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Protein

Cytochrome P450 4B1

Gene

CYP4B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei315Heme (covalent; via 1 link)By similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi453Iron (heme axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-211935 Fatty acids
R-HSA-211958 Miscellaneous substrates
R-HSA-211979 Eicosanoids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 4B1 (EC:1.14.14.1)
Alternative name(s):
CYPIVB1
Cytochrome P450-HP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP4B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000142973.12

Human Gene Nomenclature Database

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HGNCi
HGNC:2644 CYP4B1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
124075 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13584

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1580

Open Targets

More...
OpenTargetsi
ENSG00000142973

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27119

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00683 Midazolam
DB01174 Phenobarbital
DB00152 Thiamine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP4B1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48429213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000518191 – 511Cytochrome P450 4B1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei436PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13584

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13584

PeptideAtlas

More...
PeptideAtlasi
P13584

PRoteomics IDEntifications database

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PRIDEi
P13584

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52929
52930 [P13584-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13584

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13584

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the liver and lung (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000142973 Expressed in 171 organ(s), highest expression level in bronchial epithelial cell

CleanEx database of gene expression profiles

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CleanExi
HS_CYP4B1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P13584 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13584 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004331

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107952, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360991

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13584

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13584

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0157 Eukaryota
COG2124 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161441

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233833

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000182

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13584

KEGG Orthology (KO)

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KOi
K07426

Identification of Orthologs from Complete Genome Data

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OMAi
AHPLWLG

Database of Orthologous Groups

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OrthoDBi
1247045at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13584

TreeFam database of animal gene trees

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TreeFami
TF105088

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00463 EP450I
PR00385 P450

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP
60 70 80 90 100
THWLFGHALE IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA
110 120 130 140 150
KAVYSRGDPK APDVYDFFLQ WIGRGLLVLE GPKWLQHRKL LTPGFHYDVL
160 170 180 190 200
KPYVAVFTES TRIMLDKWEE KAREGKSFDI FCDVGHMALN TLMKCTFGRG
210 220 230 240 250
DTGLGHRDSS YYLAVSDLTL LMQQRLVSFQ YHNDFIYWLT PHGRRFLRAC
260 270 280 290 300
QVAHDHTDQV IRERKAALQD EKVRKKIQNR RHLDFLDILL GARDEDDIKL
310 320 330 340 350
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQHR CREEVREILG
360 370 380 390 400
DQDFFQWDDL GKMTYLTMCI KESFRLYPPV PQVYRQLSKP VTFVDGRSLP
410 420 430 440 450
AGSLISMHIY ALHRNSAVWP DPEVFDSLRF STENASKRHP FAFMPFSAGP
460 470 480 490 500
RNCIGQQFAM SEMKVVTAMC LLRFEFSLDP SRLPIKMPQL VLRSKNGFHL
510
HLKPLGPGSG K
Length:511
Mass (Da):58,991
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91FED40949507EB8
GO
Isoform 2 (identifier: P13584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-206: H → HS

Show »
Length:512
Mass (Da):59,078
Checksum:i1C5FB3436D612DD7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IZB0Q8IZB0_HUMAN
Cytochrome P450 4B1
CYP4B1
497Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8WWV1Q8WWV1_HUMAN
Cytochrome P450 4B1
CYP4B1 hCG_22100
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PML0E9PML0_HUMAN
Cytochrome P450 4B1
CYP4B1
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5Q6F5H5Q6_HUMAN
Cytochrome P450 4B1
CYP4B1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1Q8F5H1Q8_HUMAN
Cytochrome P450 4B1
CYP4B1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL36E9PL36_HUMAN
Cytochrome P450 4B1
CYP4B1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37Q → R in AAA35712 (PubMed:2574990).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055377111A → V1 PublicationCorresponds to variant dbSNP:rs45559437Ensembl.1
Natural variantiVAR_018357173R → W in allele CYP4B1*3 and allele CYP4B1*6. 2 PublicationsCorresponds to variant dbSNP:rs4646487Ensembl.1
Natural variantiVAR_048453264R → W1 PublicationCorresponds to variant dbSNP:rs45446505Ensembl.1
Natural variantiVAR_055378274R → Q1 PublicationCorresponds to variant dbSNP:rs45578838Ensembl.1
Natural variantiVAR_018358322S → G in allele CYP4B1*4. 2 PublicationsCorresponds to variant dbSNP:rs45467195Ensembl.1
Natural variantiVAR_048454329Y → S1 PublicationCorresponds to variant dbSNP:rs12094024Ensembl.1
Natural variantiVAR_018359331M → I in allele CYP4B1*2, allele CYP4B1*7 and allele CYP4B1*5. 2 PublicationsCorresponds to variant dbSNP:rs2297810Ensembl.1
Natural variantiVAR_018360340R → C in allele CYP4B1*2 and allele CYP4B1*7. 2 PublicationsCorresponds to variant dbSNP:rs4646491Ensembl.1
Natural variantiVAR_018361345V → I in allele CYP4B1*6. 1
Natural variantiVAR_048455354F → C1 PublicationCorresponds to variant dbSNP:rs17102592Ensembl.1
Natural variantiVAR_018362375R → C in allele CYP4B1*2. 2 PublicationsCorresponds to variant dbSNP:rs2297809Ensembl.1
Natural variantiVAR_048456482R → Q1 PublicationCorresponds to variant dbSNP:rs45622937Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038419206H → HS in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02871 mRNA Translation: AAA35712.1
X16699 mRNA Translation: CAA34672.1
AF491285 mRNA Translation: AAM09532.1
AY064485 mRNA Translation: AAL57720.1
AY064486 mRNA Translation: AAL57721.1
AY151048 mRNA Translation: AAN72311.1
DQ518907 Genomic DNA Translation: ABF47106.1
AL593856 Genomic DNA No translation available.
AL356793 Genomic DNA No translation available.
BC017758 mRNA Translation: AAH17758.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41328.1 [P13584-2]
CCDS542.1 [P13584-1]

Protein sequence database of the Protein Information Resource

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PIRi
S07765 O4HUB1

NCBI Reference Sequences

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RefSeqi
NP_000770.2, NM_000779.3 [P13584-1]
NP_001093242.1, NM_001099772.1 [P13584-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.436317

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271153; ENSP00000271153; ENSG00000142973 [P13584-1]
ENST00000371923; ENSP00000360991; ENSG00000142973 [P13584-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1580

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1580

UCSC genome browser

More...
UCSCi
uc001cqm.5 human [P13584-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP4B1 alleles

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02871 mRNA Translation: AAA35712.1
X16699 mRNA Translation: CAA34672.1
AF491285 mRNA Translation: AAM09532.1
AY064485 mRNA Translation: AAL57720.1
AY064486 mRNA Translation: AAL57721.1
AY151048 mRNA Translation: AAN72311.1
DQ518907 Genomic DNA Translation: ABF47106.1
AL593856 Genomic DNA No translation available.
AL356793 Genomic DNA No translation available.
BC017758 mRNA Translation: AAH17758.1
CCDSiCCDS41328.1 [P13584-2]
CCDS542.1 [P13584-1]
PIRiS07765 O4HUB1
RefSeqiNP_000770.2, NM_000779.3 [P13584-1]
NP_001093242.1, NM_001099772.1 [P13584-2]
UniGeneiHs.436317

3D structure databases

ProteinModelPortaliP13584
SMRiP13584
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107952, 1 interactor
STRINGi9606.ENSP00000360991

Chemistry databases

DrugBankiDB00683 Midazolam
DB01174 Phenobarbital
DB00152 Thiamine

PTM databases

iPTMnetiP13584
PhosphoSitePlusiP13584

Polymorphism and mutation databases

BioMutaiCYP4B1
DMDMi48429213

Proteomic databases

EPDiP13584
PaxDbiP13584
PeptideAtlasiP13584
PRIDEiP13584
ProteomicsDBi52929
52930 [P13584-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1580
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271153; ENSP00000271153; ENSG00000142973 [P13584-1]
ENST00000371923; ENSP00000360991; ENSG00000142973 [P13584-2]
GeneIDi1580
KEGGihsa:1580
UCSCiuc001cqm.5 human [P13584-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1580
DisGeNETi1580
EuPathDBiHostDB:ENSG00000142973.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP4B1
HGNCiHGNC:2644 CYP4B1
HPAiHPA004331
MIMi124075 gene
neXtProtiNX_P13584
OpenTargetsiENSG00000142973
PharmGKBiPA27119

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00940000161441
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiP13584
KOiK07426
OMAiAHPLWLG
OrthoDBi1247045at2759
PhylomeDBiP13584
TreeFamiTF105088

Enzyme and pathway databases

ReactomeiR-HSA-211935 Fatty acids
R-HSA-211958 Miscellaneous substrates
R-HSA-211979 Eicosanoids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP4B1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYP4B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1580

Protein Ontology

More...
PROi
PR:P13584

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142973 Expressed in 171 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_CYP4B1
ExpressionAtlasiP13584 baseline and differential
GenevisibleiP13584 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP4B1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13584
Secondary accession number(s): Q1HBI2
, Q8TD85, Q8WWF2, Q8WWU9, Q8WWV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 7, 2004
Last modified: January 16, 2019
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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