A611-702[»]
ProteinModelPortaliP13591
SMRiP13591
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110764, 32 interactors
DIPiDIP-59530N
IntActiP13591, 10 interactors
MINTiP13591
STRINGi9606.ENSP00000318472

Chemistry databases

ChEMBLiCHEMBL3712938

PTM databases

GlyConnecti1545
iPTMnetiP13591
PhosphoSitePlusiP13591
SwissPalmiP13591

Polymorphism and mutation databases

BioMutaiNCAM1
DMDMi205830665

Proteomic databases

EPDiP13591
jPOSTiP13591
PaxDbiP13591
PeptideAtlasiP13591
PRIDEiP13591
ProteomicsDBi52931
52932 [P13591-1]
52933 [P13591-3]
52934 [P13591-4]
52935 [P13591-5]
52936 [P13591-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4684
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316851; ENSP00000318472; ENSG00000149294 [P13591-2]
ENST00000529356; ENSP00000482205; ENSG00000149294 [P13591-6]
ENST00000531044; ENSP00000484943; ENSG00000149294 [P13591-1]
ENST00000621128; ENSP00000481083; ENSG00000149294 [P13591-4]
ENST00000621850; ENSP00000480774; ENSG00000149294 [P13591-3]
GeneIDi4684
KEGGihsa:4684
UCSCiuc031yfh.2 human [P13591-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4684
DisGeNETi4684
EuPathDBiHostDB:ENSG00000149294.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCAM1
HGNCiHGNC:7656 NCAM1
HPAiCAB000142
CAB018071
HPA039835
MIMi116930 gene
neXtProtiNX_P13591
OpenTargetsiENSG00000149294
PharmGKBiPA31459

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQJI Eukaryota
ENOG410XTGB LUCA
GeneTreeiENSGT00940000155743
HOVERGENiHBG052579
InParanoidiP13591
KOiK06491
OrthoDBi129648at2759
PhylomeDBiP13591
TreeFamiTF326195

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-419037 NCAM1 interactions
R-HSA-445144 Signal transduction by L1
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling
SIGNORiP13591

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCAM1 human
EvolutionaryTraceiP13591

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Neural_cell_adhesion_molecule

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4684

Protein Ontology

More...
PROi
PR:P13591

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149294 Expressed in 220 organ(s), highest expression level in neocortex
ExpressionAtlasiP13591 baseline and differential
GenevisibleiP13591 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033019 Ncam1
IPR009138 Neural_cell_adh
PANTHERiPTHR44059:SF2 PTHR44059:SF2, 2 hits
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
PRINTSiPR01838 NCAMFAMILY
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCAM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13591
Secondary accession number(s): A8K8T8
, P13592, P13593, Q05C58, Q15829, Q16180, Q16209, Q59FL7, Q86X47, Q96CJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 22, 2008
Last modified: January 16, 2019
This is version 201 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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